@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MP2K7_HUMAN: (2015-10-14 )
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
Atome Classification :
(65 SA)
.........10........20........30........40........50........60........70........80........90........100.......-110.......120.......130.......140.......150.......160.....--..170..-..--...180.......--190......-.--200-........----210--.-.---...--....220.......230.......240.......250.-......260.......270..-...-..280.......290.......300.......310.......320--.-----------...------------..------.330...-....340...--.--...350.......360.......370.......380.......390.......400.......410.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
A
S
S
L
E
Q
K
L
S
R
L
E
A
K
L
K
Q
E
N
R
E
A
R
R
R
I
D
L
NLDISPQRPRP
T
L
Q
L
PLANDGGSRSPSSESSPQHPTPPARP
R
H
MLGLPSTLFTPRS
M
E
S
I
E
I
D
Q
K
L
Q
E
I
M
K
QTG
Y
L
T
IG-G
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
MGSG
T
C
G
Q
V
W
K
M
R
F
RKTGH
V
I
A
V
K
Q
M
R
RSG
N
K
E
E
N
K
R
I
L
M
D
L
--
D
V
V
LKSH-DC--
P
Y
I
V
Q
C
F
G
T
F
ITN--T
D
V
F
I
A
M
E
L
-
M
--
G
-
T
-
C
A
E
K
L
K
K
R
----M----Q-G---P
I
P
--
E
R
I
L
G
K
M
T
V
A
I
V
K
A
L
Y
Y
L
K
E
KHG
V
I
HRDVKPS
N
I
L
LDE-RG
Q
I
K
L
C
DFGIS
G
R
L
VDSKAK-TRS-AGCAAYMAPERIDPPDPTKPDY
D
I
R
A
D
V
W
S
L
G
I
S
L
V
E
LATGQFPY--K-----------NCK------------
T
D
------
F
E
V
L
T
K
V
-
L
QEEPPLLPG--H--MGF
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
RKRP
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
AKTESPRTSGVLSQPHLPFFR
50
PsiBlast_CBE
75.84
37%
-128
- C1 -
1S9J
2
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------PPMA
I
-
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
102
HHSearch
75.33
47%
-126
- C1 -
3FME
1
MP2K6_HUMAN
A:
[4-289]
-------------------------------------------------------------------------------------------------------------------
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
N
S
Q
E
Q
K
R
L
L
M
D
L
--
D
I
S
M
R
T
V
-
D
C
--
P
F
T
V
T
F
Y
G
A
L
F
R
E
--
G
D
V
W
I
C
M
E
L
-
M
--
D
-
T
-
S
L
D
K
F
Y
K
Q
----
V
I
D
K
-
G
-
Q
---
T
I
P
--
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
-
L
G
Q
V
K
M
C
D
F
-----------------
A
G
C
K
P
Y
M
A
P
E
R
I
N
P
-
E
L
N
Q
--
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
--
D
-----------
S
W
G
------------
T
P
------
F
Q
Q
L
K
Q
V
-
V
E
E
P
S
P
Q
L
P
A
--
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
--------------------
7
PsiBlast_PDB
74.73
45%
-125
- C1 -
3FME
1
MP2K6_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------------
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
N
S
Q
E
Q
K
R
L
L
M
D
L
--
D
I
S
M
R
T
V
-
D
C
--
P
F
T
V
T
F
Y
G
A
L
F
R
E
--
G
D
V
W
I
C
M
E
L
-
M
--
D
-
T
-
S
L
D
K
F
Y
K
Q
----
V
----
I
-
D
K
G
Q
T
I
P
--
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
-
L
G
Q
V
K
M
C
D
F
-----------------
A
G
C
K
P
Y
M
A
P
E
R
I
N
-
P
E
L
N
Q
--
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
--
D
-----------
S
W
G
------------
T
P
------
F
Q
Q
L
K
Q
V
-
V
E
E
P
S
P
Q
L
P
A
--
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
--------------------
103
HHSearch
74.45
39%
-106
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[12-349]
------------------------------------------------------------------------------------------
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
-------
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
-
V
L
H
E
C
-
N
S
--
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
--
D
G
G
-
S
L
D
Q
V
L
K
K
----
A
------
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
-----
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
-----------
P
P
D
A
K
E
L
E
L
M
F
GCPM
A
I
------
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
---
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
47
PsiBlast_CBE
73.95
37%
-125
- C1 -
3V01
2
?
