@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MP2K4_HUMAN: (2015-10-14 )
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
Atome Classification :
(86 SA)
.........10........20........30........40........50........60........70........80........90........100-.......110.......120.......130.......140.......150.......160.......170.........----------180.-.-......190...---...---.200---........210.-----......220.......230.......240.......250.....-..-260..--.--.....-270.......-280..-......290.......300......-------------.310--------------........320.......330.-----......340.......350.......360.......370.......380....-...390.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHP
A
V
S
S
M
QGK
R
K
A
L
K
L
NFANPPFKS
T
A
R
F
T
LNPNPTGVQNP
H
I
E
R
L
R
THSIESS
G
K
L
K
ISPEQHWDF
T
A
E
D
L
-
K
D
L
G
E
IGRGAYG
S
V
N
K
M
V
HKPSG
Q
I
M
A
V
K
R
I
R
S
TV
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
VMRSSDC
P
Y
I
V
Q
F
Y
G
A
L
FR--EG
D
C
W
I
C
M
E
----------
L
M
-S-T-
S
F
D
K
F
Y
K
Y
V
Y
S
V
---
L
D
D
---V
I
P
----
E
E
I
L
G
K
I
T
L
A
T
V
-----
K
A
L
N
H
L
K
E
N
L
K
I
I
H
RDIKPS
N
I
L
L
DRSG
N
I
K
L
C
DFGI
S
G
Q
L
V
D
S
-
I
A
-
K
-TRD--A--GCRPY-MAPERIDPSA-SR-QG-Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
LATGRFPYP-------------
K
W
N
---------------
S
V
F
D
Q
L
T
Q
V
VKGDPPQLSNS
E
E
-----REF
S
P
S
F
I
N
F
V
N
L
CLTKDESKR
P
K
Y
K
E
L
L
KHP
F
I
L
M
Y
EER
A
V
E
V
A
C
Y
V
C
K
I
L
D
-QMPATPSSPMYVD
21
PsiBlast_CBE
92.89
100%
-139
- C1 -
3ALN
1
MP2K4_HUMAN
B:
[6-312]
-----------------------------------------------------------------------------------
S
G
K
L
K
I
S
P
E
Q
H
W
D
F
T
A
E
D
L
-
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
--
E
G
D
C
W
I
C
M
E
----------
L
M
-
S
-
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
---
L
D
D
---
V
I
P
----
E
E
I
L
G
K
I
T
L
A
T
V
-----
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
----------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
-------------------------------------------
D
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
A
---------
117
HHSearch
92.69
100%
-140
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[5-311]
----------------------------------------------------------------------------------
S
S
G
K
L
K
I
S
P
E
Q
H
W
D
F
T
A
E
D
L
-
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
--
E
G
D
C
W
I
C
M
E
----------
L
M
-
S
-
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
---
L
D
D
---
V
I
P
----
E
E
I
L
G
K
I
T
L
A
T
V
-----
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
-----------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
-------------
K
W
----------------------
T
Q
V
V
K
G
D
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
----------
1
PsiBlast_PDB
92.69
100%
-140
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[5-311]
----------------------------------------------------------------------------------
S
S
G
K
L
K
I
S
P
E
Q
H
W
D
F
T
A
E
D
L
-
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
--
E
G
D
C
W
I
C
M
E
----------
L
M
-
S
-
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
---
L
D
D
---
V
I
P
----
E
E
I
L
G
K
I
T
L
A
T
V
-----
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
-----------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
-------------
K
W
----------------------
T
Q
V
V
K
G
D
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
----------
2
PsiBlast_PDB
92.36
100%
-135
- C1 -
3ALO
1
MP2K4_HUMAN
A:
[17-311]
----------------------------------------------------------------------------------------------
W
D
F
T
A
E
D
L
-
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
--
E
G
D
C
W
I
C
M
E
----------
L
M
-
S
-
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
---
L
D
D
---
V
I
P
----
E
E
I
L
G
K
I
T
L
A
T
V
-----
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
V
D
S
-
I
A
-
K
-
T
R
D
--
A
--
G
C
R
P
Y
-
M
A
P
E
R
I
D
P
---------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
-------------
K
W
N
---------------
S
V
F
D
Q
L
T
Q
V
V
K
G
D
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
----------
39
PsiBlast_CBE
76.64
36%
-120
- C1 -
3EQI
1
MP2K1_HUMAN
A:
[29-349]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
