@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MELK_HUMAN: (2015-10-13 )
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
Atome Classification :
(44 SA)
.........10........20........30........40......--.----.-----50-.........60..-......70........80------.........90........100-------------.-----------------.--------...-...110.......120.......130.......140-...---.----.---....150.....---.-.-160.......170.......180.-......190.......200.......-210-...-.....220....--..--.----230--.--....----....240.......250...-....260....---...270.......280..-.....290....-----...300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
IGTG
G
F
A
K
V
K
L
A
C
H
I
LTG
E
M
V
A
I
K
I
M
DKNTL--G----S-----D--
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
TAN-------
K
I
F
M
V
L
E
YCPG
G
E
L
F
D
Y
I
I
S
Q
--------------
D
-----------------R--------L
S
E
-
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
HSQGYAHRDLKPEN
L
L
F
---
D
EY---H----
K
---
L
K
L
I
D
F
GLCAKP---K-G-NKDY
H
L
Q
T
C
C
G
S
L
A
Y
A
A
P
E
L
IQGK-SYLGSEA
D
V
W
S
M
G
I
L
L
Y
V
L
M
CGFLPF-D-D-D
N
V
-
M
A
L
Y
K
K
I
MRGKY--DV--P----K----W--LS
P
S
----
S
I
L
L
L
Q
Q
M
L
QVD
P
K
K
R
I
S
M
K
-
N
LLNHP
W
I
MQD---YNYP
V
E
WQSKNP
F
I
H
LDD-
D
C
V
T
E
L
S
V
HHRN-----N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
KARGK
P
V
R
L
R
L
SSFSCGQASATPFTDIKSNNWSLEDVTASDKN
Y
V
A
G
LIDYDWCE
D
D
L
STGAATPRT
S
Q
F
T
K
YWTESNGVESKSL
T
P
A
L
C
RT
P
A
N
KLKNKENVYTPKSAVKNE
E
Y
F
MFPEPKTPVNK
N
Q
H
K
R
E
ILTTPNRYTT
P
S
K
A
R
N
Q
C
L
KETP
I
K
I
PVNSTG
T
D
K
L
M
T
G
VI
S
P
E
R
RC
R
S
V
E
LDL
N
Q
A
H
M
E
ETPKR
K
G
A
K
V
F
G
S
L
E
R
G
L
D
K
V
I
T
V
L
T
RSKRKGSARDG
P
R
R
L
K
L
H
Y
NV
T
T
T
RLV
N
P
D
Q
L
L
N
E
I
M
S
IL
P
K
K
H
V
D
F
V
QKG
Y
T
L
K
C
Q
TQSDF
G
K
V
T
M
Q
F
E
L
E
V
C
QLQKPD
V
V
G
I
R
R
Q
RLKG
D
A
W
V
Y
K
R
L
V
E
D
I
L
S
SCKV
119
HHSearch
94.48
99%
-132
- C1 -
4BKY
1
MELK_HUMAN
A:
[4-334]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
-------------
D
--
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
-------
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--------------
D
-----------------
R
--------
L
S
E
-
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
-
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
Y
--
D
V
--
P
----
K
----
W
--
L
S
P
S
----
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
-
N
L
L
N
H
P
W
I
M
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
-
D
C
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.48
99%
-132
- C1 -
4BKY
1
MELK_HUMAN
A:
[4-334]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
-------------
D
--
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
-------
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--------------
D
-----------------
R
--------
L
S
E
-
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
-
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
Y
--
D
V
--
P
----
K
----
W
--
L
S
P
S
----
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
-
N
L
L
N
H
P
W
I
M
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
-
D
C
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.94
99%
-134
- C1 -
4BKZ
1
MELK_HUMAN
A:
[3-335]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
----------------
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
-------
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--------------
D
-----------------
R
--------
L
S
E
-
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
-
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
Y
--
D
V
--
P
----
K
----
W
--
L
S
P
S
----
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
-
N
L
L
N
H
P
W
I
M
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
-
D
C
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.39
99%
-129
- C1 -
4BL1
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
----------------
L
P
R
I
K
T
E
I
E
A
L
K
N
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
-------
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--------------
D
-----------------
R
--------
L
S
E
-
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
-
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
Y
--
D
V
--
P
----
K
----
W
--
L
S
P
S
----
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
-
N
L
L
N
H
P
W
I
M
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
-
D
C
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.55
