@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MK07_HUMAN: (2015-10-14 )
MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
Atome Classification :
(75 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120-.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280........290.......300.......310.......320.......330.......340.......350.......--360......--.370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAEPLKEEDGEDGSAEPPGPVKAEPA
H
T
A
A
S
V
A
A
K
N
L
A
L
L
K
AR
S
F
D
V
T
F
DVGD
E
Y
E
I
I
E
T
IGNG
A
Y
G
V
V
S
S
A
R
R
RLTG
Q
Q
V
A
I
K
KIP
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
FKHD
N
I
I
A
I
K
D
I
LR-PTVPYGE
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
IHSSQPL
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
RDLKPS
N
L
L
VNENC
E
L
K
IGDFGMARGLCTSP
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
WYR
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
RQLFPG
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
LGTP-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
SLPPRQPVPWETVYPGA
D
R
Q
A
L
S
L
L
G
R
M
LRFEPSA
R
I
S
A
A
A
A
LRH
P
F
L
AKYHDPDDEPDC--APPFDFAF
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
R
Q
Q
IRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAP
D
T
I
D
L
TLQPPPPVSEPAPPKKDGAISD
N
T
K
A
A
L
K
A
A
L
L
K
S
L
R
S
R
LRDGPSAPLEAPEPRKPV
T
A
Q
E
R
Q
R
E
R
E
E
K
R
R
R
R
Q
E
R
A
K
E
R
E
K
R
R
Q
E
R
E
R
K
ERGAGASGGPSTD
P
L
A
G
L
V
LSDN
D
R
S
L
L
E
R
W
T
R
MARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIAT
S
T
S
L
L
A
A
Q
SLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESP
D
V
N
L
V
T
Q
Q
L
S
K
S
QVEDPLPPVFSGTPKGSGAGYGVGF
D
L
E
E
F
L
N
Q
SFDMGVADGPQDGQA
D
S
A
S
L
S
A
S
L
L
A
D
W
L
EGHGM
N
P
A
D
I
E
S
L
Q
R
E
IQMDS
P
M
L
L
ADLPDLQDP
3
PsiBlast_PDB
95.87
100%
-135
- C1 -
4B99
1
MK07_HUMAN
A:
[48-394]
----------------------------------------------
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
-------
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
-----
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
P
F
D
F
A
F
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
95.59
100%
-130
- C1 -
4IC7
1
MK07_HUMAN
D:
[49-401]
----------------------------------------------
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
P
F
D
F
A
F
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
R
Q
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.15
100%
-129
- C1 -
4IC7
1
MK07_HUMAN
A:
[48-402]
---------------------------------------------
D
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
P
F
D
F
A
F
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
R
Q
Q
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
82.81
50%
-130
- C1 -
3I60
1
MK01_HUMAN
A:
[38-374]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
-------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
81.19
50%
-128
- C1 -
5BUJ
1
?
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
80.86
48%
-125
- C1 -
2B9H
1
FUS3_YEAST
A:
[5-351]
----------------------------------------------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
-
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
-
P
D
-
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
----------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
K
S
L
P
M
Y
P
A
A
P
L
E
K
M
F
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
E
F
D
HY
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
F
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
80.85
50%
-131
- C1 -
2OJJ
1
MK01_HUMAN
A:
[38-374]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
80.55
50%
-130
- C1 -
3I5Z
1
MK01_HUMAN
A:
[38-374]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
--------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
-----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
80.42
50%
-127
- C1 -
4O6E
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
-----------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
---
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
80.39
50%
-128
- C1 -
4FV6
2
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
--------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
80.28
48%
-122
- C1 -
2F9G
1
FUS3_YEAST
A:
[5-351]
----------------------------------------------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
-
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
-
P
D
-
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
---------------
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
K
S
L
P
M
Y
P
A
A
P
L
E
K
M
F
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
E
F
D
HY
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
F
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
80.17
48%
-123
- C1 -
2B9J
1
FUS3_YEAST
A:
[5-351]
----------------------------------------------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
-
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
-
P
D
-
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
----------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
K
S
L
P
M
Y
P
A
A
P
L
E
K
M
F
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
E
F
D
HY
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
F
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
80.11
48%
-122
- C1 -
2B9F
1
FUS3_YEAST
A:
[5-351]
----------------------------------------------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
-
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
-
P
D
-
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
----------
T
E
Y
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
K
S
L
P
M
Y
P
A
A
P
L
E
K
M
F
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
E
F
D
HY
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
F
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
79.96
48%
-124
- C1 -
2B9I
1
FUS3_YEAST
A:
[5-351]
----------------------------------------------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
-
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
-
P
D
-
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
E
---------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
K
S
L
P
M
Y
P
A
A
P
L
E
K
M
F
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
E
F
D
HY
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
F
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
79.77
50%
-122
- C1 -
5BUI
1
?
