@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MP2K1_HUMAN: (2015-10-14 )
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
Atome Classification :
(68 SA)
.........10........20........30........40........50........60........70........80........90........100.--......110.....-..120........130...--....140.......150----.....-----.--.160---.........170.......180.......190.......200.......210.......--220...-......230-----..----.-----.-----...240.......250.......260.......270.......280.......290.......300.......310.......320......---.---.330.......340.......350.......360.......370.......380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPKKKPT
P
I
Q
L
NPAPDGSAVNGTSSAET
N
L
E
A
L
Q
K
K
L
E
ELEL
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
KVGELKD
D
D
F
E
K
I
S
E
LGAGNG
G
V
V
F
K
VSHKPS
G
L
V
M
A
R
K
L
I
H
L
E
I--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
EC-NS
P
Y
I
V
G
F
YGAFYS--DG
E
I
S
I
C
M
E
HMDGG
S
L
D
----
Q
V
L
K
K
-----A--GR-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
HRDVKPS
N
I
L
VNSRG
E
I
K
L
C
DFGVS
G
Q
L
I
D
S
M
--
A
--
N
S
F
-VGTRSYM
S
P
-----
E
R----L-----Q-----GTHY
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
VGRYPIPPP
D
A
K
E
L
E
L
M
F
G
C
Q
VEGDAAETPPRPRTPGRP
L
S
SYGMDSRP
P
M
A
I
F
E
L
L
D
Y
I
VNE-PPPKLPS---G---
V
F
S
L
E
F
Q
D
F
V
N
K
C
LIKNP
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
KRSDAEEV
D
F
A
G
W
L
C
S
TIGLNQPSTPTHAAGV
7
PsiBlast_PDB
96.71
99%
-116
- C1 -
3EQI
1
MP2K1_HUMAN
A:
[6-349]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
3
PsiBlast_PDB
95.43
99%
-115
- C1 -
3EQD
1
MP2K1_HUMAN
A:
[6-349]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
106
HHSearch
95.30
99%
-117
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[6-349]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
2
PsiBlast_PDB
95.30
99%
-117
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[6-349]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
9
PsiBlast_PDB
94.70
99%
-119
- C1 -
3ZLS
1
MP2K1_HUMAN
A:
[4-347]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
5
PsiBlast_PDB
94.54
99%
-117
- C1 -
3EQG
2
MP2K1_HUMAN
A:
[6-348]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
10
PsiBlast_PDB
94.12
99%
-118
- C1 -
3ZLX
1
MP2K1_HUMAN
A:
[4-347]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
12
PsiBlast_PDB
93.01
98%
-118
- C1 -
3ZLW
1
MP2K1_HUMAN
A:
[4-347]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
A
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
8
PsiBlast_PDB
92.79
99%
-119
- C1 -
3ZLY
1
MP2K1_HUMAN
A:
[5-347]
---------------------------------------
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
4
PsiBlast_PDB
92.18
99%
-116
- C1 -
3EQF
1
MP2K1_HUMAN
A:
[6-348]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
6
PsiBlast_PDB
91.55
99%
-115
- C1 -
3EQH
2
MP2K1_HUMAN
A:
[6-348]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
27
PsiBlast_CBE
91.51
100%
-124
- C1 -
3VVH
2
?
C:
[2-321]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
--------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
11
PsiBlast_PDB
91.48
99%
-113
- C1 -
3ZM4
1
MP2K1_HUMAN
A:
[5-347]
---------------------------------------
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
-------
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
-
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
29
PsiBlast_CBE
90.89
100%
-130
- C1 -
3VVH
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--------
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
28
PsiBlast_CBE
89.83
100%
-122
- C1 -
3VVH
2
?
B:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
--------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
18
PsiBlast_PDB
89.33
100%
-125
- C1 -
3E8N
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
--
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
26
PsiBlast_CBE
88.71
100%
-122
- C1 -
4ARK
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
32
PsiBlast_CBE
87.94
100%
-120
- C1 -
4U7Z
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
--
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
13
PsiBlast_PDB
87.76
99%
-115
- C1 -
3W8Q
1
MP2K1_HUMAN
A:
[1-344]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
Q
--------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
30
PsiBlast_CBE
87.72
100%
-127
- C1 -
4U81
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
20
PsiBlast_PDB
87.58
100%
-127
- C1 -
3V04
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
25
PsiBlast_CBE
87.51
100%
-126
- C1 -
4LMN
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
31
PsiBlast_CBE
87.48
100%
-124
- C1 -
4U80
2
MP2K1_HUMAN
A:
[2-319]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
--------------
19
PsiBlast_PDB
87.37
100%
-127
- C1 -
3V01
2
?
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
14
PsiBlast_PDB
86.77
100%
-126
- C1 -
2P55
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
34
PsiBlast_CBE
86.75
99%
-124
- C1 -
3PP1
1
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
16
PsiBlast_PDB
86.65
100%
-127
- C1 -
1S9J
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
35
PsiBlast_CBE
85.90
99%
-128
- C1 -
3MBL
2
MP2K1_HUMAN
A:
[2-321]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
33
PsiBlast_CBE
85.75
100%
-127
- C1 -
3DV3
3
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
----
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
15
PsiBlast_PDB
85.07
100%
-128
- C1 -
3EQB
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
1
PsiBlast_PDB
84.93
99%
-115
- C1 -
2Y4I
1
MP2K1_RABIT
C:
[39-383]
------------------------------------
L
L
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-----------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
17
PsiBlast_PDB
84.72
100%
-126
- C1 -
3DY7
2
MP2K1_HUMAN
A:
[2-304]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
----
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
----------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-----------------------------
36
PsiBlast_CBE
81.97
90%
-123
- C1 -
3WIG
3
MP2K1_HUMAN
A:
[2-288]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
---------------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-------------
40
PsiBlast_CBE
81.79
87%
-119
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[4-304]
--------------------------------------------
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
----------
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
G
--------------------------------------------
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
----------
38
PsiBlast_CBE
81.07
90%
-120
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[2-288]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
----------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-------------
41
PsiBlast_CBE
77.90
86%
-120
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[3-282]
-----------------------------------------------------------
L
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
--
A
--
N
E
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------------------------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
43
PsiBlast_CBE
77.63
86%
-122
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[3-282]
-----------------------------------------------------------
L
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
--
A
--
N
E
---
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------------------------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
42
PsiBlast_CBE
76.36
86%
-121
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[3-282]
-----------------------------------------------------------
L
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
--
A
--
N
E
--
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------------------------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
44
PsiBlast_CBE
74.93
86%
-122
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[3-282]
-----------------------------------------------------------
L
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
--
A
--
N
E
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------------------------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
S
---
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
37
PsiBlast_CBE
74.42
90%
-132
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[2-286]
-------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
--
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
-----
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
-
P
P
P
K
L
P
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
---------------
110
HHSearch
57.66
43%
-114
- C1 -
3FME
1
MP2K6_HUMAN
A:
[3-287]
-------------------------------------------------------------
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
-----
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
-
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
--
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
L
D
----
K
F
Y
K
Q
V
I
D
K
-
G
--
Q
T
-----
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
-------------------
A
G
C
K
P
Y
M
A
P
-----
E
R
----
I
-----
N
PELN-
Q
--
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
D
S
W
----------------------------------
G
---
T
----
P
F
Q
Q
L
K
Q
V
V
E
E
-
P
S
P
Q
L
P
A
---
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