92%
-126
- C1 -
4CQG
1
MELK_MOUSE
A:
[2-312]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
K
N
A
L
--
G
----
S
-----
D
--
L
P
R
V
K
T
E
I
D
A
L
K
S
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
-------
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--------------
D
-----------------
R
--------
L
S
E
-
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
N
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
K
-----------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
------
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
-
D
-
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
Y
--
E
V
--
P
----
K
----
W
--
L
S
P
S
----
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
-
N
L
L
N
H
P
W
V
M
Q
D
---
Y
S
C
P
V
E
W
Q
S
K
T
P
L
T
H
L
D
E
-
D
C
V
T
E
L
S
V
H
H
R
S
-----
S
R
Q
T
M
E
D
L
I
S
S
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
L
E
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
64.45
37%
-124
- C1 -
3HKO
2
?
A:
[19-336]
-
G
S
L
L
E
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
--
R
Q---
K
-----
D
--
V
E
R
I
K
T
E
V
R
L
M
K
K
-
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
-------
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
K
T
QICPC
P
E
C
N
E
E
A
I
N
G
SI-F
R
E
S
L
D
F
V
Q
R
E
-
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
---
S
T
N
---
K
SF--
E
---
I
K
L
V
D
F
G
L
S
K
E
F
YKL
N
-
N
-
G
--------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
N
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
-
P
-
G
-
V
N
D
-
A
D
T
I
S
Q
V
L
N
K
K
L
--
C
F
EN
P
----
N
----
Y
NV
L
S
P
L
----
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
-
R
A
L
Q
H
P
W
I
S
Q
F
---
S
D
K
I
Y
K
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
62.63
34%
-127
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[6-266]
----------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
--
S
----
A
R
----
D
--
H
Q
K
L
E
R
E
A
R
I
C
R
L
-
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
-------
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--------------
E
-----------------
Y
--------
Y
S
E
-
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
C
----
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
---
Q
-
G
-
D
Q
Q
A
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
-
A
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
-
D
-
E
D
Q
-
H
K
L
Y
Q
Q
I
K
A
G
A
Y
--
D
F
PS
P
----
E
----
W
DT
V
T
P
E
----
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
-
E
A
L
K
H
P
W
V
C
Q
R
---
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
-
F
N
A
R
R
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
62.15
34%
-127
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[6-266]
----------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
--
S
----
A
R----
D
--
H
Q
K
L
E
R
E
A
R
I
C
R
L
-
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
-------
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--------------
E
-----------------
Y
--------
Y
S
E
-
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
C
----
K
GAA
V
K
L
A
D
F
G
L
A
I
E
V
---
Q
-
G
-
D
Q
Q
A
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
-
A
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
-
D
-
E
D
Q
-
H
K
L
Y
Q
Q
I
K
A
G
A
Y
--
D
F
PS
P
----
E
----
W
DT
V
T
P
E
----
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
-
E
A
L
K
H
P
W
V
C
Q
R
---
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
-
F
N
A
R
R
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
60.11
34%
-118
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[11-277]
-
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----------------------
S
M
E
N
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
-------
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--------------
G
-----------------
F
--------
Y
T
E
-
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
----
K
---
I
M
I
S
D
F
G
L
S
K
M
E
---
D
-
P
-
G
----------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
----
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
-
D
-
E
N
D
-
A
K
L
F
E
Q
I
L
K
A
E
Y
EF
D
S
--
P
----
Y
----
W
DD
I
S
D
S
----
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
-
Q
A
L
Q
H
P
W
I
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
59.04
36%
-125
- C1 -
3MA6
1
?