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------PPMA
I
-
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
46
PsiBlast_CBE
73.89
37%
-127
- C1 -
3V04
2
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------PPMA
I
-
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
48
PsiBlast_CBE
73.49
37%
-123
- C1 -
3E8N
2
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
---
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------PPMA
I
-
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
34
PsiBlast_CBE
72.28
37%
-121
- C1 -
4U80
2
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------PPMA
I
-
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------------
51
PsiBlast_CBE
72.12
37%
-121
- C1 -
3PP1
1
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
33
PsiBlast_CBE
71.96
37%
-127
- C1 -
4U81
2
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------PPMA
I
-
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
52
PsiBlast_CBE
71.95
37%
-122
- C1 -
3MBL
2
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-------------------
21
PsiBlast_CBE
71.82
51%
-124
- C1 -
3ALN
1
MP2K4_HUMAN
B:
[6-307]
------------------------------------------------------------------------------------------------------
S
G
K
L
K
I
S
P
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
--
D
V
V
M
R
S
S
-
D
C
--
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
--
G
D
C
W
I
C
M
E
L
-
M
--
S
-
T
-
S
F
D
K
F
Y
K
Y
V
Y
SV
L
----
D
-
D
---
V
I
P
--
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
-
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
--------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
--
P
---------------------------------------------
D
P
P
Q
L
S
N
SE
E
--
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
A
----------------
45
PsiBlast_CBE
71.80
37%
-122
- C1 -
3VVH
2
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
--------
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPDA
K
E
L
E
L
M
F-----------------PPMA
I
-
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
100
HHSearch
71.57
51%
-125
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[5-311]
-----------------------------------------------------------------------------------------------------
S
S
G
K
L
K
I
S
P
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
--
D
V
V
M
R
S
S
-
D
C
--
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
--
G
D
C
W
I
C
M
E
L
-
M
--
S
-
T
-
S
F
D
K
F
Y
K
Y
----
V
Y
SVL
D
-
D
---
V
I
P
--
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
-
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
---------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
--
P
-----------
K
W
-------------------------
T
Q
V
-
V
K
G
D
P
P
Q
L
S
N
--
S
EE
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
-----------------
35
PsiBlast_CBE
71.35
37%
-119
- C1 -
4U7Z
2
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
---
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------PPMA
I
-
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
41
PsiBlast_CBE
71.32
37%
-122
- C1 -
4LMN
2
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
--
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------PPMA
I
-
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
31
PsiBlast_CBE
70.98
37%
-125
- C1 -
3EQB
2
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------PPMA
I
-
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
32
PsiBlast_CBE
70.77
37%
-125
- C1 -
2P55
2
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------PPMA
I
-
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
53
PsiBlast_CBE
70.74
37%
-125
- C1 -
3DV3
3
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
------
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
4
PsiBlast_PDB
70.07
51%
-117
- C1 -
3ALO
1
MP2K4_HUMAN
A:
[17-307]
-----------------------------------------------------------------------------------------------------------------
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
--
D
V
V
M
R
S
S
-
D
C
--
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
--
G
D
C
W
I
C
M
E
L
-
M
--
S
-
T
-
S
F
D
K
F
Y
K
Y
V
Y
SV
L
----
D
-
D
---
V
I
P
--
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
-
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
V
D
S
I
A
K
-
T
R
D
-
A
G
C
R
P
Y
M
A
P
E
R
I
D
-
P
------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
--
P
-----------
K
W
N
------------
S
V
------
F
D
Q
L
T
Q
V
-
V
K
G
D
P
P
Q
L
S
N
S
E
E
--
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
-----------------
29
PsiBlast_CBE
69.68
37%
-122
- C1 -
2Y4I
1
MP2K1_RABIT
C:
[68-377]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
--
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPDAKELELMF
G
C
---------------PMAI--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
A
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-------------------
3
PsiBlast_PDB
69.27
51%
-125
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[5-307]
-----------------------------------------------------------------------------------------------------
S
S
G
K
L
K
I
S
P
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
--
D
V
V
M
R
S
S
-
D
C
--
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
--
G
D
C
W
I
C
M
E
L
-
M
--
S
-
T
-
S
F
D
K
F
Y
K
Y
V
Y
SV
L
----
D
-
D
---
V
I
P
--
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
-
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
---------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
--
P
-----------
K
W
-------------------------
T
Q
V
-
V
K
G
D
P
P
Q
L
S
N
SE
E
--
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
-----------------
44
PsiBlast_CBE
69.22
37%
-120
- C1 -
3VVH
2
?
B:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
--
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F-----------------MA
I
---
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
49
PsiBlast_CBE
69.16
37%
-123
- C1 -
3DY7
2
MP2K1_HUMAN
A:
[6-304]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
------
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PP--------------------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
------------------------------------
42
PsiBlast_CBE
68.87
37%
-119
- C1 -
4ARK
2
MP2K1_HUMAN
A:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
--
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPDAKELELMF-----------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
43
PsiBlast_CBE
68.27
37%
-118
- C1 -
3VVH
2
?
C:
[6-315]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
F
--
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPDA------------------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-------------------
12
PsiBlast_PDB
68.18
41%
-117
- C1 -
3WIG
3
MP2K1_HUMAN
A:
[6-283]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
PP
P
----------------------------PPMA
I
-
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
--------------------
17
PsiBlast_PDB
68.10
35%
-109
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[6-342]
----------------------------------------------------------------------------------------
E
L
E
L
D
E
--
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
-
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F
G
C
---------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
18
PsiBlast_PDB
67.09
35%
-107
- C1 -
3EQD
1
MP2K1_HUMAN
A:
[6-342]
----------------------------------------------------------------------------------------
E
L
E
L
D
E
--
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
-
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F
G
C
---------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
26
PsiBlast_CBE
66.97
35%
-112
- C1 -
3ZLX
1
MP2K1_HUMAN
A:
[4-340]
----------------------------------------------------------------------------------------
E
L
E
L
D
E
--
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
-
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F
G
C
---------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
6
PsiBlast_PDB
66.66
46%
-107
- C1 -
3VN9
1
MP2K6_HUMAN
A:
[44-333]
---------------------------------------------------------------------------------------------------------------
Q
N
F
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
A
T
V
N
S
Q
E
Q
K
R
L
L
M
D
L
--
D
I
S
M
R
T
V
-
D
C
--
P
F
T
V
T
F
Y
G
A
L
F
R
E
--
G
D
V
W
I
C
M
E
L
-
M
--
D
-
T
-
S
L
D
K
F
Y
K
Q
----
V
I
D
K
-
G
-
Q
---
T
I
P
--
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
-
L
G
Q
V
K
M
C
D
F
G
I
S
G
Y
L
V
D
S
V
A
K
-
T
I
D
-
A
G
C
K
P
Y
M
A
P
E
R
I
N
-
P
E
L
N
Q
K
G
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
--
D
-----------
S
W
G
------------
T
P
------
F
Q
Q
L
K
Q
V
-
V
E
E
P
S
P
Q
L
P
A
--
D
---
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
D
-------------------
14
PsiBlast_PDB
66.59
41%
-113
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[9-276]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
---
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
---
R
-----------
P
P
M
------------
A
I
------
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
A
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-------------------
15
PsiBlast_PDB
66.44
41%
-113
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[9-276]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
--
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
---
R
-----------
P
P
M
------------
A
I
------
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
A
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-------------------
30
PsiBlast_CBE
66.41
35%
-110
- C1 -
3ZLW
1
MP2K1_HUMAN
A:
[4-340]
----------------------------------------------------------------------------------------
E
L
E
L
D
E
--
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
-
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
A
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F
G
C
---------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
16
PsiBlast_PDB
66.23
41%
-115
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[9-276]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
---
R
-----------
P
P
M
------------
A
I
------
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
A
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-------------------
9
PsiBlast_PDB
66.15
40%
-119
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[3-296]
-----------------------------------------------------------------------------------------------
L
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
-
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
--------
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
G
----------------------------A
I
----
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
-----------------
104
HHSearch
65.88