-------------
109
HHSearch
57.04
43%
-112
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[18-311]
-------------------------------------------------------------
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
--
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
--
E
G
D
C
W
I
C
M
E
L
M
S
T
-
S
F
D
----
K
F
Y
K
Y
V
Y
SVL
D
--
D
V
-----
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
-------------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
------------------------------------------------
T
Q
V
V
K
G
-
D
P
P
Q
L
S
N
SEE
R
---
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
-
M
P
---------
49
PsiBlast_CBE
56.10
36%
-115
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[22-311]
-----------------------------------------------------------------
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
--
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
--
E
G
D
C
W
I
C
M
E
L
M
-
S
T
S
F
D
----
K
F
Y
K
Y
-----
V
--
Y
S
VLDDV
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
-------------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
------------------------------------------------
T
Q
V
V
K
G
-
D
P
P
Q
L
S
N
---
S
EER
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
---------
46
PsiBlast_CBE
54.34
37%
-109
- C1 -
3FME
1
MP2K6_HUMAN
A:
[3-289]
-------------------------------------------------------------
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
-----
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
-
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
--
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
L
D
K
F
Y
K
Q
V
I
D
K
-----
G
--
Q
T
-----
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
-------------------
A
G
C
K
P
Y
M
A
P
-----
E
R
I
N
PE
L
-----
N
-----
Q
--
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
------------------
D
S
W
G
T
P
-----------------------
F
Q
Q
L
K
Q
V
V
E
E
-
P
S
P
Q
L
P
A
---
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
-------------
48
PsiBlast_CBE
52.77
36%
-119
- C1 -
3ALN
1
MP2K4_HUMAN
B:
[22-312]
-----------------------------------------------------------------
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
--
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
--
E
G
D
C
W
I
C
M
E
L
M
-
S
T
S
F
D
----
K
F
Y
K
Y
-----
V
--
Y
S
VLD
D
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
------------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
---------------------------------------------------------
D
P
P
Q
L
S
N
---
S
EER
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
A
--------
121
HHSearch
52.05
31%
-97
- C1 -
4C2V
1
AUKBA_XENLA
A:
[12-272]
-------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
--
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
----
K
E
L
Q
K
-----
H
--
G
R
-----
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
A
P
S
L
R
--
R
--
R
T
M
-
C
G
T
L
D
Y
L
P
P
-----
E
M
----
I
-----
E
-----
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
------------------------------------------
I
V
N
V
-
D
-
L
K
F
P
P
-------
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
P
L
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
Q
S
------------------
47
PsiBlast_CBE
50.47
36%
-106
- C1 -
3ALO
1
MP2K4_HUMAN
A:
[22-311]
-----------------------------------------------------------------
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
--
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
--
E
G
D
C
W
I
C
M
E
L
M
-
S
T
S
F
D
----
K
F
Y
K
Y
-----
V
--
Y
S
VLDDV
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
V
D
S
I
--
A
--
K
T
R
D
A
G
C
R
P
Y
M
A
P
-----
E
R
----
I
-----
D
-----
P
--
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
N
-----------------------------------------
S
V
F
D
Q
L
T
Q
V
V
K
G
-
D
P
P
Q
L
S
N
---
S
EE
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
---------
45
PsiBlast_CBE
46.53
37%
-100
- C1 -
3VN9
1
MP2K6_HUMAN
A:
[47-333]
-------------------------------------------------------------
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
A
T
V
--
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
-
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
--
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
L
D
K
F
Y
K
Q
V
I
D
K
-----
G
--
Q
T
-----
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
G
I
S
G
Y
L
V
D
S
V
--
A
--
K
T
I
D
A
G
C
K
P
Y
M
A
P
-----
E
R
I
N
PE
L
-----
N
-----
Q
K
G
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
------------------
D
S
W
G
T
P
-----------------------
F
Q
Q
L
K
Q
V
V
E
E
-
P
S
P
Q
L
P
A
---
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
D
------------
127
HHSearch
46.37
33%
-105
- C1 -
4OBO
2
M4K4_HUMAN
A:
[23-294]
----------------------------------------------------------------
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
----
T
-----
E
I
K
L
E
I
N
M
-
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
----
D
L
V
K
N
-----
T
KG
N
T
-----
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
-----------
R
--
N
T
F
-
I
G
T
P
Y
W
M
A
P
-----
E
V
----
I
-----
A
CDENP
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
------------------------------------------
M
R
A
L
F
L
I
P
R
N
-
P
P
P
R
L
K
S
---
K
---
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-----------
62
PsiBlast_CBE
45.30
31%
-108
- C1 -
5AJQ
2
STK10_HUMAN
A:
[18-276]
-------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
----
A
I
M
L
E
-----
L
--
D
R
G
----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
--------
F
-
I
G
T
P
Y
W
M
A
P
EVVMC
E
T
----
M
-----
K
-----
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
-
P
P
T
L
L
T
P
---
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
--------------
72
PsiBlast_CBE
44.94
31%
-103
- C1 -
4USF
1
?
