@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MP2K3_HUMAN: (2015-10-14 )
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
Atome Classification :
(63 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120--.......130---..--..------.....140..--.-....150..---.....-..160.........170.......180.......190.......200.......210.......220..--.-.....230........-240-.-..-.....250.......260.....----------------.---.270-------..------------..------.....280---....--------------------...-290-.----.---.----------......300.......310.......320.......330.......340.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MESPASSQPASMPQSKGKSKRKK
D
L
R
I
S
CMSKPPAPNPTPPRNLDS
R
T
F
I
T
IGDR
N
F
E
VEAD
D
L
V
T
I
S
E
LGR
G
A
Y
G
V
V
E
K
V
R
H
AQSGT
I
M
A
V
K
R
I
R
A
TVN
S
Q
E
Q
K
R
L
L
M
D
LDI
N
M
R
T
V
D
C
F
Y
--
T
V
T
F
Y
G
A
L
-----FR--EG------
D
V
W
I
C
M
E
L
M
D
--
T
-
S
L
D
K
F
--
Y
R
---
K
V
L
DK-NMT--I
P
E
D
I
L
G
E
I
A
V
S
I
V
R
A
L
E
H
L
H
S
K
L
S
V
I
HRDVKPS
N
V
L
INKEG
H
V
K
M
C
DFGIS
G
Y
L
V
D
S
V
A
K
-
T
M
--D-AGCKPY-MAPERINPE-L-N-Q-KG-YNV
K
S
D
V
W
S
L
G
I
T
M
I
E
M
A
I
L
RF
P
----------------
Y
---
E
S---------WG------------
T
P
------
F
Q
Q
L
K
Q
V
V
---EEPS--------------------PQL-P---A----D---R----------FS
P
E
F
V
D
F
T
A
Q
C
L
RK
N
P
A
E
R
M
S
Y
L
E
L
M
EHP
F
F
T
LHKTKK
T
D
I
A
A
F
V
K
E
I
LGEDS
97
HHSearch
88.95
84%
-130
- C1 -
3FME
1
MP2K6_HUMAN
A:
[2-289]
--------------------------------------------------------
M
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
--
T
V
T
F
Y
G
A
L
-----
F
R
--
E
G
------
D
V
W
I
C
M
E
L
M
D
--
T
-
S
L
D
K
F
--
Y
K
---
Q
V
I
D
K
-
G
Q
T
--
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
-------------------
A
G
C
K
P
Y
-
M
A
P
E
R
I
N
P
E
-
L
-
N
-
Q
----
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
----------------
Y
---
D
S
---------
W
G
------------
T
P
------
F
Q
Q
L
K
Q
V
V
---
E
E
P
S
--------------------
P
Q
L
-
P
---
A
----
D
---
K
----------
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
---
2
PsiBlast_PDB
88.68
83%
-130
- C1 -
3FME
1
MP2K6_HUMAN
A:
[2-289]
--------------------------------------------------------
M
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
--
T
V
T
F
Y
G
A
L
-----
F
R
--
E
G
------
D
V
W
I
C
M
E
L
M
D
--
T
-
S
L
D
K
F
--
Y
K
---
Q
V
I
D
K
-
G
Q
T
--
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
-------------------
A
G
C
K
P
Y
-
M
A
P
E
R
I
N
P
E
-
L
-
N
-
Q
----
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
----------------
Y
---
D
S
---------
W
G
------------
T
P
------
F
Q
Q
L
K
Q
V
V
---
E
E
P
S
--------------------
P
Q
L
-
P
---
A
----
D
---
K
----------
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
---
1
PsiBlast_PDB
88.29
80%
-118
- C1 -
3VN9
1
MP2K6_HUMAN
A:
[44-334]
------------------------------------------------------
Q
N
F
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
A
T
V
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
--
T
V
T
F
Y
G
A
L
-----
F
R
--
E
G
------
D
V
W
I
C
M
E
L
M
D
--
T
-
S
L
D
K
F
--
Y
K
---
Q
V
I
D
K
-
G
Q
T
--
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
G
I
S
G
Y
L
V
D
S
V
A
K
-
T
I
--
D
-
A
G
C
K
P
Y
-
M
A
P
E
R
I
N
P
E
-
L
-
N
-
Q
-
K
G
-
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
----------------
Y
---
D
S
---------
W
G
------------
T
P
------
F
Q
Q
L
K
Q
V
V
---
E
E
P
S
--------------------
P
Q
L
-
P
---
A
----
D
---
K
----------
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
D
--
100
HHSearch
80.51
42%
-116
* C1 *
3EQC
2
MP2K1_HUMAN
A:
[29-348]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G-
G
-
S
L
D
Q
V
--
L
K
-------
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-------
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
---
P
P
---------
P
D
A
K
E
L
E
L
M
F
GCPM
A
I
------
