@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MAPK3_HUMAN: (2015-10-13 )
MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSSASQGCNNQ
Atome Classification :
(33 SA)
.........10........20........30........40........50........60........70..-----..-------....80--........90.-----.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190-.-...-...-.200.......210.......220.......230.......240.......250.---......260.......270.......280.......290.......300....-...310-------........320.......330.......340.......350---.........360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREP
K
K
Y
AVTD
D
Y
Q
L
S
K
Q
V
LGLGVN
G
K
V
L
E
C
F
H
R
RT
G
Q
K
C
A
L
K
-----
L
L
-------YDSP
K
A
--
R
Q
E
V
D
H
HWQAS-----GG
P
H
I
V
C
I
L
D
V
Y
ENMHHG
K
R
C
L
L
I
I
M
E
C
MEG
G
E
L
F
S
R
I
Q
E
RGDQA
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
SHNIAHRDVKPEN
L
L
Y
TSKEK
D
A
V
L
K
LTDFGFA--
K
-
E
T
T
-
Q
N
A
-LQTPCYTPYYV
A
P
E
VL
G
P
E
K
YDKSCD
M
W
S
L
G
V
I
M
Y
I
L
L
CGFPPFYSNTGQAISP
G
---
M
K
R
R
I
RLGQYGFPNP
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
LKTDPTE
R
L
T
I
T
Q
FMNHPWINQ-SMVVP--------QTP
L
H
T
A
R
V
L
Q
EDK
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
VDY
D
Q
V
K
-----
I
K
D
LKTSN
N
R
L
L
N
K
R
R
K
K
QAGSSSASQGCNNQ
129
HHSearch
85.29
100%
-114
- C1 -
3FHR
1
MAPK3_HUMAN
A:
[21-336]
---------------------------------
P
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
-----
L
L
-------
Y
D
S
P
K
A
--
R
Q
E
V
D
H
H
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
-
D
Q
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
--
K
-
E
T
------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
P
--------
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
V
--------------------------------------
1
PsiBlast_PDB
85.04
100%
-113
- C1 -
3FHR
1
MAPK3_HUMAN
A:
[20-336]
--------------------------------
E
P
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
-----
L
L
-------
Y
D
S
P
K
A
--
R
Q
E
V
D
H
H
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
-
D
Q
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
--
K
-
E
T
------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
P
--------
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
V
--------------------------------------
4
PsiBlast_PDB
84.59
100%
-114
- C1 -
3SHE
1
MAPK3_HUMAN
A:
[1-316]
--------------------------------
E
P
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
-----
L
L
-------
Y
D
S
P
K
A
--
R
Q
E
V
D
H
H
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
----
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
--
K
-
E
T
------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
Y
-----------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
P
--------
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
---------------------------------------
2
PsiBlast_PDB
83.48
100%
-113
- C1 -
3FXW
1
MAPK3_HUMAN
A:
[20-336]
--------------------------------
E
P
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
Q
V
L
G
L
G
V
-
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
-----
L
L
-------
Y
D
S
P
K
A
--
R
Q
E
V
D
H
H
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
-
D
Q
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
--
K
-
E
-------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
P
--------
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
V
--------------------------------------
3
PsiBlast_PDB
83.25
100%
-109
- C1 -
3R1N
1
MAPK3_HUMAN
A:
[1-316]
--------------------------------
E
P
K
K
Y
A
V
T
D
D
Y
Q
L
S
K
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
-----
L
L
-------
Y
D
S
P
K
A
--
R
Q
E
V
D
H
H
W
Q
A
S
-----
G
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
G
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
G
--
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
----------------------
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
Y
-----------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
I
N
Q
-
S
M
V
V
P
--------
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
---------------------------------------
14
PsiBlast_PDB
77.83
76%
-117
- C1 -
3KA0
1
MAPK2_HUMAN
A:
[9-318]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
-------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---------
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
12
PsiBlast_PDB
74.27
76%
-112
- C1 -
3FYK
1
MAPK2_HUMAN
X:
[11-320]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
S-----------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
48
PsiBlast_CBE
72.42
76%
-103
- C1 -
2PZY
1
MAPK2_HUMAN
C:
[15-319]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
-------------------------------------------------
15
PsiBlast_PDB
71.75
76%
-112
- C1 -
2PZY
1
MAPK2_HUMAN
A:
[15-306]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
---
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
--------------------------------------------------------------
49
PsiBlast_CBE
71.66
76%
-111
- C1 -
2PZY
1
MAPK2_HUMAN
B:
[15-305]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
---------------------------------------------------------------
6
PsiBlast_PDB
71.45
75%
-119
- C1 -
1NY3
1
MAPK2_HUMAN
A:
[55-345]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
S
H
----------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
---------------------------------------------------------------
10
PsiBlast_PDB
69.77
76%
-109
- C1 -
2P3G
1
MAPK2_HUMAN
X:
[11-320]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
S-----------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
75
PsiBlast_CBE
69.29
76%
-120
- C1 -
3R2Y
1
MAPK2_HUMAN
A:
[10-300]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
--------------------------
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
-------------
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
---------------------------------------------------------------
128
HHSearch
69.25
74%
-106
- C1 -
1NXK
1
MAPK2_HUMAN
A:
[51-345]
------------------------------
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
---
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
---------------------------------------------------------------
13
PsiBlast_PDB
69.19
73%
-109
- C1 -
1NXK
1
MAPK2_HUMAN
A:
[55-345]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
---
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
---------------------------------------------------------------
130
HHSearch
68.49
74%
-99
- C1 -
3M2W
1
MAPK2_HUMAN
A:
[3-299]
--------------------------
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
----------------------
G
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
11
PsiBlast_PDB
68.25
76%
-106
- C1 -
3FYJ
1
MAPK2_HUMAN
X:
[11-320]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
S-----------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
76
PsiBlast_CBE
67.62
71%
-105
- C1 -
3M42
1
MAPK2_HUMAN
A:
[11-299]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
----------------------
G
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
78
PsiBlast_CBE
67.24
71%
-106
- C1 -
3KGA
1
MAPK2_HUMAN
A:
[11-299]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
----------------------
G
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
77
PsiBlast_CBE
66.53
71%
-102
- C1 -
3M2W
1
MAPK2_HUMAN
A:
[11-299]
----------------------------------
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
-----
M
L
-------
Q
D
C
P
K
A
--
R
R
E
V
E
L
H
W
R
A
S
-----
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
--
K
-
E
T
T
----------------------
G
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------
P
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
-
S
T
K
V
P
--------
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
--------------------------------------------
102
PsiBlast_CBE
50.83
39%
-114
- C1 -
2WEI
1
?
A:
[29-282]
------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
-----
V
I
N
KASAKN
K
D
T
S
T
I
--
L
R
E
V
E
L
-
L
K
K
L
-----
D
H
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
-
C
F
Q
-
Q
N
T
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
-------
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
-
Y
S
S
E
-------------------------------------------------------------------------------------
88
PsiBlast_CBE
49.50
38%
-114
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-276]
-------------------------------
R
W
K
Q
A
E
D
I
R
D
I
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
-----
C
I
-------
A
-----------
S
M
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
G
L
S
--
K
M
E
D
P
-
G
---------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
----
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-------------------------------------------------------------------------------------------
97
PsiBlast_CBE
48.06
35%
-92
- C1 -
3NCG
1
?
A:
[29-350]
------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
-----
V
I
N
KASAKN
K
D
T
S
T
I
--
L
R
E
V
E
L
-
L
K
K
L
-----
D
H
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
-
C
F
Q
-
Q
N
T
-----
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
-------
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
ISD
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
----
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
G
V
D
S
85
PsiBlast_CBE
47.09
38%
-126
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[10-276]
--------------------------------
W
K
Q
A
E
D
I
R
D
I
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
-----
C
I
-------
A
K
E
------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
---------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
----
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
-
D
T
A
L
D
--------
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
------------------------------------------------------------
96
PsiBlast_CBE
45.98
35%
-88
- C1 -
4Y5Q
1
?
A:
[29-350]
------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
-----
V
I
N
KASAKN
K
D
T
S
T
I
--
L
R
E
V
E
L
-
L
K
K
L
-----
D
H
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
-
C
F
Q
-
Q
N
T
---
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
-------
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
ISD
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
----
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
G
V
D
S
99
PsiBlast_CBE
45.90
35%
-92
- C1 -
3IGO
8
?