PPD
A
K
E
L
E
L
M
FGC---PM-------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
43
PsiBlast_CBE
75.74
36%
-119
- C1 -
3EQD
1
MP2K1_HUMAN
A:
[29-349]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
PPD
A
K
E
L
E
L
M
F
GC---PM-------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
44
PsiBlast_CBE
75.39
36%
-127
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[29-349]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
--------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
PPD
A
K
E
L
E
L
M
F
GC---PM-------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
50
PsiBlast_CBE
75.09
35%
-120
- C1 -
3MBL
2
MP2K1_HUMAN
A:
[2-319]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPM-----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
L
------------
4
PsiBlast_PDB
74.95
58%
-114
- C1 -
3VN9
1
MP2K6_HUMAN
A:
[44-332]
--------------------------------------------------------------------------------------------
Q
N
F
E
V
K
A
D
D
L
-
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
A
T
V
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
--
E
G
D
V
W
I
C
M
E
----------
L
M
-
D
-
T
-
S
L
D
K
F
Y
K
Q
V
I
D
K
----
G
Q
---
T
I
P
----
E
D
I
L
G
K
I
A
V
S
I
V
-----
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
G
I
S
G
Y
L
V
D
S
-
V
A
-
K
-
T
I
D
--
A
--
G
C
K
P
Y
-
M
A
P
E
R
I
N
P
E
L
-
N
Q
-
K
G
-
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
D
-------------
S
W
G
---------------
T
P
F
Q
Q
L
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
--------
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
-
D
------------
19
PsiBlast_PDB
74.68
36%
-120
- C1 -
3EQB
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
--------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPPM----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
121
HHSearch
74.56
43%
-121
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[28-349]
----------------------------------------------------------------------------------------------
G
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
-
D
G
G
-
S
L
D
Q
V
L
K
K
--------
A
G
---
R
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
--------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-----
G
-
T
H
-
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
F
GCPM---
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
--------
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
L
N
-----------
47
PsiBlast_CBE
74.54
35%
-124
- C1 -
3ZLS
1
MP2K1_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FGCPM---
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
L
N
-----------
119
HHSearch
74.49
58%
-130
- C1 -
3FME
1
MP2K6_HUMAN
A:
[2-289]
----------------------------------------------------------------------------------------------
M
E
V
K
A
D
D
L
-
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
--
E
G
D
V
W
I
C
M
E
----------
L
M
-
D
-
T
-
S
L
D
K
F
Y
K
Q
V
I
D
----
K
G
Q
---
T
I
P
----
E
D
I
L
G
K
I
A
V
S
I
V
-----
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
--------------------
A
--
G
C
K
P
Y
-
M
A
P
E
R
I
N
P
E
L
-
N
Q
----
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
D
-------------
S
W
G
---------------
T
P
F
Q
Q
L
K
Q
V
V
E
E
P
S
P
Q
L
P
A
--------
D
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
--------------
33
PsiBlast_CBE
74.14
36%
-123
- C1 -
3VVH
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
------------
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPPM----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
49
PsiBlast_CBE
74.12
35%
-121
- C1 -
3PP1
1
MP2K1_HUMAN
A:
[2-319]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPM-----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
L
N
-----------
42
PsiBlast_CBE
74.00
36%
-121
- C1 -
3EQF
1
MP2K1_HUMAN
A:
[29-348]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
PPD
A
K
E
L
E
L
M
F
GC---PM-------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
41
PsiBlast_CBE
73.96
36%
-122
- C1 -
3EQG
2
MP2K1_HUMAN
A:
[29-348]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
PPD
A
K
E
L
E
L
M
FGC---PM-------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
35
PsiBlast_CBE
73.77
36%
-121
- C1 -
3V01
2
?