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
47
PsiBlast_CBE
80.05
37%
-123
- C1 -
3MBL
2
MP2K1_HUMAN
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--
48
PsiBlast_CBE
79.45
37%
-127
- C1 -
3DV3
3
MP2K1_HUMAN
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
--------
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
28
PsiBlast_CBE
79.36
37%
-124
- C1 -
2P55
2
MP2K1_HUMAN
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------PPMA
I
-
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
46
PsiBlast_CBE
79.27
37%
-121
- C1 -
3PP1
1
MP2K1_HUMAN
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
29
PsiBlast_CBE
78.94
37%
-123
- C1 -
4U81
2
MP2K1_HUMAN
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------PPMA
I
-
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
40
PsiBlast_CBE
78.57
37%
-124
- C1 -
3VVH
2
MP2K1_HUMAN
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
----------
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPDA
K
E
L
E
L
M
F----------------------------------PPMA
I
-
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
38
PsiBlast_CBE
78.57
37%
-116
- C1 -
3VVH
2
?
C:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPDA-----------------------------------------PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--
53
PsiBlast_CBE
78.44
35%
-116
- C1 -
3ZLW
1
MP2K1_HUMAN
A:
[17-345]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
A
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
FGC--------------------------------PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
31
PsiBlast_CBE
78.41
37%
-120
- C1 -
4U7Z
2
MP2K1_HUMAN
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------PPMA
I
-
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
37
PsiBlast_CBE
78.15
37%
-124
- C1 -
4ARK
2
MP2K1_HUMAN
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPDAKELELMF----------------------------------PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
16
PsiBlast_PDB
78.02
41%
-116
- C1 -
3WIG
3
MP2K1_HUMAN
A:
[2-288]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
PPP-------------------------
P
P
MA
I
---
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
---
45
PsiBlast_CBE
77.94
37%
-127
- C1 -
1S9J
2
MP2K1_HUMAN
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------PPMA
I
-
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
44
PsiBlast_CBE
77.55
37%
-124
- C1 -
3DY7
2
MP2K1_HUMAN
A:
[2-304]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
--------
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPP-------------------------------------------PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-------------------
14
PsiBlast_PDB
77.52
41%
-113
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[2-288]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
PPP--------------------------
P
MA
I
---
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
---
41
PsiBlast_CBE
77.43
37%
-128
- C1 -
3V04
2
MP2K1_HUMAN
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------PPMA
I
-
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
30
PsiBlast_CBE
77.37
37%
-119
- C1 -
4U80
2
MP2K1_HUMAN
A:
[2-319]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------PPMA
I
-
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
----
50
PsiBlast_CBE
77.36
36%
-114
- C1 -
3ZLY
1
MP2K1_HUMAN
A:
[17-345]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
---
P
P
PD
A
K
E
L
E
L
M
F
G
------------
C
-PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
19
PsiBlast_PDB
77.08
36%
-116
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[19-347]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GC--------------------------------PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
42
PsiBlast_CBE
77.01
37%
-127
- C1 -
3V01
2
?
