@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MERTK_HUMAN: (2015-10-13 )
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
Atome Classification :
(110 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580......--.--590........600......--.---610--.--........620.......630.......640..-.....650.......660.......670.......680......--.----------690--.....-...700.......710.......720.......730-----.......740.......750..--.--.--....760.......770.......780.......790.......800....-.-..810.......820.......830.......840.......850.......860........870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGP
A
P
L
P
L
L
L
G
L
F
L
P
A
L
W
R
R
A
I
T
E
A
R
EEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQ
P
A
L
M
FSPTQPGRPHTGNVAIPQVTSVESKPLPP
L
A
F
KHTV
G
H
I
I
L
SEHK
G
V
K
F
N
C
S
ISVPNIYQDT
T
I
S
W
W
KD
G
K
E
L
L
G
A
H
H
A
I
T
QFYPDD
E
V
T
A
I
I
A
S
F
S
I
T
S
V
Q
RSDNG
S
Y
I
C
K
M
K
INNEEIVSD
P
I
Y
I
E
VQGLPHFTKQPESMNVTRN
T
A
F
N
L
T
C
Q
AVGPPE
P
V
N
I
F
W
VQNSSRVNEQPEKSP
S
V
L
TVPGL
T
E
M
A
V
F
S
C
EAHNDKG
L
T
VSKG
V
Q
I
N
I
K
AIPSPP
T
E
V
S
I
RNSTA
H
S
I
L
I
S
WVPGFDGYSPFRN
C
S
I
Q
V
K
EADPLSNG
S
V
M
I
F
NTSAL
P
H
L
Y
Q
I
K
Q
L
Q
A
L
A
NY
S
I
G
V
S
C
M
N
E
I
G
W
S
AVS
P
W
I
L
A
STTEGAPSV
A
P
L
N
V
T
V
F
L
NESSDNV
D
I
R
WMKPPTKQQDGE
L
V
G
Y
R
I
S
H
V
W
Q
SAGI
S
K
E
L
L
E
E
VGQNGS
R
A
R
I
S
V
Q
V
HN
A
T
C
T
V
R
I
A
A
V
TRGGVGPFSD
P
V
K
I
F
I
PAHGWVDYAPSSTPAPGNAD
P
V
L
I
I
F
G
C
F
C
G
F
I
L
I
G
L
I
L
Y
I
S
L
A
I
R
K
R
V
Q
ETKFGNAFTE
E
D
S
E
L
V
V
N
Y
I
A
K
K
S
F
C
R
R
A
I
E
L
T
L
H
SLGV
S
E
E
L
Q
N
K
L
E
D
V
V
IDRN
L
L
I
--
L
--
G
K
-
I
LGEGEFG
S
V
MEGNLKQ--E---D----G--T
S
L
K
V
A
V
K
T
M
KLDNS
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
KDF-SH
P
N
V
I
R
L
L
G
V
C
I
E
MSSQGIPK
P
M
V
I
L
P
FMKYG
D
L
H
T
Y
L
L
Y
S
R
L--E----------TG---PKHI
P
-
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
SNR
N
F
L
H
R
D
L
A
A
RNCMLR-----DD
M
T
V
C
V
A
DFGLSKKIYS-GDY--Y--R--QGRIAKM
P
V
K
W
I
A
I
E
S
L
A
D
R
VYTSKSD
V
W
A
F
G
V
T
M
W
E
I
A
TRGMTPYPGVQN-
H
-
E
M
Y
D
Y
L
LHGHRLK
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
WRTDPLDR
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
-
L
PDVRNQA
D
V
I
Y
V
N
T
Q
L
LESSEGLAQGSTLA
P
L
D
LNIDP
D
S
I
I
ASCTPR
A
A
I
S
V
V
T
A
EVHDSKPHE
G
R
Y
I
LNGG
S
E
E
W
E
D
L
TSAPS
A
A
V
TAEKNSVLP
G
E
R
L
V
RNGVSWSHSSMLPLGSSL
P
D
E
L
L
FADDSSEGSEVLM
3
PsiBlast_PDB
94.71
100%
-148
- C1 -
3TCP
1
MERTK_HUMAN
A:
[26-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
-----
S
V
M
E
G
N
L
K
Q
--
E
---
D
----
G
--
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
--
E
----------
T
G
---
P
K
H
I
P
-
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-----
D
D
M
T
V
C
V
A
D
F
---------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
-
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
-
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
94.30
100%
-138
- C1 -
3BRB
2
B:
[24-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
---
D
----
G
--
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
--
E
----------
T
G
---
P
K
H
I
P
-
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-----
D
D
M
T
V
C
V
A
D
F
G
L
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
-
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
-
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.87
100%
-148
- C1 -
2P0C
2
MERTK_HUMAN
A:
[24-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
--
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
---
D
----
G
--
T
S
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
-------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
--
E
----------
T
G
---
P
K
H
I
P
-
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-----
D
D
M
T
V
C
V
A
D
F
G
L
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
-
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
-
L
------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
93.46
100%
-148
- C1 -
2P0C
1
B:
[24-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
G
---
S
V
M
E
G
N
L
K
Q
--
E
---
D
----
G
--
T
S
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
-------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
--
E
----------
T
G
---
P
K
H
I
P
-
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-----
D
D
M
T
V
C
V
A
D
F
G
L
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
-
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
-
L
------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
93.07
100%
-147
- C1 -
3BPR
1
MERTK_HUMAN
B:
[25-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
-
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
---
D
----
G
--
T
S
L
K
V
A
V
K
T
M
K
L
-------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
-------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
--
E
----------
T
G
---
P
K
H
I
P
-
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-----
D
D
M
T
V
C
V
A
D
F
G
L
S
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
-
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
-
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.46
100%
-144
- C1 -
3BPR
1
MERTK_HUMAN
A:
[24-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
---
D
----
G
--
T
S
L
K
V
A
V
K
T
M
K
------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
-----
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
--
E
----------
T
G
---
P
K
H
I
P
-
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-----
D
D
M
T
V
