@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MARK3_HUMAN: (2015-10-13 )
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70.....---...80........90--.-.--..----....-.100.......110.......120--.......130.......140.....---------------.-----------------------.150.......160.......170.......180......---.--190--.---........200-.....--..---..210--........220.....-..230.......240.......250.......-260.......270.--...----.--....280.......290...-.-----...300..----...----.-----.310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTRTPLPTVNERDTENHTSHGD
G
R
Q
E
V
T
S
RTSRS
G
A
R
C
R
N
S
I
A
S
C
ADEQPHIG
N
Y
R
L
L
K
T
IGKGNF
A
K
V
K
L
A
R
H
I
---LTG
R
E
V
A
I
K
I
I
DKT---Q-L--
N
P
----
T
S
L
Q
-
K
L
F
R
E
V
R
I
M
K
I
LNHP
N
I
V
K
L
F
E
V
I
--ETE
K
T
L
Y
L
I
M
E
YASG
G
E
V
F
D
Y
L
V
AH---------------G-----------------------RM
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
DLKAE
N
L
L
LDA---D--M----
N
---
I
K
I
A
DFGFS---N
E
F
TV--GG---KLDT---FCGSPPYAA
P
E
LFQGK-KYDGPEV
D
V
W
S
L
G
V
I
L
Y
T
L
VSGSLPFD
G
Q
N
L
K
-
E
L
R
E
R
V
LRGK
Y
--
R
--
I
P
F
----
Y
--MST
D
C
E
N
L
L
K
R
F
L
V
LNPIK
R
-
G
-----
T
L
E
Q
I
M
K
D
----RWI----N-----AGH
E
E
D
ELKPFVEPELDISDQ
K
R
I
D
I
M
V
GMGY
S
Q
E
E
I
Q
E
S
L
S
KM
K
Y
D
E
I
T
A
T
Y
L
L
LGRKSSELDASDSSSSSN
L
S
L
A
K
VRPSSDLNNSTGQS
P
H
H
K
V
Q
R
S
V
F
S
S
Q
K
Q
R
RYSDHAGPAIP
S
V
VAYPKRSQTSTAD
S
D
L
K
EDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRR
N
T
Y
V
CSERTT
A
D
R
H
S
V
I
QNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATP
L
S
Q
TRSRGS
T
N
L
F
S
K
L
T
S
K
L
T
RRN
M
S
F
R
F
I
K
RL
P
T
E
Y
ERNGRYEGSSRNVSAEQKDENKEAKP
R
S
L
R
F
T
W
SMKTTSSM
D
P
G
D
M
M
R
E
I
R
K
V
LDANNC
D
Y
E
Q
R
E
R
F
L
L
F
C
VHGDG
H
A
E
N
L
V
Q
W
E
M
E
V
CKLPRLSLN
G
V
R
F
K
RISGT
S
I
A
F
K
N
I
A
S
K
I
A
N
ELKL
126
HHSearch
71.06
42%
-87
- C2 -
4BKY
1
MELK_HUMAN
A:
[7-326]
--------------------------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
---
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
---------
D
L
P
-
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
--
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
---------------
D
-----------------------
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
--
H
----
K
---
L
K
L
I
D
F
G
L
C
---
A
---------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
-
A
L
Y
K
K
I
M
R
G
K
Y
--
D
--
V
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
-----
S
M
K
N
L
L
N
H
----
P
W
I
----
M
-----
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
68.35
38%
-108
- C2 -
3BHH
1
KCC2B_HUMAN
A:
[6-264]
-------------------------------------------------------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
---
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
A
----
R
D
H
Q
-
K
L
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
--
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
---------------
E
-----------------------
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
---
K
--
C
----
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
--
V
--
Q
G
---
D
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
-
A
Y
G
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
-
K
L
Y
Q
Q
I
K
A
G
A
Y
--
D
--
F
P
S
PEWD
T
--
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
-
I
-----
T
A
H
E
A
L
K
H
----
P
W
V
----
C
-----
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
67.43
38%
-107
- C2 -
3BHH
1
KCC2B_HUMAN
B:
[6-264]
-------------------------------------------------------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
---
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
A
----
R
D
H
Q
-
K
L
E
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
--
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
---------------
E
-----------------------
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
---
K
--
C
----
K
GAA
V
K
L
A
D
F
G
L
A
---
I
E
--
V
--
Q
G
---
D
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
-
A
Y
G
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
-
K
L
Y
Q
Q
I
K
A
G
A
Y
--
D
--
F
P
S
PEWD
T
--
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
-
I
-----
T
A
H
E
A
L
K
H
----
P
W
V
----
C
-----
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
66.47
41%
-95
- C2 -
4BKZ
1
MELK_HUMAN
A:
[12-313]
-------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
---
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
----------
L
P
-
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
--
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
---------------
D
-----------------------
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
--
H
----
K
---
L
K
L
I
D
F
G
L
C
---
A
---------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
-
A
L
Y
K
K
I
M
R
G
K
Y
--
D
--
V
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
-----
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.98
46%
-95
- C2 -
3AQV
1
AAPK2_HUMAN
A:
[5-276]
-----------------------------------------------
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
---
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
S
----
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
--
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
---------------
G
-----------------------
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
---
H
--
M
----
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
--
G
E
---
F
L
---------
P
N
Y
A
A
P
E
V
I
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
-
T
L
F
K
K
I
R
G
G
V
F
--
Y
--
I
P
E
----
Y
--
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
-
A
-----
T
I
K
D
I
R
E
H
----
E
W
F
--------------
K
Q
D
L
P
S
Y
L
F
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
HHSearch
65.46
37%
-94
- C2 -
3HKO
2
?