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
----------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
79.68
51%
-125
- C1 -
4H3P
1
MK01_HUMAN
D:
[20-356]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-----------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
79.55
50%
-123
- C1 -
2OJG
1
MK01_HUMAN
A:
[39-374]
------------------------------------------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
--
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
79.53
51%
-127
- C1 -
2Z7L
4
MK01_RAT
A:
[24-360]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
---
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
----------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
79.43
51%
-124
- C1 -
3ERK
1
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
79.35
50%
-129
- C1 -
1PME
1
MK01_HUMAN
A:
[38-374]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
---
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
L
V
T
H
L
M
G
A
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
----------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
79.09
50%
-126
- C1 -
4QTA
9
MK01_HUMAN
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
--------------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
79.07
51%
-119
- C1 -
4N4S
1
MK01_RAT
B:
[17-353]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
A
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
L
D
F
G
L
A
R
-
V
A
D
P
------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
78.61
50%
-125
- C1 -
5BUE
1
?
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.58
51%
-123
- C1 -
4QTB
16
MK03_HUMAN
A:
[37-372]
------------------------------------------------
F
D
V
G
P
R
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
D
H
V
R
K
T
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
-
A
S
T
L
E
A
-
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
S
Q
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
I
A
D
P
E
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
M
K
A
R
N
Y
L
Q
S
L
P
S
K
T
K
V
A
W
A
K
L
F
P
K
S
D
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
V
A
--
E
E
P
F
T
F
A
M
E
--
L
D
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
Q
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.57
51%
-123
- C1 -
4H3P
1
MK01_HUMAN
A:
[20-356]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-------
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
78.40
50%
-123
- C1 -
2OJI
1
MK01_HUMAN
A:
[38-374]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.18
51%
-118
- C1 -
3TEI
1
MK01_HUMAN
A:
[20-356]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-------
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
78.14
50%
-122
- C1 -
4QTE
22
MK01_HUMAN
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
78.02
50%
-127
- C1 -
1GOL
1
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
R
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
77.86
51%
-125
- C1 -
4ERK
1
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
77.56
46%
-129
- C1 -
3P5K
2
MK14_MOUSE
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
77.48
46%
-126
- C1 -
3FSK
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
---------
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
77.46
51%
-118
- C1 -
4QTB
6
MK03_HUMAN
B:
[37-372]
------------------------------------------------
F
D
V
G
P
R
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
D
H
V
R
K
T
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
-
A
S
T
L
E
A
-
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
S
Q
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
I
A
D
P
E
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
M
K
A
R
N
Y
L
Q
S
L
P
S
K
T
K
V
A
W
A
K
L
F
P
K
S
D
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
V
A
--
E
E
P
F
T
F
A
M
E
--
L
D
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
Q
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
77.44
51%
-116
- C1 -
4N4S
1
MK01_RAT
A:
[17-353]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
A
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
L
D
F
G
L
A
R
-
V
A
D
P
D
-------
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
77.39
46%
-123
- C1 -
3FKL
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
--------
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
77.39
46%
-123
- C1 -
3FLW
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.37
51%
-116
- C1 -
4I5H
1
MK01_RAT
A:
[17-353]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
A
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
L
D
F
G
L
A
R
-
V
A
D
P
-------
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
--------
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
77.19
46%
-123
- C1 -
3FMH
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
77.17
46%
-123
- C1 -
3FLZ
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
77.11
46%
-125
- C1 -
3FLS
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
----
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
77.10
46%
-131
- C1 -
3FL4
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
--
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
77.07
46%
-126
- C1 -
3FSF
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
-----
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
77.00
50%
-120
- C1 -
4FMQ
1
MK01_HUMAN
A:
[20-356]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