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
--------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPPM----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
40
PsiBlast_CBE
73.54
36%
-123
- C1 -
3EQH
2
MP2K1_HUMAN
A:
[29-348]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
PPD
A
K
E
L
E
L
M
F
GC---PM-------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
46
PsiBlast_CBE
73.47
35%
-123
- C1 -
3ZLX
1
MP2K1_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
--------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FGCPM---
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
L
N
-----------
34
PsiBlast_CBE
73.44
36%
-122
- C1 -
3V04
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
--------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPPM----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
18
PsiBlast_PDB
73.35
36%
-121
- C1 -
2P55
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
--------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPPM----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
29
PsiBlast_CBE
73.34
36%
-119
- C1 -
4LMN
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPPM----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
48
PsiBlast_CBE
73.08
35%
-123
- C1 -
3ZLY
1
MP2K1_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
--------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FGCPM---
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
L
N
-----------
13
PsiBlast_PDB
73.00
39%
-112
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[2-288]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
-PM-------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
--------------
51
PsiBlast_CBE
72.99
35%
-122
- C1 -
3DV3
3
MP2K1_HUMAN
A:
[2-319]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
---------
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPM-----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
L
N
-----------
15
PsiBlast_PDB
72.96
39%
-117
- C1 -
3WIG
3
MP2K1_HUMAN
A:
[2-288]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
-PPM------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
--------------
5
PsiBlast_PDB
72.94
58%
-130
- C1 -
3FME
1
MP2K6_HUMAN
A:
[6-288]
--------------------------------------------------------------------------------------------------
A
D
D
L
-
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
N
S
Q
E
Q
K
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
--
E
G
D
V
W
I
C
M
E
----------
L
M
-
D
-
T
-
S
L
D
K
F
Y
K
Q
V
I
D
K
----
G
Q
---
T
I
P
----
E
D
I
L
G
K
I
A
V
S
I
V
-----
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
--------------------
A
--
G
C
K
P
Y
-
M
A
P
E
R
I
N
P
E
L
-
N
Q
----
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
D
-------------
S
W
G
---------------
T
P
F
Q
Q
L
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
--------
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
--------------
32
PsiBlast_CBE
72.80
36%
-116
- C1 -
3VVH
2
?
B:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FM------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
36
PsiBlast_CBE
72.74
36%
-120
- C1 -
3E8N
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
----
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPPM----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
38
PsiBlast_CBE
72.40
36%
-121
- C1 -
1S9J
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
--------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPPM----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
31
PsiBlast_CBE
72.17
36%
-114
- C1 -
3VVH
2
?
C:
[6-321]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
APM------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
53
PsiBlast_CBE
72.10
35%
-126
- C1 -
3ZLW
1
MP2K1_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
A
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
-
D
-
G
G
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
--------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
PPD
A
K
E
L
E
L
M
FGC---PM-------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
L
N
-----------
24
PsiBlast_CBE
72.09
36%
-116
- C1 -
4U80
2
MP2K1_HUMAN
A:
[6-319]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
--------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPPM----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
11
PsiBlast_PDB
71.63
40%
-118
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[5-282]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
-
M
A
---
N
E
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
-------------
P
M
----------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
45
PsiBlast_CBE
71.54
35%
-118
- C1 -
3ZM4
1
MP2K1_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-----------
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FGCPM---
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
-
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
L
N
-----------
23
PsiBlast_CBE
