@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MAST3_HUMAN: (2015-10-13 )
MDESSLLRRRGLQKELSLPRRGRGCRSGNRKSLVVGTPSPTLSRPLSPLSVPTAGSSPLDSPRNFSAASALNFPFARRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQPTPDELHFLSKHFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERFPKATAQMEGRLQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFLEMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAAEGHAREGQGIKTDLPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRRKPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQPTPTFAERSFSEDREEGWERSEVDYGRRLSADIRLRSWTSSGSSCQSSSSQPERGPSPSLLNTISLDTMPKFAFSSEDEGVGPGPAGPKRPVFILGEPDPPPAATPVMPKPSSLSADTAALSHARLRSNSIGARHSTPRPLDAGRGRRLGGPRDPAPEKSRASSSGGSGGGSGGRVPKSASVSALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPSPVCGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAGLRAGDLITHINGESVLGLVHMDVVELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMARRSKRSRRRETQDRRKSLFKKISKQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPSASPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPRSPSPLPGHPPAPARSPRLRRGQSADKLGTGERLDGEAGRRTRGPEAELVVMRRLHLSERRDSFKKQEAVQEVSFDEPQEEATGLPTSVPQIAVEGEEAVPVALGPTGRD
Atome Classification :
(53 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.....---..390.......400...-....410.......420-.......430.......440.......450......-.460.......470.......480.......490.......500.......510.......520.......530-------------........540.......550.-----.-----..----...560.......570.......580.......590.--.--..--...600.......610.......620......--.630.......640-.....--...650--..--.....660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
E
S
S
L
L
R
R
RG
L
Q
K
E
LSLPRRGRGCRSGNR
K
S
L
V
V
GTPSPTLSRPLSPLSVPTAGSSPLDSPRNFSAASALNFPFARRADGRRWSLASLPSSGYGTNTPSSTLSSSS
S
S
R
E
R
L
H
QLPFQPT
P
D
E
L
H
F
L
S
K
HFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNE
I
V
M
M
N
H
V
Y
R
E
RFP
K
A
T
A
Q
M
E
G
R
L
Q
E
F
L
T
A
YAPG
A
R
L
A
L
A
D
G
V
L
G
F
I
H
H
Q
I
V
E
L
A
R
D
C
L
A
KSGE
N
L
V
T
S
R
Y
F
L
E
M
Q
E
K
L
E
R
L
L
Q
D
A
HERSD
S
E
E
V
S
F
I
V
Q
L
V
R
K
L
L
I
I
ISR
P
A
R
L
L
E
C
LEF
D
P
E
E
F
Y
H
L
L
E
A
AEGHAREGQGIKTD
L
P
Q
Y
I
I
G
QLGLAKD
P
L
E
E
MVP
L
S
H
LEEEQPPAPESPE
S
R
A
L
VGQSRRKP
C
E
S
D
F
E
T
I
K
L
ISNGA
Y
G
A
V
Y
L
V
RHR---D
T
R
Q
R
F
A
I
K
KINKQ
N
L
I
L
-
R
N
Q
I
Q
Q
V
F
V
ER
D
I
L
T
FA-EN
P
F
V
V
S
M
F
CSF
E
T
R
R
H
L
C
M
V
M
E
Y
VEGG
D
C
A
T
L
L
K
N-MGPL
P
V
D
M
A
R
L
Y
F
A
E
T
V
L
A
L
E
Y
L
H
NYGIVHRDLKPD
N
L
L
I
T
SLG
H
I
K
L
TDFG
L
S
K
I
G
L
M
S
M
A
T
N
L
Y
EG
H
I
E
K
D
--------------
A
R
E
F
I
D
K
QVCGTPEYI
A
P
E
V
I
F
-----R-----QG----YGK
P
V
D
W
W
A
M
G
V
V
L
Y
E
F
L
V
G
C
VPFFGD
T
P
E
E
L
F
G
Q
V
V
--S--DE--IMWPEGDEALPA
D
A
Q
D
L
I
T
R
L
L
R
QS
P
L
D
RLGT--GGTHEVKQH
P
F
F
L
--
A
L
D
W
A
--
G
L
L
R
H
K
--
A
E
--FVPQLEAEDDTSY
F
D
T
R
S
E
R
Y
R
HLGSEDDETNDEESSTEIPQ
F
S
S
C
S
H
R
F
S
K
VYSSS
E
F
L
A
VQPTP
T
F
A
E
RSF
S
E
D
R
E
EGWERSEVDYGRRLS
A
D
I
R
L
R
S
WTSSGSSCQSSSSQPERGPSPS
L
L
N
T
ISLDTMPKFAFSSEDEGVGPGPAGPKR
P
V
F
I
L
GEPDPPPAATPVMPKPSSLS
A
D
T
A
A
L
S
H
A
R
LRSNSIGARHSTPRPLDAGRGRRLGGPRDPAPEKSRASSSGGSGGGSGGRVPKSAS
V
S
A
L
S
L
I
I
T
ADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPSPVCGSLRP
P
I
V
I
HSSGKKY
G
F
S
L
R
A
I
R
V
Y
MGDS
D
V
Y
T
V
H
H
V
V
W
SVEDGS
P
A
Q
E
AGLRAG
D
L
I
T
HINGE
S
V
L
G
L
V
H
M
D
V
V
E
L
L
L
KSG
N
K
I
S
L
R
T
T
ALEN
T
S
I
K
VGPARK
N
V
A
K
G
R
M
A
R
R
S
K
R
S
R
R
R
E
T
Q
D
R
R
K
S
L
F
K
K
I
S
K
Q
T
S
V
LHTSRS
F
S
SGLHHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPSASPSSSSPASPAAAGHTR
P
S
S
L
H
G
L
A
A
KLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPRSPSPLPGHPPAPARSPRLRRGQSADKLGTGERLDGEAGRRTRGP
E
A
E
L
V
V
M
R
R
L
H
L
S
E
R
R
D
S
F
K
K
Q
E
A
V
Q
EVSFDE
P
Q
E
EATGLPTSV
P
Q
I
A
VEGEEA
V
P
V
ALGPTGRD
45
PsiBlast_CBE
86.87
38%
-103
- C2 -
5BML
1
ROCK1_HUMAN
B:
[75-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
--
N
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------
D
L
E
E
---
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
86.17
38%
-103
- C2 -
4YVE
1
ROCK1_HUMAN
B:
[75-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
--
N
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------
D
L
-----
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
85.90
38%
-98
- C2 -
2ETK
1
ROCK1_HUMAN
B:
[75-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
--
N
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
84.78
38%
-105
- C2 -
5BML
1
ROCK1_HUMAN
A:
[75-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
--
N
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------
D
L
-----
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
84.58
38%
-101
- C2 -
2ETK
1
ROCK1_HUMAN
A:
[75-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
--
N
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
84.55
38%
-96
- C2 -
3D9V
1
ROCK1_HUMAN
B:
[75-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
--
N
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
84.16
38%
-98
- C2 -
2ESM
1
ROCK1_HUMAN
B:
[75-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
--
N
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
83.98
38%
-97
- C2 -
2ETR
1
ROCK1_HUMAN
B:
[75-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
--
N
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
83.93
38%
-100
- C2 -
2ETR
1
ROCK1_HUMAN
A:
[75-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
--
N
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
83.55
38%
-110
- C2 -
2F2U
1
ROCK2_BOVIN
A:
[76-370]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
D
E
T
---
G
M
V
H
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
--
N
S
--
L
C
F
P
E
-
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
Q
H
P
F
F
K
ND
Q
W
N
W
D
--
N
I
R
E
T
A
--
A
P
--
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
V
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
83.51
38%
-99
- C2 -
3D9V
1
ROCK1_HUMAN
A:
[75-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
--
N
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
83.30
38%
-98
- C2 -
2ESM
1
ROCK1_HUMAN
A:
[75-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
N
K
---
E
G
M
V
R
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
--
N
HK
N
S
--
L
T
F
P
D
-
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
--
N
D
Q
W
A
WE
T
L
R
D
T
V
--
A
P
--
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
82.81
38%
-108
* C2 *
2F2U
1
ROCK2_BOVIN
B:
[76-370]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
D
E
T
---
G
M
V
H
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
DH
K
--
N
S
--
L
C
F
P
E
-
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
Q
H
P
F
F
K
ND
Q
W
N
W
D
--
N
I
R
E
T
A
--
A
P
--
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
T
F
P
I
P
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
81.05
37%
-99
- C2 -
3VQH
2
KAPCA_HUMAN
A:
[44-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
80.82
33%
-100
- C2 -
4L42
1
KS6B1_HUMAN
A:
[20-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
-----------------------------
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
-----
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
--
K
--
C
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GP
G
D
A
G
E
V
Q
A
H
P
F
F
R
--
H
I
N
W
E
--
E
L
L
A
R
K
VE
P
P
--
F
K
-----------------------------------
E
M
F
R
D
F
E
Y
I
A
D
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.65
37%
-95
- C2 -
2GNI
1
KAPCA_BOVIN
A:
[43-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
80.20
38%
-102
- C2 -
2H9V
1
ROCK2_BOVIN
A:
[76-370]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
---
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
D
-
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
----
M
K
M
D
E
T
---
G
M
V
H
C
D
--------------
T
-------
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
-----
S
-----
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
--
N
S
--
L
C
F
P
E
-
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
-
R
L
G
R
--
N
G
V
E
E
I
K
Q
H
P
F
F
K
ND
Q
W
N
W
D
--
N
I
R
E
T
A
--
A
P
--
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
I
P
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
79.89
37%
-98
- C2 -
3OWP
1
KAPCA_HUMAN
A:
[44-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
79.76
37%
-98
- C2 -
3OOG
1
KAPCA_HUMAN
A:
[44-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
79.34
37%
-97
- C2 -
3OVV
2
KAPCA_HUMAN
A:
[44-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
78.84
37%
-100
- C2 -
2UZT
1
KAPCA_BOVIN
A:
[29-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
D
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
78.71
37%
-96
- C2 -
2GNH
2
KAPCA_BOVIN
A:
[43-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.67
37%
-96
- C2 -
2GNF
1
KAPCA_BOVIN
A:
[43-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
78.51
37%
-100
- C2 -
2UZW
1
KAPCA_BOVIN
E:
[29-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
D
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
78.33
37%
-95
- C2 -
3AGM
1
KAPCA_HUMAN
A:
[44-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.20
37%
-101
- C2 -
1CDK
2
KAPCA_PIG
A:
[43-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
D
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
78.14
37%
-102
- C2 -
2F7Z
1
KAPCA_BOVIN
E:
[44-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
78.12
37%
-99
- C2 -
2OH0
1
KAPCA_BOVIN
E:
[44-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
78.05
37%
-96
- C2 -
2F7X
1
KAPCA_BOVIN
E:
[44-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.90
34%
-88
- C2 -
4LQS
1
CBK1_YEAST
A:
[103-454]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
---
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K
-
K
---------------
S
-
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
-
W
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
Y
--------NRQQ
I
Q
T
W
R
K----
S
R
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
-----
Y
-----
Q
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
--
N
--
F
E
QT
L
Q
F
P
D
-
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
-
Q
R
L
G
R
H-
G
G
A
D
E
I
K
S
H
P
F
F
R
--
G
V
D
W
N
--
T
I
R
Q
V
E
--
A
P
--
Y
I
P
K
L
S
S
I
T
D
T
R
F
F
P
T
D
E
L
E
N
V
P
D
S
P
A
M
I
G
Y
T
Y
S
R
F
D
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
77.82
37%
-96
- C2 -
3L9L
1
KAPCA_HUMAN
A:
[44-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
77.67
37%
-98
- C2 -
2OJF
1
KAPCA_BOVIN
E:
[44-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
77.41
32%
-97
- C2 -
4L43
1
KS6B1_HUMAN
A:
[20-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
----------------------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
-----
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
--
K
--
C
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GP
G
D
A
G
E
V
Q
A
H
P
F
F
R
--
H
I
N
W
E
--
E
L
L
A
R
K
VE
P
P
--
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
V
----------
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
77.33
37%
-98
- C2 -
2F7E
1
KAPCA_BOVIN
E:
[44-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
77.12
37%
-94
- C2 -
3AGL
1
KAPCA_HUMAN
A:
[44-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
77.06
32%
-89
- C2 -
3QFV
2
MRCKB_HUMAN
A:
[70-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
---
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
--------------
L
K
M
N
D
--------------
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
-----
A
M
E
DGM
G
K
----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
--
N
--
H
E
ER
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
-
L
I
C
S
R
E
R
R
L
G
Q
--
N
G
I
E
D
F
K
K
H
A
F
F
E
--
G
L
N
W
E
--
N
I
R
N
L
E
--
A
P
--
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
-------------------
S
G
L
H
L
P
-
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
76.87
31%
-87
- C2 -
3TKU
3
MRCKB_HUMAN
B:
[86-431]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
---
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
--------------
L
K
M
N
D
--------------
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
-----
A
MEDGM
G
K
----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
--
N
--
H
E
ER
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
-
L
I
C
S
R
E
R
R
L
G
Q
--
N
G
I
E
D
F
K
K
H
A
F
F
E
--
G
L
N
W
E
--
N
I
R
N
L
E
--
A
P
--
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
-------------------
F
S
G
L
H
L
P
-
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
76.80
31%
-87
- C2 -
3TKU
3
MRCKB_HUMAN
A:
[86-431]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
---
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
--------------
L
K
M
N
D
--------------
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
-----
A
M
E
D
G