A:
[34-291]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
--
K
QK--
T
-----
D
--
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--------------
K
-----------------
R
--------
F
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
---
E
---
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
-
G
-
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
----
Q
----
W
K
K
V
S
E
S
----
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
-
D
A
L
D
H
E
W
I
Q
T
Y
---
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
58.64
32%
-121
- C1 -
3C0I
1
CSKP_HUMAN
A:
[22-292]
------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
--
T
S
SPG
L
-----
S
--
T
E
D
L
K
R
E
A
S
I
C
H
M
-
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
-------
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--------------
A
D
A
G
F
-------------
V
--------
Y
S
E
-
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
---
A
S
K
---
E
----
N
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
---
G
---
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
-
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
-
Y
-
G
-
T
K
--
E
R
L
F
E
G
I
I
K
G
K
Y
--
K
M
--
N
PRQW
S
----
H
--
I
S
E
S
----
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
-
E
A
L
N
H
P
W
L
K
E
R
---
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
-
F
N
A
R
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
58.06
34%
-135
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-279]
----
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
------------------------
N
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
-------
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--------------
G
-----------------
F
--------
Y
T
E
-
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
----
K
---
I
M
I
S
D
F
G
--------------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
-
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
-
D
-
E
N
D
-
A
K
L
F
E
Q
I
L
K
A
E
Y
EF
D
S
--
P
----
Y
----
W
DD
I
S
D
S
----
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
-
Q
A
L
Q
H
P
W
I
A
G
D
---
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
-
F
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
58.01
47%
-117
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[10-275]
-------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
--
R
----
S
L
D---
V
--
V
G
K
I
K
R
E
I
Q
N
L
K
L
-
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
-------
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
--------------
G
-----------------
R
--------
V
E
E
-
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
N
M
M
---
S
-
D
-
G
E
--
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
-
D
-
E
H
V
-
P
T
L
F
K
K
I
R
G
G
V
F
--
Y
I
--
P
----
E
----
Y
--
L
N
R
S
----
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
-
D
I
R
E
H
E
W
F
K
Q
D
LPS
Y
L
F
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
57.60
36%
-119
- C1 -
3MA6
1
?
B:
[34-291]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
--
K
Q---
T
-----
D
--
K
E
S
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
-------
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--------------
K
-----------------
R
--------
F
S
E
-
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
---
E
-
A
-
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
-
G
-
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
Y
TF
E
L
--
P
----
Q
----
W
KK
V
S
E
S
----
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
-
D
A
L
D
H
E
W
I
Q
T
Y
---
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
57.27
33%
-118
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[7-276]
----
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
--
K
----
S
SRRGV
S
--
R
E
D
I
E
R
E
V
S
I
L
K
E
-
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--------------
E
-----------------
S
--------
L
T
E
-
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VP
K
P
R
---
I
K
I
I
D
F
G
L
A
H
K
I
---
D
-
F
-
G
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
-
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
-
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
Y
--
E
F
--
E
----
D
EYFS
N
--
T
S
A
L
----
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
-
D
S
L
Q
H
P
W
I
K
P
K
---
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
-
K
K
F
A
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
56.96
36%
-106
- C1 -
4CZU
3
CIPKN_ARATH
A:
[13-302]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
--
L
----
K
-----
N
KM
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--------------
G
-----------------
R
--------
L
K
E
-
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
L
P
---
Q
-
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
-
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
--
P
----
P
----
W
--
F
S
A
S
----
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
---
Y
K
A
P
---
K
F
E
N
-----
D
D
V
D
A
I
F
D
D
S
G
E
S
K
N
LVV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
56.93
36%
-111
- C1 -
4CZT
2
CIPKN_ARATH
B:
[13-295]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
--
L
----
K
-----
N
KM
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--------------
G
-----------------
R
--------
L
K
E
-
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
L
P
---
Q
-
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
-
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
--
P
----
P
----
W
--
F
S
A
S
----
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
---
Y
K
A
P
---
K
F
E
------
D
D
V
D
A
I
F
D
D
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
56.91