71.29
36%
-116
- C1 -
4U81
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
--------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPPM----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
30
PsiBlast_CBE
71.20
36%
-116
- C1 -
4ARK
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
AKELELMFPM-----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
12
PsiBlast_PDB
70.89
40%
-119
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[5-282]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
-
M
A
---
N
E
F
--
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
-------------
P
M
----------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
20
PsiBlast_PDB
70.32
36%
-115
- C1 -
4U7Z
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
----
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
FPPM----
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
10
PsiBlast_PDB
70.32
40%
-119
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[5-282]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
-
M
A
---
N
E
------
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
-------------
P
M
----------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
52
PsiBlast_CBE
69.47
35%
-120
- C1 -
3W8Q
1
MP2K1_HUMAN
A:
[24-341]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
A
K
E
L
E
L
M
F
GCQRPPM
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
L
N
-----------
9
PsiBlast_PDB
69.18
40%
-116
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[5-282]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
-
M
A
---
N
E
F
--
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
-------------
P
M
----------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
14
PsiBlast_PDB
68.69
39%
-120
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[2-286]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
----------------M--------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
----------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
----------------
17
PsiBlast_PDB
68.35
35%
-115
- C1 -
2Y4I
1
MP2K1_RABIT
C:
[64-383]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
-
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
-
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
D
AKELELMFGCPM---
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
37
PsiBlast_CBE
68.19
36%
-119
- C1 -
3DY7
2
MP2K1_HUMAN
A:
[6-304]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
-
M
A
-
N
---------
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-------------
P
P
-PM-------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
------------------------------
16
PsiBlast_PDB
68.08
40%
-123
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[25-300]
---------------------------------------------------------------------------------------------------
D
D
F
-
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
-
G
-
S
L
D
Q
V
L
K
K
A
G
R
-----------
I
P
----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
---------
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
G
-------------------------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-
L
N
Q
----------
75
PsiBlast_CBE
57.01
32%
-103
- C1 -
4AOT
1
STK10_HUMAN
A:
[15-279]
----------------------------------------------------------------------------------------
L
D
P
N
E
V
W
E
I
--------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
----------
F
C
P
G
-
G
-
A
V
D
A
----
I
M
L
E
---
L
D
R
---
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
-----
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-------------------
G
T
P
Y
W
-
M
A
P
E
V
V
M
----------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
-------------
E
L
N
---------------
P
M
-
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
S
-------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
-
V
------------
123
HHSearch
53.88
33%
-111
- C1 -
4OBO
2
M4K4_HUMAN
A:
[29-292]
---------------------------------------------------------------------------------------------------------
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-------
E
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
D
D
Q
L
W
L
V
M
E
----------
F
C
-
G
-
A
G
S
I
T
D
L
V
K
N
---
T
---
K
G
N
---
T
L
K
----
E
D
W
I
A
Y
I
S
R
E
I
L
-----
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
-------------R
N
T
F
--
I
--
G
T
P
Y
W
-
M
A
P
E
V
I
A
C
D
E
N
P
D
-
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
-------------
D
M
H
---------------
P
-
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
--------
K
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
-
T
R
-----------
60
PsiBlast_CBE
53.76
33%
-106
- C1 -
3GGF
1
STK26_HUMAN
A:
[23-292]
---------------------------------------------------------------------------------------------------
E
L
F
-
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
GGGS
A
L
D
L
L
R
-
A
-
G
-
P
F
D
E
F
Q
--
I
A
T
M
---
L
K
E
---
I
L
----------------------
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