A:
[15-276]
----------------------------------------------------------------
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
--
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
-
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
----
A
V
M
L
E
-----
L
--
E
R
P----
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
----------------
T
P
Y
W
M
A
P
-----
E
V
----
V
M
C
E---------
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-
H
H
E
L
N
----------------------------------
P
M
R
V
--
L
L
K
I
A
K
S
E
-
P
P
T
L
A
Q
P
---
S
---
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
--------------
71
PsiBlast_CBE
44.45
31%
-99
- C1 -
4USF
1
?
B:
[15-276]
----------------------------------------------------------------
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
--
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
-
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
----
A
V
M
L
E
-----
L
--
E
R
P
----
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
-----------
F
-
I
G
T
P
Y
W
M
A
P
-----
E
V
----
V
MCETS
K
-----
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-
H
H
E
L
N
----------------------------------
P
M
R
V
--
L
L
K
I
A
K
S
E
-
P
P
T
L
A
Q
P
---
S
---
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
--------------
56
PsiBlast_CBE
42.72
32%
-91
- C1 -
3GGF
1
STK26_HUMAN
A:
[25-278]
-------------------------------------------------------------------
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
--
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
L
-
R
-----
A
--
G
P
-----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
----------R-
N
T
F
-
V
G
T
P
F
W
M
A
P
-----
E
V
----
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
----------------------------------
D
M
H
P
M
R
V
L
F
----
L
I
P
K
N
-
N
P
P
T
L
-
V
---
G
---
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
------
54
PsiBlast_CBE
42.22
34%
-91
* C1 *
4O27
1
STK24_HUMAN
B:
[8-261]
-------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
--
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
L
-
E
-----
P
--
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
--
I
K
R
N
E
F
-
V
G
T
P
F
W
M
A
P
-----
E
V
----
I
-----
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
----------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
-
N
P
P
T
L
-
E
---
G
---
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
---------
73
PsiBlast_CBE
40.98
31%
-109
- C1 -
2UV2
6
SLK_HUMAN
A:
[36-297]
----------------------------------------------------------------
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
--
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
-
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
----
A
V
M
L
E
-----
L
--
E
R
P
----
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
--
Q
R
R
D
S
F
-
I
G
T
P
Y
W
M
A
P
-----
E
V
----
V
M
CETS
K
-----
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-
H
H
E
L
N
----------------------------------
P
M
R
V
--
L
L
K
I
A
K
S
E
-
P
P
T
L
A
Q
P
---
S
---
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
----------------
65
PsiBlast_CBE
40.65
31%
-108
- C1 -
4USD
1
?
B:
[21-279]
-------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
--
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
----
A
I
M
L
E
-----
L
--
D
R
G
----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
------------------
G
T
P
Y
W
M
A
P
EVVMC---------------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
-
P
P
T
L
L
T
P
---
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
------------
74
PsiBlast_CBE
40.27
31%
-106
- C1 -
2J51
5
SLK_HUMAN
A:
[36-297]
----------------------------------------------------------------
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
--
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
-
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
----
A
V
M
L
E
-----
L
--
E
R
P----
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
--
Q
R
R
D
S
F
-
I
G
T
P
Y
W
M
A
P
-----
E
V
----
V
M
CETS
K
-----
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-
H
H
E
L
N
----------------------------------
P
M
R
V
--
L
L
K
I
A
K
S
E
-
P
P
T
L
A
Q
P
---
S
---
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
----------------
120
HHSearch
40.04
34%
-98
- C1 -
2J7T
1
STK10_HUMAN
A:
[17-282]
---------------------------------------------------------------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
----
A
I
M
L
E
L
----
D
--
R
G
-----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K-------
I
G
T
P
Y
W
M
A
P
-----
E
V
----
V
M
C
E
T
M
K
-----
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
------------------------------------------
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
---
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
---------
58
PsiBlast_CBE
39.02
32%
-90
- C1 -
4FZF
1
?