C
V
A
D
F
G
L
S
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
-
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
-
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
92.44
100%
-144
- C1 -
3BPR
1
D:
[24-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
---
D
----
G
--
T
S
L
K
V
A
V
K
T
M
K
--------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
-----
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
--
E
----------
T
G
---
P
K
H
I
P
-
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-----
D
D
M
T
V
C
V
A
D
F
G
L
S
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
-
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
-
L
P
D
----------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
91.84
100%
-140
- C1 -
3TCP
1
B:
[25-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
G
---
S
V
M
E
G
N
L
K
Q
--
E
---
D
----
G
--
T
S
L
K
V
A
V
K
T
M
K
--------------
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
--
E
----------
T
G
---
P
K
H
I
P
-
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-----
D
D
M
T
V
C
V
A
D
F
--------------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
-
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
-
L
------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
90.87
100%
-139
- C1 -
4MHA
1
B:
[26-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
---
D
----
G
--
T
S
L
K
V
A
V
K
T
M
K
--------------------
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
--
E
----------
T
G
---
P
K
H
I
P
-
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-----
D
D
M
T
V
C
V
A
D
F
---------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
-
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
-
L
P
-----------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
90.59
100%
-154
- C1 -
4M3Q
1
B:
[26-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
-----
S
V
M
E
G
N
L
K
----------------
S
L
K
V
A
V
K
T
M
------------
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--------
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
--
E
----------
T
G
---
P
K
H
I
P
-
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-----
D
D
M
T
V
C
V
A
D
F
G
--------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
-
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
-
L
------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
82.23
62%
-141
- C1 -
3QUP
1
A:
[16-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
P
---
F
T
--
L
--
G
R
-
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
------------------
V
K
V
A
V
K
M
L
------
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
-
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
------
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
I
------------------
P
F
N
L
P
-
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
-----
E
D
M
T
V
C
V
A
D
F
G
L
------------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
-
A
-
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
H
--------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.03
61%
-141
- C1 -
3QUP
1
A:
[16-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
P
---
F
T
--
L
--
G
R
-
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
------------------
V
K
V
A
V
K
M
L
------
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
-
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
------
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
I
------------------
P
F
N
L
P
-
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
-----
E
D
M
T
V
C
V
A
D
F
G
L
------------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
-
A
-
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
H
--------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
78.31
44%
-135
- C1 -
3EFK
1
B:
[15-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
-----
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
---------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
E
H
Y
V
H
-----------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
77.23
61%
-134
- C1 -
4FEQ
1
A:
[22-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
F
T
--
L
--
G
R
-
M
L
G
K
G
---
S
V
R
E
A
Q
L
K
-------
D
----
G
--
S
F
V
K
V
A
V
K
M
L
------------
F
L
R
E
A
A
C
M
K
E
F
-
D
H
P
H
V
A
K
L
V
G
V
S
----------
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
I
----------------------
P
-
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
-----
E
D
M
T
V
C
V
A
D
F
G
---------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
-
A
-
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
H
-
L
------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
76.99
44%
-125
- C1 -
3EFK
1
MET_HUMAN
A:
[15-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
---------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
E
H
Y
V
H
-----------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
75.92
44%
-130
- C1 -
2RFN
1
B:
[15-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
----
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
----------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
E
H
Y
V
H
-----------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
75.83
44%
-122
- C1 -
3U6H
1
A:
[14-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
--------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
E
H
Y
V
H
-----------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.26
44%
-118
- C1 -
