@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MP2K2_HUMAN: (2015-10-14 )
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
Atome Classification :
(54 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120....-....130.......--140.......150....----...160----.--..-----.....170.......180.......190.......200.......210.......220.--.--...-..230......----.-----240---.........250.......260.......270.......280.......290.......300.......310.......320.......330-...---.---...340.......350.......360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLARRKPV
L
P
A
L
TINPTIAEGPSPTSEGASEA
N
L
V
D
L
Q
K
K
L
E
E
LEL
D
E
Q
Q
K
K
R
L
E
A
F
L
T
QKAKVGELKD
D
D
F
E
R
I
S
E
LGAGNG
G
V
V
T
K
V
QHRPS
G
L
I
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
EC-NS
P
Y
I
V
G
F
YGAFYS--DG
E
I
S
I
C
M
E
HMDGG
S
L
D
----
Q
V
L
K
E
-----
A
--
K
R
-----
I
P
E
E
I
L
G
K
V
S
I
A
V
L
R
G
L
A
Y
L
R
E
K
H
Q
I
M
HRDVKPS
N
I
L
VNSRG
E
I
K
L
C
DFGVS
G
Q
L
I
D
S
M
--
A
--
N
S
F-VGTRSYMA
P
E
R----L-----Q-----GTHY
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
L
A
VGRYPIPPP
D
A
K
E
L
E
A
I
FGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDS
R
P
A
M
A
I
F
E
L
L
D
Y
I
VNEPPPK-LPN---G---VFTP
D
F
Q
E
F
V
N
K
C
LIKNPA
E
R
A
D
L
K
M
LTNHTFIKRSEVEEV
D
F
A
G
W
L
C
K
T
LRLNQPGTPTRTAV
78
HHSearch
95.18
86%
-110
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[6-349]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
1
PsiBlast_PDB
94.90
85%
-110
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[6-349]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
10
PsiBlast_PDB
94.23
85%
-111
- C1 -
3ZLX
1
MP2K1_HUMAN
A:
[4-347]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
8
PsiBlast_PDB
93.87
85%
-112
- C1 -
3ZLY
1
MP2K1_HUMAN
A:
[5-347]
-------------------------------------------
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
6
PsiBlast_PDB
93.80
85%
-108
- C1 -
3EQI
1
MP2K1_HUMAN
A:
[6-349]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
4
PsiBlast_PDB
93.42
85%
-112
- C1 -
3EQG
2
MP2K1_HUMAN
A:
[6-348]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
2
PsiBlast_PDB
93.37
85%
-108
- C1 -
3EQD
1
MP2K1_HUMAN
A:
[6-349]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
9
PsiBlast_PDB
93.12
85%
-111
- C1 -
3ZLS
1
MP2K1_HUMAN
A:
[4-347]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
12
PsiBlast_PDB
92.45
85%
-110
- C1 -
3ZLW
1
MP2K1_HUMAN
A:
[4-347]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
A
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
5
PsiBlast_PDB
91.73
85%
-108
- C1 -
3EQH
2
MP2K1_HUMAN
A:
[6-348]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
25
PsiBlast_CBE
91.68
85%
-119
- C1 -
3VVH
2
?
C:
[2-321]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
------------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
3
PsiBlast_PDB
90.78
85%
-110
- C1 -
3EQF
1
MP2K1_HUMAN
A:
[6-348]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
11
PsiBlast_PDB
90.74
85%
-107
- C1 -
3ZM4
1
MP2K1_HUMAN
A:
[5-347]
-------------------------------------------
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
-------
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
-
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
17
PsiBlast_PDB
90.68
85%
-123
- C1 -
3V01
2
?
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
----------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
27
PsiBlast_CBE
90.51
85%
-125
- C1 -
3VVH
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--------
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
----------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
18
PsiBlast_PDB
90.27
85%
-123
- C1 -
3V04
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
----------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
26
PsiBlast_CBE
90.04
85%
-117
- C1 -
3VVH
2
?
B:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
------------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
16
PsiBlast_PDB
89.78
85%
-120
- C1 -
3E8N
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
--
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
----------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
20
PsiBlast_PDB
89.67
85%
-122
- C1 -
4LMN
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
----------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
29
PsiBlast_CBE
89.62
85%
-120
- C1 -
4U80
2
MP2K1_HUMAN
A:
[2-319]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
----------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
-------------
34
PsiBlast_CBE
89.59
85%
-124
- C1 -
3MBL
2
MP2K1_HUMAN
A:
[2-321]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-----------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
14
PsiBlast_PDB
89.44
85%
-123
- C1 -
1S9J
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
----------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
31
PsiBlast_CBE
89.00
85%
-123
- C1 -
3EQB
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
----------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
28
PsiBlast_CBE
88.90
85%
-120
- C1 -
4U81
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
----------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
33
PsiBlast_CBE
88.81
85%
-119
- C1 -
3PP1
1
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-----------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
19
PsiBlast_PDB
88.49
85%
-118
- C1 -
4ARK
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-----------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
32
PsiBlast_CBE
88.24
85%
-122
- C1 -
2P55
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
------
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
----------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
30
PsiBlast_CBE
88.15
85%
-114
- C1 -
4U7Z
2
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
--
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
----------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
13
PsiBlast_PDB
87.83
85%
-111
- C1 -
3W8Q
1
MP2K1_HUMAN
A:
[1-344]
------------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
Q
------------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
35
PsiBlast_CBE
87.69
85%
-122
- C1 -
3DV3
3
MP2K1_HUMAN
A:
[2-322]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
----
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-----------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
----------
7
PsiBlast_PDB
86.40
79%
-110
- C1 -
2Y4I
1
MP2K1_RABIT
C:
[39-383]
----------------------------------------
L
L
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
15
PsiBlast_PDB
84.37
85%
-124
- C1 -
3DY7
2
MP2K1_HUMAN
A:
[2-304]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
----
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
--------------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
----------------------------
40
PsiBlast_CBE
83.05
78%
-116
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[4-304]
------------------------------------------------
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
----------
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
G
------------------------------------------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
---------
36
PsiBlast_CBE
82.19
79%
-117
- C1 -
3WIG
3
MP2K1_HUMAN
A:
[2-288]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
-------------------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
------------
38
PsiBlast_CBE
81.99
79%
-114
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[2-288]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
--------------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
------------
41
PsiBlast_CBE
80.51
75%
-118
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[3-282]
---------------------------------------------------------------
L
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
--
A
--
N
E
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
----------------------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
43
PsiBlast_CBE
80.23
75%
-118
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[3-282]
---------------------------------------------------------------
L
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
--
A
--
N
E
---
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
----------------------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
42
PsiBlast_CBE
79.48
75%
-118
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[3-282]
---------------------------------------------------------------
L
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
--
A
--
N
E
--
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
----------------------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
44
PsiBlast_CBE
79.03
75%
-119
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[3-282]
---------------------------------------------------------------
L
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
--
A
--
N
E
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
----------------------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
S
---
A
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-----------
37
PsiBlast_CBE
76.75
79%
-127
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[2-286]
-----------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
----
Q
V
L
K
K
-----
A
--
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
--
N
S
F
-
V
G
T
R
S
Y
M
S
P
E
R
----
L
-----
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-----------------------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
-
L
P
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
--------------
82
HHSearch
61.13
42%
-110
- C1 -
3FME
1
MP2K6_HUMAN
A:
[3-287]
-----------------------------------------------------------------
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
-
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
--
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
L
D
----
K
F
Y
K
Q
V
I
D
K
-
G
--
Q
T
-----
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
-------------------
A
G
C
K
P
Y
M
A
P
E
R
----
I
-----
N
PELN-
Q
--
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
D
S
W
G
-----------------------------------------
T
----
P
F
Q
Q
L
K
Q
V
V
E
E
P
S
P
Q
-
L
P
A
---
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
------------
48
PsiBlast_CBE
60.96
37%
-111
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[22-311]
---------------------------------------------------------------------
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
--
E
G
D
C
W
I
C
M
E
L
M
-
S
T
S
F
D
----
K
F
Y
K
Y
-----
V
--
Y
S
VLDDV
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
--------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
----------------------------------------------------
T
Q
V
V
K
G
D
P
P
Q
-
L
S
N
---
S
EER
