@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MARK2_HUMAN: (2015-10-13 )
MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
Atome Classification :
(38 SA)
.........10........20........30........40........50........60........70..---......80.......-.--90-.----.......100....-...110.......--120.......130.......140...----....150.......160.......170.......180...---..----.---.190.....---..200-.-.-.---....210.......220.......230.......240.......250-.....-...260.....--..270---.--.......280.......290.-----...-...300..----.....310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIG
N
Y
R
L
L
K
T
IGKGNF
A
K
V
K
L
A
R
H
I
---LTG
K
E
V
A
V
K
I
I
D
KTQ-L--
N
S
-
S
----
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
-LNHP
N
I
V
K
L
F
E
V
I
--ETE
K
T
L
Y
L
V
M
E
YASG
G
E
V
F
D
Y
L
V
AHG----R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
HRDLKAE
N
L
L
LDA---DM----
N
---
I
K
I
A
DFGFS---NEFTF-G-N-K---L
D
T
FCGSPPYAA
P
E
LFQGKKYDGPEV
D
V
W
S
L
G
V
I
L
Y
T
L
VSGSLPFD--
G
Q
N
L
K
-
E
L
R
E
R
V
LRGK
Y
--
R
I
P
F
----
Y
--MST
D
C
E
N
L
L
K
K
F
LILNPSKR
G
-----
T
L
E
-
Q
I
M
K
D
R
WM----NVGHEDDELK
P
Y
VEPLPDYKDPR
R
T
E
L
M
V
SMGY
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
LGYKSSELEG
D
T
I
T
LKPRPSADLTNSSAPS
P
S
H
K
V
Q
R
SVSAN
P
K
QRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRP
E
E
D
R
ESGRKASSTAKVPASPLPGLERKKTTPTPSTN
S
V
L
STSTNRSRNS
P
L
L
E
R
ASLGQ
A
S
IQNGKDSLTMPGSRASTASAS
A
A
VSAAR
P
R
Q
H
Q
K
SMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFH
A
G
Q
L
R
Q
V
R
DQQNLPYGVTPASPSGHSQGRRGAS
G
S
I
F
S
K
F
T
S
K
F
V
R
RN
L
S
F
R
F
A
RRNLNEPE
S
K
D
R
V
E
T
LRP
H
V
VGSGGN
D
K
E
K
E
E
F
R
EAKPR
S
L
R
F
T
W
SMKTTSSM
E
P
N
E
M
M
R
E
I
R
K
V
LD
A
N
S
C
Q
S
E
L
H
E
K
Y
M
L
L
C
MHGTPG
H
E
D
F
V
Q
W
E
M
E
V
CKLPRLSLN
G
V
R
F
K
RISG
T
S
M
A
F
K
N
I
A
S
K
I
A
N
ELKL
124
HHSearch
67.37
41%
-86
- C1 -
4BKY
1
MELK_HUMAN
A:
[7-334]
-----------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
---
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
-
L
----------
D
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
--
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
----
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
H
----
K
---
L
K
L
I
D
F
G
L
C
---
A
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
D
N
V
M
-
A
L
Y
K
K
I
M
R
G
K
Y
--
D
V
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
-
N
L
L
N
H
P
W
I
----
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
--
K
A
R
G
K
P
V
R
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.41
48%
-100
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[4-265]
-------------------------------------------
H
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
---
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
--
R
S
L
D
----
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
-
F
R
H
P
H
I
I
K
L
Y
Q
V
I
--
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
----
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
---
H
M
----
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
-
E
-
F
---
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
--
D
E
H
V
P
-
T
L
F
K
K
I
R
G
G
V
F
--
Y
I
P
E
----
Y
--
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
-
D
I
R
E
H
E
W
F
----
K
Q
D
L
P
S
Y
L
F
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
64.15
42%
-93
- C1 -
4BKZ
1
MELK_HUMAN
A:
[12-313]
----------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
---
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
-
L
-----------
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
--
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
----
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
H
----
K
---
L
K
L
I
D
F
G
L
C
---
A
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
D
N
V
M
-
A
L
Y
K
K
I
M
R
G
K
Y
--
D
V
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
-
N
L
L
N
H
P
W
I
MQDY
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
63.09
41%
-92
- C1 -
4CZT
4
CIPKN_ARATH
D:
[10-273]
-------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
N
-
K
----
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
-
G
-
L
---
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
--
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
-
E
V
I
E
N
E
W
F
----
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
62.32
41%
-87
- C1 -
4CQG
1
MELK_MOUSE
A:
[11-311]
----------------------------------------------------
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
---
L
T
G
E
M
V
A
I
K
I
M
D
K
N
A
-
L
--
G
S
-
D
-----
L
P
R
V
K
T
E
I
D
A
L
K
S
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
--
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
----
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
N
H
----
K
---
L
K
L
I
D
F
G
L
C
---
A
K
----------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
D
N
V
M
-
A
L
Y
K
K
I
M
R
G
K
Y
--
E
V
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
R
-
N
L
L
N
