@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MAST2_HUMAN: (2015-10-13 )
MKRSRCRDRPQPPPPDRREDGVQRAAELSQSLPPRRRAPPGRQRLEERTGPAGPEGKEQDVVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVHSSVGQVTWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTCSPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHLSPPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEVVGARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTEEGPENSQGAQELSLAPHPEVSQSVAPKGAGESGEEDPFPSRDPRSLGPMVPSLLTGITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNLGQSGATDPIPPEGCWKAQHLHTQALTALSPSTSGLTPTSSCSPPSSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGLANLQDLENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWLWESECAQAVKEDPALSITQVPDASGDRRQDVPCRGCPLTQKSEPSLRRGQEPGGHQKHRDLALVPDELLKQT
Atome Classification :
(45 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500......-.510.......520........530---.......540.......-550........560.....-.-.570.......580.-......590.......600..-.....610.......620.......630.......640....-...650...----....660.......670....--------------...680.......690.......700-.----........710.......720.--......730........--.--740-........750.......760.......770.--......780.....--..790-......--..--800.......810------.........820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKRSRCRDRPQPPPP
D
R
R
E
D
G
V
Q
R
A
A
E
L
S
Q
SLPPRRRAPP
G
R
Q
R
L
E
E
RTGPAGPEGKE
Q
D
V
V
T
G
V
S
P
L
L
F
R
KLSNPDIFSSTG
K
V
K
L
Q
R
QLSQ
D
D
C
K
L
W
R
G
N
L
A
SSLSG
K
Q
L
LPL
S
S
S
V
H
S
SV
G
Q
V
T
WQSSGE
A
S
N
L
V
R
M
R
N
Q
SLGQSA
P
S
L
T
A
G
L
K
ELSLPRRGSFCRTSNR
K
S
L
I
V
TSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAP
A
H
F
S
F
V
PARRTDGRRWSLASLPSSGYGTNTPS
S
T
V
S
SSCS
S
Q
E
K
L
H
QLPFQP
T
A
D
E
L
H
F
L
T
K
HFSTESVPDEEGRQSPAMRPRSRSLSPGRSPVSFDSE
I
I
M
M
N
H
V
Y
K
E
RFP
K
A
T
A
Q
M
E
E
R
L
A
E
F
I
SSNTPDSVLPL
A
D
G
A
L
S
F
I
H
H
Q
V
I
E
M
A
R
D
C
L
D
KSRSGL
I
T
S
Q
Y
F
Y
E
L
Q
D
N
L
E
K
L
L
Q
D
A
H
ERSES
S
E
V
A
F
V
M
Q
L
V
K
K
L
M
I
I
IAR
P
A
R
L
L
E
C
LEF
D
P
E
E
F
Y
H
L
L
E
A
AEGHAKEGQGIKCD
I
P
R
Y
I
V
S
QLGL
T
R
D
P
L
E
E
M
A
Q
L
SSCDSPDTPETDDSIEGHGASLPSKKTP
S
-
E
EDF
E
T
I
K
L
ISNG-A
Y
G
A
V
F
L
V
RHK---
S
T
R
Q
R
F
A
M
K
K
INKQ
N
L
I
-
L
-
R
N
Q
I
Q
Q
A
F
V
E
R
D
I
L
T
FA-E-N
P
F
V
V
S
M
F
CSFDT
K
R
-
H
L
C
M
V
M
E
Y
VEGG
D
C
A
T
L
L
K
NI-GAL
P
V
D
M
V
R
L
Y
F
A
E
T
V
L
A
L
E
Y
L
H
NYGIVHRDLKPD
N
L
L
I
T
SM-G
H
I
K
L
TDFG----
L
S
KI
G
L
M
S
L
T
T
N
L
Y
EG
H
I
E
K
D
--------------
A
R
E
F
L
D
K
QVCGTPEYI
A
P
E
V
I
L
RQ---G----YGK
P
V
D
W
W
A
M
G
I
I
L
Y
E
F
L
V
G
C
V--PFFGD
T
P
--
E
E
L
F
G
Q
V
I--S--DE--IVWPEGDEALPP
D
A
Q
D
L
T
S
K
L
L
H
Q
N
P
L
E
R
LGT--GSA
Y
E
VKQHPFFTG--L
D
W
T
--
G
L
L
R
Q
K
--
A
E
--
F
IPQLESEDDT--------SY
F
D
T
R
S
E
R
YHHMDSE
D
E
E
E
VSEDG
C
L
E
I
R
Q
FSSCS
P
R
F
N
K
V
Y
S
S
M
E
R
L
S
L
L
E
ERRTPPPTKR
S
L
S
E
EKEDHSDGLAGLKGRDR
S
W
VIG
S
P
E
I
L
R
K
R
LSVSESSHTESDSSP
P
M
T
V
R
R
R
C
SGLLDAPRFPE
G
P
E
E
A
S
S
T
L
RRQPQE
G
I
W
V
LTPPSGEGVSGPVTEHSGEQRPKL
D
E
E
AVGRSSGSSP
A
M
ETRGR
G
T
S
Q
L
AEG
A
T
A
K
A
I
S
D
L
A
V
R
R
A
R
H
R
LLSGDSTEKRTAR
P
V
N
K
V
I
K
SASA
T
A
L
S
L
L
IPSEHHTCSPLASPMSPHSQSSNPSSRDSSPS
R
D
F
L
P
A
LGSMRP
P
I
I
I
H
RAGKKY
G
F
T
L
R
A
I
R
V
YMGDSD
V
Y
T
V
H
H
M
V
W
H
VEDGGPASEAGLRQG
D
L
I
T
HVNGEPVH
G
L
V
H
T
E
V
V
E
L
I
L
KSG
N
K
V
A
I
S
TTPLENT
S
I
K
VGPARKG
S
Y
K
A
K
M
A
R
R
S
K
RSRGKD
G
Q
E
S
R
K
R
S
S
L
F
R
K
I
T
K
Q
A
S
L
L
H
T
S
R
S
L
S
S
L
N
R
S
LSSGESGPGSPTHSHSLSPRSPTQ
G
Y
R
V
T
P
D
A
V
HSVGGNSSQSSSPSSSVPSSPAGSGHTRP
S
S
L
HGL
A
P
K
L
Q
R
Q
Y
RSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSG
H
V
A
QAFP
T
K
L
HLSPPL
G
R
QLSRPKSAEP
P
R
S
P
L
L
K
R
V
Q
S
A
E
K
L
A
A
