@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MLTK_HUMAN: (2015-10-14 )
MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSPFFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRPSPAKTNKERARGDHRGWRNF
Atome Classification :
(90 SA)
.........10........20........30.....-.-..40....----------..------..50------------.....-----...60........70.-.-....-..80........90....-....-100.......110.......120.......130.......140...-....150.----...-...160...--...----.---170-........---180.......190.......200.-..-.....210-........220----.......230.......240.......250......-.260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSLG
A
S
F
V
Q
I
K
F
D
D
L
Q
F
F
E
NCGGGSFG
S
V
Y
R
A
K
WI-S-Q
D
K
E
V
A
V
K
----------
K
L
------
L
K
I
E
------------
K
E
A
E
I
-----
L
S
V
L
SHR
N
I
I
Q
F
Y
G
V
I
-L-EPPN-Y
G
I
V
T
E
Y
A
S
L
G
S
L
Y
D
Y
I
N-SNRS-EEM
D
M
D
H
I
M
T
W
A
T
D
V
A
KG
M
H
Y
L
HMEA
P
V
K
V
I
H
R
D
LKSR
N
V
V
I
AADG-
V
L
K
I
C
DF
G
----
A
S
R
-FHNHTT
H
M
S
--
L
V
G----T---FP--WM
A
P
E
V
I
Q
---SLPVSETCD
T
Y
S
Y
G
V
V
L
W
E
M
L
T
-
R
-EV-PFKGLEG--
L
Q
V
A
W
L
V
V
EKN----E
R
L
TI
P
S
S
C
P
R
S
F
A
E
L
L
H
Q
C
W
E
A
D
AKKRP
S
F
K
Q
I
I
S
-
I
L
E
S
MSNDTSL
P
D
K
C
N
S
F
L
HNKA
E
W
R
C
E
I
E
A
T
L
E
R
L
K
K
L
E
R
DLS
F
K
E
Q
E
L
K
E
R
E
R
R
L
K
M
W
E
Q
K
L
TEQSNTPLLPSFEIGAWTE
D
D
V
Y
C
W
V
Q
Q
L
V
RKGDS
S
A
E
M
S
V
Y
A
S
L
F
K
ENNITG
K
R
L
L
L
L
EEED
L
K
DMGIVSKG
H
I
I
H
F
K
S
A
I
E
K
L
T
H
D
Y
I
N
L
FHFPPLIKDSGGEPEENE
E
K
I
V
N
L
E
L
V
F
G
F
HLKPGTGPQDC
K
W
K
M
Y
M
E
MDG
D
E
I
A
I
T
Y
I
K
D
V
T
FNTNLP
D
A
E
I
LKMTKP
P
F
V
M
E
K
W
I
V
GIAKS
Q
T
V
E
C
T
V
T
YESDVRTPKSTK
H
V
H
S
I
QWSRTK
P
Q
D
E
V
K
A
V
Q
L
A
I
Q
T
L
FTNSDGNPGSRSDSSA
D
C
Q
W
L
D
T
L
R
M
R
Q
I
ASNTSLQRSQSNPILGS
P
F
F
SHFDGQ
D
S
Y
A
A
A
VRRPQV
P
I
K
Y
Q
QITPVNQSRSSSPTQYGLTKN
F
S
S
L
HLNSRDSGFSSGNTDTSSERGRYSDRSRNKYGR
G
S
I
SLNSSPRGRYSGKSQHSTPSRGRYP
G
K
F
Y
R
V
S
Q
SALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGG
W
T
K
V
E
YRKKPHRPSPAKT
N
K
E
RARGDHRGWRNF
1
PsiBlast_PDB
91.26
40%
-117
- C2 -
3P86
1
CTR1_ARATH
A:
[32-296]
--------
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
-
G
-
S
D
--
V
A
V
K
----------
I
L
------
M
E
Q
D
FH
A
E
R
V
N
E
F
L
--
R
E
V
A
I
-----
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
-
T
-
Q
P
P
N
-
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
K
S
G
A
R
-
E
Q
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
-
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
-
T
V
K
V
C
D
F
----------------------
G
----
T
---
P
E
--
W
M
A
P
E
V
L
R
---
D
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
-
Q
Q
-
P
W
G
N
L
N
P
--
A
Q
V
V
A
A
V
G
F
K
C
----
K
R
L
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
-
L
L
R
P
L
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.16
40%
-108
- C2 -
3PPZ
1
CTR1_ARATH
A:
[32-296]
--------
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
-
G
-
S
D
--
V
A
V
K
----------
I
L
------
M
E
--AE
R
V
N
E
F
L
----
R
E
V
A
I
-----
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
-
T
-
Q
P
P
N
-
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
K
S
G
A
R
-
E
Q