M
G
K
----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
--
N
--
H
E
ER
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
-
L
I
C
S
R
E
R
R
L
G
Q
--
N
G
I
E
D
F
K
K
H
A
F
F
E
--
G
L
N
W
E
--
N
I
R
N
L
E
--
A
P
--
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
-------------------
S
G
L
H
L
P
-
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
75.84
37%
-99
- C2 -
2UZU
1
KAPCA_BOVIN
E:
[29-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
D
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
75.44
32%
-85
- C2 -
3QFV
3
MRCKB_HUMAN
B:
[70-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
---
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
--------------
L
K
M
N
D
--------------
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
-----
A
MEDGM
G
K
----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
--
N
--
H
E
ER
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
-
L
I
C
S
R
E
R
R
L
G
Q
--
N
G
I
E
D
F
K
K
H
A
F
F
E
--
G
L
N
W
E
--
N
I
R
N
L
E
--
A
P
--
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
------------------
G
F
S
G
L
H
L
P
-
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
75.35
31%
-86
- C2 -
4UAK
2
MRCKB_HUMAN
A:
[72-418]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
---
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
--------------
L
K
M
N
D
--------------
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
-----
A
M
E
DG
M
G
K
----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
--
N
--
H
E
ER
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
-
L
I
C
S
R
E
R
R
L
G
Q
--
N
G
I
E
D
F
K
K
H
A
F
F
E
--
G
L
N
W
E
--
N
I
R
N
L
E
--
A
P
--
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
---------------
S
H
T
G
F
S
G
L
H
L
P
-
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
75.27
32%
-91
- C2 -
4L44
1
KS6B1_HUMAN
A:
[20-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
----------------------------------
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
-----
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
--
K
--
C
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GP
G
D
A
G
E
V
Q
A
H
P
F
F
R
--
H
I
N
W
E
--
E
L
L
A
R
K
VE
P
P
--
F
K
P
L
L
Q
S
E
E
D
V
S
Q
-
D
S
K
F
T
R
Q
T
----------
S
E
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
74.77
31%
-84
- C2 -
4AW2
3
MRCKA_RAT
A:
[73-416]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
---
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
----------------------------
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
GG
K
-----
G
R
----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
--
N
--
H
K
ER
F
Q
F
P
T
Q
V
T
D
V
S
E
N
A
K
D
L
I
R
R
-
L
I
C
S
R
E
H
R
L
G
Q
--
N
G
I
E
D
F
K
K
H
P
F
F
S
--
G
I
D
W
D
--
N
I
R
N
C
E
--
A
P
--
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
------------------
S
G
H
H
L
P
-
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.59
34%
-88
- C2 -
4LQQ
1
CBK1_YEAST
A:
[103-454]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
---
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K
-
K
---------------
S
-
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
-
W
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
Y
--------L
T
M
S
N
RQQ
I
Q
T
W
R
K
S
R
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
-----
Y
-----
Q
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
--
N
--
F
E
QT
L
Q
F
P
D
-
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
-
Q
R
L
G
R
H-
G
G
A
D
E
I
K
S
H
P
F
F
R
--
G
V
D
W
N
--
T
I
R
Q
V
E
--
A
P
--
Y
I
P
K
L
S
S
I
T
D
T
R
F
F
P
T
D
E
L
E
N
V
P
D
S
P
A
M
I
G
Y
E
Y
S
R
F
D
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.25
38%
-98
- C2 -
4Q9Z
1
KPCT_HUMAN
A:
[6-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
------------
D
--------------
A
K
T
---
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
-----
G
-----
Q
K
----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
L
F
H
S
I
R
--
M
--
D
N
--
P
F
Y
P
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
--
R
G
--
D
I
R
Q
H
P
L
F
R
--
E
I
N
W
E
--
E
L
E
R
K
E
--
I
D
PP
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
L
I
N
S
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
E
R
L
I
S
