@TOME V2.3
(Nov 2016)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : MARK1_HUMAN: (2015-10-13 )
MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGPERKKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSVASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPDRTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKFVRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL

Atome Classification :

(38 SA) .........10........20........30........40........50........60........70........80--.........90...---.-.--.---.----.100........110.-......120....--...130.......140.......150--------------.----------------.--------..---....160.......170.......180.......190---.--.----.---....200..---....-.---210-.---.......220.......230........240.......250......--.260.-......270..--.--...----.--280.......290.......300---...-......310---........320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790...
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHV---LTGREVAVKIIDKT---Q-L--N---P----TSL-QKLFREVRIMKI-LNHPNIVKLFEVI--ETEKTLYLVMEYASGGEVFDYLVAH---------------G----------------R--------MK---EKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDG---D--M----N---IKIADFGFS---NEFT-V---G-N-K---LDTFCGSPPYAAPELFQGK-KYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLK-ELRERVLRGKY--R--IPF----Y--MSTDCENLLKKLLVLNPIKRG-----SLE-QIMKDRWM----NVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGPERKKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSVASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPDRTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKFVRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMREIRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
124 HHSearch 69.1341% -91 - C2 -4BKY MELK_HUMAN A:[7-324] ------------------------------------------------------ELLKYYELHETIGTGGFAKVKLACHI---LTGEMVAIKIMDKN---T-L------------DL-PRIKTEIEALKN-LRHQHICQLYHVL--ETANKIFMVLEYCPGGELFDYIISQ---------------D----------------R--------LS---EEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDE---Y--H----K---LKLIDFGLC---A----------------------SLAYAAPELIQGK----GSEADVWSMGILLYVLMCGFLPFD--DDNVM-ALYKKIMRGKY--D--VPK----W--LSPSSILLLQQMLQVDPKKRI-----SMK-NLLNHPWI----MQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85 PsiBlast_CBE 69.0438%-101 - C2 -3BHH KCC2B_HUMAN B:[2-264] -------------------------------------------------MTDE------YQLYEDIGK---SVVRRCVKL---CTGHEYAAKIINTK---K-L--S---A----RDH-QKLEREARICRL-LKHSNIVRLHDSI--SEEGFHYLVFDLVTGGELFEDIVAR---------------E----------------Y--------YS---EADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLAS---K--C----KGAAVKLADFGLA---IEVQ-G---D-Q-QA--WFGFAGTPGYLSPEVLRKE-AYGKP-VDIWACGVILYILLVGYPPFW--DEDQH-KLYQQIKAGAY--D--FPSPEWDT--VTPEAKNLINQMLTINPAKRI-----TAH-EALKHPWV----CQRSTVASMMHRQETVECLKKFNARRKLK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86 PsiBlast_CBE 67.7438%-101 - C2 -3BHH KCC2B_HUMAN A:[1-264] ------------------------------------------------SMTDE------YQLYEDIG----SVVRRCVKL---CTGHEYAAKIINTK---K-L--S---A----RDH-QKLEREARICRL-LKHSNIVRLHDSI--SEEGFHYLVFDLVTGGELFEDIVAR---------------E----------------Y--------YS---EADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLAS---K--C----KGAAVKLADFGLA---IEVQ-G---D-Q-QA--WFGFAGTPGYLSPEVLRKE-AYGKP-VDIWACGVILYILLVGYPPFW--DEDQH-KLYQQIKAGAY--D--FPSPEWDT--VTPEAKNLINQMLTINPAKRI-----TAH-EALKHPWV----CQRSTVASMMHRQETVECLKKFNARRKLK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24 