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
-
P
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
-
T
V
K
V
C
D
F
G
----
L
S
R
-
L
K
A
S
T
F
L
S
S
KS
A
A
G
----
T
---
P
E
--
W
M
A
P
E
V
L
R
---
D
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
-
Q
Q
-
P
W
G
N
L
N
P
--
A
Q
V
V
A
A
V
G
F
K
C
----
K
R
L
E
I
P
R
N
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
-
L
L
R
P
L
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Fugue
83.94
33%
-110
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-276]
-------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G----
N
K
V
A
V
K
----------
C
I
K
NDA--
Q
A
F
L
------------
A
E
A
S
V
-----
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
-
V
---
E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
-
S
R
G
R
-
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
---
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
-
V
A
K
V
S
D
F
G
---------------------------LLP
V
K
--
W
T
A
P
E
A
L
R
---
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
-
F
G
R
V
-
P
Y
P
R
I
P
L
---
K
D
V
V
P
R
V
E
K
G
----
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
-
Q
L
E
H
I
K
T
H
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.05
36%
-110
- C2 -
2YIY
1
M3K7_HUMAN
A:
[1-261]
------
S
L
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
W
----
R
A
K
D
V
A
I
K
----------
Q
I
E-----
S
E
S
E
------------
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
-
N
P
---
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
-
G
A
E
P
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
S
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
T
V
L
K
I
C
D
F
G
---------------------
G
----
S
---
A
A
--
W
M
A
P
E
V
F
E
---
G
S
N
Y
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
-
R
-
R
K
-
P
F
D
E
I
G
G
P
A
F
R
I
M
W
-
A
V
H
N
G
----
T
R
P
P
L
I
K
N
L
P
K
P
I
E
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
-
I
M
T
H
L
M
R
Y
F
P
G
A
D
E
P
L
Q
Y
P
C
Q
H
S
L
P
P
G
E
D
G
R
V
E
P
Y
V
D
F
A
E
F
Y
R
L
W
S
V
D
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
82.03
32%
-115
- C2 -
3D7T
1
CSK_HUMAN
A:
[9-262]
----------
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
----
R
G
N
K
V
A
V
K
----------
C
I
K
NDATA
Q
A
F
L
------------
A
E
A
S
V
-----
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
-
V
-
E
E
K
G
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
-
S
R
G
R
-
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
---
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
-
V
A
K
V
S
D
F
G
-------------------------------
P
VK
W
T
A
P
E
A
L
R
---
E
A
A
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
-
R
V
-
P
Y
P
R
I
P
---
L
K
D
V
V
P
R
V
E
K
G
----
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
-
Q
L
E
H
I
K
T
H
E
L
H
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
78.79
32%
-101
- C2 -
1OPJ
2
ABL1_MOUSE
B:
[19-290]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
78.61
32%
-106
- C2 -
1OPL
1
ABL1_HUMAN
B:
[260-518]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.07
38%
-100
- C2 -
4UEU
1
?
