@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MATK_HUMAN: (2015-10-13 )
MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP
Atome Classification :
(106 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130......--.--140.--........150.......160-----.......170...-.-....180.......190.......200.....--..210.......------------220......-..230.......-240.......250..-------.-------.---------.-..260...-.------.---.---.---270.......280.-......290..-...-.--.--300.......310.......320-------------.------.......330.......340.......350.......360.......370...----.--..----.-----380----.-----...-----.....390.......400.......410.......420.......430-........440.......450.......460.......470.......480.......490.......500.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGRGSL
V
S
W
R
AFHGC
D
S
A
E
ELPRV
S
P
R
F
L
RAWHPPPVSARMPTRRWAP
G
T
Q
C
I
T
K
CEHTRPKPGE
L
A
FRKGD
V
V
T
I
L
E
A
CENK
S
W
Y
R
V
KHHTSGQE
G
L
L
A
A
G
ALR
E
R
E
ALSADPK
L
S
LMPWFHGKIS
G
Q
E
A
V
Q
QLQP--P--E--D--
G
L
F
L
V
R
ESARHPG
D
Y
V
L
C
VSF-----GRD
V
I
H
Y
R
V
-LHR-D-G
H
L
T
I
D
E
A
V
F
F
C
N
L
M
D
M
V
E
H
YSK
D
K
G
A
I
C
T
K
L--VR
P
K
RKHGT
K
S
A
------------
E
-
E
E
L
A
RAG-
W
L
L
N
L
Q
H
L
T
LGA-QIGEGE
F
G
A
V
L
QGEY-------L-------G---------
Q
-
K
V
A
V
K
N
I
K
-
C
------
D
---
V
---
T
---
A
Q
A
F
L
D
E
T
A
V
M
T
K
M
-
Q
H
E
N
L
V
R
L
L
G
V
-
I
L
H-Q--
G
--
L
Y
I
V
M
E
HVSKG
N
L
V
N
F
L
R
T
R
G
R
--------------
A
------
L
V
N
T
A
Q
L
L
Q
F
S
L
H
V
A
E
G
M
E
Y
L
E
S
K
K
L
V
H
R
D
L
A
ARNILV
S
E
D
L
V
A
K
V
S
D
FGL
A
K
----
A
--
E
R----K-----G------L-----DSS-----RL
P
V
K
WT
A
P
E
A
L
KHGKFTSK
S
D
V
W
S
F
G
V
L
L
W
E
V
F
SYGRAPYPKM
S
L
-
K
-
E
V
S
E
A
V
EKGYRMEPPEGCP
G
P
V
H
V
L
M
S
S
CWEAEPARRP
P
F
R
K
L
A
E
K
L
A
R
E
L
R
SAGAPASVSGQDADGSTSPRSQEP
114
HHSearch
86.24
37%
-98
- C2 -
2H8H
1
SRC_HUMAN
A:
[87-523]
---------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
------
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
--
A
EN
P
--
R
--
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
NAK
G
L
N
V
K
H
Y
K
I
-
R
K
L
D
S
-
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
--
T
T
V
C
P
T
S
K
--
P
Q
------------
T
-
Q
G
L
A
K
D
A
-
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
-------
G
---------
T
T
R
V
A
I
K
T
L
K
-
P
------
G
T--
M
---
S
---
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
--
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
--------------
K
------
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
----
L
--
I
E
----
D
N
E
Y
T
-
A
------
R
-----
Q
G
A
-----
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
-
R
-
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
----------------
8
PsiBlast_PDB
83.51
39%
-104
- C2 -
2SRC
1
SRC_HUMAN
A:
[18-431]
-----------------------------------------------------------------
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
E
G
-
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
------
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
--
A
--
E
--
N
PR
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
NAK
G
L
N
V
K
H
Y
K
I
-
R
K
L
-
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
TT
V
C
P
T
S
K
P
Q
T
Q
G
-----------------
L
A
K
D
A
-
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
-------
G
---------
T
T
R
V
A
I
K
T
L
K
P
G
------
T
---
M
---
S
---
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
--
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
--------------
K
------
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
LIED
N
--
E
Y
----
T
-----
A
------
R
-----
Q
G
A
-----
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
-
R
-
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
------------
29
PsiBlast_CBE
83.05
37%
-106
- C2 -
3VS5
1
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
11
PsiBlast_PDB
82.46
39%
-103
- C2 -
4K11
1
SRC_HUMAN
A:
[16-429]
-----------------------------------------------------------------
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
E
G
-
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
------
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
--
A
--
E
--
N
PR
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
NAK
G
L
N
V
K
H
Y
K
I
-
R
K
L
-
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
TT
V
C
P
T
S
K
P
Q
T
Q
G
-----------------
L
A
K
D
A
-
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
-------
G
---------
T
T
R
V
A
I
K
T
L
K
P
G
------
T
---
M
---
S
---
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
--
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
--------------
K
------
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
LIED
N
--
E
Y
----
T
-----
A
------
R
-----
Q
G
A
-----
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
-
R
-
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
--------------
9
PsiBlast_PDB
82.44
39%
-110
- C2 -
1Y57
1
SRC_HUMAN
A:
[18-431]
-----------------------------------------------------------------
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
E
G
-
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
------
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
--
A
--
E
--
N
PR
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
NAK
G
L
N
V
K
H
Y
K
I
-
R
K
L
-
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
TT
V
C
P
T
S
K
P
Q
T
Q
G
-----------------
L
A
K
D
A
-
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
-------
G
---------
T
T
R
V
A
I
K
T
L
K
P
G
------
T
---
M
---
S
---
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
--
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