PsiBlast_CBE 65.0340% -91 - C2 -4CZT CIPKN_ARATH D:[10-273] --------------------------------------------------------VGKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKE---KVL--K---N----KMI-AQIKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G----------------R--------LK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA---N--G----A---LKVSDFGLSALPQQVR-E---D-G-L---LHTTCGTPNYVAPEVINNK-GYDGAKADLWSCGVILFVLMAGYLPFE--DSNLT-SLYKKIFKAEF--T--CPP----W--FSASAKKLIKRILDPNPATRI-----TFA-EVIENEWF----KKGYKAPKFENADVSLDDVDAIFDDSNLVVERRE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20 PsiBlast_PDB 65.0246% -92 - C2 -3AQV AAPK2_HUMAN A:[4-276] --------------------------------------------------HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQ---LTGHKVAVKILNRQ---K-I--R---S----LDVVGKIKREIQNLKL-FRHPHIIKLYQVI--STPTDFFMVMEYVSGGELFDYICKH---------------G----------------R--------VE---EMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA---H--M----N---AKIADFGLS---NMMS-D---G-E-F---L------PNYAAPEVISGR-LYAGPEVDIWSCGVILYALLCGTLPFD--DEHVP-TLFKKIRGGVF--Y--IPE----Y--LNRSVATLLMHMLQVDPLKRA-----TIK-DIREHEWF---------KQDLPSYLFPE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28 PsiBlast_CBE 64.4340% -90 - C2 -4CZU CIPKN_ARATH D:[10-273] --------------------------------------------------------VGKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKE---KVL--K---N----KMI-AQIKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G----------------R--------LK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA---N--G----A---LKVSDFGLSALPQQVR-E---D-G-L---LHDTCGTPNYVAPEVINNK-GYDGAKADLWSCGVILFVLMAGYLPFE--DSNLT-SLYKKIFKAEF--T--CPP----W--FSASAKKLIKRILDPNPATRI-----TFA-EVIENEWF----KKGYKAPKFENADVSLDDVDAIFDDSNLVVERRE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29 PsiBlast_CBE 63.6840% -97 - C2 -4CZU CIPKN_ARATH C:[10-273] --------------------------------------------------------VGKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKE---KVL--K---N----KMI-AQIKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G----------------R--------LK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA---N--G----A---LKVSDFGLSALPQQVR-E---D-G-L---LHDTCGTPNYVAPEVINNK-GYDGAKADLWSCGVILFVLMAGYLPFE--DSNLT-SLYKKIFKAEF--T--CPP----W--FSASAKKLIKRILDPNPATRI-----TFA-EVIENEWF----KKGYKAPKFENADVDAIFDDS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25 PsiBlast_CBE 63.4540% -96 - C2 -4CZT CIPKN_ARATH C:[10-273] --------------------------------------------------------VGKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKE---KVL--K---N----KMI-AQIKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G----------------R--------LK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA---N--G----A---LKVSDFGLSALPQQVR-E---D-G-L---LHTTCGTPNYVAPEVINNK-GYDGAKADLWSCGVILFVLMAGYLPFE--DSNLT-SLYKKIFKAEF--T--CPP----W--FSASAKKLIKRILDPNPATRI-----TFA-EVIENEWF----KKGYKAPKFENADVSLDDVDAIFDDSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144 HHSearch 63.3337% -91 - C2 -3HKO ? A:[26-336] ---------------------------------------------------------KKYHLKGAIGQGSYGVVRVAIEN---QTRAIRAIKIMNKNKIRQ-------------KDV-ERIKTEVRLMKK-LHHPNIARLYEVY--EDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAINGSI-FRESLDFVQR---EKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFST---NKSF----E---IKLVDFGLS---KEFY-KLNNG-----------AGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLLLMGAVPFP--GVNDA-DTISQVLNKKL--C--FENPNYNV--LSPLARDLLSNLLNRNVDERF-----DAM-RALQHPWI----SQFSDKIYKMS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84 