A:
[20-267]
----------------------
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
-
N
-
Y
N
I
E
V
A
V
K
----------
T
L
KEGT--
M
S
V
E
E
F
L
---------
Q
E
A
Q
I
-----
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
-
T
K
E
P
P
I
-
Y
-
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
-
D
C
E
G
-
H
T
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
-
V
V
K
V
A
D
F
G
----
L
A
R
-
L
I
----------------
A
K--
F
P
IK
W
T
A
P
E
A
I
S
---
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
-
Y
G
Q
V
-
P
Y
P
G
M
S
G
--
S
E
V
I
-
E
Q
V
E
R
G
----
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
-
A
L
E
T
M
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
77.97
32%
-103
- C2 -
2HZI
1
ABL1_HUMAN
A:
[18-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
77.87
32%
-103
- C2 -
2HZI
1
ABL1_HUMAN
B:
[18-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
------
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.62
32%
-105
- C2 -
1OPL
2
ABL1_HUMAN
A:
[260-525]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
77.52
32%
-103
- C2 -
2FO0
3
ABL1_HUMAN
A:
[218-483]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
77.35
32%
-101
- C2 -
3DK3
1
ABL1_MOUSE
A:
[12-273]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K------
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
F
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
P
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
77.32
32%
-102
- C2 -
1OPJ
2
ABL1_MOUSE
A:
[19-288]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
77.22
32%
-105
- C2 -
1OPK
3
ABL1_MOUSE
A:
[221-486]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
77.18
32%
-97
- C2 -
2G2H
1
ABL1_HUMAN
B:
[16-279]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
P
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
77.12
33%
-106
- C2 -
3QRK
1
ABL1_HUMAN
A:
[19-274]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
E
DT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.10
38%
-107
- C2 -
4CSV
1
?
A:
[20-267]
----------------------
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
-
N
-
Y
N
I
E
V
A
V
K
----------
T
L
KEGT--
M
S
V
E
E
F
L
---------
Q
E
A
Q
I
-----
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
-
T
K
E
P
P
I
-
Y
-
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
-
D
C
-----
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
-
V
V
K
V
A
D
F
G
------------------------------
F
P
IK
W
T
A
P
E
A
I
S
---
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
-
Y
G
Q
V
-
P
Y
P
G
M
S
G
--
S
E
V
I
-
E
Q
V
E
R
G
----
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
-
A
L
E
T
M
F
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
76.78
33%
-107
- C2 -
3QRI
1
ABL1_HUMAN
A:
[19-274]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K
--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
76.75
32%
-104
- C2 -
3MS9
2
ABL1_MOUSE
A:
[19-276]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
--------
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
--
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
76.28
34%
-103
- C2 -
3EQR
1
ACK1_HUMAN
A:
[9-276]
--------------
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V
---------
K
C
------
L
K
P
-
E
A
M
D
D
F
I
-----
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
G
-
H
F
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
----
L
M
R
A
L
P
Q
N
D
D
H
Y
V
--
M
Q
E
HRKV
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
Q
P
T
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
76.28
32%
-101
- C2 -
3K5V
2
ABL1_MOUSE
A:
[19-288]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
E
D---
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
76.24
35%
-102
- C2 -
3GVU
2
ABL2_HUMAN
A:
[33-292]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
-
E
P
P
F
-
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
V
V
K
V
A
D
F
G
----
L
S
R
----
G
D
T
Y
T
----------
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
D
L
L
E
K
G
----
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
-
A
F
E
T
M
F
H
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
76.13
34%
-109
- C2 -
1U4D
1
ACK1_HUMAN
B:
[19-284]
--------------
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V
---------
K
C
------
L
---A
M
D
D
F
I
------
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
----
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
----
L
M
R
A
L
P
Q
N
D
D
H
Y
V
--
M
Q
E
HRKV
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
76.12
32%
-104
- C2 -
3CS9
1
ABL1_HUMAN
D:
[18-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
76.06
35%
-109
- C2 -
3HMI
1
ABL2_HUMAN
A:
[33-292]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
-
E
P
P
F
-
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
V