A
L
A
A
S
E
K
K
L
ATSRKHSLDL
P
H
S
E
L
K
KELPPREVSP
L
E
VVGA
R
S
VLSGKGALPGKGVLQPA
P
S
R
A
L
G
T
L
R
Q
D
R
A
E
R
R
E
S
L
Q
K
Q
E
A
I
R
E
VDSSEDDTEEGPENSQG
A
Q
ELSLAPHP
E
V
S
QSVAPKGAGESGEEDPFPSRDPRSLG
P
M
V
P
S
L
L
TGITLGPPRMESPSGPHRRLG
S
P
Q
A
I
E
E
A
ASSSSAGPNLGQSGATDPIPPEGCW
K
A
Q
H
L
H
T
Q
A
L
TALSPSTSGLTPTSSCSPPSSTSGK
L
S
M
W
S
W
K
S
L
IEGPDRASPSR
K
A
T
M
AGGL
A
N
L
Q
D
LENTTPAQPKNLSPREQGKTQPPSAPRLAHPSYEDPSQGWL
W
E
S
E
C
A
Q
A
V
KEDPA
L
S
I
T
QVPDASGDRRQDVPCRGCPLTQKSEPSLRRGQEPGGHQKHRDLALV
P
D
E
L
LKQT
57
PsiBlast_CBE
86.07
39%
-87
- C3 -
2ETK
1
ROCK1_HUMAN
A:
[74-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
-
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
-
G
H
L
K
L
A
D
F
G
----
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
--
P
F
Y
A
D
S
L
--
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
--
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
--------
S
N
F
D
D
L
E
E
-----
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
85.77
39%
-86
- C3 -
2ETK
1
ROCK1_HUMAN
B:
[74-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
-
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
-
G
H
L
K
L
A
D
F
G
----
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
--
P
F
Y
A
D
S
L
--
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
--
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
--------
S
N
F
D
D
L
E
E
-----
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
85.14
39%
-87
- C3 -
3D9V
1
ROCK1_HUMAN
A:
[74-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
-
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
-
G
H
L
K
L
A
D
F
G
----
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
--
P
F
Y
A
D
S
L
--
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
--
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
--------
S
N
F
D
D
L
E
E
-----
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
84.92
39%
-84
* C3 *
2ESM
1
ROCK1_HUMAN
A:
[74-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
-
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
-
G
H
L
K
L
A
D
F
G
----
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
--
P
F
Y
A
D
S
L
--
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
--
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
--------
S
N
F
D
D
L
E
E
-----
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
84.80
39%
-83
- C3 -
2ESM
1
ROCK1_HUMAN
B:
[74-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
-
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
-
G
H
L
K
L
A
D
F
G
----
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
--
P
F
Y
A
D
S
L
--
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
--
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
--------
S
N
F
D
D
L
E
E
-----
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
84.72
39%
-86
- C3 -
2ETR
1
ROCK1_HUMAN
A:
[74-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
-
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
-
G
H
L
K
L
A
D
F
G
----
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
--
P
F
Y
A
D
S
L
--
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
--
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
--------
S
N
F
D
D
L
E
E
-----
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
84.29
39%
-82
- C3 -
3D9V
1
ROCK1_HUMAN
B:
[74-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
-
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
-
G
H
L
K
L
A
D
F
G
----
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
--
P
F
Y
A
D
S
L
--
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
--