PsiBlast_CBE 63.2938%-104 - C2 -4YUR PLK4_HUMAN A:[8-268] ----------------------------------------------------IGEKIEDFKVGNLLGKGSFAGVYRAESI---HTGLEVAIKMIDKK---A-M--Y---K----AGMVQRVQNEVKIHCQ-LKHPSILELYNYF--EDSNYVYLVLEMCHNGEMNRYL--K---------------N----------------R--------VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTR---N--M----N---IKIADF----------------------------------------------GLESDVWSLGCMFYTLLIGRPPF-----TVK-NTLNKVVLADY--E--MPS----F--LSIEAKDLIHQLLRRNPADRL-----SLS-SVLDHPFM----S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30 PsiBlast_CBE 63.2640% -90 - C2 -4CZU CIPKN_ARATH B:[10-273] --------------------------------------------------------VGKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKE---KVL--K---N----KMI-AQIKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G----------------R--------LK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA---N--G----A---LKVSDFGLSALPQQVR-E---D-G-L---LHDTCGTPNYVAPEVINNK-GYDGAKADLWSCGVILFVLMAGYLPFE--DSNLT-SLYKKIFKAEF--T--CPP----W--FSASAKKLIKRILDPNPATRI-----TFA-EVIENEWF----KKGYKAPKFEDDVDAIFDDSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136 HHSearch 63.2435% -95 - C2 -2Y0A DAPK1_HUMAN A:[11-276] ---------------------------------------------------------DYYDTGEELGSGQFAVVKKCREK---STGLQYAAKFIKKR---R-T--K---SSRRGVSR-EDIEREVSILKE-IQHPNVITLHEVY--ENKTDVILILELVAGGELFDFLAEK---------------E----------------S--------LT---EEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLD---R--NVPKPR---IKIIDFGLA---HKID-F---G-N-E---FKNIFGTPEFVAPEIVNYE-PL-GLEADMWSIGVITYILLSGASPFL--GDTKQ-ETLANVSAVNY--E--FEDEYFSN--TSALAKDFIRRLLVKDPKKRM-----TIQ-DSLQHPWI----KPKDTQQALSRKASAVNMEKFKKFAAR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26 PsiBlast_CBE 63.2340% -91 - C2 -4CZT CIPKN_ARATH B:[10-273] --------------------------------------------------------VGKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKE---KVL--K---N----KMI-AQIKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G----------------R--------LK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA---N--G----A---LKVSDFGLSALPQQVR-E---D-G-L---LHTTCGTPNYVAPEVINNK-GYDGAKADLWSCGVILFVLMAGYLPFE--DSNLT-SLYKKIFKAEF--T--CPP----W--FSASAKKLIKRILDPNPATRI-----TFA-EVIENEWF----KKGYKAPKFEDDVDAIFDDSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139 HHSearch 62.6135% -91 - C2 -1RDQ KAPCA_MOUSE E:[36-299] ----------------------------------------------------NTAQLDQFDRIKTLGTGSFGRVMLVKHK---ESGNHYAMKILDKQ---K-V--VK--L----KQI-EHTLNEKRILQA-VNFPFLVKLEFSF--KDNSNLYMVMEYVAGGEMFSHLRRI---------------G----------------R--------FS---EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQ---Q--G----Y---IQVTDFGFA---KRV------K-G-R---TWTLCGTPEALAPEIILSK-GYN-KAVDWWALGVLIYEMAAGYPPFF--ADQPI-QIYEKIVSGKV--R--FPS----H--FSSDLKDLLRNLLQVDLTKRFGNLKNGVN-DIKNHKWF----ATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102 PsiBlast_CBE 62.5438%-107 - C2 -4JXF PLK4_HUMAN