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
73.42
31%
-85
- C2 -
4UAL
2
MRCKB_HUMAN
A:
[72-418]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
---
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
--------------
L
K
M
N
D
--------------
D
G
T
V
---
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
-----
A
M
E
D
--
G
K
----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
--
N
--
H
E
ER
F
Q
F
P
S
H
V
T
D
V
S
E
E
A
K
D
L
I
Q
R
-
L
I
C
S
R
E
R
R
L
G
Q
--
N
G
I
E
D
F
K
K
H
A
F
F
E
--
G
L
N
W
E
--
N
I
R
N
L
E
--
A
P
--
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
---------
I
L
P
P
--
H
T
G
F
S
G
L
H
L
P
-
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
73.41
33%
-107
- C2 -
3A61
1
KS6B1_HUMAN
A:
[19-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
GA
N
T
G
K
I
F
A
M
K
V
L
K
---------------
A
E
R
N
I
L
E
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
---------------------------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
-----
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
--
K
--
C
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GP
G
D
A
G
E
V
Q
A
H
P
F
F
R
--
H
I
N
W
E
--
E
L
L
A
R
K
VE
P
P
--
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
73.36
38%
-93
- C2 -
4Q9Z
1
B:
[6-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
-
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
------------
D
--------------
A
K
T
---
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
-----
G
-----
Q
K
----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
L
F
H
S
I
R
--
M
--
D
N
--
P
F
Y
P
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
--
R
G
--
D
I
R
Q
H
P
L
F
R
--
E
I
N
W
E
--
E
L
E
R
K
E
--
I
D
PP
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
N
M
F
R
N
F
S
F
M
N
P
G
M
E
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
72.64
37%
-96
- C2 -
2UZV
1
KAPCA_BOVIN
A:
[29-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
D
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.00
34%
-87
- C2 -
4LQP
1
CBK1_YEAST
A:
[103-454]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
---
D
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K
-
K
------------
L
A
G
S
-
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
-
W
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
Y
--------QTWRK---------
S
R
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
-----
Y
-----
Q
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
--
N
--
F
E
QT
L
Q
F
P
D
-
D
I
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
-
Q
R
L
G
R
H-
G
G
A
D
E
I
K
S
H
P
F
F
R
--
G
V
D
W
N
--
T
I
R
Q
V
E
--
A
P
--
Y
I
P
K
L
S
S
I
T
D
T
R
F
F
P
T
D
E
L
E
N
V
P
D
S
P
A
M
F
I
G
Y
E
Y
S
R
F
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
69.01
33%
-102
- C2 -
3A60
1
KS6B1_HUMAN
A:
[19-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
GA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
-----------
K
A
E
R
N
I
L
E
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
------------------------------------------
T
I
E
Y
M
A
P
E
I
L
M
-----
R
-----
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
--
K
--
C
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GP
G
D
A
G
E
V
Q
A
H
P
F
F
R
--
H
I
N
W
E
--
E
L
L
A
R
K
VE
P
P
--
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
62.80
33%
-97
- C2 -
3A60
1
KS6B1_HUMAN
B:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
---------------------------------------
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
-----
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
--
K
--
C
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
GP
G
D
A
G
E
V
Q
A
H
P
F
F
R
--
H
I
N
W
E
--
E
L
L
A
R
K
VE
P
P
--
F
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
39.71
37%
-35
- C2 -
4WB8
2
KAPCA_HUMAN
A:
[30-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
---------------
R
V
K
--------------
G
R
T
W
---
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-----
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
--
S
--
G
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
LK
N
G
V
N
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
--
A
I
Y
Q
R
K
--
V
E
AP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------