B:
[10-263]
-------------------------------------------------------------------
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
--
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
L
-
R
-----
A
--
G
P
-----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
--
I
KR
N
T
F
-
V
G
T
P
F
W
M
A
P
-----
E
V
----
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
----------------------------------
D
M
H
P
M
R
V
L
F
----
L
I
P
K
N
-
N
P
P
T
L
-
V
---
G
---
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
---------
69
PsiBlast_CBE
38.92
31%
-102
- C1 -
4AOT
1
STK10_HUMAN
A:
[21-279]
-------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
--
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
----
A
I
M
L
E
-----
L
--
D
R
G
----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
----------------
G
T
P
Y
W
M
A
P
EVVM----------------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
-
P
P
T
L
L
T
P
---
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
------------
60
PsiBlast_CBE
38.86
32%
-82
- C1 -
4FZA
3
STK26_HUMAN
B:
[10-263]
-------------------------------------------------------------------
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
--
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
L
-
R
-----
A
--
G
P
-----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
--
I
KR
N
T
F
-
V
G
T
P
F
W
M
A
P
-----
E
V
----
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
----------------------------------
D
M
H
P
M
R
V
L
F
----
L
I
P
K
N
-
N
P
P
T
L
-
V
---
G
---
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
---------
68
PsiBlast_CBE
38.34
31%
-98
- C1 -
4AOT
1
STK10_HUMAN
B:
[21-279]
-------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
--
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
----
A
I
M
L
E
-----
L
--
D
R
G
----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
--------------
I
G
T
P
Y
W
M
A
P
EVVM---------------------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
-
P
P
T
L
L
T
P
---
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
------------
61
PsiBlast_CBE
36.65
31%
-108
- C1 -
4BC6
2
STK10_HUMAN
A:
[13-271]
-------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
--
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
----
A
I
M
L
E
-----
L
--
D
R
G----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
--
Q
---------
P
Y
W
M
A
P
E
V
V
M
C
E
T
----
M
-----
K
-----
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
E
------
P
P
H
-------------
H
E
L
N
P
M
R
V
--
L
L
K
I
A
K
S
D
-
P
P
T
L
L
T
P
---
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
----------
57
PsiBlast_CBE
36.57
32%
-85
- C1 -
4NZW
1
STK25_HUMAN
B:
[13-274]
--------------------------------------------------------
H
S
R
V
D
P
--
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
--
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
--
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
L
-
K
-----
P
--
G
P
-----
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
-----------------
T
P
F
W
M
A
P
-----
E
V
----
I
-----
K
-----
Q
--
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
----------------------------------
D
L
H
P
M
R
V
L
F
----
L
I
P
K
N
-
S
P
P
T
L
-
E
---
G
---
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
----------
66
PsiBlast_CBE
35.69
31%
-108
- C1 -
4EQU
2
STK10_HUMAN
B:
[21-279]
-------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
E
L
E
D
Y
I
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
----
A
I
M
L
E
-----
L
--
D
R
G
----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
----------
F
-
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
----
M
-----
K
-----
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
-
P
P
T
L
L
T
P
---
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
---------
64
PsiBlast_CBE
35.35
31%
-106
- C1 -
4USE
1
?
A:
[21-279]
-------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
--
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
----
A
I
M
L
E
-----
L
--
D
R
G
----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
--
Q
--------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
----
M
-----
K
-----
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
-
P
P
T
L
L
T
P
---
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
----------
63
PsiBlast_CBE
33.17
31%
-108
- C1 -
4USE
1
?
B:
[21-279]
-------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
E
L
E
D
Y
I
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-------
W
I
M
I
E
F
C
P
G
G
A
V
D
----
A
I
M
L
E
-----
L
--
D
R
G
----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
--
Q
K-------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
----
M
-----
K
-----
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
-
P
P
T
L
L
T
P
---
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
----------
67
PsiBlast_CBE
32.44
31%
-111
- C1 -
4EQU
2
STK10_HUMAN
A:
[21-279]
-------------------------------------------------------------------
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
--------
L
E
D
Y
I
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
----
A
I
M
L
E
-----
L
--
D
R
G
----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
----
M
-----
K
-----
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
-
P
P
T
L
L
T
P
---
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
---------