A:[6-262] --------------------------------------------------------IEDFKVGNLLGKGSFAGVYRAESI---HTGLEVAIKMIDKK---A-M--Y---K----AGMVQRVQNEVKIHCQ-LKHPSILELYNYF--EDSNYVYLVLEMCHNGEMNRYL--K---------------N----------------R--------VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTR---N--M----N---IKIADFGLA---TQLK-M---P-HE------------------------------SDVWSLGCMFYTLLIGRPPF------VK-NTLNKVVLADY--E--MPS----F--LSIEAKDLIHQLLRRNPADRL-----SLS-SVLDHPFM----SR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33 PsiBlast_CBE 62.1745% -96 - C2 -4BKZ MELK_HUMAN A:[12-286] -----------------------------------------------------------YELHETIGTG--AKVKLACHI---LTGEMVAIKIMDKN---T-L-------------L-PRIKTEIEALKN-LRHQHICQLYHVL--ETANKIFMVLEYCPGGELFDYIISQ---------------D----------------R--------LS---EEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDE---Y--H----K---LKLIDFGLC---A----------------------SLAYAAPELIQG-----GSEADVWSMGILLYVLMCGFLPFD--DDNVM-ALYKKIMRGKY--D--VPK----W--LSPSSILLLQQMLQVDPKKRI-----SMK-NLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31 PsiBlast_CBE 62.1540% -88 - C2 -4CZU CIPKN_ARATH A:[10-273] --------------------------------------------------------VGKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKE---KVL--K---N----KMI-AQIKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G----------------R--------LK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA---N--G----A---LKVSDFGLSALPQQVR-E---D-G-L---LHDTCGTPNYVAPEVINNK-GYDGAKADLWSCGVILFVLMAGYLPFE--DSNLT-SLYKKIFKAEF--T--CPP----W--FSASAKKLIKRILDPNPATRI-----TFA-EVIENEWF----KKGYKAPKFENDDVDAIFDDSGESKNLVV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141 HHSearch 61.0537% -97 - C2 -3TKI CHK1_HUMAN A:[3-268] -----------------------------------------------------VPFVEDWDLVQTLGEGAYGEVQLAVNR---VTEEAVAVKIVDMK----------------------NIKKEICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I----------------G--------MP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---R--D----N---LKISDFGLA---TVFR-Y---N-N-RERLLNKMCGTLPYVAPELLKRR-EFHAEPVDVWSCGIVLTAMLAGELPWD--QPSDSCQEYSDWKEKKT--Y--LNPWK--K--IDSAPLALLHKILVENPSARI-----TIP-DIKKDRWY----NKPLKKGAKRPRVTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27 PsiBlast_CBE 60.9440% -85 - C2 -4CZT CIPKN_ARATH A:[10-273] --------------------------------------------------------VGKYELGRTLGEGTFAKVKFARNV---ENGDNVAIKVIDKE---KVL--K---N----KMI-AQIKREISTMKL-IKHPNVIRMFEVM--ASKTKIYFVLEFVTGGELFDKISSN---------------G----------------R--------LK---EDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA---N--G----A---LKVSDFGLSALPQQVR-E---D-G-L---LHTTCGTPNYVAPEVINNK-GYDGAKADLWSCGVILFVLMAGYLPFE--DSNLT-SLYKKIFKAEF--T--CPP----W--FSASAKKLIKRILDPNPATRI-----TFA-EVIENEWF----KKGYKAPKFENVSLDDVDAIFDDSGES-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65 PsiBlast_CBE 60.4840% -92 - C2 -3MA6 ? B:[34-295] -----------------------------------------------------------YKGQRVLGKGSFGEVILCKDK---ITGQECAVKVISKR---Q-VK-Q--------TDK-ESLLREVQLLKQ-LDHPNIMKLYEFF--EDKGYFYLVGEVYTGGELFDEIISR---------------K----------------R--------FS---EVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKD--A----N---IRIIDFGLS---THFE-A---S-K-K---MKDKIGTAYYIAPEVLHG--TYD-EKCDVWSTGVILYILLSGCPPFN--GANEY-DILKKVEKGKYTFE--LPQ----WKKVSESAKDLIRKMLTYVPSMRI-----SAR-DALDHEWI----QTYT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137 HHSearch 60.2934% -91 - C2 -3C0I CSKP_HUMAN