----------
R
-
N
T
F
--
V
--
G
T
P
F
W
-
M
A
P
E
V
I
Q
Q
S
A
-------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
-------------
D
M
H
---------------
P
M
-
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
----
T
S
Y
L
T
E
L
I
D
-
R
F
K
R
W
K
A
E
G
H
S
--
61
PsiBlast_CBE
53.08
33%
-100
- C1 -
2UV2
6
SLK_HUMAN
A:
[33-297]
----------------------------------------------------------------------------------------
L
N
P
E
D
F
W
E
I
--------
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
-
V
L
A
A
A
K
V
I
D
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
----------
F
C
-
A
-
G
-
G
A
---
V
D
A
V
M
L
E
---
L
E
R
---
P
L
T
----
E
S
Q
I
Q
V
V
C
K
Q
T
L
-----
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
-
I
Q
-
R
--
R
D
--
S
FI
G
T
P
Y
W
-
M
A
P
E
V
V
M
C
E
T
-
S
K
D
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
-------------
E
L
N
---------------
P
M
-
R
V
L
L
K
I
A
K
S
E
P
P
T
L
--
A
Q
P
-----
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
-----------------
59
PsiBlast_CBE
52.96
33%
-105
- C1 -
3GGF
1
STK26_HUMAN
B:
[23-292]
---------------------------------------------------------------------------------------------------
E
L
F
-
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
GGGS
A
L
D
L
L
R
-
A
-
G
-
P
F
D
E
F
Q
--
I
A
T
M
---
L
K
E
---
I
L
----------------------
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
------------
N
T
F
--
V
--
G
T
P
F
W
-
M
A
P
E
V
I
Q
Q
S
A
-------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
-------------
D
M
H
---------------
P
M
-
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
----
T
S
Y
L
T
E
L
I
D
-
R
F
K
R
W
K
A
E
-----
73
PsiBlast_CBE
52.66
32%
-105
- C1 -
4EQU
2
STK10_HUMAN
B:
[15-279]
----------------------------------------------------------------------------------------
L
D
P
N
E
V
W
E
I
--------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
----------
F
C
P
G
-
G
-
A
V
D
A
----
I
M
L
E
---
L
D
R
---
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
-----
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
--------------FI
G
T
P
Y
W
-
M
A
P
E
V
V
M
C
E
T
-
M
K
-
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
-------------
E
L
N
---------------
P
M
-
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
S
-------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
-
V
M
E
E
---------
62
PsiBlast_CBE
52.56
33%
-98
- C1 -
2J51
5
SLK_HUMAN
A:
[33-297]
----------------------------------------------------------------------------------------
L
N
P
E
D
F
W
E
I
--------
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
-
V
L
A
A
A
K
V
I
D
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
----------
F
C
-
A
-
G
-
G
A
---
V
D
A
V
M
L
E
---
L
E
R
---
P
L
T
----
E
S
Q
I
Q
V
V
C
K
Q
T
L
-----
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
-
I
Q
-
R
--
R
D
--
S
FI
G
T
P
Y
W
-
M
A
P
E
V
V
M
C
E
T
-
S
K
D
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
-------------
E
L
N
---------------
P
M
-
R
V
L
L
K
I
A
K
S
E
P
P
T
L
--
A
Q
P
-----
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
-----------------
127
HHSearch
51.89
34%
-109
- C1 -
2J7T
1
STK10_HUMAN
A:
[24-282]
---------------------------------------------------------------------------------------------------------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
----------
F
C
-
P
-
G
G
A
V
D
A
I
M
L
----
E
---
L
D
R
---
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
-----
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
-
L
Q
-
K
------
I
--
G
T
P
Y
W
-
M
A
P
E
V
V
M
C
E
T
M
K
D
-
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
-------------
E
L
N
---------------
P
-
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
-
V
M
E
E
---------
74
PsiBlast_CBE
51.18
32%
-107
- C1 -
4EQU
2
STK10_HUMAN
A:
[15-279]
----------------------------------------------------------------------------------------
L
D
P
N
E
V
W
E
I
--------
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-
E
------
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
----------
F
C
P
G
-
G
-
A
V
D
A
----
I
M
L
E
---
L
D
R
---
G
L
T
----
E
P
Q
I
Q
V
V
C
R
Q
M
L
-----
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
--------------I-
G
T
P
Y
W
-
M
A
P
E
V
V
M
C
E
T
-
M
K
-
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
-------------
E
L
N
---------------
P
M
-
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
S
-------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
-
V
M
E
E
---------
68
PsiBlast_CBE
50.12
33%
-95
- C1 -
4FZA
3
STK26_HUMAN
B:
[8-277]
---------------------------------------------------------------------------------------------------
E
L
F
-
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
GGGS
A
L
D
L
L
R
-
A
-
G
-
P
F
D
E
F
Q
--
I
A
T
M
---
L
K
E
---
I
L
----------------------
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
-
R
-
N
T
F
--
V
--
G
T
P
F
W
-
M
A
P
E
V
I
Q
Q
S
A
-------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