--------------
K
------
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
LIED
N
--
E
Y
----
T
-----
A
------
R
-----
Q
G
A
-----
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
-
R
-
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
------------
113
HHSearch
82.14
36%
-100
- C2 -
1QCF
1
HCK_HUMAN
A:
[6-443]
-----------------------------------------------
G
I
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
S
--
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
------
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
NM
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
D
N
-
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
----------------
P
W
E
K
D
A
-
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
H--------
T
-
K
V
A
V
K
T
M
K
-
P
------
G
S--
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
--
I
E
D
N
E
Y
T
-----
A
------
R
-----
E
G
A
-----
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
41
PsiBlast_CBE
82.06
37%
-104
- C2 -
2C0I
1
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
YDPRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
13
PsiBlast_PDB
81.69
37%
-105
- C2 -
2C0I
1
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
40
PsiBlast_CBE
81.56
37%
-103
- C2 -
2C0O
1
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
YDPRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
20
PsiBlast_PDB
81.48
37%
-105
- C2 -
3VS2
1
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
24
PsiBlast_CBE
81.27
37%
-110
- C2 -
4LUD
2
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
---
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
RQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
--
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P---------------
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
----
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
14
PsiBlast_PDB
81.09
37%
-102
- C2 -
2C0O
1
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
38
PsiBlast_CBE
81.05
37%
-107
- C2 -
3VRY
1
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-----------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
37
PsiBlast_CBE
80.70
37%
-105
- C2 -
3VRZ
1
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-----------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
27
PsiBlast_CBE
80.65
37%
-103
- C2 -
3VS6
1
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-----------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
39
PsiBlast_CBE
80.60
37%
-102
- C2 -
2C0T
1
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
10
PsiBlast_PDB
80.49
39%
-101
- C2 -
1KSW
1
SRC_HUMAN
A:
[18-431]
-----------------------------------------------------------------
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
E
G
-
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
------
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
--
A
--
E
--
N
PR
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
NAK
G
L
N
V
K
H
Y
K
I
-
R
K
L
-
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
TT
V
C
P
T
S
K
P
Q
T
Q
G
-----------------
L
A
K
D
A
-
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
-------
G
---------
T
T
R
V
A
I
K
T
L
K
P
G
------
T
---
M
---
S
---
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
--
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
--------------
K
------
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
LIED
N
--
E
Y
----
T
-----
A
------
R
-----
Q
G
A
-----
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
-
R
-
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
------------
30
PsiBlast_CBE
80.48
37%
-104
- C2 -
3VS4
1
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-----------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
36
PsiBlast_CBE
80.30
37%
-103
- C2 -
3VS0
1
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
31
PsiBlast_CBE
79.97
37%
-102
- C2 -
3VS4
1
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
-------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
IE----------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
34
PsiBlast_CBE
79.77
37%
-105
- C2 -
3VS2
1
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
15
PsiBlast_PDB
79.73
37%
-103
- C2 -
2C0T
1
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
-------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
28
PsiBlast_CBE
79.61
37%
-105
- C2 -
3VS5
1
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
-------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
115
HHSearch
79.48
35%
-96
- C2 -
1OPK
3
ABL1_MOUSE
A:
[44-478]
--------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
------
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
--
I
--
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
-
N
T
A
S
D
-
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
--
H
Y
P
A
P
K
R
N
K
P
T
I
------------
Y
G
V
S
P
N
Y
D
K
-
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
KY-----
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
P-
P
--
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
G
D
T
Y
T
-----
A
------
H
-----
A
G
A
-----
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
----------
17
PsiBlast_PDB
79.30
37%
-106
- C2 -
3VRZ
1
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
22
PsiBlast_CBE
79.24
37%
-102
- C2 -
4LUE
3
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---------------
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
---------------
33
PsiBlast_CBE
79.16
37%
-104
- C2 -
3VS3
1
