@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MK06_HUMAN: (2015-10-13 )
MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYSTEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHLN
Atome Classification :
(81 SA)
.........10........20........30........40-.........50-----.--.--.--..-.--.-.60.---.......70........80...-.....90........100.......110.......120----.--.......130.......140.......150.......160--........170....-...180-.......190.......200.......210.......220.......230.....----..240......----.250--...---------.....260------.-......---.270.-...---...280----..--.------------....290.......300.......310.......320....-------...330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
E
K
F
E
S
L
M
N
I
HGFDLGS
R
Y
M
D
L
K
PLGCGGN
G
L
V
F
S
AVDN--DCDK
R
V
A
I
K
K
I
-----
V
--L--T--
D
P
-
Q
--
S
-
V
K
H
A
---
L
R
E
I
K
I
I
R
RLDH
D
N
I
V
K
V
F
E
I
L-GPSGS
Q
L
T
D
D
VG
S
L
TEL
N
S
V
Y
I
V
Q
E
Y
M
E
T
D
L
A
N
V
L
E
Q-----G--P
L
L
E
E
H
A
R
L
F
M
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
RDLKP
A
N
L
F
I
N---TE
D
L
V
L
K
IGDF
G
L
A
R
-IMDPHY-SHKGHLSE
G
L
V
T
K
W
YRSP
R
L
L
LSPNNYT
K
A
I
D
M
W
A
A
G
C
I
F
A
E
M
LTGK
T
L
F
A
G
A
H
E
----
L
E
Q
M
Q
L
I
L
E
SI----PVV---
H
E
E
---------
D
R
Q
E
L
L
-
S
------
V
-
I
P
V
Y
I
R---NDMTE-PHK---
P
L
T
Q
L
L----PG--I------------
S
R
E
A
L
D
F
L
E
Q
I
LTFS
P
M
D
R
L
T
A
E
E
A
LSH
P
Y
M
S
I
YSFPMDEP-------ISSHPFHIEDEVD
D
I
L
L
MDET
H
S
HIYNWE
R
Y
HDCQFSEHDWPVHNNFD
I
D
E
V
QL
D
P
R
ALSDVTD
E
E
EVQV
D
P
R
KYLDG
D
R
E
K
YLEDPAFDTNYSTEPCWQYSDHHENK
Y
C
D
L
E
CSHTCNYKTR
S
S
S
Y
L
D
N
L
V
WRESEVNHYYE
P
K
L
I
I
DLSN
W
K
E
Q
S
KEKSDKKGK
S
K
C
ERNG
L
V
K
A
Q
I
A
L
E
E
A
S
Q
Q
L
AGKEREKNQGFD
F
D
S
F
I
A
G
T
I
Q
LSSQHE
P
T
D
V
V
D
K
L
N
D
L
N
S
S
V
S
Q
L
E
L
K
S
L
I
S
K
S
V
S
Q
E
K
Q
E
K
G
M
A
N
L
A
Q
L
E
A
L
Y
Q
SSWDSQFVSGGE
D
C
F
F
I
N
Q
F
C
E
VRKDEQVEKEN
T
Y
T
S
Y
L
D
K
F
FSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSG
E
F
L
F
N
K
Q
L
E
SIGIPQFHSPVG
S
P
L
K
S
I
Q
A
TLT
P
S
A
MKSSPQI
P
H
Q
T
Y
S
S
I
L
K
HLN
9
PsiBlast_PDB
77.87
46%
-119
- C1 -
5BUJ
1
?
A:
[20-339]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
----
G
S
P
---
S
Q
E
---------
D
---
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
77.81
45%
-121
- C1 -
3I60
1
MK01_HUMAN
A:
[39-358]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
--------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.54
46%
-119
- C1 -
5BUE
1
?
A:
[20-339]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
----
G
S
P
---
S
Q
E
---------
D
---
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
76.78
46%
-116
- C1 -
5BVD
1
?
A:
[20-339]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
-----------------
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
----
G
S
P
---
S
Q
E
---------
D
---
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
76.51
46%
-116
- C1 -
5BVE
1
?