A:
[26-336]
-----------------------------------------------------
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
---
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q
----------
K
D
V
E
-
R
I
K
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
--
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KT
Q
ICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
---
N
KS
F
----
E
---
I
K
L
V
D
F
G
L
S
---
K
E
F
Y
K
LN
N
G
-----------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
N
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
-
D
T
I
S
Q
V
L
N
K
K
L
--
C
--
F
E
N
PNYN
V
--
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
-
F
-----
D
A
M
R
A
L
Q
H
----
P
W
I
----
S
-----
Q
F
S
D
K
I
Y
K
M
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
64.37
41%
-93
- C2 -
4CZU
3
CIPKN_ARATH
B:
[10-273]
----------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
N
----
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
--
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
--
D
G
---
L
L
H
D
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
--
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
-----
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
64.34
42%
-93
- C2 -
4CZT
2
CIPKN_ARATH
B:
[10-273]
----------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
N
----
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
--
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
--
D
G
---
L
L
H
T
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
--
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
-----
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
64.06
42%
-94
- C2 -
4CZT
4
CIPKN_ARATH
D:
[10-273]
----------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
N
----
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
--
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
--
D
G
---
L
L
H
T
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
--
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
-----
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
63.32
41%
-93
- C2 -
4CZU
3
CIPKN_ARATH
D:
[10-273]
----------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
N
----
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
--
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
--
D
G
---
L
L
H
D
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
--
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
-----
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
62.99
41%
-99
- C2 -
4CZU
3
CIPKN_ARATH
C:
[10-273]
----------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
N
----
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
--
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
--
D
G
---
L
L
H
D
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
--
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
-----
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
G
Y
K
A
P
K
F
E
N
A
D
V
D
A
I
F
D
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
62.60
42%
-99
- C2 -
4CZT
3
CIPKN_ARATH
C:
[10-273]
----------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
N
----
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
--
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
--
D
G
---
L
L
H
T
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
--
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
-----
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
62.39
41%
-93
- C2 -
4BL1
1
MELK_HUMAN
A:
[12-313]
-------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
---
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
----------
L
P
-
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
--
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
---------------
D
-----------------------
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
--
H
----
K
---
L
K
L
I
D
F
G
L
C
---
A
K
--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
-
A
L
Y
K
K
I
M
R
G
K
Y
--
D
--
V
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
-----
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
HHSearch
62.27
36%
-95
- C2 -
2Y0A
1
DAPK1_HUMAN
A:
[12-277]
------------------------------------------------------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
---
R
-
T
--
K
S
SRRG
V
S
R
E
-
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
--
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---------------
E
-----------------------
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
---
R
--
N
VP
K
P
R
---
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
--
G
N
---
E
F
K
N
---
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
-
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
--
E
--
F
E
D
EYFS
N
--
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
-
M
-----
T
I
Q
D
S
L
Q
H
----
P
W
I
----
K
-----
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
62.25
42%
-87
- C2 -
4CZT
3
CIPKN_ARATH
A:
[10-273]
----------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
N
----
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
--
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
--
D
G
---
L
L
H
T
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
--
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
-----
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
G
Y
K
A
P
K
F
E
N
V
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
62.23
39%
-96
- C2 -
3MA6
1
?
B:
[34-295]
-------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-----
T
D
K
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
--
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
---------------
K
-----------------------
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
--
A
----
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
--
S
K
---
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
-----
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-----
T
Y
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
61.91
31%
-109
- C2 -
3EFW
1
AURKA_HUMAN
B:
[126-385]
---------------------------------------
R
---------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
K
----
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
---------------
S
-----------------------
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
--
G
----
E
---
L
K
I
A
D
F
-----------------------------
L
D
Y
L
P
P
E
M
I
E
------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
-
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
-----
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
N
S
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
61.91
41%
-93
- C2 -
4CZU
3
CIPKN_ARATH
A:
[10-273]
----------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
N
----
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
---------------
G
-----------------------
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
--
G
----
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
--
D
G
---
L
L
H
D
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
--
T
--
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
-----
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
G
Y
K
A
P
K
F
E
N
D
D
V
D
A
I
F
D
D
S
G
E
S
K
N
L
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
61.87
39%
-93
- C2 -
3MA6
1
?