2WD1
3
A:
[7-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
75.13
44%
-121
- C1 -
3EFJ
1
MET_HUMAN
A:
[15-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
---------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
E
H
Y
V
H
-----------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
75.10
44%
-129
- C1 -
2RFN
1
MET_HUMAN
A:
[15-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
----
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
----------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
E
H
Y
V
H
-----------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.98
44%
-123
- C1 -
3U6I
1
A:
[14-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
-------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
E
H
Y
V
H
-----------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
74.96
44%
-117
- C1 -
4R1V
4
A:
[7-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
----
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
-----------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
74.70
44%
-123
- C1 -
4DEI
1
A:
[14-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
---------------
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
74.53
44%
-131
- C1 -
3CCN
1
A:
[15-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-----------------
K
I
H
C
A
V
K
S
L
N
-
R
-----
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
---------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
---
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
74.27
44%
-114
- C1 -
3RHK
1
B:
[33-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
74.25
44%
-130
- C1 -
4KNB
2
MET_HUMAN
C:
[2-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
------------------
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
----
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
74.13
44%
-126
- C1 -
4DEG
1
A:
[14-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-----------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
74.11
36%
-117
* C1 *
4AOJ
1
NTRK1_HUMAN
A:
[38-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
--
L
--
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
LL
P
------------
K
M
L
V
A
V
K
A
L
K
E
A
--
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
-----
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
--
D
---------------
P
G
P
L
G
-
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-----------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
-
T
-
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
-
P
P
-----------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
73.78
44%
-115
- C1 -
2WGJ
1
A:
[12-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
---------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
-----------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
73.76
44%
-115
- C1 -
3RHK
1
MET_HUMAN
A:
[33-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.76
44%
-125
- C1 -
4EEV
1
A:
[32-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
------------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
73.64
44%
-129
- C1 -
4KNB
3
MET_HUMAN
A:
[5-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
----------------
K
I
H
C
A
V
K
S
L
----
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.63
44%
-122
- C1 -
4R1Y
3
A:
[8-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-----------------
I
H
C
A
V
K
S
L
N
---------
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
----
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
73.61
44%
-128
- C1 -
3I5N
1
A:
[14-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
-----
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
---------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
-------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
73.59
44%
-119
- C1 -
4XMO
1
A:
[14-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-----------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
-----------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
73.53
44%
-113
- C1 -
3ZZE
1
A:
[12-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
-----------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
73.51
44%
-112
- C1 -
2WKM
1
A:
[12-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
-----------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
73.33
43%
-114
- C1 -
1OPL
1
ABL1_HUMAN
B:
[256-517]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
73.30
44%
-126
- C1 -
3CD8
1
A:
[15-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-----------------
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
---------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
---
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
72.95
44%
-126
- C1 -
3EFJ
1
B:
[15-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
----------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
E
H
Y
V
H
-----------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
72.90
44%
-128
- C1 -
2RFS
1
A:
[21-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-----------------
K
I
H
C
A
V
K
S
L
N
-----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
----
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
72.89
44%
-119
- C1 -
4XYF
1
A:
[14-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
----------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
72.87
43%
-112
- C1 -
1OPK
3
ABL1_MOUSE
A:
[217-478]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
G
K
------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
72.86
44%
-129
- C1 -
3F66
3
B:
[11-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
---------------
K
K
I
H
C
A
V
K
S
L
N
-------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S--------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
E
H
Y
-------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
72.84
41%
-123
- C1 -
3DKG
1
A:
[16-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
------
C
V
Y
H
G
T
L
L
D
--------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----
E
H
Y
V
H
V
N
A
T
Y
--------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.82
44%
-113
- C1 -
4MXC
1
A:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV-------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.81
44%
-123
- C1 -
4DEH
1
A:
[14-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-----------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
----
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
72.73
41%
-117
- C1 -
3DKF
1
A:
[16-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
----------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
E
---------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
72.72
42%
-116
- C1 -
3C1X
1
A:
[74-373]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
--
V
H
F
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
--------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
72.66
43%
-115
- C1 -
3IK3
1
ABL1_MOUSE
A:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
--------
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
G
K
R
-----------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
72.64
44%
-114
- C1 -
3ZXZ
1
A:
[12-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
---------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
-----------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
72.45
44%
-113
- C1 -
4AP7
1
A:
[12-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
---------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
-----------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
72.28
42%
-114
- C1 -
1R0P
1
A:
[13-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
---------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
F
DS
V
--
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
--------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
72.18
43%
-115
- C1 -
3K5V
2
ABL1_MOUSE
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
----
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
72.15
43%
-113
- C1 -
1OPL
2
ABL1_HUMAN
A:
[256-517]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
G
K
------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
72.12
44%
-115
- C1 -
4AOI
1
A:
[12-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
---------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
72.05
44%
-113
- C1 -
3ZC5
1
A:
[12-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
---------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
-----------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
71.95
42%
-115
- C1 -
3F82
1
A:
[15-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
----------------
K
I
H
C
A
V
K
S
L
N
-
R
----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
------------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
71.89
43%
-108
- C1 -
3KFA
1
ABL1_MOUSE
A:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
71.86
44%
-114
- C1 -
3LQ8
1
A:
[13-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
--
D
-
K
E
Y
--
Y
S--------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
-----------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
71.69
41%
-104
- C1 -
3DKC
1
A:
[16-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
F
D
S
V
--
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
E
G
--------------------------------------------------------------------------------------------------------------------
124
HHSearch
71.66
35%
-112
- C1 -
4FYO
1
A:
[11-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
--
L
--
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
--
K
--------
K
--
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
------
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
---------------------
R
H
V
K
-
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
--
Y
--
K
--
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
-
S
-
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
-
V
V
N
E
G
H
H
------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
71.66
43%
-109
- C1 -
3OY3
1
ABL1_MOUSE
A:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
71.63
44%
-129
- C1 -
4KNB
1
D:
[5-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
-----------
G
--
K
K
I
H
C
A
V
K
S
L
-----
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
----
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
----------------------
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
----------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
---
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
71.62
42%
-112
- C1 -
3QTI
1
MET_HUMAN
A:
[15-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
---------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
F
--------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
----