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
--------
81
HHSearch
60.69
45%
-107
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[18-311]
-----------------------------------------------------------------
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
--
E
G
D
C
W
I
C
M
E
L
M
S
T
-
S
F
D
----
K
F
Y
K
Y
V
Y
SVL
D
--
D
V
-----
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
--------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
----------------------------------------------------
T
Q
V
V
K
G
D
P
P
Q
-
L
S
N
SEE
R
---
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
-
M
P
--------
47
PsiBlast_CBE
60.56
37%
-118
- C1 -
3ALN
1
MP2K4_HUMAN
B:
[22-312]
---------------------------------------------------------------------
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
--
E
G
D
C
W
I
C
M
E
L
M
-
S
T
S
F
D
----
K
F
Y
K
Y
-----
V
--
Y
S
VLD
D
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
-------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
------------------------------------------------------------
D
P
P
Q
-
L
S
N
---
S
EER
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
A
-------
46
PsiBlast_CBE
57.59
37%
-102
- C1 -
3ALO
1
MP2K4_HUMAN
A:
[22-311]
---------------------------------------------------------------------
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
--
E
G
D
C
W
I
C
M
E
L
M
-
S
T
S
F
D
----
K
F
Y
K
Y
-----
V
--
Y
S
VLDDV
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
V
D
S
I
--
A
--
K
T
R
D
A
G
C
R
P
Y
M
A
P
E
R
----
I
-----
D
-----
P
--
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
N
---------------------------------------------
S
V
F
D
Q
L
T
Q
V
V
K
G
D
P
P
Q
-
L
S
N
---
S
EE
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
--------
49
PsiBlast_CBE
57.04
36%
-110
- C1 -
3FME
1
MP2K6_HUMAN
A:
[3-284]
-----------------------------------------------------------------
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
-
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
--
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
L
D
K
F
Y
K
Q
V
I
D
K
-----
G
--
Q
T
-----
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
-------------------
A
G
C
K
P
Y
M
A
P
E
R
I
N
PE
L
-----
N
-----
Q
--
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
D
S
---------
W
G
T
P
------------------------------------
F
Q
Q
L
K
Q
V
V
E
E
P
S
P
Q
-
L
P
A
---
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
------------
100
HHSearch
52.47
33%
-106
* C1 *
4OBO
2
M4K4_HUMAN
A:
[23-293]
--------------------------------------------------------------------
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-------
E
I
K
L
E
I
N
M
-
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
----
D
L
V
K
N
-----
T
KG
N
T
-----
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
-----------
R
--
N
T
F
-
I
G
T
P
Y
W
M
A
P
E
V
----
I
-----
A
CDENP
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
----------------------------------------------
R
A
L
F
L
I
P
R
N
P
P
P
R
-
L
K
S
---
K
---
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
----------
45
PsiBlast_CBE
51.74
36%
-97
- C1 -
3VN9
1
MP2K6_HUMAN
A:
[47-328]
-----------------------------------------------------------------
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
A
T
V
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
-
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
--
E
G
D
V
W
I
C
M
E
L
M
D
T
-
S
L
D
K
F
Y
K
Q
V
I
D
K
-----
G
--
Q
T
-----
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
G
I
S
G
Y
L
V
D
S
V
--
A
--
K
T
I
D
A
G
C
K
P
Y
M
A
P
E
R
I
N
PE
L
-----
N
-----
Q
K
G
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
D
S
---------
W
G
T
P
------------------------------------
F
Q
Q
L
K
Q
V
V
E
E
P
S
P
Q
-
L
P
A
---
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
D
-----------
56
PsiBlast_CBE
48.88
32%
-92
- C1 -
4O27
1
STK24_HUMAN
B:
[8-261]
-----------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
L
-
E
-----
P
--
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
--
I
K
R
N
E
F
-
V
G
T
P
F
W
M
A
P
E
V
----
I
-----
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
-------------------------
P
P
H
S
-----------------
E
L
H
P
M
K
V
L
F
----
L
I
P
K
N
N
P
P
T
-
L
-
E
---
G
---
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
--------
91
HHSearch
47.93
33%
-97
- C1 -
2J7T
1
STK10_HUMAN
A:
[17-282]
-------------------------------------------------------------------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
----
A
I
M
L
E
L
----
D
--
R
G
-----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K-------
I
G
T
P
Y
W
M
A
P
E
V
----
V
M
C
E
T
M
K
-----
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
----------------------------------------------
K
I
A
K
S
D
P
P
T
L
L
T
P
---
S
---
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
--------
54
PsiBlast_CBE
47.69
32%
-91
- C1 -
3GGF
1
STK26_HUMAN
A:
[25-278]
-----------------------------------------------------------------------
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
L
R
------
A
--
G
P
-----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
----------R-
N
T
F
-
V
G
T
P
F
W
M
A
P
E
V
----
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
--------------------------------------
D
M
H
P
M
R
V
L
F
----
L
I
P
K
N
N
P
P
T
-
L
V
----
G
---
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
-----
60
PsiBlast_CBE
45.06
31%
-83
- C1 -
4FZA
3
STK26_HUMAN
B:
[10-263]
-----------------------------------------------------------------------
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
L
R
------
A
--
G
P
-----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
--
I
KR
N
T
F
-
V
G
T
P
F
W
M
A
P
E
V
----
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
--------------------------------------
D
M
H
P
M
R
V
L
F
----
L
I
P
K
N
N
P
P
T
-
L
V
----
G
---
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------
57
PsiBlast_CBE
45.01
31%
-86
- C1 -
4NZW
1
STK25_HUMAN
B:
[13-274]
------------------------------------------------------------
H
S
R
V
D
P
--
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
--
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
L
K
P
-----
G
--
P
------
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
-----------------
T
P
F
W
M
A
P
E
V
----
I
-----
K
-----
Q
--
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
--------------------------------------
D
L
H
P
M
R
V
L
F
----
L
I
P
K
N
S
P
P
T
-
L
-
E
---
G
---
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
---------
58
PsiBlast_CBE
44.19
31%
-91
- C1 -
4FZF
1
?
B:
[10-263]
-----------------------------------------------------------------------
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
----
D
L
L
R
------
A
--
G
P
-----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
--
I
KR
N
T
F
-
V
G
T
P
F
W
M
A
P
E
V
----
I
-----
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
--------------------------------------
D
M
H
P
M
R
V
L
F
----
L
I
P
K
N
N
P
P
T
-
L
V
----
G
---
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------