H
P
W
V
----
M
Q
D
Y
S
C
P
V
E
W
Q
S
K
T
P
L
T
H
L
D
E
D
C
V
T
E
L
S
V
H
H
R
S
S
R
Q
T
M
E
D
L
I
S
S
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
L
E
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
HHSearch
61.98
36%
-94
- C1 -
3C0I
1
CSKP_HUMAN
A:
[24-291]
--------------------------------------------------
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
---
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
-
F
--
T
S
-
S
PGL-
S
T
E
D
L
K
R
E
A
S
I
C
H
M
-
L
K
H
P
H
I
V
E
L
L
E
T
Y
--
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
---
K
E
----
N
S
A
P
V
K
L
G
G
F
G
V
A
---
I
Q
L
G
E
-
S
-
G
L
V
---
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
--
G
T
K
-
E
-
R
L
F
E
G
I
I
K
G
K
Y
--
K
M
N
P
RQWS
H
--
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
-
E
A
L
N
H
P
W
L
----
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
61.76
40%
-98
- C1 -
4CZU
3
CIPKN_ARATH
C:
[10-273]
-------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
N
-
K
----
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
-
G
-
L
---
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
--
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
-
E
V
I
E
N
E
W
F
----
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
D
A
I
F
D
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
61.71
40%
-92
- C1 -
4CZU
3
CIPKN_ARATH
D:
[10-273]
-------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
N
-
K
----
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
-
G
-
L
---
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
--
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
-
E
V
I
E
N
E
W
F
----
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
61.66
41%
-96
- C1 -
4CZT
3
CIPKN_ARATH
C:
[10-273]
-------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
N
-
K
----
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
-
G
-
L
---
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
--
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
-
E
V
I
E
N
E
W
F
----
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
61.56
40%
-94
- C1 -
3MA6
1
?
A:
[34-292]
----------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
-
V
K-
Q
K
-
T
----
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
--
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
----
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
--
S
-
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
----
Q
T
Y
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
61.46
41%
-92
- C1 -
4CZT
2
CIPKN_ARATH
B:
[10-273]
-------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
N
-
K
----
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
-
G
-
L
---
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
--
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
-
E
V
I
E
N
E
W
F
----
K
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
61.44
42%
-89
- C1 -
4BL1
1
MELK_HUMAN
A:
[12-313]
----------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
---
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
-
L
-----------
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
--
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
----
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
H
----
K
---
L
K
L
I
D
F
G
L
C
---
A
K
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
--
D
D
N
V
M
-
A
L
Y
K
K
I
M
R
G
K
Y
--
D
V
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
-
N
L
L
N
H
P
W
I
MQDY
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
61.11
40%
-90
- C1 -
4CZU
3
CIPKN_ARATH
B:
[10-273]
-------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
N
-
K
----
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
-
G
-
L
---
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
--
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
-
E
V
I
E
N
E
W
F
----
K
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
HHSearch
61.07
35%
-92
- C1 -
1RDQ
3
KAPCA_MOUSE
E:
[36-300]
---------------------------------------------
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
--
V
K
L
K
----
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
----
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
---
K
-
G
-
R
---
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
--
A
D
Q
P
I
-
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
-
D
I
K
N
H
K
W
F
----
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
60.75
40%
-96
- C1 -
3MA6
1
?
B:
[34-292]
----------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
-
V
K-
Q
--
T
----
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
--
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
----
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
-
K
-
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
--
G
A
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
-
D
A
L
D
H
E
W
I
----
Q
T
Y
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
59.95
39%
-93
- C1 -
2WEI
1
?