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------------------------------------------------
116
HHSearch
71.49
43%
-125
- C1 -
3C1X
1
A:
[71-358]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
----
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
--------------------
T
H
N
P
T
-
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
--------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
--------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.46
44%
-116
- C1 -
4GG7
1
A:
[37-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
71.35
43%
-108
- C1 -
3KFA
1
ABL1_MOUSE
B:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
71.24
43%
-115
- C1 -
2Z60
1
ABL1_MOUSE
A:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
71.07
43%
-113
- C1 -
3MS9
2
ABL1_MOUSE
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
---
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
71.02
43%
-114
- C1 -
2FO0
3
ABL1_HUMAN
A:
[214-475]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
70.94
40%
-98
- C1 -
4CKJ
16
A:
[19-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
K
N
L
V
--
L
--
G
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
--
L
---
K
----
G
RA
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
G
-----
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
--
V
----------------
R
A
L
T
-
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
-
E
D
S
--
Y
--
V
--
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
P
-
E
-
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
-
R
R
-----------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
70.92
42%
-112
- C1 -
3CTH
1
A:
[15-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
-------------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
70.85
43%
-117
- C1 -
2QOH
1
ABL1_MOUSE
B:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
70.72
44%
-111
- C1 -
3ZBX
1
A:
[12-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
---------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
-----------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
70.66
43%
-111
- C1 -
3IK3
1
ABL1_MOUSE
B:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
G
K
R
-----------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
70.55
44%
-130
- C1 -
4KNB
2
MET_HUMAN
B:
[8-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
----------------
K
I
H
C
A
V
K
S
-------
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV---------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
----------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
70.49
43%
-115
- C1 -
3KF4
1
ABL1_MOUSE
A:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
G
K
R
G
----------------------------------------------------------------------------------------------------------------------------
118
HHSearch
70.47
40%
-115
- C1 -
3PLS
1
A:
[3-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
A
L
L
A
E
V
K
D
V
L
I
P
H
E
R
V
V
--
T
HS
D
R
-
V
I
G
K
G
H
F
G
V
V
Y
H
G
E
Y
I
D
--
Q
---
A
----
Q
--
N
R
I
Q
C
A
I
K
S
L
S
R
I
-
T
E
M
Q
Q
V
E
A
F
L
R
E
G
L
L
M
R
G
L
-
N
H
P
N
V
L
A
L
I
G
I
M
L
P
P
E
G
----
L
P
H
V
L
L
P
Y
M
C
H
G
D
L
L
Q
F
I
R
S
P
--------------------
Q
R
N
P
T
-
V
K
D
L
I
S
F
G
L
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
S
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
D
-
R
E
Y
--
Y
--
S
VQ
Q
H
R
H
A
R
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
G
A
P
P
Y
R
H
I
D
P
-
F
-
D
L
T
H
F
L
A
Q
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
R
V
L
V
G
E
V
E
Q
I
V
S
A
-
L
L
G
D
H
Y
V
Q
L
P
---------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
70.24
42%
-110
- C1 -
3L8V
1
A:
[15-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
-------------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
70.12
42%
-116
- C1 -
3CE3
1
A:
[15-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
-------------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
70.09
43%
-112
- C1 -
3KF4
1
ABL1_MOUSE
B:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
---
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
-----------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
70.07
43%
-109
- C1 -
1OPJ
2
ABL1_MOUSE
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
70.07
43%
-109
- C1 -
3QRJ
1
ABL1_HUMAN
B:
[15-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
70.03
43%
-112
- C1 -
3K5V
2
ABL1_MOUSE
B:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
69.96
44%
-117
- C1 -
3F66
4
MET_HUMAN
A:
[10-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
----------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV-------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
I
G
E
H
Y
-------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.93
44%
-117
- C1 -
4GG5
1
A:
[37-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
----
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
-
F
------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
69.91
43%
-113
- C1 -
3MS9
2
ABL1_MOUSE
B:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
---
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
69.72
42%
-117
- C1 -
3CTJ
1
A:
[15-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
--------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
69.68
43%
-112
- C1 -
1OPJ
2
ABL1_MOUSE
B:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
G
K
------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
69.50
37%
-97
- C1 -
1T46
1
?