34%
-139
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[11-279]
-
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
-----------------------
N
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
-------
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--------------
G
-----------------
F
--------
Y
T
E
-
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
----
K
---
I
M
I
S
D
F
------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
-
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
-
D
-
E
N
D
-
A
K
L
F
E
Q
I
L
K
A
E
Y
EF
D
S
--
P
----
Y
----
W
DD
I
S
D
S
----
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
-
Q
A
L
Q
H
P
W
I
A
G
D
---
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
-
F
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
56.91
36%
-103
- C1 -
4CZU
3
CIPKN_ARATH
D:
[13-306]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
--
L
----
K
-----
N
KM
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--------------
G
-----------------
R
--------
L
K
E
-
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
L
P
---
Q
-
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
-
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
--
P
----
P
----
W
--
F
S
A
S
----
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
---
Y
K
A
P
---
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
----
N
LVVER
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
56.61
36%
-112
- C1 -
4CZU
3
CIPKN_ARATH
B:
[13-295]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
--
L
----
K
-----
N
KM
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--------------
G
-----------------
R
--------
L
K
E
-
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
L
P
---
Q
-
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
-
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
--
P
----
P
----
W
--
F
S
A
S
----
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
---
Y
K
A
P
---
K
F
E
------
D
D
V
D
A
I
F
D
D
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
56.42
36%
-100
- C1 -
4CZT
4
CIPKN_ARATH
D:
[13-306]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
--
L
----
K
-----
N
KM
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--------------
G
-----------------
R
--------
L
K
E
-
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
L
P
---
Q
-
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
-
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
--
P
----
P
----
W
--
F
S
A
S
----
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
---
Y
K
A
P
---
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
----
N
L
V
V
E
R
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
56.21
35%
-130
- C1 -
3COK
1
PLK4_HUMAN
A:
[8-267]
-----
E
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
----
G
-----
M
--
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
-
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
-------
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
--------------
V
-----------------
K
P-------
F
S
E
-
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
G
L
A
T
Q
L
---
K
---------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-
D
-
T
-
D
T
V
-
K
-----
V
V
L
A
D
Y
--
E
M
--
P
----
S
----
F
--
L
S
I
E
----
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
-
S
V
L
D
H
P
F
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
56.06
34%
-135
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[14-279]
----
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-------------------------
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
-------
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--------------
G
-----------------
F
--------
Y
T
E
-
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
----
K
---
I
M
I
S
D
F
-----------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
-
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
-
D
-
E
N
D
-
A
K
L
F
E
Q
I
L
K
A
E
Y
EF
D
S
--
P
----
Y
----
W
DD
I
S
D
S
----
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
-
Q
A
L
Q
H
P
W
I
A
G
D
---
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
-
F
A
K
S
K
W
K
Q
A
F
N
A
-----
T
A
V
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
56.05
35%
-121
- C1 -
2W4O
1
KCC4_HUMAN
A:
[49-320]
----
D
A
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
--------------------------
I
G
V
L
L
R
-
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
-------
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
--------------
G
-----------------
Y
--------
Y
S
E
-
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
---
A
T
P
APD
A
----
P
---
L
K
I
A
D
F
-----------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
-
A
Y
-
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
-
E
-
R
G
D
-
Q
F
M
F
R
R
I
L
N
C
E
Y
--
Y
F
IS
P
----
W
----
W
DE
V
S
L
N
----
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
-
Q
A
L
Q
H
P
W
V
T
G
-----------
K
A
A
N
-
F
V
H
M
D
T
-
A
Q
K
K
L
Q
E
F
N
A
R
R
-----
K
L
K
A
A
V
K
A
V
V
A
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
55.84
34%
-134
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[11-279]
-
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
----------------------
E
N
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
-------
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--------------
G
-----------------
F
--------
Y
T
E
-
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
----
K
---
I
M
I
S
D
F
-------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
-
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
-
D
-
E
N
D
-
A
K
L
F
E
Q
I
L
K
A
E
Y