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------PPMA
I
-
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
36
PsiBlast_CBE
76.85
37%
-124
- C1 -
4LMN
2
MP2K1_HUMAN
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------PPMA
I
-
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
98
HHSearch
76.81
56%
-131
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[14-308]
-----------------------------------------------------
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
--
I
V
Q
F
Y
G
A
L
-----
F
R
--
E
G
------
D
C
W
I
C
M
E
L
M
S
--
T
-
S
F
D
K
F
--
Y
K
---
Y
V
Y
S
V
L
D
D
V
--
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
----------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
----------------
Y
---
P
K
---------
W
-------------------------
T
Q
V
V
---
K
G
D
P
--------------------
P
Q
L
-
S
---
N
----
S
EER
E
----------
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
20
PsiBlast_PDB
76.63
36%
-116
- C1 -
3EQD
1
MP2K1_HUMAN
A:
[19-347]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GC--------------------------------PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
23
PsiBlast_CBE
76.60
36%
-115
- C1 -
3EQI
1
MP2K1_HUMAN
A:
[19-347]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
FGC--------------------------------PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
43
PsiBlast_CBE
76.34
37%
-124
- C1 -
3E8N
2
MP2K1_HUMAN
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------PPMA
I
-
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
51
PsiBlast_CBE
76.29
36%
-114
- C1 -
3ZLX
1
MP2K1_HUMAN
A:
[17-345]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
---
P
P
PD
A
K
E
L
E
L
M
F
G
------------
C
-PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
27
PsiBlast_CBE
76.28
37%
-122
- C1 -
3EQB
2
MP2K1_HUMAN
A:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--------
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------PPMA
I
-
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
25
PsiBlast_CBE
76.25
36%
-118
- C1 -
3EQG
2
MP2K1_HUMAN
A:
[19-347]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
FGC--------------------------------PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--
39
PsiBlast_CBE
75.92
37%
-116
- C1 -
3VVH
2
?
B:
[2-320]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F----------------------------------MA
I
---
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
12
PsiBlast_PDB
75.89
41%
-114
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[5-281]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
-
E
-----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
R
---
P
P
---------
M
A
------------
I
-------
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
A
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--
21
PsiBlast_CBE
75.73
55%
-126
- C1 -
3ALN
1
MP2K4_HUMAN
B:
[14-309]
-----------------------------------------------------
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
--
I
V
Q
F
Y
G
A
L
-----
F
R
--
E
G
------
D
C
W
I
C
M
E
L
M
S
--
T
-
S
F
D
K
F
--
Y
K
Y
V
Y
S
V
L
D
D
---
V
--
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
---------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
----------------
Y
---
P
---------------------------------------------
D
P
--------------------
P
Q
L
-
S
---
N
----
S
EER
E
----------
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
26
PsiBlast_CBE
75.40
36%
-119
- C1 -
3EQF
1
MP2K1_HUMAN
A:
[19-347]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GC--------------------------------PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--
24
PsiBlast_CBE
75.40
36%
-115
- C1 -
3EQH
2
MP2K1_HUMAN
A:
[19-347]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GC--------------------------------PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--
9
PsiBlast_PDB
75.34
40%
-116
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[11-301]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
-------
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
---
G
--------------------------A
I
----
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
5
PsiBlast_PDB
75.27
55%
-120
- C1 -
3ALO
1
MP2K4_HUMAN
A:
[17-309]
--------------------------------------------------------
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
--
I
V
Q
F
Y
G
A
L
-----
F
R
--
E
G
------
D
C
W
I
C
M
E
L
M
S
--
T
-
S
F
D
K
F
--
Y
K
Y
V
Y
S
V
L
D
D
---
V
--
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
V
D
S
I
A
K
-
T
R
--
D
-
A
G
C
R
P
Y
-
M
A
P
E
R
I
D
P
-----------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
----------------
Y
---
P
K
---------
W
N
------------
S
V
------
F
D
Q
L
T
Q
V
V
---
K
G
D
P
--------------------
P
Q
L
-
S
---
N
----
S