32%
-112
- C1 -
4OBO
2
M4K4_HUMAN
A:
[26-311]
------------------------------------------------------------------------------------------------------------------------
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-------
E
I
K
L
E
I
--
N
M
L
K
K
Y
S
-
H
H
--
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SD
D
Q
L
W
L
V
M
E
F
-
C
--
G
-
A
G
S
I
T
D
L
V
K
N
----
T
----
K
G
N
---
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
----------
R
-
N
T
F
-
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
--
C
-----------
D
M
-------------
H
P
------
M
R
A
L
F
L
I
-
P
R
N
P
P
P
R
L
K
---
S
--
K
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
-
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-----------------
20
PsiBlast_PDB
65.74
35%
-105
- C1 -
3EQG
2
MP2K1_HUMAN
A:
[6-342]
----------------------------------------------------------------------------------------
E
L
E
L
D
E
--
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
-
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F
G
C
---------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-------------------
10
PsiBlast_PDB
65.73
41%
-114
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[6-283]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
PP-----------------------------PPMA
I
-
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
--------------------
24
PsiBlast_CBE
65.12
35%
-107
- C1 -
3EQH
2
MP2K1_HUMAN
A:
[6-342]
----------------------------------------------------------------------------------------
E
L
E
L
D
E
--
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
-
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F
G
C
---------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-------------------
28
PsiBlast_CBE
64.90
35%
-113
- C1 -
3ZLY
1
MP2K1_HUMAN
A:
[5-340]
-----------------------------------------------------------------------------------------
L
E
L
D
E
--
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
-
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F
G
C
---------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
27
PsiBlast_CBE
64.88
35%
-110
- C1 -
3ZLS
1
MP2K1_HUMAN
A:
[4-340]
----------------------------------------------------------------------------------------
E
L
E
L
D
E
--
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
-
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F
G
C
---------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
23
PsiBlast_CBE
64.77
35%
-106
- C1 -
3EQI
1
MP2K1_HUMAN
A:
[6-342]
----------------------------------------------------------------------------------------
E
L
E
L
D
E
--
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
-
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F
G
C
---------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
25
PsiBlast_CBE
64.33
35%
-109
- C1 -
3ZM4
1
MP2K1_HUMAN
A:
[5-340]
-----------------------------------------------------------------------------------------
L
E
L
D
E
--
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
-
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
-------
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F
G
C
---------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
-
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
19
PsiBlast_PDB
63.37
35%
-109
- C1 -
3EQF
1
MP2K1_HUMAN
A:
[6-342]
----------------------------------------------------------------------------------------
E
L
E
L
D
E
--
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
-
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F
G
C
---------------PMA
I
--
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-------------------
11
PsiBlast_PDB
62.75
41%
-120
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[6-283]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P------------------------------MA
I
---
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
------
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
----------------------
36
PsiBlast_CBE
62.44
35%
-106
- C1 -
3W8Q
1
MP2K1_HUMAN
A:
[2-337]
-----------------------------------------------------------------------------------------
L
E
L
D
E
--
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
-
Q
K
V
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
-
S
-
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
--
P
PPD
A
K
E
L
E
L
M
F
G
C
Q
--------------RPPMA
I
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
G
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------
13
PsiBlast_PDB
61.93
41%
-115
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[9-276]
----------------------------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
--
Q
V
L
---
H
-
E
C
NS
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
--
G
E
I
S
I
C
M
E
H
-
M
DG
G
-
S
-
L
D
Q
V
L
K
K
----------
A
-
G
---
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
--
N
E
F
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
-----
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
---
R
-----------
P
P
M
------------
A
I
------
F
E
L
L
D
Y
I
-
V
N
E
P
P
P
K
L
P