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
--------
S
N
F
D
D
L
E
E
-----
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
83.96
39%
-84
- C3 -
2ETR
1
ROCK1_HUMAN
B:
[74-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
-
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
-
G
H
L
K
L
A
D
F
G
----
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
--
P
F
Y
A
D
S
L
--
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
--
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
--------
S
N
F
D
D
L
E
E
-----
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
83.86
35%
-81
- C3 -
4L46
1
KS6B1_HUMAN
A:
[12-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
K
I
R
P
---
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
----
L
C
K
E
S
I
H
D
---------------------------------
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
--
P
F
T
G
E
N
R
--
K
K
T
I
D
K
I
L
--
K
--
C
K
--
L
N
L
P
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GP
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
--
I
N
W
E
--
E
L
L
A
R
K
VE
P
P
--
F
K
P
L
---
E
E
D
V
--------
S
Q
F
D
S
K
F
T
R
Q
T
P
V
-------------
Q
V
F
L
G
F
T
Y
V
A
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
81.97
35%
-84
- C3 -
4L42
1
KS6B1_HUMAN
A:
[13-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
R
P
---
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
----
L
C
K
E
S
I
H
D
G
T
V
T
-----------------------------
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
--
P
F
T
G
E
N
R
--
K
K
T
I
D
K
I
L
--
K
--
C
K
--
L
N
L
P
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GP
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
--
I
N
W
E
--
E
L
L
A
R
K
VE
P
P
--
F
K
-------------------------------------------
E
M
F
R
D
F
E
Y
I
A
D
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
81.86
37%
-82
- C3 -
3VQH
2
KAPCA_HUMAN
A:
[34-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
81.85
35%
-80
- C3 -
4L43
1
KS6B1_HUMAN
A:
[12-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
K
I
R
P
---
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
----
L
C
K
E
S
----------------------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
--
P
F
T
G
E
N
R
--
K
K
T
I
D
K
I
L
--
K
--
C
K
--
L
N
L
P
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GP
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
--
I
N
W
E
--
E
L
L
A
R
K
VE
P
P
--
F
K
P
L
L
Q
S
E
E
D
V
--------
S
Q
F
D
S
K
F
T
R
Q
T
P
V
----------
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
81.14
35%
-76
- C3 -
4L44
1
KS6B1_HUMAN
A:
[12-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
K
I
R
P
---
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
----
L
C
K
E
S
I
H
----------------------------------
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
--
P
F
T
G
E
N
R
--
K
K
T
I
D
K
I
L
--
K
--
C
K
--
L
N
L
P
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GP
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
--
I
N
W
E
--
E
L
L
A
R
K
VE
P
P
--
F
K
P
L
L
Q
S
E
E
D
V
--------
S
Q
-
D
S
K
F
T
R
Q
T
----------
S
E
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
80.67
37%
-82
- C3 -
1L3R
3
KAPCA_MOUSE
E:
[33-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.67
37%
-86
- C3 -
1CDK
2
KAPCA_PIG
A:
[33-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
D
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
80.44
37%
-83
- C3 -
2UZW
1
KAPCA_BOVIN
E:
[19-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
D
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.40
37%
-81
- C3 -
2GU8
1
KAPCA_HUMAN
A:
[20-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