A:
[20-339]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
-----------------
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
----
G
S
P
---
S
Q
E
---------
D
---
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.82
45%
-119
- C1 -
4FV6
2
MK01_HUMAN
A:
[19-338]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
---------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.47
45%
-121
- C1 -
4FV4
2
MK01_HUMAN
A:
[19-338]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
--
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
C
-
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
-------------
V
A
T
R
W
Y
R
A
P
E
I
M
-----
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
74.97
45%
-115
- C1 -
4O6E
1
MK01_HUMAN
A:
[27-346]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
NKV
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
---
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.97
46%
-111
- C1 -
5BUI
1
?
A:
[20-339]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-
D
----------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
----
G
S
P
---
S
Q
E
---------
D
---
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
74.46
45%
-116
- C1 -
4FV8
2
MK01_HUMAN
A:
[19-338]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
C
-
D
L
K
I
C
D
F
G
L
A
R
-
V
A
--------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
73.89
45%
-116
- C1 -
3I5Z
1
MK01_HUMAN
A:
[39-358]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
---------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
-----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
NKV
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
73.75
45%
-103
- C1 -
2OJI
1
MK01_HUMAN
A:
[39-358]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
73.71
39%
-111
- C1 -
2B9H
1
FUS3_YEAST
A:
[5-321]
-----------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
--
P
T
G
E
I
V
A
I
K
K
I
-----
E
--
P
--
F
D-
K
P
-
L
--
F
-
A
L
R
T
---
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
-
R
P
D
S
---------
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
-----
Q
--
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
---
S
-
N
C
D
L
K
V
C
D
F
G
L
A
R
-
I
I
D
----------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
----
R
H
Q
L
L
L
I
F
G
I
I
----
G
T
P
---
H
S
D
NDLRCIES
P
R
A
R
E
Y
I
-
K
------
S
-
L
P
----------
M
Y
-
P
A
A
---
P
L
E
K
M
F
----
P
R
--
V
------------
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
-------
E
G
E
P
I
P
P
S
F
F
E
F
D
H
Y
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
F
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
73.65
45%
-109
- C1 -
1GOL
1
MK01_RAT
A:
[23-342]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
L
N
K
V
R
V
A
I
R
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
----
G
S
P
---
S
Q
E
---------
D
---
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
NKV
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
73.16
45%
-106
- C1 -
4H3P
1
MK01_HUMAN
A:
[21-340]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
--------
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
NKV
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
72.95
45%
-109
- C1 -
4H3P
1
MK01_HUMAN
D:
[21-340]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
------------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
NKV
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
72.80
45%
-105
- C1 -
3TEI
1
MK01_HUMAN
A:
[21-340]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
--------
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.80
45%
-104
- C1 -
4FMQ
1
MK01_HUMAN
A:
[21-340]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
NKV
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
72.16
45%
-106
- C1 -
2ZOQ
1
MK03_HUMAN
A:
[39-358]
-------------
F
D
V
G
P
R
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
D
H
--
V
R
K
T
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
-
R
A
S
---------
T
L
E
A
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
S
-----
Q
--
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
---
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
-
I
A
D
P
E
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
----
G
S
P
---
S
Q
E
---------
D
---
L
N
-
C
------
I
-
I
N
M
K
A
R
---
N
Y
L
Q
S
L
P
S
K
TKV
A
W
A
K
L
F
----
P
K
--
S
------------
D
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
-------
V
A
E
E
P
F
T
F
A
M
E
L
D
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
Q
P
G
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
72.02
45%
-105
- C1 -
2OJJ
1
MK01_HUMAN
A:
[39-358]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
NKV
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
71.95
45%
-111
- C1 -
4XJ0
1
?