76.99
50%
-124
- C1 -
2ZOQ
1
MK03_HUMAN
B:
[39-374]
------------------------------------------------
F
D
V
G
P
R
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
D
H
V
R
K
T
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
-
A
S
T
L
E
A
-
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
S
Q
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
I
A
D
P
E
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
M
K
A
R
N
Y
L
Q
S
L
P
S
K
T
K
V
A
W
A
K
L
F
P
K
S
D
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
V
A
--
E
E
P
F
T
F
A
M
E
--
L
D
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
Q
P
G
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
76.93
46%
-124
- C1 -
3FML
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
------
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
-
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
76.90
46%
-126
- C1 -
2GFS
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
----
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
76.81
46%
-126
- C1 -
1BMK
1
MK14_HUMAN
A:
[37-367]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
76.75
50%
-114
- C1 -
1WZY
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
76.71
46%
-123
- C1 -
3FLQ
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
76.70
46%
-126
- C1 -
3P7C
2
MK14_MOUSE
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
76.69
46%
-128
- C1 -
3P78
2
MK14_MOUSE
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
76.52
46%
-125
- C1 -
3FMN
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.47
50%
-122
- C1 -
2ZOQ
1
MK03_HUMAN
A:
[39-374]
------------------------------------------------
F
D
V
G
P
R
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
D
H
V
R
K
T
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
-
A
S
T
L
E
A
-
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
S
Q
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
I
A
D
P
E
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
M
K
A
R
N
Y
L
Q
S
L
P
S
K
T
K
V
A
W
A
K
L
F
P
K
S
D
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
V
A
--
E
E
P
F
T
F
A
M
E
--
L
D
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
Q
P
G
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
76.38
46%
-125
- C1 -
3FMJ
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
---
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
76.27
46%
-122
- C1 -
3FLY
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
76.18
46%
-128
- C1 -
3P79
2
MK14_MOUSE
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
75.99
46%
-118
- C1 -
4LOO
1
MK14_MOUSE
A:
[19-349]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
75.97
50%
-118
- C1 -
1TVO
1
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
75.74
46%
-125
- C1 -
3P7A
2
MK14_MOUSE
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
75.72
46%
-127
- C1 -
1OZ1
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
75.70
46%
-126
- C1 -
3P7B
2
MK14_MOUSE
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
75.62
46%
-124
- C1 -
4FA2
3
MK14_HUMAN
A:
[41-371]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
75.31
50%
-118
- C1 -
4XJ0
1
?
A:
[7-343]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
-
N
D
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
-
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
--
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
75.21
46%
-123
- C1 -
3FKN
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
74.68
50%
-117
- C1 -
4XJ0
1
?
B:
[7-343]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
-
N
D
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
-------
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
74.54
48%
-128
- C1 -
3GC9
1
MK11_HUMAN
A:
[36-354]
------------------------------------------------------------
V
G
S
G
A
Y
G
S
V
C
S
A
Y
D
A
R
L
R
Q
K
V
A
V
K
K
L
S
R
P
F
Q
S
L
I
H
A
R
R
T
Y
R
E
L
R
L
L
K
H
L
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
T
S
I
E
D
F
S
E
V
Y
L
V
T
T
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
A
L
S
D
E
H
V
Q
F
L
V
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
G
I
I
H
R
D
L
K
P
S
N
V
A
V
N
E
D
S
E
L
R
I
L
D
F
G
L
A
------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
Q
G
K
A
L
F
P
G
S
D
Y
I
D
Q
L
K
R
I
M
E
V
V
G
T
P
-
S
P
E
V
L
A
K
I
S
S
E
H
A
R
T
Y
I
Q
S
L
P
P
M
P
Q
K
D
L
S
S
I
F
R
G
A
N
P
L
A
I
D
L
L
G
R
M
L
V
L
D
S
D
Q
R
V
S
A
A
E
A
L
A
H
A
Y
F
S
Q
Y
H
D
P
E
D
E
P
E
---
A
E
P
Y
D
E
S
V
E
--
A
K
E
R
T
L
E
E
W
K
E
L
T
Y
Q
E
V
L
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
74.48
46%
-124
* C1 *
3HVC
2
MK14_HUMAN
A:
[20-350]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
74.42
46%
-125
- C1 -
4F9W
5
MK14_HUMAN
A:
[41-371]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
73.39
46%
-123
- C1 -
4F9Y
6
MK14_HUMAN
A:
[41-371]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
73.34
50%
-110
- C1 -
4H3Q
1
MK01_HUMAN
A:
[20-356]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
S
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
G
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
P
F
K
F
D
M
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
Y
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
PsiBlast_CBE
73.30
46%
-118
- C1 -
4L8M
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
-----------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
72.81
46%
-122
- C1 -
4TYH
1
?