E
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
80.26
37%
-78
- C3 -
2GNI
1
KAPCA_BOVIN
A:
[33-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
79.81
37%
-94
- C3 -
2F2U
1
ROCK2_BOVIN
A:
[75-370]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
-
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
-
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
-
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
--------------------------------
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
--
P
F
Y
A
D
S
L
--
V
G
T
Y
S
K
I
M
D
H
K
--
N
S
--
L
C
F
P
E
-
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
Q
H
P
F
F
K
N
DQ
W
N
W
D
--
N
I
R
E
T
A
--
A
P
--
V
V
P
E
L
S
S
D
I
D
S
--------
S
N
F
D
D
I
E
V
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
79.78
37%
-78
- C3 -
2GNH
2
KAPCA_BOVIN
A:
[33-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
79.55
37%
-80
- C3 -
2F7X
1
KAPCA_BOVIN
E:
[34-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
79.53
37%
-94
- C3 -
2F2U
1
ROCK2_BOVIN
B:
[75-370]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
-
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
-
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
-
G
H
L
K
L
A
D
F
G
TCMK
M
D
E
T
G
M
V
H
C
D
T
A
V
--------------------------------
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
--
P
F
Y
A
D
S
L
--
V
G
T
Y
S
K
I
M
DH
K
--
N
S
--
L
C
F
P
E
-
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
Q
H
P
F
F
K
N
DQ
W
N
W
D
--
N
I
R
E
T
A
--
A
P
--
V
V
P
E
L
S
S
D
I
D
S
--------
S
N
F
D
D
I
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
79.38
37%
-85
- C3 -
2F7Z
1
KAPCA_BOVIN
E:
[34-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
79.35
37%
-80
- C3 -
1BX6
1
KAPCA_MOUSE
A:
[33-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
79.33
37%
-83
- C3 -
2OH0
1
KAPCA_BOVIN
E:
[34-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
79.15
37%
-82
- C3 -
2UZT
1
KAPCA_BOVIN
A:
[19-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
D
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.07
35%
-74
- C3 -
4LQS
1
CBK1_YEAST
A:
[102-454]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
H
T
V
K
V
I
G
K
G
-
A
F
G
E
V
R
L
V
Q
K
K
---
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
-
K
-
K
---------------
S
-
D
-
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
-
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
-
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
-
G
H
I
K
L
S
D
F
G
----
L
S
T
G
F
H
K
T
H
D
S
N
Y
--------NRQQ
I
Q
T
W
R
K----
S
R
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
Q
---
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
--
P
F
C
S
E
T
P
--
Q
E
T
Y
R
K
I
M
--
N
--
F
E
QT
L
Q
F
P
D
-
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
-
Q
R
L
G
R
H-
G
G
A
D
E
I
K
S
H
P
F
F
R
G
--
V
D
W
N
--
T
I
R
Q
V
E
--
A
P
--
Y
I
P
K
L
S
S
I
T
D
T
--------
R
F
F
P
T
D
E
L
E
N
V
P
D
S
P
A
M
I
G
Y
T
Y
S
R
F
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
78.95
37%
-75
- C3 -
3AGL
1
KAPCA_HUMAN
A:
[34-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
78.92
37%
-79
- C3 -
1BKX
1
KAPCA_MOUSE
A:
[33-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
78.73
37%
-86
- C3 -
2H9V
1
ROCK2_BOVIN
A:
[75-370]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
H
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
-
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
-
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
-
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
--------------------------------