-------------
D
M
H
---------------
P
M
-
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
----
T
S
Y
L
T
E
L
I
D
-
R
F
K
R
W
K
A
E
-----
67
PsiBlast_CBE
49.39
33%
-102
- C1 -
4FZD
1
STK26_HUMAN
B:
[8-277]
---------------------------------------------------------------------------------------------------
E
L
F
-
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
GGGS
A
L
D
L
L
R
-
A
-
G
-
P
F
D
E
F
Q
--
I
A
T
M
---
L
K
E
---
I
L
----------------------
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
--------
N
T
F
--
V
--
G
T
P
F
W
-
M
A
P
E
V
I
Q
Q
S
A
-------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
-------------
D
M
H
---------------
P
M
-
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
----
T
S
Y
L
T
E
L
I
D
-
R
F
K
R
W
K
A
E
-----
63
PsiBlast_CBE
49.15
33%
-94
- C1 -
4NZW
1
STK25_HUMAN
B:
[13-288]
---------------------------------------------------------------------------------------------
H
S
R
V
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
--
S
T
K
L
W
I
I
M
E
----------
Y
L
-
G
-
G
-
G
---------
S
A
---
L
D
L
---
L
K
P
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
-----
K
G
L
D
Y
L
H
S
E
R
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
--------------------
T
P
F
W
-
M
A
P
E
V
I
K
Q
---------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
-------------
D
L
H
---------------
P
M
-
R
V
L
F
L
I
P
K
N
S
P
P
T
L
----
E
-----
G
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
----
T
S
F
L
T
E
L
I
D
-
R
Y
K
R
W
K
S
------
83
PsiBlast_CBE
48.84
31%
-87
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[5-285]
----------------------------------------------------------------------------------------------
W
S
I
N
R
D
D
Y
-
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
-
G
G
S
V
L
D
I
I
K
H
I
V
A
K
---
G
E
H
KSG
V
L
D
----
E
S
T
I
A
T
I
L
R
E
V
L
-----
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
-
G
D
-
I
-
T
R
N
F-
V
--
G
T
P
C
W
-
M
A
P
E
V
M
E
Q
V
-----
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
-------------
K
Y
P
---------------
P
M
-
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
DKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
-----------------------------
85
PsiBlast_CBE
48.57
31%
-86
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[5-285]
----------------------------------------------------------------------------------------------
W
S
I
N
R
D
D
Y
-
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
-
G
G
S
V
L
D
I
I
K
H
I
V
A
K
---
G
E
H
KSG
V
L
D
----
E
S
T
I
A
T
I
L
R
E
V
L
-----
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
-
G
---------
V
--
G
T
P
C
W
-
M
A
P
E
V
M
E
Q
V
-----
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
-------------
K
Y
P
---------------
P
M
-
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
DKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
-----------------------------
66
PsiBlast_CBE
48.50
33%
-97
- C1 -
4FZF
1
?
B:
[8-277]
---------------------------------------------------------------------------------------------------
E
L
F
-
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
YLGGGS
A
L
D
L
L
R
-
A
-
G
-
P
F
D
E
F
Q
--
I
A
T
M
---
L
K
E
---
I
L
----------------------
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
-
R
-
N
T
F
--
V
--
G
T
P
F
W
-
M
A
P
E
V
I
Q
Q
S
A
-------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
-------------
D
M
H
---------------
P
M
-
R
V
L
F
L
I
P
K
N
N
P
P
T
L
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
----
T
S
Y
L
T
E
L
I
D
-
R
F
K
R
W
K
A
E
-----
86
PsiBlast_CBE
48.32
31%
-95
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[10-291]
----------------------------------------------------------------------------------------------
W
S
I
N
R
D
D
Y
-
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
-
G
G
S
V
L
D
I
I
K
H
I
V
A
K
---
G
E
H
KSG
V
L
D
----
E
S
T
I
A
T
I
L
R
E
V
L
-----
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
-
G
-------TF
V
--
G
T
P
C
W
-
M
A
P
E
V
M
E
Q
V
-----
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
-------------
K
Y
P
---------------
P
M
-
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
DKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
N
K
E
--------------------------
131
HHSearch
48.03
31%
-89
* C1 *
4JDI
1
PAK4_HUMAN
A:
[77-329]
-------------------------------------------------------------------------------------------------------
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
--
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
----------
F
L
-
E
G
G
-
A
L
T
D
I
V
T
---------
H
T
---
R
M
N
----
E
E
Q
I
A
A
V
C
L
A
V
L
-----
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
-
V
P
R
R
-
K
S
L
--
V
--
G
T
P
Y
W
-
M
A
P
E
L
I
S
-----
R
-
L
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
-------------
N
E
P
----------------
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
----------------
81
PsiBlast_CBE
47.92
33%
-96
- C1 -
5D9H
1
?