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
D
L
L
E
K
G
----
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
-
A
F
E
T
M
F
H
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
75.97
32%
-98
- C2 -
2G1T
1
ABL1_HUMAN
C:
[16-280]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K
--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
75.94
32%
-101
- C2 -
1IEP
1
ABL1_MOUSE
A:
[19-276]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
75.88
32%
-102
- C2 -
3K5V
2
ABL1_MOUSE
B:
[19-288]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K-----
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
75.83
32%
-103
- C2 -
3CS9
1
ABL1_HUMAN
B:
[18-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
T-----
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
-------------------------------
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
75.76
31%
-96
- C2 -
3IK3
1
ABL1_MOUSE
B:
[14-286]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
E
DT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
75.61
32%
-102
- C2 -
2G1T
1
ABL1_HUMAN
D:
[16-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
75.52
32%
-105
- C2 -
3CS9
1
ABL1_HUMAN
A:
[18-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KE------
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
75.51
34%
-102
- C2 -
3EQR
1
ACK1_HUMAN
B:
[9-274]
--------------
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V
---------
K
C
------
L
K
P
D
VLSQ
P
E
A
M
D
D
F
I
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
G
-
H
F
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
----
L
M
R
A
L
P
Q
N
D
D
H
Y
V
--
M
--RKV-
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
75.40
34%
-101
- C2 -
3EQP
1
ACK1_HUMAN
B:
[9-276]
--------------
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V---------
K
C
------
L
---QPEAMDDFI---
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
G
-
H
F
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
----
L
M
R
A
L
P
Q
N
D
D
H
Y
V
--
M
Q
E
HRKV
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
Q
P
T
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
75.40
32%
-102
- C2 -
2HIW
1
ABL1_HUMAN
A:
[16-274]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
75.31
35%
-102
- C2 -
4XLI
1
?
A:
[9-268]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KE------
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
-
E
P
P
F
-
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
S
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
V
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
D
L
L
E
K
G
----
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
-
A
F
E
T
M
F
H
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
75.29
32%
-104
- C2 -
3PYY
1
ABL1_HUMAN
A:
[27-286]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KE------
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
75.28
32%
-101
- C2 -
1IEP
1
ABL1_MOUSE
B:
[19-276]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
75.25
32%
-102
- C2 -
2G1T
1
ABL1_HUMAN
B:
[16-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K
--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
75.17
32%
-105
- C2 -
3MS9
2
ABL1_MOUSE
B:
[19-276]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
T-----
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
75.07
32%
-96
- C2 -
3KF4
1
ABL1_MOUSE
B:
[14-274]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
T-----
M
E
V
E
EF
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
75.04
32%
-95
- C2 -
2F4J
1
ABL1_HUMAN
A:
[15-279]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
E
DT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
P
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
74.92
32%
-107
- C2 -
2HYY
1
ABL1_HUMAN
A:
[14-271]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KDT---
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
74.78
32%
-96
- C2 -
1M52
3
ABL1_MOUSE
B:
[19-281]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
74.70
32%
-101
- C2 -
2HYY
1
ABL1_HUMAN
B:
[14-271]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
ET---
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
74.68
32%
-103
- C2 -
2HIW
1
ABL1_HUMAN
B:
[16-274]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
74.64
32%
-104
- C2 -
2HYY
1
ABL1_HUMAN
C:
[14-271]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
ET---
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
---
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
74.59
35%
-99
- C2 -
2XYN
4
ABL2_HUMAN
B:
[33-291]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
DT----
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
-
E
P
P
F
-
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
V
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
D
L
L
E
K
G
----
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