A:[24-292] ---------------------------------------------------------DVYELCEVIGKGPFSVVRRCINR---ETGQQFAVKIVDVA---K-F--TSSPG----LST-EDLKREASICHM-LKHPHIVELLETY--SSDGMLYMVFEFMDGADLCFEIVKR---------------ADAGF------------V--------YS---EAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLAS---K--E----NSAPVKLGGFGVA---IQLG-E---S-GLV---AGGRVGTPHFMAPEVVKRE-PY-GKPVDVWGCGVILFILLSGCLPFY--GTK-E-RLFEGIIKGKY--K--MNPRQWSH--ISESAKDLVRRMLMLDPAERI-----TVY-EALNHPWL----KERDRYAYKIHLPETVEQLRKFNARRK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32 PsiBlast_CBE 60.2445% -94 - C2 -4BL1 MELK_HUMAN A:[12-286] -----------------------------------------------------------YELHETIGTGGFAKVKLACHI---LTGEMVAIKIMDKN---T-L-------------L-PRIKTEIEALKN-LRHQHICQLYHVL--ETANKIFMVLEYCPGGELFDYIISQ---------------D----------------R--------LS---EEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDE---Y--H----K---LKLIDFGLC---AK---------------------SLAYAAPELIQGK----GSEADVWSMGILLYVLMCGFLPFD--DDNVM-ALYKKIMRGKY--D--VPK----W--LSPSSILLLQQMLQVDPKKRI-----SMK-NLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98 PsiBlast_CBE 60.0637% -89 - C2 -2HY0 CHK1_HUMAN A:[3-265] ------------------------------------------------------PFVEDWDLVQTLGEGAYGEVQLAVNR---VTEEAVAVKIVDMK------------------NI-KK---EICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I----------------G--------MP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---R--D----N---LKISDFGLA---TVFR-Y---N-N-RERLLNKMCGTLPYVAPELLKRR-EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ-EYSDWKEKKTY--L--NPWK---K--IDSAPLALLHKILVENPSARI-----TIP-DIKKDRWY----NKPLKKGAKRPRVTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66 PsiBlast_CBE 60.0040% -89 - C2 -3MA6 ? A:[34-296] -----------------------------------------------------------YKGQRVLGKGSFGEVILCKDK---ITGQECAVKVISKR---Q-VK-Q---K----TDK-ESLLREVQLLKQ-LDHPNIMKLYEFF--EDKGYFYLVGEVYTGGELFDEIISR---------------K----------------R--------FS---EVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKD--A----N---IRIIDFGLS---THFE-----S-K-K---MKDKIGTAYYIAPEVLHG--TYD-EKCDVWSTGVILYILLSGCPPFN--GANEY-DILKKVEKGKYTFE--LPQ----WKKVSESAKDLIRKMLTYVPSMRI-----SAR-DALDHEWI----QTYTK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79 PsiBlast_CBE 59.8239% -87 - C2 -2WEI ? A:[24-286] -----------------------------------------------------------YNIVCMLGKGSFGEVLKCKDR---ITQQEYAVKVINKA---S-A--K---N----KDT-STILREVELLKK-LDHPNIMKLFEIL--EDSSSFYIVGELYTGGELFDEIIKR---------------K----------------R--------FS---EHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKD--C----D---IKIIDFGLS---TCFQ-Q---N-T-K---MKDRIGTAYYIAPEVLRG--TYD-EKCDVWSAGVILYILLSGTPPFY--GKNEY-DILKRVETGKY--AFDLPQ----WRTISDDAKDLIRKMLTFHPSLRI-----TAT-QCLEHPWI----QKYSSE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138 HHSearch 59.5234% -89 - C2 -3WF7 KS6B1_HUMAN A:[15-285] -----------------------------------------------------KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKA---M-IVRN---A----KDT-AHTKAERNILEE-VKHPFIVDLIYAF--QTGGKLYLILEYLSGGELFMQLERE---------------G----------------I--------FM---EDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNH---Q--G----H---VKLTDFGLC---KESIHD-----------THTFCGTIEYMAPEILMRS-GH-NRAVDWWSLGALMYDMLTGAPPFT--GENRK-KTIDKILKCKL--N--LPP----Y--LTQEARDLLKKLLKRNAASRLGAGPGDAG-EVQAHPFF----RHINWEELLARKVEPPFKPLLQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103 PsiBlast_CBE 59.4637% -89 - C2 -3TKI CHK1_HUMAN