EE
R
E
----------
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
52
PsiBlast_CBE
74.81
36%
-116
- C1 -
3ZLS
1
MP2K1_HUMAN
A:
[17-345]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
---
P
P
PD
A
K
E
L
E
L
M
F
G
------------
C
-PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
4
PsiBlast_PDB
74.50
55%
-129
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[14-309]
-----------------------------------------------------
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
--
I
V
Q
F
Y
G
A
L
-----
F
R
--
E
G
------
D
C
W
I
C
M
E
L
M
S
--
T
-
S
F
D
K
F
--
Y
K
Y
V
Y
S
V
L
D
D
---
V
--
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
----------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
----------------
Y
---
P
K
---------
W
-------------------------
T
Q
V
V
---
K
G
D
P
--------------------
P
Q
L
-
S
---
N
----
S
EER
E
----------
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
11
PsiBlast_PDB
73.99
41%
-115
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[5-281]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
-
E
------
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
R
---
P
P
---------
M
A
------------
I
-------
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
A
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--
49
PsiBlast_CBE
73.59
36%
-111
- C1 -
3ZM4
1
MP2K1_HUMAN
A:
[17-345]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
---------
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
---
P
P
PD
A
K
E
L
E
L
M
F
G
------------
C
-PMA
I
--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
-
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
10
PsiBlast_PDB
73.19
41%
-117
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[5-281]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
-
E
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
R
---
P
P
---------
M
A
------------
I
-------
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
A
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--
18
PsiBlast_PDB
72.78
36%
-118
- C1 -
3W8Q
1
MP2K1_HUMAN
A:
[14-342]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GCQ-------------------------------RPPMA
I
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
G
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-
13
PsiBlast_PDB
72.70
41%
-119
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[5-281]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
-
E
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
R
---
P
P
---------
M
A
------------
I
-------
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
A
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--
17
PsiBlast_PDB
71.28
36%
-114
- C1 -
2Y4I
1
MP2K1_RABIT
C:
[54-382]
-----------------------------------------------
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPDAKELELMFGC--------------------------------PMAI--
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
---
S
----
A
---
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--
15
PsiBlast_PDB
69.49
41%
-120
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[2-286]
---------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
--
I
V
G
F
Y
G
A
F
-----
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
--
G
G
S
L
D
Q
---------
V
L
K
K
-
A
G
R
--
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
----
V
G
T
R
S
Y
-
M
S
P
E
R
-----
L
-
Q
-
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
P-----------------------------MA
I
---
F
E
L
L
D
Y
I
V
---
N
E
P
P
--------------------
P
K
L
-
P
------------
V
----------
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
-----
102
HHSearch
60.48
33%
-106
- C1 -
4OBO
2
M4K4_HUMAN
A:
[23-294]
------------------------------------------------------------
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-------
E
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
--
I
A
T
Y
Y
G
A
F
-----
I
K
K
S
D
D
------
Q
L
W
L
V
M
E
F
C
G
--
A
G
S
I
T
D
L
--
V
K
---
N
--
T
K
-
G
N
T
--
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
-----------R
N
T
--
F
-
I
G
T
P
Y
W
-
M
A
P
E
V
I
A
C
D
-
E
-
N
P
D
-
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
----------------
L
---
C
D
---------
M
-------------
H
P
------
M
R
A
L
F
L
I
P
---
R
N
P
P
--------------------
P
R
L
-
K
---
S
----
K
---
K
----------
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-
108
HHSearch
59.92
33%
-111
- C1 -
2J7T
1
STK10_HUMAN
A:
[21-293]
---------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
--
I
V
K
L
L
G
A
Y
-----
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
--
G
G
A
V
D
A
I
--
M
L
---
E
---
L
-
D
R
G
--
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
-------
I
G
T
P
Y
W
-
M
A
P
E
V
V
M
C
E
-
T
M
K
-
D
-