EF
D
S
--
P
----
Y
----
W
DD
I
S
D
S
----
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
-
Q
A
L
Q
H
P
W
I
A
G
D
---
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
-
F
A
K
S
K
W
K
Q
A
F
N
A
-----
T
A
V
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
55.83
35%
-123
- C1 -
4JXF
2
PLK4_HUMAN
A:
[4-264]
-----
E
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
----
G
-----
M
--
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
-
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
-------
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
--------------
V
-----------------
K
P-------
F
S
E
-
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
G
L
A
T
Q
L
---
K
-
M
-
P
H
E
----------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-------
V
-
K
N
T
L
N
K
V
V
L
A
D
Y
--
E
M
--
P
----
S
----
F
--
L
S
I
E
----
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
-
S
V
L
D
H
P
F
M
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
55.63
36%
-101
- C1 -
4CZT
3
CIPKN_ARATH
A:
[13-297]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
--
L
----
K
-----
N
KM
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--------------
G
-----------------
R
--------
L
K
E
-
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
L
P
---
Q
-
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
-
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
--
P
----
P
----
W
--
F
S
A
S
----
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
---
Y
K
A
P
---
K
F
E
N
--
V
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
54.87
36%
-114
- C1 -
4CZU
3
CIPKN_ARATH
C:
[13-294]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
--
L
----
K
-----
N
KM
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--------------
G
-----------------
R
--------
L
K
E
-
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
L
P
---
Q
-
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
-
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
--
P
----
P
----
W
--
F
S
A
S
----
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
---
Y
K
A
P
---
K
F
E
N
A
D
V
-----
D
A
I
F
D
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
54.78
36%
-115
- C1 -
4CZT
3
CIPKN_ARATH
C:
[13-295]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
--
L
----
K
-----
N
KM
I
A
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--------------
G
-----------------
R
--------
L
K
E
-
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
L
P
---
Q
-
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
-
E
-
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
--
T
C
--
P
----
P
----
W
--
F
S
A
S
----
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
---
Y
K
A
P
---
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
54.14
35%
-131
- C1 -
4YUR
1
PLK4_HUMAN
A:
[10-269]
-----
E
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
----
G
-----
M
--
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
-
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
-------
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
--------------
V
-----------------
K
P-------
F
S
E
-
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
-----------------------------------------
G
L
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
------
T
V
-
K
N
T
L
N
K
V
V
L
A
D
Y
--
E
M
--
P
----
S
----
F
--
L
S
I
E
----
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
-
S
V
L
D
H
P
F
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
52.56
34%
-111
- C1 -
3TKI
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
-------
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--------------
I
-----------------
G
--------
M
P
E
-
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
V
F
---
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
-
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
--
N
----
P
----
W
KK
I
D
S
A
----
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
51.20
34%
-108
- C1 -
4FSN
2
CHK1_HUMAN
A:
[7-276]
----------
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------
E
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
-------
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--------------
I
-----------------
G
--------
M
P
E
-
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
V
F
---
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
-
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
--
N
----
P
----
W
KK
I
D
S
A
----
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
50.83
34%
-110
- C1 -
2HOG
1
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
-------
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--------------
I
-----------------
G
--------
M
P
E
-
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
V
F
---
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
-
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
--
N
----
P
----
W
K
K
I
D
S
A
----
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
50.79
34%
-109
- C1 -
4RVM
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
-------
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--------------
I
-----------------
G
--------
M
P
E
-
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
V
F
---
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
-
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
--
N
----
P
----
W
KK
I
D
S
A
----
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
50.77
34%
-107
- C1 -
2HY0
1
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
-------
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--------------
I
-----------------
G
--------
M
P
E
-