B:
[26-294]
------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
S
H
-
P
N
V
V
T
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
-
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
GEH
K
N
G
---
V
L
E
----
E
A
I
I
A
T
I
L
K
E
V
L
-----
E
G
L
D
Y
L
H
R
N
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
-
G
D
-
V
-
T
R
N
-----
G
T
P
C
W
-
M
A
P
E
V
M
E
Q
V
-----
R
G
-
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
-------------
K
Y
P
---------------
P
M
-
K
V
L
M
L
T
L
Q
N
D
P
P
T
L
E
T
G
V
E
DKEMM
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
K
N
R
E
Y
L
I
E
K
L
L
T
------------------
87
PsiBlast_CBE
47.81
31%
-90
- C1 -
2VWI
1
OXSR1_HUMAN
C:
[10-291]
----------------------------------------------------------------------------------------------
W
S
I
N
R
D
D
Y
-
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
-
G
G
S
V
L
D
I
I
K
H
I
V
A
K
---
G
E
H
KSG
V
L
D
----
E
S
T
I
A
T
I
L
R
E
V
L
-----
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
-
G
D
-
I
-
T
R
N
KV---
G
T
P
C
W
-
M
A
P
E
V
M
E
Q
V
-----
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
-------------
K
Y
P
---------------
P
M
-
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
--------
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
--------------------------------
88
PsiBlast_CBE
47.19
31%
-93
- C1 -
2VWI
1
OXSR1_HUMAN
B:
[10-291]
----------------------------------------------------------------------------------------------
W
S
I
N
R
D
D
Y
-
E
L
Q
E
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
-
G
G
S
V
L
D
I
I
K
H
I
V
A
K
---
G
E
H
KSG
V
L
D
----
E
S
T
I
A
T
I
L
R
E
V
L
-----
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
-
G
D
------------
T
P
C
W
-
M
A
P
E
V
M
E
Q
V
-----
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
-------------
K
Y
P
---------------
P
M
-
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
--ML---
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
--------------------------------
89
PsiBlast_CBE
46.84
31%
-102
- C1 -
2VWI
2
OXSR1_HUMAN
A:
[13-291]
-------------------------------------------------------------------------------------------------
N
R
D
D
Y
-
E
L
Q
E
V
I
G
---
T
A
V
V
Q
A
A
Y
C
----
E
K
V
A
I
K
R
I
N
----------------
A
-
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
-
G
G
S
V
L
D
I
I
K
H
I
V
A
K
---
G
E
H
KSG
V
L
D
----
E
S
T
I
A
T
I
L
R
E
V
L
-----
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
----------------
G
T
P
C
W
-
M
A
P
E
V
M
E
Q
V
-----
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
-------------
K
Y
P
---------------
P
M
-
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
---EML--
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
--------------------------------
84
PsiBlast_CBE
46.64
31%
-86
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[5-285]
----------------------------------------------------------------------------------------------
W
S
I
N
R
D
D
Y
-
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
-
G
G
S
V
L
D
I
I
K
H
I
V
A
K
---
G
E
H
KSG
V
L
D
----
E
S
T
I
A
T
I
L
R
E
V
L
-----
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
-
G
D
------------
T
P
C
W
-
M
A
P
E
V
M
E
Q
V
-----
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
-------------
K
Y
P
---------------
P
M
-
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
DKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
-----------------------------
93
PsiBlast_CBE
46.20
32%
-103
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[29-275]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
Q
----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----------
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
---------------
58
PsiBlast_CBE
45.67
34%
-84
- C1 -
4O27
1
STK24_HUMAN
B:
[6-274]
---------------------------------------------------------------------------------------------------
E
L
F
-
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
----------
Y
L
-
G
-
G
-
G
---------
S
A
---
L
D
L
---
L
E
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
-----
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
-
R
-
N
E
F
--
V
--
G
T
P
F
W
-
M
A
P
E
V
I
K
Q
S
A
-------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
-------------
E
L
H
---------------
P
M
-
K
V
L
F
L
I
P
K
N
N
P
P
T
L
----
E
-----
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
----
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
-
R
Y
K
R
W
K
A
E
-----
97
PsiBlast_CBE
45.26
32%
-106
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[29-275]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
-----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-