A:
[29-350]
------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
-----
V
I
N
KASAKN
K
-
T
S
T
I
--
L
R
E
V
E
L
-
L
K
K
L
-----
D
H
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
-
C
F
Q
-
Q
N
T
-------
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
-------
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
ISD
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
----
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
G
V
D
S
104
PsiBlast_CBE
45.88
35%
-115
- C1 -
3KN5
1
KS6A5_HUMAN
A:
[11-291]
-----------------------------------------
D
L
D
L
K
D
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
-----
I
I
-------
S
K
R
M
E
A
N
T
Q
K
E
I
T
A
L
K
L
C
E
-----
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
----
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
--
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
----
L
E
I
K
I
I
D
F
G
F
A
R
L
K
-
P
P
------------------------
N
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
-------
C
T
S
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
L
R
Y
N
E
W
L
Q
D
-
G
S
Q
L
S
--------
S
N
P
L
M
T
P
D
I
L
G
S
S
G
A
A
V
H
T
C
V
K
A
T
F
H
A
F
N
K
Y
K
R
E
G
-----------------------------------------
98
PsiBlast_CBE
45.21
35%
-89
- C1 -
3MWU
1
?
A:
[29-350]
------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
-----
V
I
N
KASAKN
K
D
T
S
T
I
--
L
R
E
V
E
L
-
L
K
K
L
-----
D
H
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
-
C
F
Q
-
Q
N
----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
-------
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
ISD
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
----
D
E
T
K
Q
L
T
E
I
F
R
K
L
D
T
N
N
D
G
M
L
D
R
D
E
L
V
R
G
Y
H
E
F
M
R
L
K
G
V
D
S
84
PsiBlast_CBE
44.84
38%
-123
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-276]
------------------------------------
E
D
I
R
D
I
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
-----
C
I
-------
A
K
-------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
G
----------
G
S
V
-
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
----
D
A
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
-
D
T
A
L
D
--------
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
------------------------------------------------------------
103
PsiBlast_CBE
44.64
35%
-108
- C1 -
3KN5
1
B:
[11-291]
-----------------------------------------
D
L
D
L
K
D
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
-----
I
I
-------
S
K
R
M
E
A
N
T
Q
K
E
I
T
A
L
K
L
C
E
-----
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
----
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
--
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
----
L
E
I
K
I
I
D
F
G
F
A
R
L
K
-
P
P
------------------------
N
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
S
H
D
R
S
L
T
C
T
S
A
V
E
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
L
R
Y
N
E
W
L
Q
D
-
G
S
Q
L
S
--------
S
N
P
L
M
T
P
D
I
L
G
S
S
G
A
A
V
H
T
C
V
K
A
T
F
H
A
F
N
K
Y
K
R
E
G
-----------------------------------------
81
PsiBlast_CBE
40.35
38%
-100
- C1 -
4MVF
2
CDPK2_PLAFK
A:
[56-364]
----------------------------------------
E
D
K
Y
I
I
D
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
E
E
K
KD
R
L
-------
K
N
I
N
R
F
--
F
Q
E
I
E
I
-
M
K
K
L
-----
D
H
P
N
I
V
K
L
Y
E
T
Y
E
N
D
N
Y
----
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
S
I
I
E
N
G
--
S
F
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
F
Q
S
E
N
K
D
S
L
L
K
I
I
D
F
G
L
S
--
K
-
N
L
-------------------------
K
Y
D
K
K
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
Y
-----------------------
C
F
Y
E
N
D
W
G
S
I
S
S
D
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
T
I
E
E
A
L
N
H
P
W
I
T
Q
--
M
T
K
S
----------
H
V
E
L
S
S
T
L
L
K
N
L
K
N
F
K
K
E
N
E
L
K
K
I
A
L
T
I
I
A
K
H
L
C
D
V
E
-----
I
N
N
L
R
N
I
F
I
A
L
D
V
D
N
S
G
T
L
S
S
Q
E
I
L
D
G
L
K
K
I
G
83
PsiBlast_CBE
38.89
40%
-109
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[15-266]
-----------------------------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
-----
C
I
-------
K
K
S
--------
S
L
E
N
E
I
A
V
L
K
K
I-
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
----
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
--
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
I
M
I
T
D
F
G
L
S
--
K
-
M
E
Q
-
N
G
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
----
E
S
K
---
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
-
N
T
A
L
H
--------
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
----------------------------------------------------------
82
PsiBlast_CBE
37.11
40%
-108
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[15-266]
-----------------------------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
-----
C
I
-------
K
K
S
--------
S
L
E
N
E
I
A
V
L
K
K
I-
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
----
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
--
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
I
M
I
T
D
F
G
L
S
--
K
-
M
E
Q
-
N
G
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
----
E
S
K
---
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
-
N
T
A
L
H
--------
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
-----------------------------------------------------------