@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MARK4_HUMAN: (2015-10-13 )
MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
Atome Classification :
(29 SA)
.........10........20........30........40........50........60........70........80........90...-.-....100-........110.......120.......130.......140.......150-.......160.......170.......180.......190--........200.---......210.......220.......230.......240.......250.......260.......270.--....----.--.280.......290.......-300.....----------..310..----.....320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSS
R
T
V
LAPGNDRNSDTHGTLGSGRSSDKGPSWSSR
S
L
G
A
R
C
R
N
S
I
ASCPEEQPHVG
N
Y
R
L
L
R
T
IGKGNF
A
K
V
K
L
A
R
H
I
LTG
R
E
V
A
I
K
I
I
DKTQ-L-
N
P
S
S
L
-
Q
-
K
L
F
R
E
V
R
I
M
KGLNH
P
N
I
V
K
L
F
E
V
I
ETE
K
T
L
Y
L
V
M
EYASA
G
E
V
F
D
Y
L
V
SHGR-M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
QKN
I
V
H
R
DLKAE
N
L
L
LDA---EA
N
I
K
I
A
DFGFS---NEFTLGSK
L
D
T
FCGSPPYAA
P
E
LFQGKKYDGPE
V
D
I
W
S
L
G
V
I
L
Y
T
L
VSGSLPFDGH
N
L
K
E
L
R
E
R
V
LRGKY--RV
P
F
----
Y
--MST
D
C
E
S
I
L
R
R
F
L
VLN
P
A
K
R
C
-
T
L
E
Q
I
M
K
D----------K
W
I
NIGY----EGEELKPYTE
P
E
E
DFGD
T
K
R
I
E
V
M
V
GMGY
T
R
E
E
I
K
E
S
L
T
S
Q
K
Y
N
E
V
T
A
T
Y
L
L
LGRKTEEGGDRGAPG
L
A
L
A
R
V
RAPSDTTNGTSSSKGTSHSKGQRSSS
S
T
Y
H
R
Q
RRHSDFCGPSPAPLHPKRSPTST
G
E
A
E
L
K
E
ERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNP
N
K
A
EIPERRKDSTSTPNNL
P
P
S
M
M
TRRN
T
Y
V
CTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSG
E
R
S
RLARGST
I
R
STFHGGQ
V
R
DRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRP
T
T
N
L
F
T
K
L
T
S
K
L
T
R
R
VAD
E
P
E
RIGGPEV
T
S
C
HLPWDQTETAP
R
L
L
RF
P
W
S
V
K
LTSSR
P
P
E
A
L
M
A
A
L
R
Q
A
T
A
A
A
RCRCRQPQ
P
F
L
L
A
C
L
HGGAGGPEPLS
H
F
E
V
E
VCQLPRP
G
L
R
G
V
L
F
R
R
VA
G
T
A
L
A
F
R
T
L
V
T
R
I
SNDLEL
34
PsiBlast_CBE
65.57
41%
-101
- C3 -
4CQG
1
MELK_MOUSE
A:
[11-311]
----------------------------------------------------------
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
K
N
A
-
L
-
G
-
S
D
L
-
P
-
R
V
K
T
E
I
D
A
L
K
S
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
N
H
K
L
K
L
I
D
F
G
L
C
---
A
K
----------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
--
E
V
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-
S
M
R
N
L
L
N
H
----------
P
W
V
M
Q
D
Y
SCPV
E
W
Q
S
K
T
P
L
T
H
L
D
E
D
C
----
V
T
E
L
S
V
H
H
R
S
S
R
Q
T
M
E
D
L
I
S
S
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
L
E
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
64.81
42%
-104
- C3 -
4CZT
4
CIPKN_ARATH
D:
[10-274]
-------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
-
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
64.28
42%
-104
- C3 -
4CZU
3
CIPKN_ARATH
D:
[10-274]
-------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
-
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
64.24
35%
-117
- C3 -
3DJ5
1
AURKA_MOUSE
A:
[9-265]
-----------------------------------------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
-
L
-
E
K
A
G
V
-
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
N
G
E
L
K
I
A
D
F
G
W
-------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
--
T
F
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-
T
L
A
E
V
L
E
H
----------
P
W
I
K
A
N
S
----
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
64.21
42%
-109
- C3 -
4CZT
3
CIPKN_ARATH
C:
[10-274]
-------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
-
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
63.93
35%
-116
- C3 -
3DJ6
1
AURKA_MOUSE
A:
[9-265]
-----------------------------------------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
-
L
-
E
K
A
G
V
-
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
N
G
E
L
K
I
A
D
F
G
W
-------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
--
T
F
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-
T
L
A
E
V
L
E
H
----------
P
W
I
K
A
N
S
----
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
63.65
42%
-109
- C3 -
4CZU
3
CIPKN_ARATH
C:
[10-274]
-------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
-
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
P
K
F
E
N
A
D
V
D
A
I
F
D
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
63.55
45%
-109
- C3 -
4BKY
1
MELK_HUMAN
A:
[12-286]
----------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
-
L
----
D
L
-
P
-
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
H
K
L
K
L
I
D
F
G
L
C
---
A
-------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
--
D
V
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
63.26
34%
-121
* C3 *
3EFW
1
AURKA_HUMAN
B:
[132-383]
---------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
-
E
K
A
G
V
-
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
---------------------
L
D
Y
L
P
P
E
M
I
E
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-
M
L
R
E
V
L
E
H
----------
P
W
I
T
A
N
S
----
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
63.12
35%
-109
- C3 -
3DJ7
1
AURKA_MOUSE
A:
[8-265]
----------------------------------------------------
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
-
L
-
E
K
A
G
V
-
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
N
G
E
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
--
T
F
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-
T
L
A
E
V
L
E
H
----------
P
W
I
K
A
N
S
----
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
63.10
42%
-103
- C3 -
4CZU
3
CIPKN_ARATH
A:
[10-274]
-------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
-
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
P
K
F
E
N
D
D
V
D
A
I
F
D
D
S
G
E
S
K
N
L
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
63.07
45%
-104
- C3 -
3AQV
1
AAPK2_HUMAN
A:
[10-276]
-------------------------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
R
S
L
D
V
V
-
G
-
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
---
H
M
N
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
--
Y
I
P
E
----
Y
--
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
S
Y
L
F
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
62.88
45%
-109
- C3 -
4BKZ
1
MELK_HUMAN
A:
[12-286]