A:
[34-296]
-------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
K
----
T
D
K
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
--
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
---------------
K
-----------------------
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
--
A
----
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
---
S
K
---
K
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
-
D
I
L
K
K
V
E
K
G
K
Y
TF
E
--
L
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
-----
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-----
T
Y
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
61.21
31%
-112
- C2 -
3EFW
1
AURKA_HUMAN
A:
[126-385]
---------------------------------------
R
---------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
K
----
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
---------------
S
-----------------------
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
--
G
----
E
---
L
K
I
A
D
F
-----------------------------
L
D
Y
L
P
P
E
M
I
E
--------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
-
E
T
Y
K
R
I
S
R
V
E
F
--
T
--
F
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
-----
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
N
S
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
60.29
34%
-92
- C2 -
3WF7
2
KS6B1_HUMAN
A:
[14-286]
------------------------------------------------
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
---
M
-
I
V
R
N
A
----
K
D
T
A
-
H
T
K
A
E
R
N
I
L
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
--
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
---------------
G
-----------------------
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
---
Q
--
G
----
H
---
V
K
L
T
D
F
G
L
C
---
K
E
S
I
H
D-------
T
H
T
---
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-
G
H
-
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
-
K
T
I
D
K
I
L
K
C
K
L
--
N
--
L
P
P
----
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-
L
GAGP
G
D
A
G
E
V
Q
A
H
----
P
F
F
----
R
-----
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
60.27
38%
-91
- C2 -
2WEI
1
?
A:
[24-286]
-------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
-
A
--
K
N
----
K
D
T
S
-
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
--
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
---------------
K
-----------------------
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
KEK
D
--
C
----
D
---
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
--
N
T
---
K
M
K
D
---
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
--
T
Y
D
-
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
-
D
I
L
K
R
V
E
T
G
K
Y
--
A
FD
L
P
Q
----
W
RT
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
-
I
-----
T
A
T
Q
C
L
E
H
----
P
W
I
----
Q
-----
K
Y
S
S
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
HHSearch
59.57
36%
-97
- C2 -
3TKI
1
CHK1_HUMAN
A:
[3-270]
-------------------------------------------------
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
---------------
I
-----------------------
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
--
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
--
N
N
R
E
R
L
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
--
L
N
P
WK--
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
-----
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
-----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
59.43
32%
-90
- C2 -
2W5A
5
NEK2_HUMAN
A:
[5-276]
----------------------------------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
---
S
-
M
--
T
E
----
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
---------------
T
K
E
R
Q
-------------------
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
---
K
--
Q
----
N
---
V
K
L
G
D
F
G
L
A
---
R
I
L
-----
T
S
--
F
A
K
T
---
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
--
Y
N
-
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
-
E
L
A
G
K
I
R
E
G
K
F
R-
R
--
I
P
Y
----
R
--
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
-
P
-----
S
V
E
E
I
L
E
N
----
P
L
I
----
L
-----
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
59.13
36%
-89
- C2 -
2YEX
8
CHK1_HUMAN
A:
[4-270]
--------------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
---
V
----
D
C
P
E
-
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
--
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
---------------
I
-----------------------
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
---
R
--
D
----
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
--
N
N
R
E
R
L
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
--
L
N
P
WK--
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
-----
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
-----
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
56.91
33%
-74
- C2 -
2F7Z
1
KAPCA_BOVIN
E:
[35-342]
----------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
L
----
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
---------------
G
-----------------------
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
--
G
----
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
--
K
G
---
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-----
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
56.89
33%
-67
- C2 -
2OH0
1
KAPCA_BOVIN
E:
[35-342]
----------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
L
----
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
---------------
G
-----------------------
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
--
G
----
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
--
K
G
---
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-----
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
56.73
33%
-64
- C2 -
2F7X
1
KAPCA_BOVIN
E:
[35-342]
----------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
L
----
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
---------------
G
-----------------------
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
--
G
----
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
--
K
G
---
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-----
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
56.42
33%
-66
- C2 -
2OJF
1
KAPCA_BOVIN
E:
[35-342]
----------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
L
----
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
---------------
G
-----------------------
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
--
G
----
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
--
K
G
---
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-----
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
55.71
33%
-65
- C2 -
2F7E
1
KAPCA_BOVIN
E:
[35-342]
----------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
L
----
K
Q
I
E
-
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
---------------
G
-----------------------
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
--
G
----
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
--
K
G
---
R
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
-
Q
I
Y
E
K
I
V
S
G
K
V
--
R
--
F
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-----
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------