-
A
F
E
T
M
F
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.58
32%
-98
- C2 -
2G2F
1
ABL1_HUMAN
B:
[16-277]
--------------
D
I
T
M
K
H
K
L
G
-----
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
P
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
74.56
32%
-92
- C2 -
3KFA
1
ABL1_MOUSE
B:
[14-284]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
74.55
32%
-102
- C2 -
2HYY
1
ABL1_HUMAN
D:
[14-271]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KE----
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
74.52
32%
-101
- C2 -
3QRJ
1
ABL1_HUMAN
B:
[19-274]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.50
32%
-96
- C2 -
4XEY
1
ABL1_HUMAN
B:
[126-389]
--------------
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
T-----
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
74.42
32%
-103
- C2 -
2G1T
1
ABL1_HUMAN
A:
[16-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K
--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.38
32%
-97
- C2 -
4WA9
1
ABL1_HUMAN
B:
[15-279]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
74.27
32%
-92
- C2 -
3UE4
1
ABL1_HUMAN
A:
[16-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
74.26
34%
-101
- C2 -
1U54
1
ACK1_HUMAN
B:
[19-282]
--------------
D
L
R
L
L
E
K
L
G
D
G
---
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V
---------
K
C
------
L
---EAM
D
D
F
I
-----
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
G
-
H
F
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
----
L
M
R
A
L
P
Q
N
D
D
H
Y
V
--
M
Q
E
HRKV
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
74.24
32%
-104
- C2 -
1FPU
1
ABL1_MOUSE
A:
[19-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
74.22
32%
-97
- C2 -
2G2H
1
ABL1_HUMAN
A:
[16-279]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
P
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
74.09
34%
-101
- C2 -
4ID7
1
ACK1_HUMAN
A:
[9-269]
--------------
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V
---------
K
C
------
L
K
P
-PEA
M
D
D
F
I
----
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
G
-
H
F
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
----
L
M
R
A
L
P
Q
N
D
D
H
Y
V
--
M
Q
E
HRKV
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
-
F
L
L
E
A
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
74.04
32%
-93
- C2 -
2QOH
1
ABL1_MOUSE
B:
[14-284]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K-----
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
74.02
32%
-100
- C2 -
3UE4
1
ABL1_HUMAN
B:
[16-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
E
DT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
74.01
35%
-98
- C2 -
2XYN
2
ABL2_HUMAN
A:
[33-291]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
DT----
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
-
E
P
P
F
-
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
V
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
D
L
L
E
K
G
----
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
-
A
F
E
T
M
F
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
73.91
31%
-99
- C2 -
4WO5
1
B:
[38-298]
-------------------
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
-----
H
G
D
V
A
V
K
M
L
NVTAPT
P
Q
Q
L
------
Q
A
F
K
------------
N
E
V
G
V
-----
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
-
K
P
-
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
-
A
S
E
T
-
K
-
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-
T
V
K
I
G
D
F
G
LAT------------------
G
----
S
---
I
L
--
W
M
A
P
E
V
I
R
MQD
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
--
R
D
Q
I
I
E
M
V
G
R
G
SLSP
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
-
E
I
E
E
L
A
R
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
73.75
32%
-95
- C2 -
3OY3
1
ABL1_MOUSE
A:
[14-278]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
73.74
32%
-96
- C2 -
2G2I
1
ABL1_HUMAN
B:
[16-275]
--------------
D
I
T
M
K
H
K
L
G
G
----
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
P
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
73.70
32%
-93
- C2 -
3KFA
1
ABL1_MOUSE
A:
[14-284]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
73.58
32%
-98
- C2 -
2QOH
1
ABL1_MOUSE
A:
[14-274]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
E-----
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
73.56
35%
-100
- C2 -
2XYN
4
ABL2_HUMAN
C:
[33-290]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KT----
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
-
E
P
P
F
-
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
V
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
D
L
L
E
K
G
----
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
-
A
F
E
T
M
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
73.51
35%
-102
* C2 *
4XLI
1
?