B:
[13-343]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
H
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
---------------
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
-----
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
Q
M
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
P
Y
D
Q
S
F
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
69.19
48%
-116
- C1 -
3GC8
1
MK11_HUMAN
A:
[36-354]
------------------------------------------------------------
V
G
S
G
A
Y
G
S
V
C
S
A
Y
D
A
R
L
R
Q
K
V
A
V
K
K
L
S
R
P
F
Q
S
L
I
H
A
R
R
T
Y
R
E
L
R
L
L
K
H
L
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
T
S
I
E
D
F
S
E
V
Y
L
V
T
T
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
A
L
S
D
E
H
V
Q
F
L
V
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
G
I
I
H
R
D
L
K
P
S
N
V
A
V
N
E
D
S
E
L
R
I
L
D
F
G
L
A
R
-----
Q
A
D
E
E
--
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
Q
G
K
A
L
F
P
G
S
D
Y
I
D
Q
L
K
R
I
M
E
V
V
G
T
P
-
S
P
E
V
L
A
K
I
S
S
E
H
A
R
T
Y
I
Q
S
L
P
P
M
P
Q
K
D
L
S
S
I
F
R
G
A
N
P
L
A
I
D
L
L
G
R
M
L
V
L
D
S
D
Q
R
V
S
A
A
E
A
L
A
H
A
Y
F
S
Q
Y
H
D
P
E
D
E
P
E
---
A
E
P
Y
D
E
S
V
E
--
A
K
E
R
T
L
E
E
W
K
E
L
T
Y
Q
E
V
L
S
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
68.76
48%
-116
- C1 -
3GC9
1
MK11_HUMAN
B:
[36-354]
------------------------------------------------------------
V
G
S
G
A
Y
G
S
V
C
S
A
Y
D
A
R
L
R
Q
K
V
A
V
K
K
L
S
R
P
F
Q
S
L
I
H
A
R
R
T
Y
R
E
L
R
L
L
K
H
L
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
T
S
I
E
D
F
S
E
V
Y
L
V
T
T
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
A
L
S
D
E
H
V
Q
F
L
V
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
G
I
I
H
R
D
L
K
P
S
N
V
A
V
N
E
D
S
E
L
R
I
L
D
F
G
L
A
R
----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
Q
G
K
A
L
F
P
G
S
D
Y
I
D
Q
L
K
R
I
M
E
V
V
G
T
P
-
S
P
E
V
L
A
K
I
S
S
E
H
A
R
T
Y
I
Q
S
L
P
P
M
P
Q
K
D
L
S
S
I
F
R
G
A
N
P
L
A
I
D
L
L
G
R
M
L
V
L
D
S
D
Q
R
V
S
A
A
E
A
L
A
H
A
Y
F
S
Q
Y
H
D
P
E
D
E
P
E
---
A
E
P
Y
D
E
S
V
E
--
A
K
E
R
T
L
E
E
W
K
E
L
T
Y
Q
E
V
L
S
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
66.78
48%
-112
- C1 -
3GC8
1
MK11_HUMAN
B:
[36-354]
------------------------------------------------------------
V
G
S
G
A
Y
G
S
V
C
S
A
Y
D
A
R
L
R
Q
K
V
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K
K
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L
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H
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L
L
D
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-
P
A
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Y
L
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A
D
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N
I
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-
K
C
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D
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L
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A
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N
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D
S
E
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I
L
D
F
G
L
A
R
-----
Q
A
D
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E
--
M
T
G
Y
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A
T
R
W
Y
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A
P
E
I
M
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M
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Q
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V
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-
S
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D
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A
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P
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A
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M
L
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A
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D
P
E
D
E
P
E
---
A
E
P
Y
D
E
S
V
E
--
A
K
E
R
T
L
E
E
W
K
E
L
T
Y
Q
E
V
L
S
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------