A:[4-266] ------------------------------------------------------PFVEDWDLVQTLGEGAYGEVQLAVNR---VTEEAVAVKIVDMK------------------NI-KK---EICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I----------------G--------MP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---R--D----N---LKISDFGLA---TVFR-Y---N-N-RERLLNKMCGTLPYVAPELLKRR-EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ-EYSDWKEKKTY--L--NPWK---K--IDSAPLALLHKILVENPSARI-----TIP-DIKKDRWY----NKPLKKGAKRPRVTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145 HHSearch 59.4135% -84 - C2 -1XJD A:[16-275] --------------------------------------------------------IEDFILHKMLGKGSFGKVFLAEFK---KTNQFFAIKALKKD---V-VL-M---D----DDV-ECTMVEKRVLSLAWEHPFLTHMFCTF--QTKENLFFVMEYLNGGDLMYHIQSC---------------H----------------K--------FD---LSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDK---D--G----H---IKIADFGMC---KENM-L---GDA-K---TNTFCGTPDYIAPEILLGQ-KYN-HSVDWWSFGVLLYEMLIGQSPFH--GQDEE-ELFHSIRMDNP--F--YPR----W--LEKEAKDLLVKLFVREPEKRL-----GVRGDIRQHPLF----REINWEELERKEIDPQNMFRNFSF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129 HHSearch 59.1437% -87 - C2 -2YEX CHK1_HUMAN A:[4-270] ------------------------------------------------------PFVEDWDLVQTLGEGAYGEVQLAVNR---VTEEAVAVKIVDMK---R-A------V----DCP-ENIKKEICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I----------------G--------MP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---R--D----N---LKISDFGLA---TVFR-Y---N-N-RERLLNKMCGTLPYVAPELLKRR-EFHAEPVDVWSCGIVLTAMLAGELPWD--QPSDSCQEYSDWKEKKT--Y--LNPWK--K--IDSAPLALLHKILVENPSARI-----TIP-DIKKDRWY----NKPLK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105 PsiBlast_CBE 59.1437% -89 - C2 -2R0U CHK1_HUMAN A:[4-266] ------------------------------------------------------PFVEDWDLVQTLGE---GEVQLAVNR---VTEEAVAVKIVDMK------------------NI-KK---EICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I----------------G--------MP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---R--D----N---LKISDFGLA---TVFR-Y---N-N-RERLLNKMCGTLPYVAPELLKRR-EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ-EYSDWKEKKTY--L--NPWK---K--IDSAPLALLHKILVENPSARI-----TIP-DIKKDRWY----NKPLKKGAKRPRVTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89 PsiBlast_CBE 59.1438%-106 - C2 -3COK PLK4_HUMAN A:[10-266] --------------------------------------------------------IEDFKVGNLLGKGSFAGVYRAESI---HTGLEVAIKMIDKK---A-M--Y---K----AGMVQRVQNEVKIHCQ-LKHPSILELYNYF--EDSNYVYLVLEMCHNGEMNRYL--K---------------N----------------R--------VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTR---N--M----N---IKIADFGLA---TQLK--------------------------------------ESDVWSLGCMFYTLLIGRPPFD--TDTVK------VVLADY--E--MPS----F--LSIEAKDLIHQLLRRNPADRL-----SLS-SVLDHPFM----S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101 PsiBlast_CBE 58.8237% -90 - C2 -2HOG CHK1_HUMAN A:[3-265] ------------------------------------------------------PFVEDWDLVQTLGEGAYGEVQLAVNR---VTEEAVAVKIVDMK------------------NI-KK---EICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I----------------G--------MP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---R--D----N---LKISDFGLA---TVFR-Y---N-N-RERLLNKMCGTLPYVAPELLKRR-EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ-EYSDWKEKKTY--L--NPWK---K--IDSAPLALLHKILVENPSARI-----TIP-DIKKDRWY----NKPLKKGAKRPRVTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106 PsiBlast_CBE 58.7837% -92 - C2 -2QHN CHK1_HUMAN