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
--
P
F
Y
A
D
S
L
--
V
G
T
Y
S
K
I
M
D
H
K
--
N
S
--
L
C
F
P
E
-
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
Q
H
P
F
F
K
N
DQ
W
N
W
D
--
N
I
R
E
T
A
--
A
P
--
V
V
P
E
L
S
S
D
I
D
S
--------
S
N
F
D
D
I
E
I
P
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
78.59
37%
-81
- C3 -
2OJF
1
KAPCA_BOVIN
E:
[34-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
78.31
37%
-80
- C3 -
2F7E
1
KAPCA_BOVIN
E:
[34-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
77.73
37%
-80
- C3 -
2UZU
1
KAPCA_BOVIN
E:
[19-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
D
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
77.48
37%
-81
- C3 -
3TNQ
1
KAPCA_MOUSE
B:
[33-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
77.32
37%
-81
- C3 -
4NTT
1
KAPCA_MOUSE
A:
[33-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.25
35%
-74
- C3 -
4LQQ
1
CBK1_YEAST
A:
[102-454]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
H
T
V
K
V
I
G
K
G
-
A
F
G
E
V
R
L
V
Q
K
K
---
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
-
K
-
K
---------------
S
-
D
-
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
-
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
-
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
-
G
H
I
K
L
S
D
F
G
----
L
S
T
G
F
H
K
T
H
D
S
N
Y
--------L
T
M
S
N
RQQ
I
Q
T
W
R
K
S
R
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
Q
---
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
--
P
F
C
S
E
T
P
--
Q
E
T
Y
R
K
I
M
--
N
--
F
E
QT
L
Q
F
P
D
-
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
-
Q
R
L
G
R
H-
G
G
A
D
E
I
K
S
H
P
F
F
R
G
--
V
D
W
N
--
T
I
R
Q
V
E
--
A
P
--
Y
I
P
K
L
S
S
I
T
D
T
--------
R
F
F
P
T
D
E
L
E
N
V
P
D
S
P
A
M
I
G
Y
E
Y
S
R
F
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
76.85
38%
-81
- C3 -
4Q9Z
1
KPCT_HUMAN
A:
[5-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
----
M
C
K
E
N
M
L
G
------------
D
--------------
A
K
T
---
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
--
P
F
H
G
Q
D
E
--
E
E
L
F
H
S
I
R
--
M
--
D
N
--
P
F
Y
P
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
--
R
G
--
D
I
R
Q
H
P
L
F
R
E
--
I
N
W
E
--
E
L
E
R
K
E
--
I
D
PP
F
R
P
K
V
K
S
P
F
D
C
--------
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
L
I
N
S
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
E
R
L
I
S
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.66
38%
-76
- C3 -
4Q9Z
1
B:
[5-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
----
M
C
K
E
N
M
L
G
------------
D
--------------
A
K
T
---
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
--
P
F
H
G
Q
D
E
--
E
E
L
F
H
S
I
R
--
M
--
D
N
--
P
F
Y
P
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
--
R
G
--
D
I
R
Q
H
P
L
F
R
E
--
I
N
W
E
--
E
L
E
R
K
E
--
I
D
PP
F
R
P
K
V
K
S
P
F
D
C
--------
S
N
F
D
K
N
M
F
R
N
F
S
F
M
N
P
G
M
E
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
74.96
35%
-90
- C3 -
3A61
1
KS6B1_HUMAN
A:
[15-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
---
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
GA
N
T
G
K
I
F
A
M
K
V
L
K
----------------
A
E
R
N
I
L
E
E
V
-
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
-------------------------------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
--
P
F
T
G
E
N
R
--
K
K
T
I
D
K
I
L
--
K
--
C
K
--
L
N
L
P
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GP
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
--
I
N
W
E
--
E
L
L
A
R
K
VE
P
P
--
F
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
72.42
35%
-85
- C3 -
3A60
1