T
K
-----------
96
PsiBlast_CBE
44.99
32%
-104
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[29-275]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
Q
-----
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
--------------
102
PsiBlast_CBE
44.98
32%
-101
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[28-274]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
---------
S
-
K
-
R
S
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-
T
K
-----------
92
PsiBlast_CBE
44.97
32%
-103
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[29-275]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
-----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----------
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
---------------
99
PsiBlast_CBE
44.24
32%
-98
- C1 -
4O0R
1
PAK1_HUMAN
A:
[27-273]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
-
Q
S
-
K
-
R
S
E
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-
T
------------
98
PsiBlast_CBE
44.19
32%
-94
- C1 -
4O0T
1
PAK1_HUMAN
A:
[27-273]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
-
Q
S
-
K
-
R
S
E
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-
T
K
-----------
82
PsiBlast_CBE
43.56
33%
-92
- C1 -
5D9H
1
?
A:
[26-294]
------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
S
H
-
P
N
V
V
T
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
-
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
GEH
K
N
G
---
V
L
E
----
E
A
I
I
A
T
I
L
K
E
V
L
-----
E
G
L
D
Y
L
H
R
N
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
-
G
D
-
V
-
T
R
---
V
--
G
T
P
C
W
-
M
A
P
E
V
M
E
Q
V
-----
R
G
-
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
-------------
K
Y
P
---------------
P
M
-
K
V
L
M
L
T
L
Q
N
D
P
P
T
L
E
T
G
V
-KEMM-
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
K
N
R
E
Y
L
I
E
K
L
L
-------------------
104
PsiBlast_CBE
43.36
32%
-95
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[28-274]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
Q
Q
-
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
-
Q
S
-
K
-
R
S
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-
T
K
-----------
106
PsiBlast_CBE
42.80
32%
-98
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[28-274]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
L
Q
Q
-
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
-
Q
S
-
K
-
R
S
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-
T
------------
103
PsiBlast_CBE
42.28
32%
-95
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[28-274]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
----
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
-
Q
S
-
K
-
R
S
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-
T
K
-----------
95
PsiBlast_CBE
39.92
32%
-95
- C1 -
4ZJI
1
?
C:
[29-275]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
--
N
-----
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
------
S
-
K
-
R
S
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-
T
------------
94
PsiBlast_CBE
39.65
32%
-99
- C1 -
4ZJI
1
?
D:
[29-275]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
--
N
-----
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
CRECL
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
----
S
-
K
-
R
S
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-
T
------------
105
PsiBlast_CBE
39.47
32%
-91
- C1 -
4ZY5
1
PAK1_HUMAN
A:
[28-274]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-------
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
-----
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
-
Q
S
-
K
-
R
S
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-
T
K
-----------
91
PsiBlast_CBE
37.93
32%
-99
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[29-275]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
--
N
L
Q
---
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
----
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-------
E
-
Q
S
-
K
-
R
S
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
---
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-
T
K
-----------
90
PsiBlast_CBE
37.39
32%
-100
- C1 -
4ZJJ
1
PAK1_HUMAN
D:
[29-275]
-----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
Q
M
--
N
L
---
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
----
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
-
G
-
G
----------
S
---
L
T
D
---
V
V
T
----
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
----
P
E
-
Q
S
-
K
-
R
S
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
-------------
N
E
N
---------------
P
-
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-
T
------------