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
----------------
H
---
H
E
---------
L
-------------
N
P
------
M
R
V
L
L
K
I
A
---
K
S
D
P
--------------------
P
T
L
L
T
---
P
----
S
---
K
----------
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
-
A
L
R
E
L
V
A
E
A
K
A
E
V
M
116
HHSearch
59.01
31%
-109
- C1 -
2B9H
1
FUS3_YEAST
A:
[11-312]
-------------------------------------------------------------
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
-
L
K
H
F
K
H
E
N
--
I
I
T
I
F
N
I
Q
RPDSF
E
N
--
F
N
------
E
V
Y
I
I
Q
E
L
M
Q
--
T
-
D
L
H
R
V
--
I
S
---
T
------
Q
M
--
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
-
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
--------V
E
F
-
V
A
T
R
W
Y
-
R
A
P
E
V
M
----
L
-
T
-
S
-
A
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
----------------
F
---
P
G
---------
R
-------------
D
Y
------
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
SDNDLRCIES
P
R
A
R
E
Y
I
K
S
L
P
M
Y
-
P
AAP
L
E
K
M
F
P
---
R
----------
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
E
P
I
P
P
S
F
F
E
F
73
PsiBlast_CBE
57.36
34%
-104
- C1 -
4U45
1
M4K4_HUMAN
A:
[32-290]
---------------------------------------------------------------------
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
RN
I
A
T
Y
Y
G
A
F
-----
I
K
--
K
S
PPD
D
--
Q
L
W
L
V
M
E
F
C
G
--
A
G
S
I
T
D
L
--
V
K
---
N
T
--
K
-
G
N
T
--
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
----------
N
--
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
-
E
-
N
-
P
-
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
----------------
L
---
C
D
---------
M
-------------
H
P
------
M
R
A
L
F
L
I
P
---
R
N
P
P
--------------------
P
R
L
-
K
---
S
----
K
---
K
----------
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
75
PsiBlast_CBE
57.29
34%
-109
- C1 -
4U43
1
M4K4_HUMAN
A:
[32-290]
---------------------------------------------------------------------
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
RN
I
A
T
Y
Y
G
A
F
-----
I
K
--
K
S
PPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
--
A
G
S
I
T
D
L
--
V
K
---
N
T
--
K
-
G
N
T
--
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
------------
N
--
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
-
E
-
N
-
P
-
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
----------------
L
---
C
D
---------
M
-------------
H
P
------
M
R
A
L
F
L
I
P
---
R
N
P
P
--------------------
P
R
L
-
K
---
S
----
K
---
K
----------
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
74
PsiBlast_CBE
55.65
34%
-102
- C1 -
4U44
2
M4K4_HUMAN
A:
[32-290]
---------------------------------------------------------------------
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
RN
I
A
T
Y
Y
G
A
F
-----
I
K
--
K
S
HD
D
---
Q
L
W
L
V
M
E
F
C
G
--
A
G
S
I
T
D
L
--
V
K
---
N
T
--
K
-
G
N
T
--
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
-------------
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
-
E
-
N
-
P
-
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
----------------
L
---
C
D
---------
M
-------------
H
P
------
M
R
A
L
F
L
I
P
---
R
N
P
P
--------------------
P
R
L
-
K
---
S
----
K
---
K
----------
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-
69
PsiBlast_CBE
54.32
31%
-93
- C1 -
4USF
1
?
B:
[21-282]
------------------------------------------------------------------
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
-
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
C
D
H
P
N
--
I
V
K
L
L
D
A
F
-----
Y
Y
--
E
N
------
N
L
W
I
L
I
E
F
C
A
--
G
-
G
A
V
D
A
--
V
M
---
L
E
L
E
R
-
P
L
T
----
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
-------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
-
T
-
S
-
K
D
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
----------------
H
---
H
E
---------
L
N
-------------
P
------
M
R
V
L
L
K
I
A
---
K
S
E
P
--------------------
P
T
L
-
A
---
Q
P---
S
---
R
----------
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
----
62
PsiBlast_CBE
53.82
34%
-97
- C1 -
4AOT
1
STK10_HUMAN
A:
[24-280]
------------------------------------------------------------------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
--
I
V
K
L
L
G
A
Y
-----
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
--
G
-
G
A
V
D
A
--
I
M
---
L
E
L
D
R
-
G
L
T
--
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-----------------
G
T
P
Y
W
M
A
P
E
V
V
M
------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
----------------
H
---
H
E
---------
L
N
------------
P
M
------
R
V
L
L
K
I
A
K
---
S
D
P
P
--------------------
T
L
L
-
T
---
P
----
S
---
K
----------
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
--
59
PsiBlast_CBE
51.00
34%
-98
- C1 -
4USD
1
?