B:
[8-327]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
I
C
-
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
----
G
S
P
---
S
Q
E
---------
D
------------------
K
A
R
---
N
Y
L
L
S
L
P
H
K
NKV
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
71.83
45%
-109
- C1 -
4ERK
1
MK01_RAT
A:
[23-342]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
L
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
NKV
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
71.82
37%
-106
- C1 -
3CTQ
1
MK14_HUMAN
A:
[14-339]
-------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
H
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
A
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
--------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
A
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
71.81
45%
-105
- C1 -
3ERK
1
MK01_RAT
A:
[23-342]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
L
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.79
45%
-113
- C1 -
4FV5
2
MK01_HUMAN
A:
[19-338]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
C
-
D
L
K
I
C
D
F
G
L
A
R
-
V
A
---------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
71.33
46%
-101
- C1 -
4QTB
16
MK03_HUMAN
A:
[35-355]
-----------
Q
P
F
D
V
G
P
R
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
D
H
--
V
R
K
T
R
V
A
I
K
K
I
-----
S
--
P
--
F
E-
H
Q
-
T
--
Y
-
C
Q
R
T
---
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
-
R
A
S
T
---------
L
E
A
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
S
-----
Q
--
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
---
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
-
I
A
D
P
E
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
----
G
S
P
---
S
Q
E
---------
D
L
N
C
I
I
-
N
------
M
K
A
R
N
Y
L
Q
---
S
L
P
S
K
-
T
K
V
---
A
W
A
K
L
F
----
P
K
--
S
------------
D
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
-------
V
A
E
E
P
F
T
F
A
M
E
L
D
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
71.25
37%
-111
- C1 -
3P7B
2
MK14_MOUSE
A:
[24-349]
-------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
--
K
T
G
H
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
A
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
71.25
45%
-104
- C1 -
4FV3
4
MK01_HUMAN
A:
[19-338]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
C
-
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
NKV
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
71.20
45%
-102
- C1 -
1WZY
1
MK01_HUMAN
A:
[27-346]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
NKV
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
71.13
37%
-108
- C1 -
4F9W
5
MK14_HUMAN
A:
[36-366]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
A
--------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
71.12
37%
-108
- C1 -
4F9Y
6
MK14_HUMAN
A:
[36-366]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
A
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
70.96
45%
-107
- C1 -
2ZOQ
1
MK03_HUMAN
B:
[39-358]
-------------
F
D
V
G
P
R
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
D
H
--
V
R
K
T
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
-
R
A
S
---------
T
L
E
A
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
S
-----
Q
--
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
---
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
-
I
A
D
P
E
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
I
L
----
G
S
P
---
S
Q
E
---------
D
---
L
N
-
C
------
I
-
I
N
M
K
A
R
---
N
Y
L
Q
S
L
P
S
K
TKV
A
W
A
K
L
F
----
P
K
--
S
------------
D
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
-------
V
A
E
E
P
F
T
F
A
M
E
L
D
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
Q
P
G
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
70.95
37%
-113
- C1 -
3P79
2
MK14_MOUSE
A:
[24-349]
-------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
--
K
T
G
H
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
A
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
70.77
37%
-107
- C1 -
2PUU
1
MK14_MOUSE
A:
[14-339]
-------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
------
S
V
C
A
A
F
D
T
--
K
T
G
H
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
A
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
--------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
A
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
70.76
37%
-113
- C1 -
3P7C
2
MK14_MOUSE
A:
[24-349]
-------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
--
K
T
G
H
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E-----
S
-
A
R
N
Y
I
Q
---
S
L
A
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
70.64
37%
-113
- C1 -
3P5K
2
MK14_MOUSE
A:
[24-349]
-------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
--
K
T
G
H
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
A
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
70.62
37%
-107
- C1 -
4FA2
3
MK14_HUMAN
A:
[36-366]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
70.61
37%
-114
- C1 -
3P78
2
MK14_MOUSE
A:
[24-349]
-------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
--