B:
[9-268]
--------------
D
I
T
M
K
H
K
L
G
G
----
E
V
Y
V
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
-
E
P
P
F
-
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
-
E
C
S
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
V
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
D
L
L
E
K
G
----
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
-
A
F
E
T
M
F
H
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
73.47
31%
-92
- C2 -
2Z60
1
ABL1_MOUSE
A:
[14-284]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
E-----
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
73.31
32%
-103
- C2 -
1FPU
1
ABL1_MOUSE
B:
[19-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
------
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
73.26
32%
-98
- C2 -
3DK3
1
ABL1_MOUSE
B:
[12-276]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
------
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
F
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
P
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
73.21
32%
-97
- C2 -
1M52
1
ABL1_MOUSE
A:
[19-280]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
73.20
32%
-93
- C2 -
2G2I
1
ABL1_HUMAN
A:
[16-277]
--------------
D
I
T
M
K
H
K
L
G
G
G
---
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
P
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
73.05
33%
-101
- C2 -
2HZ0
1
ABL1_HUMAN
B:
[14-269]
--------------
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
------
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
--------------------------
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
72.93
31%
-103
- C2 -
4FK3
1
BRAF_HUMAN
A:
[30-287]
-------------------
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
-----
H
G
D
V
A
V
K
M
L
NVTAPT
P
Q
Q
L
------
Q
A
F
K
------------
N
E
V
G
V
-----
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
-
K
P
-
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
-
A
S
E
T
-
K
-
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-
T
V
K
I
G
D
F
G
--------------------
S
G
----
S
---
I
L
--
W
M
A
P
E
V
I
R
M---
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
--
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
-
E
I
E
E
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
72.85
32%
-98
- C2 -
3PYY
3
ABL1_HUMAN
B:
[27-291]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
--------
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
----------------------
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
72.73
32%
-97
- C2 -
3OY3
1
ABL1_MOUSE
B:
[14-278]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
KEDT--
M
E
V
E
EFL---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
72.72
32%
-96
- C2 -
4XEY
1
ABL1_HUMAN
A:
[126-388]
--------------
D
I
T
M
K
H
K
L
G
G
----
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
72.66
31%
-99
- C2 -
3IK3
1
ABL1_MOUSE
A:
[14-286]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
E
DT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
-------
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
72.65
33%
-95
- C2 -
2HZ0
1
ABL1_HUMAN
A:
[14-269]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
72.46
32%
-93
- C2 -
3KF4
1
ABL1_MOUSE
A:
[14-287]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K-------
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.45
32%
-94
- C2 -
2G2F
1
ABL1_HUMAN
A:
[16-280]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
P
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
72.37
32%
-101
- C2 -
2HZ4
1
ABL1_HUMAN
B:
[14-271]
--------------
D
I
T
M
K
H
K
L
G
-----
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
72.12
31%
-107
- C2 -
4WO5
1
BRAF_HUMAN
A:
[38-298]
-------------------
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
-----
H
G
D
V
A
V
K
M
L
NVTAPT
P
Q
Q
L
------
Q
A
F
K
------------
N
E
V
G
V
-----
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
-
K
P
-
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
-
A
S
E
--
K
-
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
---
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
-
W
S
----
F
E
Q
--
L
S
G
----
S
---
I
L
--
W
M
A
P
E
V
I
R
M---
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
-
Q
L
-
P
Y
S
N
I
N
N
--
R
D
Q
I
I
E
M
V
G
R
G
SLSP
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
-
E
I
E
E
L
A
R
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
72.11
34%
-101
- C2 -
1U4D
1
ACK1_HUMAN
A:
[19-283]
--------------
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
-
A
P
S
G
K
T
V
S
V
A
V
---------
K
C
----------P
E
A
M
D
D
F
I
----
R
E
V
N
A
-----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
P
P
--
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
-
K
H
Q
G
-
H
F
L
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
---
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
-
L
V
K
I
G
D
F
G
----
L
M
R
A
L
P
Q
--
D
H
Y
V
--
M
--V---
P
---
F
A
--
W
C
A
P
E
S
L
K
---
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
-
Y
G
Q
E
-
P
W
I
G
L
N
G
--
S
Q
I
L
H
K
I
D
K
E
G
----
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
D
F
L
L
E
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
72.06
32%
-97
- C2 -
4WA9
1
ABL1_HUMAN
A:
[15-278]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------------------------------------------
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
----
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
71.92
32%
-102
- C2 -
4TWP
1
ABL1_HUMAN
B:
[9-270]
--------------
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-
K
-
Y
S
L
T
V
A
V
K
----------
T
L
K
EDT--
M
E
V
E
E
F
L
---------
K
E
A
A
V
-----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
-
R
E
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
-
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
---
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
-
L
V
K
V
A
D
F
G
----
L
S
R
-
L
M
T
G
D
T
Y
T
A
--
H
A
G
----
A
K--
F
P
IK
W
T
A
P
E
S
L
A
---
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
-
Y
-
G
M
S
P
Y
P
G
I
D
L
--
S
Q
V
-
Y
E
L
L
E
K
D
----
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
-
A
F
E
T
M
F
Q
E
S
S
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------