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-----------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
35
PsiBlast_CBE
79.03
37%
-104
- C2 -
3VS1
1
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
26
PsiBlast_CBE
79.01
37%
-104
- C2 -
3VS6
1
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
YDPRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-----------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
25
PsiBlast_CBE
78.70
37%
-102
- C2 -
3VS7
1
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
------------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
118
HHSearch
78.65
35%
-105
- C2 -
2OZO
1
ZAP70_HUMAN
A:
[155-603]
-----------------------------------------------------------------------------------------------------------------
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
GA
Q
--
T
--
D
--
G
K
F
L
L
R
P
R
-
K
E
Q
G
T
Y
A
L
S
L
I
Y
-----
G
K
T
V
Y
H
Y
L
I
-
S
Q
D
K
A
-
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
--
K
E
A
C
P
N
------MDTSVFESPFSD
P
-
E
E
L
K
D
K
K
-
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
-------
R
M
RK
K
---
Q
---------
I
-
D
V
A
I
K
V
L
K
-
Q
------
G
TEK
A
---
D
---
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
-
C
Q
A
-
E
--
A
--
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
---------------
E
------
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
----
A
--
L
G
---------------------------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
G
-
P
-
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
S
K
V
E
G
G
S
A
L
E
V
A
---------
21
PsiBlast_CBE
78.58
37%
-103
- C2 -
4LUE
4
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P-----------------------
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
---
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
---------------
32
PsiBlast_CBE
78.12
37%
-104
- C2 -
3VS3
1
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
IE---------------------------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
16
PsiBlast_PDB
77.94
37%
-104
- C2 -
3VRY
1
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
-------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-----------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
19
PsiBlast_PDB
77.47
37%
-97
- C2 -
3VS1
1
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
----------
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
18
PsiBlast_PDB
77.29
37%
-102
- C2 -
3VS0
1
HCK_HUMAN
A:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
------
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
--------------
43
PsiBlast_CBE
77.12
37%
-100
- C2 -
1AD5
1
HCK_HUMAN
B:
[18-423]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
YDPRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
----------------------------
G
A
-----
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
--------------
42
PsiBlast_CBE
76.84
37%
-99
- C2 -
2HCK
1
HCK_HUMAN
B:
[18-423]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
YDPRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
----------------------------
G
A
-----
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
--------------
23
PsiBlast_CBE
76.11
37%
-102
- C2 -
4LUD
3
HCK_HUMAN
B:
[24-439]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
--
P
--
G
--
N
ML
G
S
F
M
I
R
D
S
E
T
---
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-------------------
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
P
------------
W
-
E
K
D
A
----
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-------
N
-------
K
---------
H
T
K
V
A
V
K
T
M
K
P
G
--------------
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
-
E
--
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
-
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
----------------
46
PsiBlast_CBE
75.99
36%
-99
- C2 -
2FO0
4
ABL1_HUMAN
A:
[57-466]
------------------------------------------------------------------
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
--
C
E
A
Q
T
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
------
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
--
I
--
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
-
D
-
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
--
H
Y
P
A
P
K
R
N
K
P
T
V
------------
Y
-
G
V
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-----------
45
PsiBlast_CBE
75.91
36%
-101
- C2 -
1OPL
2
ABL1_HUMAN
A:
[99-508]
------------------------------------------------------------------
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
--
C
E
A
Q
T
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
------
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
--
I
--
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
-
D
-
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
--
H
Y
P
A
P
K
R
N
K
P
T
V
------------
Y
-
G
V
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
----------
44
PsiBlast_CBE
73.40
36%
-105
- C2 -
1OPL
1
ABL1_HUMAN
B:
[140-508]
-------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
------
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
--
I
--
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
-
D
-
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
--
H
Y
P
A
P
---------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-----------------------
101
Fugue
72.20
59%
-106
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
W
A
L
N
M
K
E
L
K
L
L
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
-------
R
-------
G
---------
N
-
K
V
A
V
K
C
I
K
------------
N
---
D
---
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