B:
[24-280]
------------------------------------------------------------------
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
--
I
V
K
L
L
G
A
Y
-----
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
--
G
-
G
A
V
D
A
--
I
M
---
L
E
L
D
R
-
G
L
T
--
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
-------------------
G
T
P
Y
W
M
A
P
E
V
V
M
C
-----------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
----------------
H
---
H
E
---------
L
N
------------
P
M
------
R
V
L
L
K
I
A
K
---
S
D
P
P
--------------------
T
L
L
-
T
---
P
----
S
---
K
----------
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
--
64
PsiBlast_CBE
49.77
34%
-101
- C1 -
5AJQ
2
STK10_HUMAN
A:
[21-277]
------------------------------------------------------------------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
--
I
V
K
L
L
G
A
Y
-----
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
--
G
-
G
A
V
D
A
--
I
M
---
L
E
L
D
R
-
G
L
T
--
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
----------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
-
K
-
D
-
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
----------------
H
---
H
E
---------
L
N
------------
P
M
------
R
V
L
L
K
I
A
K
---
S
D
P
P
--------------------
T
L
L
-
T
---
P
----
S
---
K
----------
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
----
60
PsiBlast_CBE
49.29
34%
-103
- C1 -
4EQU
2
STK10_HUMAN
B:
[24-280]
------------------------------------------------------------------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
--
I
V
K
L
L
G
A
Y
-----
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
--
G
-
G
A
V
D
A
--
I
M
---
L
E
L
D
R
-
G
L
T
--
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
-
K
-
D
-
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
----------------
H
---
H
E
---------
L
N
------------
P
M
------
R
V
L
L
K
I
A
K
---
S
D
P
P
--------------------
T
L
L
-
T
---
P
----
S
---
K
----------
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
71
PsiBlast_CBE
48.85
31%
-91
- C1 -
4O27
1
STK24_HUMAN
B:
[11-265]
------------------------------------------------------------------
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
D
S
P
Y
--
V
T
K
Y
Y
G
S
Y
-----
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
GG
S
-
A
L
D
L
L
--
E
P
---
G
P
L
D
---------
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
-
R
N
--
E
F
V
G
T
P
F
W
-
M
A
P
E
V
I
K
-------
Q
-
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
----------------
H
---
S
E
---------
L
-------------
H
P
------
M
K
V
L
F
L
I
P
---
K
N
N
P
--------------------
P
T
L
-
E
---
G
----
N
--------------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
57
PsiBlast_CBE
46.31
34%
-98
- C1 -
4USE
1
?
B:
[24-280]
------------------------------------------------------------------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
--
I
V
K
L
L
G
A
Y
-----
Y
-------------
W
I
M
I
E
F
C
P
--
G
-
G
A
V
D
A
--
I
M
---
L
E
L
D
R
-
G
L
T
--
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
----------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
-
K
-
D
-
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
----------------
H
---
H
E
---------
L
N
------------
P
M
------
R
V
L
L
K
I
A
K
---
S
D
P
P
--------------------
T
L
L
-
T
---
P
----
S
---
K
----------
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
85
PsiBlast_CBE
39.74
33%
-85
- C1 -
2PML
1
?