----------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
-
L
-----
L
-
P
-
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
H
K
L
K
L
I
D
F
G
L
C
---
A
-------------
S
L
A
Y
A
A
P
E
L
I
Q
G
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
--
D
V
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
62.76
35%
-113
- C3 -
3D2I
1
AURKA_MOUSE
A:
[8-265]
----------------------------------------------------
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
-
L
-
E
K
A
G
V
-
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
N
G
E
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
--
T
F
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-
T
L
A
E
V
L
E
H
----------
P
W
I
K
A
N
S
----
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
62.73
42%
-103
- C3 -
4CZT
2
CIPKN_ARATH
B:
[10-274]
-------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
-
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
62.66
35%
-107
- C3 -
3D14
1
AURKA_MOUSE
A:
[8-265]
----------------------------------------------------
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
-
L
-
E
K
A
G
V
-
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
N
G
E
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
--
T
F
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-
T
L
A
E
V
L
E
H
----------
P
W
I
K
A
N
S
----
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
62.63
42%
-103
- C3 -
4CZU
3
CIPKN_ARATH
B:
[10-274]
-------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
-
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
62.53
34%
-127
- C3 -
3EFW
1
AURKA_HUMAN
A:
[132-383]
---------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
-
E
K
A
G
V
-
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
---------------------
L
D
Y
L
P
P
E
M
I
E
-------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
--
T
F
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-
M
L
R
E
V
L
E
H
----------
P
W
I
T
A
N
S
----
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
62.05
42%
-98
- C3 -
4CZT
3
CIPKN_ARATH
A:
[10-274]
-------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
-
A
-
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
---
N
G
A
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
P
K
F
E
N
V
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
61.93
45%
-107
- C3 -
4BL1
1
MELK_HUMAN
A:
[12-286]
----------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
-
L
-----
L
-
P
-
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
---
Y
H
K
L
K
L
I
D
F
G
L
C
---
A
K
------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
--
D
V
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
61.78
39%
-105
- C3 -
3MA6
1
?
A:
[34-292]
----------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
-
V
K
Q
K
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
N
I
R
I
I
D
F
G
L
S
---
T
H
F
E
-
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
P
Q
----
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-
S
A
R
D
A
L
D
H
----------
E
W
I
Q
T
Y
T
----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
61.25
38%
-102
- C3 -
2WEI
1
?
A:
[24-286]
----------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
-
A
-
K
N
K
D
T
-
S
-
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
KEK
D
C
D
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
N
T
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
-
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
--
A
F
D
L
PQWR
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-
T
A
T
Q
C
L
E
H
----------
P
W
I
Q
-
K
Y
----
S
S
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
60.95
35%
-108
- C3 -
3D15
1
AURKA_MOUSE
A:
[8-265]
----------------------------------------------------
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
-
L
-
E
K
A
G
V
-
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
N
G
E
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
S
-------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
--
T
F
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-
T
L
A
E
V
L
E
H
----------
P
W
I
K
A
N
S
----
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
58.81
39%
-108
- C3 -
3MA6
1
?
B:
[34-292]
----------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
-
V
K
Q
-
T
D
K
-
E
-
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSK
D
A
N
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
-
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-
S
A
R
D
A
L
D
H
----------
E
W
I
Q
T
Y
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
PsiBlast_CBE
58.80
33%
-73
- C3 -
2F7X
1
KAPCA_BOVIN
E:
[40-343]
------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
K
L
K
Q
I
-
E
-
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
Y
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
58.33
33%
-77
- C3 -
2OJF
1
KAPCA_BOVIN
E:
[40-343]
------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
K
L
K
Q
I
-
E
-
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
Y
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
PsiBlast_CBE
58.10
33%
-78
- C3 -
2OH0
1
KAPCA_BOVIN
E:
[40-343]
------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
K
L
K
Q
I
-
E
-
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
Y
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
57.98
37%
-112
- C3 -
3COK
1
PLK4_HUMAN
A:
[1-261]
--------------------------------------------
S
L
A
T
C
I
G
E
K
--
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
-
M
-
Y
K
A
G
M
V
Q
-
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
---
N
M
N
I
K
I
A
D
F
G
L
A
---
T
Q
L
K
----------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
D
T
V
K
-----
V
V
L
A
D
Y
--
E
M
P
S
----
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-
S
L
S
S
V
L
D
H
----------
P
F
M
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
PsiBlast_CBE
57.46
33%
-80
- C3 -
2F7Z
1
KAPCA_BOVIN
E:
[40-343]
------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
K
L
K
Q
I
-
E
-
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
Y
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
--
R
F
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------