A:[4-266] ------------------------------------------------------PFVEDWDLVQTLG----GEVQLAVNR---VTEEAVAVKIVDMK------------------NI-KK---EICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I----------------G--------MP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---R--D----N---LKISDFGLA---TVFR-Y---N-N-RERLLNKMCGTLPYVAPELLKRR-EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ-EYSDWKEKKTY--L--NPWK---K--IDSAPLALLHKILVENPSARI-----TIP-DIKKDRWY----NKPLKKGAKRPRVTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104 PsiBlast_CBE 58.6437% -93 - C2 -3TKH CHK1_HUMAN A:[4-266] ------------------------------------------------------PFVEDWDLVQTLGEGAYGEVQLAVNR---VTEEAVAVKIV---------------------NI-KK---EICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I----------------G--------MP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---R--D----N---LKISDFGLA---TVFR-Y---N-N-RERLLNKMCGTLPYVAPELLKRR-EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ-EYSDWKEKKTY--L--NPWK---K--IDSAPLALLHKILVENPSARI-----TIP-DIKKDRWY----NKPLKKGAKRPRVTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100 PsiBlast_CBE 58.5937% -81 - C2 -2HXL CHK1_HUMAN A:[3-265] ------------------------------------------------------PFVEDWDLVQTLGEGAYGEVQLAVNR---VTEEAVAVKIVDMK---R----C---P----ENI-KK---EICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I----------------G--------MP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---R--D----N---LKISDFGLA---TVFR-Y---N-N-RERLLNKMCGTLPYVAPELLKRR-EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ-EYSDWKEKKTY--L--NPWK---K--IDSAPLALLHKILVENPSARI-----TIP-DIKKDRWY----NKPLKKGAKRP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127 HHSearch 58.2832% -91 - C2 -2W5A NEK2_HUMAN A:[5-272] --------------------------------------------------------AEDYEVLYTIGTGSYGRCQKIRRK---SDGKILVWKELDYG---S-M--T---E----AEK-QMLVSEVNLLRE-LKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKG---------------TKERQ------------Y--------LD---EEFVLRVMTQLTLALKECHRRS-LHRDLKPANVFLDG---K--Q----N---VKLGDFGLA---RIL-------TS-F---AKTFVGTPYYMSPEQMNRM--YN-EKSDIWSLGCLLYELCALMPPFT--AFSQK-ELAGKIREGKFR-R--IPY----R--YSDELNEIITRMLNLKDYHRP-----SVE-EILENPLI----LEHHHHHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107 PsiBlast_CBE 57.8837% -86 - C2 -2QHM CHK1_HUMAN A:[4-266] ------------------------------------------------------PFVEDWDLVQTLG----GEVQLAVNR---VTEEAVAVKIVDMK------------------NI-KK---EICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I----------------G--------MP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---R--D----N---LKISDFGLA---TVFR-Y---N-N-RERLLNKMCGTLPYVAPELLKRR-EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ-EYSDWKEKKTY--L--NPWK---K--IDSAPLALLHKILVENPSARI-----TIP-DIKKDRWY----NKPLKKGAKRPRVTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99 PsiBlast_CBE 57.8337% -83 - C2 -2HXQ CHK1_HUMAN A:[3-265] ------------------------------------------------------PFVEDWDLVQTLGEGAYGEVQLAVNR---VTEEAVAVKIVDMK---R----C---P----ENI-KK---EICINKM-LNHENVVKFYGHR--REGNIQYLFLEYCSGGELFDRIEPD---------------I----------------G--------MP---EPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---R--D----N---LKISDFGLA---TVFR-Y---N-N-RERLLNKMCGTLPYVAPELLKRR-EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ-EYSDWKEKKTY--L--NPWK---K--IDSAPLALLHKILVENPSARI-----TIP-DIKKDRWY----NKPLKKGAKRP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------