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
V
F
---
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
-
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
--
N
----
P
----
W
KK
I
D
S
A
----
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
50.75
34%
-113
- C1 -
3TKH
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-----------------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
-------
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--------------
I
-----------------
G
--------
M
P
E
-
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
V
F
---
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
-
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
--
N
----
P
----
W
KK
I
D
S
A
----
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
50.24
34%
-106
- C1 -
2QHM
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
-------
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--------------
I
-----------------
G
--------
M
P
E
-
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
V
F
---
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
-
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
--
N
----
P
----
W
KK
I
D
S
A
----
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
50.09
34%
-111
- C1 -
2QHN
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
-------
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--------------
I
-----------------
G
--------
M
P
E
-
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
V
F
---
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
-
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
--
N
----
P
----
W
KK
I
D
S
A
----
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
49.96
30%
-125
- C1 -
1ZY4
1
GCN2_YEAST
A:
[5-289]
-------
A
S
D
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
T
E
--------
E
-----
K
--
L
S
T
I
L
S
E
V
M
L
L
A
S
-
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
E
R
R
N
F
VK
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
L
I
H
S
E
--------------
N
-----------------
L
--------
N
Q
Q
R
D
E
Y
W
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
I
I
H
R
D
L
K
P
M
N
I
F
I
---
D
E
S
---
R
----
N
---
V
K
I
G
D
F
G
L
A
K
N
V
---
H
-
R
-------------
A
M
Y
V
A
T
E
V
L
D
G
T
-
G
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
---
P
F
-
S
T
G
-
M
E
R
-
V
N
I
L
K
K
L
R
S
V
S
I
--
E
F
--
P
----
P
----
D
--
F
D
D
N
KM
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
-
T
L
L
N
S
G
W
L
P
V
K
---
H
Q
D
E
V
I
K
E
A
L
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
49.45
34%
-102
- C1 -
2YEX
8
CHK1_HUMAN
A:
[4-269]
-----
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
--
V
----
D
-----
C
--
P
E
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
-------
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--------------
I
-----------------
G
--------
M
P
E
-
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
V
F
---
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
-
Q
-
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
--
N
----
P
----
W
KK
I
D
S
A
----
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
Y
N
K
P
---
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
49.30
34%
-108
- C1 -
2R0U
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
-------
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--------------
I
-----------------
G
--------
M
P
E
-
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
V
F
---
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
-
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
--
N
----
P
----
W
KK
I
D
S
A
----
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
49.05
34%
-102
- C1 -
2HXQ
1
CHK1_HUMAN
A:
[8-275]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
--------------
C
--
P
E
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
-------
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--------------
I
-----------------
G
--------
M
P
E
-
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
V
F
---
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
-
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
--
N
----
P
----
W
KK
I
D
S
A
----
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
48.74
34%
-103
- C1 -
2HXL
1
CHK1_HUMAN
A:
[8-275]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
--------------
C
--
P
E
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
-------
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--------------
I
-----------------
G
--------
M
P
E
-
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
V
F
---
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
-
D
-
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
T
--
Y
L
--
N
----
P
----
W
K
K
I
D
S
A
----
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
-------
Y
N
K
P
L
K
K
G
A
K
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
47.40
30%
-104
- C1 -
1XJD
1
A:
[17-274]
--------
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
----
D
-----
D
--
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-------
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
--------------
H
-----------------
K
--------
F
D
L
-
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
---
D
K
D
---
G
----
H
---
I
K
I
A
D
F
G
M
C
K
E
N
---
M
-
L
-
G
-
D
A
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-
K
Y
-
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
-
H
-
G
-
Q
D
E
-
E
E
L
F
H
S
I
R
M
D
N
P
--
F
Y
--
P
----
R
----
W
--
L
E
K
E
----
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
---
N
W
E
E
L
E
R
K
E
I
D
P
Q
N
M
F
R
N
-
F
S
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------