K
T
G
H
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
A
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
70.58
37%
-109
- C1 -
3KF7
1
MK14_HUMAN
A:
[13-343]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
70.16
41%
-113
- C1 -
4B99
1
MK07_HUMAN
A:
[50-364]
-------------
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
--
L
T
G
Q
Q
V
A
I
K
K
I
PNAFD
V
--
V
--
T
--
N
-------
A
K
R
T
---
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
-
R
P
T
V
P
--------
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
-----
S
Q
-
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
----
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
--------
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
----
V
H
Q
L
Q
L
I
M
M
V
L
GTPS
P
A
V
---
I
Q
--------------
R
V
-
R
----------
A
Y
I
Q
---
S
L
P
P
R
-
Q
P
V
---
P
W
E
T
V
Y
----
P
G
--
A
------------
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
-------
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
69.97
37%
-109
- C1 -
3K3J
2
MK14_HUMAN
A:
[15-345]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
--
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
-----------
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
---------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
69.81
45%
-107
- C1 -
4N4S
1
MK01_RAT
B:
[18-337]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
L
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
A
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
L
D
F
G
L
A
R
-
V
A
D
P
-------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
NKV
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
69.68
37%
-106
- C1 -
3HL7
2
MK14_HUMAN
A:
[13-343]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
A
-------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
69.48
45%
-103
- C1 -
4H3Q
1
MK01_HUMAN
A:
[21-340]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
S
-
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
G
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
69.43
37%
-107
- C1 -
3ROC
2
MK14_HUMAN
A:
[13-343]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
69.24
42%
-102
- C1 -
4IC7
1
MK07_HUMAN
A:
[50-368]
------------
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
--
L
T
G
Q
Q
V
A
I
K
K
I
-----
P
--
N
--
A
FD
V
V
-
T
--
N
-
A
K
R
T
---
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
-
R
P
T
V
P
--------
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S----
Q
--
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
---
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
-
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
----
V
H
Q
L
Q
L
I
M
M
V
L
----
G
T
P
---
S
P
A
---------
V
I
Q
A
V
G
A
E
------
R
-
V
R
A
Y
I
Q
---
S
L
P
P
R
-
Q
P
V
---
P
W
E
T
V
Y
----
P
G
--
A
------------
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
-------
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
R
Q
Q
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
69.19
37%
-106
- C1 -
3FLS
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
----
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
---
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
69.05
37%
-107
- C1 -
3HLL
3
MK14_HUMAN
A:
[13-343]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
69.04
37%
-107
- C1 -
3HP5
3
MK14_HUMAN
A:
[13-343]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
-----
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
--------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
69.01
37%
-109
- C1 -
3P7A
2
MK14_MOUSE
A:
[24-349]
-------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
--
K
T
G
H
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
A
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
68.83
37%
-104
- C1 -
3FLW
1
MK14_HUMAN
A:
[25-355]
--------
L
N
-
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
----
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
68.77
45%
-104
- C1 -
4FV1
6
MK01_HUMAN
A:
[19-338]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
C
-
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
KV
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
---
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
68.71
37%
-105
- C1 -
3FMJ
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
---
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
--
R
-
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
68.70
45%
-103
- C1 -
4N4S
1
MK01_RAT
A:
[18-337]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
L
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
A
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
L
D
F
G
L
A
R
-
V
A
D
P
D
--------
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
68.69
37%
-100
- C1 -
3FKL
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
A
-------------
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
68.67
37%
-105
- C1 -
3ZSG
2
MK14_HUMAN
A:
[15-345]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
A
--------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
68.65
45%
-105
- C1 -
1TVO
1
MK01_HUMAN
A:
[19-338]