-
I
V
-----
E
EG
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
--------------
S
------
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
-------------------------------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
-
K
-
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
---------------------
119
HHSearch
71.07
57%
-109
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
W
A
L
N
M
K
E
L
K
L
L
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
-------
R
-------
G
---------
N
-
K
V
A
V
K
C
I
K
-
N
------
D
---
A
--------
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
-
I
V
E
-
E
--
G
--
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
--------------
S
------
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
L
-------------------------------------------
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
-
K
-
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
---------------------
2
PsiBlast_PDB
70.94
57%
-111
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
W
A
L
N
M
K
E
L
K
L
L
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
-------
R
-------
G
---------
N
-
K
V
A
V
K
C
I
K
-
N
------
D
---
A
--------
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
-
I
V
E
-
E
--
G
--
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
--------------
S
------
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
L
-------------------------------------------
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
-
K
-
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
---------------------
47
PsiBlast_CBE
70.02
39%
-103
- C2 -
4XEY
1
ABL1_HUMAN
B:
[12-374]
-------------------------------------------------------------------------------------------------------------------------
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
--
I
--
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
-
D
-
G
K
L
Y
V
S
---
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
--
H
Y
P
A
P
K
-------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
------
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
----------T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
------------------
50
PsiBlast_CBE
68.12
40%
-92
- C2 -
3BKB
9
A:
[15-369]
-------------------------------------------------------------------------------------------------------------------------
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
------
H
--
S
--
G
D
F
L
V
R
E
S
-
Q
G
K
Q
E
Y
V
L
S
V
L
W
-----
D
G
L
P
R
H
F
I
I
-
Q
S
L
-
D
--
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
----------
Q
P
L
T
K
K
S
G
V
V
L
------------
H
-
R
A
V
P
K
D
K
-
W
V
L
N
H
E
D
L
V
L
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-------
R
-------
A
---------
D
-
N
T
L
V
A
V
K
S
-
C
R
ETLP
P
D
---
L
---
K
---
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
-
C
T
Q
K
Q
--
P
--
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
---------------
A
------
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
----
E
--
E
A
----
D
-----
G
------
V
-----
Y
A
A
SGGLR
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
-
Q
-
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
----------------------
121
HHSearch
68.07
40%
-98
- C2 -
4FYO
1
A:
[11-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
-------
Q
M
KK
V
---
V
---------
K
-
T
V
A
V
K
I
L
--------------P
A
-
L
---
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
-
C
E
A
-
E
--
S
--
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
H
----------------------
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
----
A
--
L
R
----
A
-----
D
ENYYKA--------------
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
-
S
-
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
E
G
H
H
----------------
3
PsiBlast_PDB
67.77
58%
-108
- C2 -
3D7T
1
CSK_HUMAN
A:
[7-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
L
N
M
K
E
L
K
L
L
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
-------
R
-------
G
---------
N
-
K
V
A
V
K
C
I
K
-
N
------
D
---
A
---
T
---
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
-
I
V
E
-
E
KG
G
--
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
--------------
S
------
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
---------------------------------------------
P
V
K
W
T
A
P
E
A
L
R
E
A
A
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
-
K
-
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
H
L
-------------------
131
HHSearch
67.01
37%
-103
* C2 *
4AOJ
1
NTRK1_HUMAN
A:
[37-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
NLLP----------
K
---------
M
-
L
V
A
V
K
A
L
K
-
E
------
A
---
S
E
S
-
A
---
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
-
C
T
E
-
G
R-
P
--
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
--------------
D
PG----
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
-------------------------------------
T
-----
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
-
T
-
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
---------------------
77
PsiBlast_CBE
66.49
44%
-98
- C2 -
2G1T
1
ABL1_HUMAN
D:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
--------------------
79
PsiBlast_CBE
66.32
44%
-99
- C2 -
2G1T
1
ABL1_HUMAN
B:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HA
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
--------------------
78
PsiBlast_CBE
66.16
44%
-98
- C2 -
2G1T
1
ABL1_HUMAN
C:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
---------------
52
PsiBlast_CBE
65.77
45%
-107
- C2 -
4CSV
1
?