KS6B1_HUMAN
A:
[13-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
---
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
GA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
------------
K
A
E
R
N
I
L
E
E
V
-
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
----
L
C
K
E
------------------------------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
--
P
F
T
G
E
N
R
--
K
K
T
I
D
K
I
L
--
K
--
C
K
--
L
N
L
P
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GP
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
--
I
N
W
E
--
E
L
L
A
R
K
VE
P
P
--
F
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
71.80
35%
-72
- C3 -
4LQP
1
CBK1_YEAST
A:
[102-454]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
H
T
V
K
V
I
G
K
G
-
A
F
G
E
V
R
L
V
Q
K
K
---
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
-
K
-
K
------------
L
A
G
S
-
D
-
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
-
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
-
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
-
G
H
I
K
L
S
D
F
G
----
L
S
T
G
F
H
K
T
H
D
S
N
Y
--------QTWRK---------
S
R
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
Q
---
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
--
P
F
C
S
E
T
P
--
Q
E
T
Y
R
K
I
M
--
N
--
F
E
QT
L
Q
F
P
D
-
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
-
Q
R
L
G
R
H-
G
G
A
D
E
I
K
S
H
P
F
F
R
G
--
V
D
W
N
--
T
I
R
Q
V
E
--
A
P
--
Y
I
P
K
L
S
S
I
T
D
T
--------
R
F
F
P
T
D
E
L
E
N
V
P
D
S
P
A
M
F
I
G
Y
E
Y
S
R
F
D
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Fugue
69.52
31%
-70
- C3 -
1CDK
2
KAPCA_PIG
A:
[8-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
------H
L
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
--
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
--N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
-S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
-Q
G
Y
I
Q
V
T
D
F
G
----
F
A
--------
K
R
V
-
K
--
G
--
R
--------------
T
-----
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-KGY------
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
--YP
P
F
F
A
D
--
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
S
---------------------------------------------------
H
F
S
S
D
L
--
K
D
--
L
L
R
N
L
L
Q
V
D
L
T
KRFGNLKD
G
V
N
D
I
K
N
H
K
W
F
A
-------
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
--------
N
E
K
C
G
K
E
F
S
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
69.24
35%
-77
- C3 -
3A60
1
KS6B1_HUMAN
B:
[13-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
---
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
-------------------------
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
----
L
C
K
E
S
---------------------------------------
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
--
P
F
T
G
E
N
R
--
K
K
T
I
D
K
I
L
--
K
--
C
K
--
L
N
L
P
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GP
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
--
I
N
W
E
--
E
L
L
A
R
K
VE
P
P
--
F
K
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
49.27
37%
-20
- C3 -
4WB8
2
KAPCA_HUMAN
A:
[20-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
33.74
37%
16
- C3 -
2UZV
1
KAPCA_BOVIN
A:
[19-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Q
N
T
A
H
-
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
----
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
--
P
F
F
A
D
Q
P
--
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
D
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
--------
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------