X:
[104-341]
-------------------------------------------------------------------------------------------------------------------------
Y
--
C
L
T
C
E
G
I
I
-----
T
N
--
Y
D
------
E
V
Y
I
I
Y
E
Y
M
E
--
N
D
S
I
L
K
F
DE
Y
F
---
F
V
L
D
K
-
N
Y
T
CF
I
P
I
Q
V
I
K
C
I
I
K
S
V
L
N
S
F
S
Y
I
H
N
E
K
N
I
C
H
R
D
V
K
P
S
N
I
L
M
D
K
N
G
R
V
K
L
S
D
F
G
E
S
E
Y
M
V
D
K
K
I
K
-
G
---
S
-
R
G
T
Y
E
F
-
M
P
P
E
F
F
S
N
E
-
S
-
S
-
Y
-
N
G
---
A
K
V
D
I
W
S
L
G
I
C
L
Y
V
M
F
Y
N
V
V
P
----------------
F
----
S
---------
L
K
------------
I
S
------
L
V
E
L
F
N
N
I
---
R
T
K
N
--------------------
I
E
Y
-
P
---
L
----
D
---
R
NHFLYPLTNF
L
S
N
E
D
I
D
F
L
K
L
F
L
R
K
N
P
A
E
R
I
T
S
E
D
A
L
K
H
E
W
--
L
A
D
T
N
I
E
D
L
R
E
F
S
K
E
L
Y
K
K
R
K
84
PsiBlast_CBE
37.41
33%
-86
- C1 -
2PMN
1
?
X:
[104-341]
-------------------------------------------------------------------------------------------------------------------------
Y
--
C
L
T
C
E
G
I
I
-----
T
N
--
Y
D
------
E
V
Y
I
I
Y
E
Y
M
E
--
N
D
S
I
L
K
F
DE
Y
F
---
F
V
L
D
K
-
N
Y
T
CF
I
P
I
Q
V
I
K
C
I
I
K
S
V
L
N
S
F
S
Y
I
H
N
E
K
N
I
C
H
R
D
V
K
P
S
N
I
L
M
D
K
N
G
R
V
K
L
S
D
F
G
E
S
E
Y
M
V
D
K
K
I
K
-
G
---
S
-
R
G
T
Y
E
F
-
M
P
P
E
F
F
S
N
E
-
S
-
S
-
Y
-
N
G
---
A
K
V
D
I
W
S
L
G
I
C
L
Y
V
M
F
Y
N
V
V
P
----------------
F
----
S
---------
L
K
------------
I
S
------
L
V
E
L
F
N
N
I
---
R
T
K
N
--------------------
I
E
Y
-
P
---
L
----
D
---
R
NHFLYPLTNF
L
S
N
E
D
I
D
F
L
K
L
F
L
R
K
N
P
A
E
R
I
T
S
E
D
A
L
K
H
E
W
--
L
A
D
T
N
I
E
D
L
R
E
F
S
K
E
L
Y
K
K
R
K
83
PsiBlast_CBE
37.35
33%
-85
- C1 -
2PMO
1
?
X:
[104-341]
-------------------------------------------------------------------------------------------------------------------------
Y
--
C
L
T
C
E
G
I
I
-----
T
N
--
Y
D
------
E
V
Y
I
I
Y
E
Y
M
E
--
N
D
S
I
L
K
F
DE
Y
F
---
F
V
L
D
K
-
N
Y
T
CF
I
P
I
Q
V
I
K
C
I
I
K
S
V
L
N
S
F
S
Y
I
H
N
E
K
N
I
C
H
R
D
V
K
P
S
N
I
L
M
D
K
N
G
R
V
K
L
S
D
F
G
E
S
E
Y
M
V
D
K
K
I
K
-
G
---
S
-
R
G
T
Y
E
F
-
M
P
P
E
F
F
S
N
E
-
S
-
S
-
Y
-
N
G
---
A
K
V
D
I
W
S
L
G
I
C
L
Y
V
M
F
Y
N
V
V
P
----------------
F
----
S
---------
L
K
------------
I
S
------
L
V
E
L
F
N
N
I
---
R
T
K
N
--------------------
I
E
Y
-
P
---
L
----
D
---
R
NHFLYPLTNF
L
S
N
E
D
I
D
F
L
K
L
F
L
R
K
N
P
A
E
R
I
T
S
E
D
A
L
K
H
E
W
--
L
A
D
T
N
I
E
D
L
R
E
F
S
K
E
L
Y
K
K
R
K