A:
[6-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
S
E
I
T
L
E
R
-
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
RN-----
Y
-------
N
---------
I
-
E
V
A
V
K
T
L
K
E
G
------
T
---
M
---
S
---
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
-
C
T
K
-
E
--
P
P-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
------------------------
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
--------------------------------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
-
S
-
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
------------------------
70
PsiBlast_CBE
65.30
44%
-108
- C2 -
3CS9
1
ABL1_HUMAN
B:
[12-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
----------T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
---------------------------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
----------------------
125
HHSearch
64.72
37%
-95
- C2 -
1T46
1
?
A:
[17-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
F
P
R
N
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
GLIKSD
A
-------
A
---------
M
-
T
V
A
V
K
M
L
K
-
P
------
S
---
A
H
L
T
E
---
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
-
C
T
I
-
G
G-
P
--
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
--------------
S
FL----
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
----
D
--
I
K
----
N
-----
D
SN
Y
V
V
-
K
-----
G
N
A
-----
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
-
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
T
N
--------------------
68
PsiBlast_CBE
64.08
44%
-98
- C2 -
3PYY
1
ABL1_HUMAN
A:
[21-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------------------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
----------------------
80
PsiBlast_CBE
64.07
44%
-98
- C2 -
2G1T
1
ABL1_HUMAN
A:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HA
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
--------------------
67
PsiBlast_CBE
64.06
44%
-110
- C2 -
3PYY
3
ABL1_HUMAN
B:
[21-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
---------------------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
---------------------------------------GA---
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
------------
93
PsiBlast_CBE
64.00
43%
-102
- C2 -
3IK3
1
ABL1_MOUSE
A:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---------------------------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
---------
122
HHSearch
63.80
39%
-96
- C2 -
1U59
1
A:
[4-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
-------
R
K------
Q
---------
I
-
D
V
A
I
K
V
L
K
-
Q
------
G
---
T
E
K
A
D
---
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
-
C
Q
A
-
E
--
A
--
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
---------------
E
------
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
----
A
--
L
G
----
A
-----
D
D
S
Y
Y
T
A
R
-----
S
A
G
-----
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
G
-
P
-
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
S
K
V
E
G
H
H
H
H
H
H
----------
56
PsiBlast_CBE
63.43
44%
-97
- C2 -
3QRI
1
ABL1_HUMAN
A:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AG
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
------------------------
130
HHSearch
63.35
43%
-99
- C2 -
2PVF
1
A:
[28-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
-------
V
GIDKDKP----------
V
-
T
V
A
V
K
M
L
K
-
D
------
D
---
A
---
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
-
C
T
Q
-
D
G-
P
--
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
--------------
P
GMEYSY
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
----
D
--
I
N
----
N
IDYYK
K
------
T
-----
T
N
G
-----
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
---------------------
124
HHSearch
63.16
44%
-96
- C2 -
3TT0
1
FGFR1_HUMAN
A:
[62-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
-
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
-------
I
-------
G
LDKDKPN
R
V
T
-
K
V
A
V
K
M
L
K
-
S
------
D
---
A
---
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
-
C
T
Q
-
D
G-
P
--
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGLEYSYNPSHNP
E
E
------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
--
I
H
----
H
I
D
YYK
K
------
T
-----
T
N
G
-----
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
------------------
71
PsiBlast_CBE
63.12
44%
-95
- C2 -
3CS9
1
ABL1_HUMAN
A:
[12-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------------------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
----------------------
133
HHSearch
62.70
40%
-90
- C2 -
2I1M
1
A:
[39-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
-------
F
-------
G
LGKEDAV--
L
-
K
V
A
V
K
M
L
K
-
S
------
T
---
A
---
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
-
C
T
H
-
G
G-
P
--
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
S
R
V
L
ETD---------
S
------
T
A
S
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
----
D
--
I
M
----
N
-----
D
SNYIV-
K
-----
G
N
A
-----
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
-
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
E
D
R
R
E
R
------------------
55
PsiBlast_CBE
62.58
44%
-97
- C2 -
3QRK
1
ABL1_HUMAN
A:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--------------------------
89
PsiBlast_CBE
62.57
44%
-96
- C2 -
2HZ0
1
ABL1_HUMAN
A:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-------------------------
99
PsiBlast_CBE
62.41
45%
-103
- C2 -
4MXY