A:
[19-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
--
F
--
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
LI
K
---
S
----
D
--
A
A
M
T
V
A
V
K
M
L
K
P
S
A
-
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
-----
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
SF-----------------
L
A
L
D
-
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
-----
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
-
D
S
N
--
Y
--
V
--
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
-
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
-
S
T
N
----------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
69.22
43%
-108
- C1 -
1FPU
1
ABL1_MOUSE
B:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-------
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
69.18
43%
-115
- C1 -
4XEY
1
ABL1_HUMAN
B:
[122-383]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
------
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
---
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
--------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
69.01
42%
-116
- C1 -
3QTI
2
B:
[15-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
---------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
---------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
F
--------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
-----
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
68.98
43%
-109
- C1 -
1IEP
1
ABL1_MOUSE
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
68.95
43%
-108
- C1 -
3OY3
1
ABL1_MOUSE
B:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
68.81
43%
-112
- C1 -
1M52
3
ABL1_MOUSE
B:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
68.52
41%
-93
- C1 -
2XIR
1
A:
[23-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
K
--
L
--
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
--
I
DK-
T
----
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
----
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
--
E
----------
F
V
PYY
K
D
F
L
T
-
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
-----
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
-
D
P
D
Y
-
V
--
R
--
K
G
D
-
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
-
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
-
N
A
-----------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
68.35
37%
-106
- C1 -
3L9P
4
A:
[68-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
N
I
T
--
L
--
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
--------------
S
P
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
-----
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R-
P
----------
S
Q
---
P
S
S
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
G
Y
--
Y
--
R
--
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
-
Q
-
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
--------
V
I
N
T
A
L
P
I
E
-----------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
68.34
43%
-113
- C1 -
1M52
1
ABL1_MOUSE
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
68.15
42%
-107
- C1 -
3ZBF
1
A:
[30-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
E
K
L
T
--
L
--
R
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
D
--
I
LGV
G
----
S
--
G
E
I
K
V
A
V
K
T
L
K
K
G
S
T
-
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
E
-----
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
--
A
----------
T
F
Y--
G
P
L
L
T
-
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
VKDYT
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
-------------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
N
-
L
-
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
-
F
L
N
S
I
Y
K
S
R
----------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
68.01
36%
-106
- C1 -
3CBL
3
A:
[110-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
V
--
L
--
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
--------------
D
N
T
L
V
A
V
K
S
C
R
E
T
-
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-----
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
--------------------
G
A
R
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-----
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
-
G
V
Y
--
A
--
A
--
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
-
Q
-
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
-
H
------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
68.01
43%
-106
- C1 -
1IEP
1
ABL1_MOUSE
B:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
68.00
42%
-109
- C1 -
3A4P
3
A:
[22-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
--
E
----------
T
------
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
--------------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
-
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
67.89
43%
-115
- C1 -
4TWP
1
ABL1_HUMAN
B:
[5-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
67.27
40%
-100
- C1 -
3TT0
1
FGFR1_HUMAN
A:
[65-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
--
L
--
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
--
L
---
D
KDKP
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
-----
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--
P
GLEYSYNPSH
N
P
---
E
E
Q
L
S
-
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
-
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
-
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
-
T
S
N
Q
E
--------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
66.97
43%
-111
- C1 -
4XEY
1
ABL1_HUMAN
A:
[122-383]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
----
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
66.72
43%
-107
- C1 -
1FPU
1
ABL1_MOUSE
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
65.48
43%
-103
- C1 -
2HZN
1
ABL1_MOUSE
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
---
E
V
Y
E
G
V
W
K
K
--------------
Y
S
L
T
V
A
V
K
T
L
--
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
----------
C
N
---
R
Q
E
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
-
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.60
61%
-132
- C1 -
4FF8
1
A:
[80-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
-
D
H
P
H
V
A
K
L
V
----------------
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
I
----------------------
P
-
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
-----
E
D
M
T
V
C
V
A
------------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
-
A
-
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
--
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
----------------------------------------------------------------------------------------------------------------------------------------------