A:
[24-280]
----------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
-
A
--
K
N
-
K
----
D
T
S
T
I
L
R
E
V
E
L
L
K
K
-
L
D
H
P
N
I
M
K
L
F
E
I
L
--
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
KEK
D
C
----
D
---
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
-
N
-
T
-
K
---
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
-
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
--
G
K
N
E
Y
-
D
I
L
K
R
V
E
T
G
K
Y
--
A
F
D
L
PQWR
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
-
Q
C
L
E
H
P
W
I
----
Q
K
Y
S
S
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
HHSearch
59.94
34%
-91
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[14-284]
---------------------------------------------
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
-
I
V
R
N
A
-
K
----
D
T
A
H
T
K
A
E
R
N
I
L
E
E
-
V
K
H
P
F
I
V
D
L
I
Y
A
F
--
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
---
Q
G
----
H
---
V
K
L
T
D
F
G
L
C
---
K
E
S
I
H
D--------
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
-
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
--
G
E
N
R
K
-
K
T
I
D
K
I
L
K
C
K
L
--
N
L
P
P
----
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGP
G
D
A
G
-
E
V
Q
A
H
P
F
F
----
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
59.91
40%
-89
- C1 -
4CZU
3
CIPKN_ARATH
A:
[10-273]
-------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
N
-
K
----
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
-
G
-
L
---
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
--
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
-
E
V
I
E
N
E
W
F
----
K
K
G
Y
K
A
P
K
F
E
N
D
D
V
D
A
I
F
D
D
S
G
E
S
K
N
L
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
59.89
36%
-96
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[11-276]
--------------------------------------------------
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
-
T
--
K
S
-
S
RRGV
S
R
E
D
I
E
R
E
V
S
I
L
K
E
-
I
Q
H
P
N
V
I
T
L
H
E
V
Y
--
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
---
R
N
VP
K
P
R
---
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
-
G
-
N
-
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
--
E
F
E
D
EYFS
N
--
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
-
D
S
L
Q
H
P
W
I
----
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
59.14
41%
-86
- C1 -
4CZT
3
CIPKN_ARATH
A:
[10-273]
-------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
N
-
K
----
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
-
G
-
L
---
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
--
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
-
E
V
I
E
N
E
W
F
----
K
K
G
Y
K
A
P
K
F
E
N
V
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
58.09
37%
-95
- C1 -
2HOG
1
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K
---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
57.95
37%
-93
- C1 -
2HY0
1
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
PsiBlast_CBE
57.89
37%
-91
- C1 -
4QYH
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
57.84
37%
-93
- C1 -
4RVM
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
57.64
37%
-94
- C1 -
4RVL
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
------
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
57.62
37%
-92
- C1 -
4RVK
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
HHSearch
57.54
37%
-98
- C1 -
3TKI
1
CHK1_HUMAN
A:
[3-267]
----------------------------------------------
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
N
P
WK--
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
57.18
37%
-93
- C1 -
2R0U
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
57.17
37%
-90
- C1 -
4QYH
1
CHK1_HUMAN
B:
[4-266]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
57.16
37%
-95
- C1 -
2QHN
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
57.11
37%
-89
- C1 -
2YEX
8
CHK1_HUMAN
A:
[4-268]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
-
A
--
V
--
D
----
C
P
E
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
--
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
N
P
WK--
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
56.59
37%
-93
- C1 -
3TKI
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
55.83
37%
-89
- C1 -
2QHM
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
55.70
37%
-86
- C1 -
2HXL
1
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
-------
C
----
P
-
E
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K
---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
K
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
55.65
37%
-96
- C1 -
3TKH
1
CHK1_HUMAN
A:
[4-266]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
-------------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
HHSearch
55.29
34%
-83
- C1 -
1XJD
1
A:
[16-275]
-------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
-
V
L
-
M
D
-
D
----
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
--
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
----
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
---
D
G
----
H
---
I
K
I
A
D
F
G
M
C
---
K
E
N
M
L
-
G
D
A
-
K
---
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
Y
N
-
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
--
G
Q
D
E
E
-
E
L
F
H
S
I
R
M
D
N
P
--
F
Y
P
R
----
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
-----
G
V
R
G
D
I
R
Q
H
P
L
F
----
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
Q
N
M
F
R
N
F
S
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
55.08
37%
-89
- C1 -
2HXQ
1
CHK1_HUMAN
A:
[3-265]
-----------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
-------
C
----
P
-
E
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
-
N
-
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
QP
S
D
S
C
Q
-
E
Y
S
D
W
K
E
K
K
T
Y
--
L
N
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
-
D
I
K
K
D
R
W
Y
----
N
K
P
L
K
K
G
A
K
R
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
53.07
32%
-86
- C1 -
2W5A
5
NEK2_HUMAN
A:
[5-278]
-------------------------------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
-
M
--
T
E
-
A
----
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
---
K
Q
----
N
---
V
K
L
G
D
F
G
L
A
---
R
I
L
----T
S
-
F
---
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
-
Y
N
-
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
--
A
F
S
Q
K
-
E
L
A
G
K
I
R
E
G
K
F
R-
R
I
P
Y
----
R
--
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
-
E
I
L
E
N
P
L
I
----
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------