1
SRC_HUMAN
B:
[11-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
-
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
-------
G
---------
T
T
R
V
A
I
K
T
L
K
P
G
------
T
---
M
---
S
---
P
E
A
F
L
Q
E
A
Q
V
L
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
--
P
--
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
--------------
K
------
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
LI---------------------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
-
R
-
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
------------
97
PsiBlast_CBE
62.41
45%
-103
- C2 -
4MXZ
1
SRC_HUMAN
B:
[11-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
-
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
-------
G
---------
T
T
R
V
A
I
K
T
L
K
P
G
------
T
---
M
---
S
---
P
E
A
F
L
Q
E
A
Q
V
L
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
--
P
--
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
--------------
K
------
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
LI---------------------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
-
R
-
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
------------
100
PsiBlast_CBE
62.40
45%
-103
- C2 -
4MXY
1
SRC_HUMAN
A:
[10-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
-
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
-------
G
---------
T
T
R
V
A
I
K
T
L
K
P
G
------
T
---
M
---
S
---
P
E
A
F
L
Q
E
A
Q
V
L
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
--
P
--
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
--------------
K
------
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
LIE--------------------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
-
R
-
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
------------
98
PsiBlast_CBE
62.40
45%
-103
- C2 -
4MXZ
1
SRC_HUMAN
A:
[10-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
-
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-------
N
-------
G
---------
T
T
R
V
A
I
K
T
L
K
P
G
------
T
---
M
---
S
---
P
E
A
F
L
Q
E
A
Q
V
L
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
-
E
--
P
--
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
--------------
K
------
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
LIE--------------------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
-
R
-
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
------------
128
HHSearch
62.30
40%
-92
- C2 -
2XIR
1
A:
[20-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
-------
F
GIDKTA
T
C
---------
R
-
T
V
A
V
K
M
L
K
-
E
------
G
---
A
---
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
-
C
T
K
-
P
GG
P
--
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
EFVPYYK-------
D
------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
--
I
Y
----
K
-----
D
------
P
D
Y
V
R
K
G
D
A
-----
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
-
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
---------------------
132
HHSearch
62.18
34%
-93
- C2 -
4OTW
1
A:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
R
I
F
K
E
T
E
L
R
K
L
K
-
V
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-------
I
P
E
-----
G
ES
I
K
-----
I
-
P
V
C
I
K
V
I
E
-
D
------
K
---
S
---
G
RQS
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
-
D
H
A
H
I
V
R
L
L
G
L
-
C
P
G
-
S
--
S
--
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
R
---------------
G
------
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
----
L
--
L
P
----
P
-----
D
--------------------
K
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
-
A
-
E
V
P
D
L
L
E
K
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
---------------
53
PsiBlast_CBE
62.15
44%
-96
- C2 -
3QRJ
1
ABL1_HUMAN
B:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-------------------------
72
PsiBlast_CBE
62.08
44%
-102
- C2 -
2HZI
1
ABL1_HUMAN
B:
[12-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
-------------
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
----------------------
69
PsiBlast_CBE
61.85
44%
-90
- C2 -
3CS9
1
ABL1_HUMAN
D:
[12-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
---------------------------
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
----------------------
57
PsiBlast_CBE
61.74
44%
-96
- C2 -
4WA9
1
ABL1_HUMAN
B:
[9-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
--------------
85
PsiBlast_CBE
61.72
44%
-95
- C2 -
2HYY
1
ABL1_HUMAN
C:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
-------T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
-----------------------
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
------------------------
73
PsiBlast_CBE
61.47
44%
-97
- C2 -
2HZI
1
ABL1_HUMAN
A:
[12-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
----------------------
88
PsiBlast_CBE
61.20
44%
-107
- C2 -
2HZ0
1
ABL1_HUMAN
B:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
------
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
-------------
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
--------------------------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-------------------------
91
PsiBlast_CBE
61.12
43%
-91
- C2 -
3OY3
1
ABL1_MOUSE
A:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-----------
92
PsiBlast_CBE
61.05
43%
-96
- C2 -
3IK3
1
ABL1_MOUSE
B:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
---------
54
PsiBlast_CBE
60.86
44%
-97
- C2 -
4TWP
1
ABL1_HUMAN