-------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
--
V
N
K
V
R
V
A
I
K
K
I
-----
S
--
P
--
F
--
E
H
-
Q
--
T
Y
C
Q
R
T
---
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
Q
M
K
D
----------
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-----
Q
--
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
---
T
T
-
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
----
L
D
Q
L
N
H
I
L
G
-------
I
L
---
G
S
P
---------
S
Q
E
D
L
N
-
C
------
I
-
I
N
L
K
A
R
---
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
----
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
-------
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
68.62
37%
-100
- C1 -
1YW2
1
MK14_MOUSE
A:
[13-343]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
H
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
-
A
R
-
H
---------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
A
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
68.59
41%
-105
- C1 -
4IC7
1
MK07_HUMAN
D:
[51-365]
-------------
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
--
L
T
G
Q
Q
V
A
I
K
K
I
PNAFD
V
--
V
--
T
--
N
-------
A
K
R
T
---
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
-
R
P
T
V
P
--------
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
-----
S
Q-
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
----
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
-
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
----
V
H
Q
L
Q
L
I
M
M
V
L
GTPS
P
A
V
---
I
Q
A
---------
V
G
A
E
R
V
-
R
----------
A
Y
I
Q
---
S
L
P
P
R
-
Q
P
V
---
P
W
E
T
V
Y
----
P
G
--
A
------------
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
-------
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
R
Q
Q
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
68.53
37%
-102
- C1 -
3FSK
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
-------
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
68.41
37%
-104
- C1 -
3HP2
3
MK14_HUMAN
A:
[13-343]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
L
D
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
68.28
37%
-101
- C1 -
3FLZ
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
---
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
68.22
37%
-109
- C1 -
3FSF
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
-----
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
----
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
67.51
37%
-103
- C1 -
3ZS5
6
MK14_HUMAN
A:
[15-345]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
A
--------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
67.42
37%
-106
- C1 -
3FML
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
------
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
-
L
A
R
-
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
67.38
37%
-105
- C1 -
1OZ1
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----------
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
A
R
-
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
67.31
37%
-105
- C1 -
3FMN
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
-----
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
67.15
37%
-100
- C1 -
3FKN
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
----
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
67.15
37%
-97
- C1 -
4LOO
1
MK14_MOUSE
A:
[14-344]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
H
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
A
R
-
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
A
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
67.09
37%
-100
- C1 -
2GFS
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
-----
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
67.03
37%
-101
- C1 -
3FMH
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
---
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
66.97
37%
-105
- C1 -
3FLQ
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
A
R
-
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
66.71
37%
-102
- C1 -
3FLY
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
---
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
66.66
41%
-98
- C1 -
4O2Z
1
?
A:
[40-353]
------------
P
F
E
V
P
S
K
Y
T
L
L
K
I
L
G
M
G
A
Y
G
I
A
C
S
C
L
D
G
--
D
T
G
E
K
V
S
I
K
K
C
-----
R
DV
F
--
R
--
D
V
-
E
--
D
-
G
K
R
V
---
L
R
E
I
D
M
M
R
F
F
H
H
E
N
L
L
N
V
V
N
I
L
-
P
P
L
K
R
E
-------
Y
H
S
F
E
D
V
Y
V
V
T
P
L
M
D
V
D
M
N
V
V
L
R
S
R----
Q
--
V
L
E
E
S
H
M
Q
Y
F
V
Y
Q
I
L
R
G
L
K
Y
L
H
S
A
N
V
A
H
R
D
L
K
P
A
N
L
V
T
N
---
I
-
S
C
E
L
K
I
I
D
F
G
L
S
R
-
S
--
V
P
Y
-
S
---
E
L
T
D
Y
V
I
T
R
W
Y
R
P
P
E
L
L
L
E
N
T
N
Y
S
T
A
V
D
I
W
S
V
G
C
I
F
A
E
M
Y
N
R
K
P
V
F
P
G
R
N
T
----
M
D
Q
L
R
M
I
A
Q
H
I
----
G
K
P
PAS
I
V
E
---------
H
R
E
A
L
E
-
K
------
L
----------
N
E
L
P
D
-
G
S
L
---
N
I
P
K
L
V
----
P
G
LA
G
------------
N
T
E
G
I
D
F
L
S
K
M
W
T
L
D
P
S
K
R
P
T
A
A
D
M
L
A
H
P
Y
L
A
H
L
H
D
E
E
D
E
P
-------
T
C
P
C
P
F
L
W
A
H
E
S
T
P
M
G
V
S
E
L
R
R
A
F
W
A
D
I
V
D
Y
N
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
66.08
37%
-104
- C1 -
3FL4
1
MK14_HUMAN
A:
[25-355]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
------
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----------
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
-----
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
65.79
37%
-100
- C1 -
3RIN
1
MK14_HUMAN
A:
[13-343]
--------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
---------
L
--
S
--
R
P
F
Q
--
S
-
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
-
T
P
A
R
S
--------
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-----
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
----
E
D
C
E
L
K
I
L
D
F
G
L
A
R
-
H
T
D
-------
D
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
----
I
D
Q
L
K
L
I
L
R
L
V
----
G
T
P
---
G
A
E
---------
L
L
K
K
I
S
-
S
E
-----
S
-
A
R
N
Y
I
Q
---
S
L
T
Q
M
-
P
K
M
---
N
F
A
N
V
F
----
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-------
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
-
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
62.87
34%
-105
- C1 -
3TTJ
1
MK10_HUMAN
A:
[58-367]
-------------
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
D
A
--
V
L
D
R
N
V
A
I
K
K
L
-----
S
--
R
PF
Q
--
N
Q
-
T
--
H
-
A
K
R
A
---
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
-
T
P
Q
K
T
--------
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
------
M
--
E
L
D
H
E
R
M
S
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
---
S
-
D
C
T
L
K
I
L
D
F
G
L
A
------
S
F
-----
M
M
----
V
T
R
Y
Y
R
A
P
E
V
I
L
G
-
M
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
----
I
D
Q
W
N
K
V
I
E
Q
L
----
G
T
P
---
C
P
E
---------
F
M
K
K
L
Q
-
P
------
T
-
V
R
N
Y
V
E
---
N
R
P
K
Y
-
A
G
L
---
T
F
P
K
L
F
----
P
D
--
S
LFPADS
E
H
N
K
L
K
A
S
Q
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
-------
A
P
P
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
M
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
HHSearch
61.42
34%
-104
- C1 -
4NST
3
CDK12_HUMAN
A:
[8-313]
------------
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
--
D
T
G
E
L
V
A
L
K
K
V
-----
R
--
L
--
D
--
N
E
-
K
EG
F
-
P
I
T
A
---
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
-
T
D
K
Q
D
------------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
-----
G
L
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
---
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
-
L
Y
N
S
E
E
-
S
R
--
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
----
L
A
Q
L
E
L
I
S
R
L
C
----
G
S
P
---
C
P
A
---------
V
W
P
D
V
I
-
K
--------
L
P
Y
F
N
T
M--
K
P
K
K
Q
-
Y
R
R
---
R
L
R
E
E
F
----
S
F
--
I
------------
P
S
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
A
P
-------
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
HHSearch
59.81
32%
-106
- C1 -
4F6U
10
CDK8_HUMAN
A:
[27-361]
-----------------------
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
DG
K
D
D
K
D
Y
A
L
K
Q
I
-----
E
--
G
--
T
--
G
-----
I
-
S
M
S
A
---
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
-
L
S
H
A
------------
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
V
--
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
E
R
G
R
V
K
I
A
D
M
G
F
-------------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
E
P
I
F
H
C
R
Q
E
NPYH
H
D
Q
L
D
R
I
F
N
V
M
----
G
F
P
---
A
D
K
---------
D
W
E
D
I
K
-
K
MPE
H
S
T
L
-
M
K
D
F
R
R
---
N
T
Y
---
T
N
C
---
S
L
I
K
Y
M
E
K
H
K
V
K
--
P
------------
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
FAGCQIP
Y
P
K
R
E
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
59.21
35%
-97
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-300]
--------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
--
N
T
N
Q
I
V
A
I
K
K
I
----------------------
N
R
T
A
---
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
-
G
H
K
--------------
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
-----
N
SL
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
---
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
-
S
F
G
S
P
----
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
P
F
L
P
G
D
S
D
----
L
D
Q
L
T
R
I
F
E
T
L
----
G
T
P
---
T
E
E
---------
Q
W
P
D
M
C
-
S
--------
L
P
D
Y
V
T
----
F
K
S
F
-
P
G
I
---
P
L
H
H
I
F
----
S
A
--
A
------------
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
P
T
P
G
C
-------
Q
L
P
R
P
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
HHSearch
57.93
31%
-107
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[10-301]
---------------
V
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
--
E
T
H
E
I
V
A
I
K
K
F
-----
K
--------------
V
-
K
E
T
T
---
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
-
R
R
--------------
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
P---
N
--
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
---
H
-
N
D
V
L
K
L
C
D
F
G
F
A
R
-
N
L
S
E
--------------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
----
I
D
Q
L
F
T
I
Q
K
V
L
----
G
P
L
---
P
S
E
---------
Q
M
K
L
F
Y
-
S
--------
N
P
R
F
H
G
LRF
P
A
V
N
H
-
P
Q
S
---
L
E
R
R
Y
L
----
G
I
--
L
------------
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------