B:
[3-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
-------------------
86
PsiBlast_CBE
60.79
44%
-91
- C2 -
2HYY
1
ABL1_HUMAN
B:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
-------T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
------------------------
63
PsiBlast_CBE
60.69
44%
-97
- C2 -
2G2H
1
ABL1_HUMAN
B:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
PAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
------------------
75
PsiBlast_CBE
60.64
44%
-99
- C2 -
3UE4
1
ABL1_HUMAN
B:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
A
GA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
--------------------
60
PsiBlast_CBE
60.40
44%
-95
- C2 -
2HIW
1
ABL1_HUMAN
A:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-----------------------
66
PsiBlast_CBE
60.19
44%
-95
- C2 -
2G2F
1
ABL1_HUMAN
A:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
P
A
GA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
----------------
64
PsiBlast_CBE
60.18
44%
-97
- C2 -
2G2H
1
ABL1_HUMAN
A:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
P
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
------------------
84
PsiBlast_CBE
59.77
44%
-93
- C2 -
2HYY
1
ABL1_HUMAN
D:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
----------
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
------------------------
96
PsiBlast_CBE
59.74
45%
-96
- C2 -
4XLI
1
?
A:
[3-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------------------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
--
P
--
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
--------------
E
------
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
S
----------------------
90
PsiBlast_CBE
59.53
43%
-90
- C2 -
3OY3
1
ABL1_MOUSE
B:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-----------
76
PsiBlast_CBE
59.51
44%
-91
- C2 -
3UE4
1
ABL1_HUMAN
A:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
--------------------
87
PsiBlast_CBE
58.92
44%
-92
- C2 -
2HYY
1
ABL1_HUMAN
A:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
--------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
------------------------
82
PsiBlast_CBE
58.43
44%
-100
- C2 -
2HZ4
1
ABL1_HUMAN
B:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
-----
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
A
GA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
------------------------
61
PsiBlast_CBE
57.78
44%
-98
- C2 -
2G2I
1
ABL1_HUMAN
B:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
----
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
PAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
----------------------
94
PsiBlast_CBE
57.69
43%
-94
- C2 -
2Z60
1
ABL1_MOUSE
A:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
--------------
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-----------
51
PsiBlast_CBE
57.26
45%
-97
- C2 -
4UEU
1
?
A:
[6-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
S
E
I
T
L
E
R
-
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
RN-----
Y
-------
N
---------
I
-
E
V
A
V
K
T
L
K
E
G
------
T
---
M
---
S
---
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
-
C
T
K
-
E
--
P
P-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
G
--------------
H
------
T
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
----
L
I----------------------------
A
-----
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
-
S
-
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-------------------------
62
PsiBlast_CBE
57.25
44%
-95
- C2 -
2G2I
1
ABL1_HUMAN
A:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
---
G
E
V
Y
E
G
V
W
K
K-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
PAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
--------------------
59
PsiBlast_CBE
56.99
44%
-89
- C2 -
2HIW
1
ABL1_HUMAN
B:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-----------------------
74
PsiBlast_CBE
56.86
44%
-91
- C2 -
2F4J
1
ABL1_HUMAN
A:
[9-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
P
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
Q
---------
65
PsiBlast_CBE
56.76
44%
-94
- C2 -
2G2F
1
ABL1_HUMAN
B:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
-----
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
P
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
--------------------
48
PsiBlast_CBE
56.23
39%
-96
- C2 -
4XEY
1
ABL1_HUMAN
A:
[116-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
----
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
P-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
-------------------
95
PsiBlast_CBE
55.98
45%
-96
- C2 -
4XLI
1
?
B:
[3-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
----
G
E
V
Y
V
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
--
P
--
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
--------------
E
------
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
S
----------------------
58
PsiBlast_CBE
54.84
44%
-86
- C2 -
4WA9
1
ABL1_HUMAN
A:
[10-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK-----
Y
-------
S
---------
L
-
T
V
A
V
K
-----------------------------------
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
-
E
--
P
----
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
------
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
--
M
T
----
G
-----
D
------
T
-----
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
------------------