S
--
A
--
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
-------------------
79
PsiBlast_CBE
55.05
32%
-101
- C1 -
2CLQ
1
B:
[30-283]
------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-----
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
--
K
N
I
V
Q
Y
L
G
S
F
S
E
N
--
G
F
I
K
I
F
M
E
Q
-
V
P-
G
-
G
-
S
L
S
A
L
L
R
S
----
K
----
W
-
G
---
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
-----------
E
L
G
------------
E
P
------
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------
82
PsiBlast_CBE
54.30
32%
-99
- C1 -
4BIE
2
M3K5_HUMAN
A:
[27-280]
------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-----
P
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
--
K
N
I
V
Q
Y
L
G
S
F
S
E
N
--
G
F
I
K
I
F
M
E
Q
-
V
P-
G
-
G
-
S
L
S
A
L
L
R
S
----
K
----
W
-
G
---
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
-------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
-----------
E
L
G
------------
E
P
------
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------
83
PsiBlast_CBE
53.80
32%
-96
- C1 -
4BID
1
B:
[27-280]
------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-----
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
--
K
N
I
V
Q
Y
L
G
S
F
S
E
N
--
G
F
I
K
I
F
M
E
Q
-
V
P-
G
-
G
-
S
L
S
A
L
L
R
S
----
K
----
W
-
G
---
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
----------F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
-----------
E
L
G
------------
E
P
------
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------
85
PsiBlast_CBE
53.57
32%
-97
- C1 -
4BIC
2
M3K5_HUMAN
A:
[27-280]
------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-----
P
E
-----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
--
K
N
I
V
Q
Y
L
G
S
F
S
E
N
--
G
F
I
K
I
F
M
E
Q
-
V
P
-
G
-
G
-
S
L
S
A
L
L
R
S
----
K
----
W
-
G
---
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
-------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
-----------
E
L
G
------------
E
P
------
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------
84
PsiBlast_CBE
53.24
32%
-96
- C1 -
4BIC
2
B:
[27-280]
------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-----
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
--
K
N
I
V
Q
Y
L
G
S
F
S
E
N
--
G
F
I
K
I
F
M
E
Q
-
V
P-
G
-
G
-
S
L
S
A
L
L
R
S
----
K
----
W
-
G
---
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
-----------
E
L
G
------------
E
P
------
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
------------------------------------
81
PsiBlast_CBE
53.14
32%
-94
- C1 -
4BIE
2
B:
[27-280]
------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-----
P
E
R
-------
L
H
E
E
I
A
L
H
K
H
L
K
H
--
K
N
I
V
Q
Y
L
G
S
F
S
E
N
--
G
F
I
K
I
F
M
E
Q
-
V
P-
G
-
G
-
S
L
S
A
L
L
R
S
----
K
----
W
-
G
---
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
-----------
E
L
G
------------
E
P
------
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
------------------------------------
54
PsiBlast_CBE
53.12
36%
-106
- C1 -
4NZW
1
STK25_HUMAN
B:
[25-275]
---------------------------------------------------------------------------------------------------------------------------
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
---
T
V
L
S
Q
C
-
D
S
--
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
--
T
K
L
W
I
I
M
E
Y
-
L
--
G
---
G
G
S
A
L
D
L
L
----
K
----
P
-
G
---
P
L
E
--
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
G
---------------
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
--
S
-----------
D
L
H
------------
P
-------
M
R
V
L
F
L
I
-
P
K
N
S
P
P
T
L
E
G
--
Q
--
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
-----------------
86
PsiBlast_CBE
52.56
32%
-95
- C1 -
4BIB
1
B:
[27-280]
------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-----
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
--
K
N
I
V
Q
Y
L
G
S
F
S
E
N
--
G
F
I
K
I
F
M
E
Q
-
V
P-
G
-
G
-
S
L
S
A
L
L
R
S
----
K
----
W
-
G
---
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
----------F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
-----------
E
L
G
------------
E
P
------
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------
80
PsiBlast_CBE
52.50
32%
-96
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[30-283]
------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-----
P
E
R
D
S
---
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
--
K
N
I
V
Q
Y
L
G
S
F
S
E
N
--
G
F
I
K
I
F
M
E
Q
-
V
P-
G
-
G
-
S
L
S
A
L
L
R
S
----
K
----
W
-
G
---
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
------
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
-----------
E
L
G
------------
E
P
------
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------
89
PsiBlast_CBE
52.46
32%
-95
- C1 -
4BF2
2
M3K5_HUMAN
A:
[43-296]
------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-----
P
E
---------E-
E
I
A
L
H
K
H
L
K
H
--
K
N
I
V
Q
Y
L
G
S
F
S
E
N
--
G
F
I
K
I
F
M
E
Q
-
V
P-
G
-
G
-
S
L
S
A
L
L
R
S
----
K
----
W
-
G
---
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
-----------
E
L
G
------------
E
P
------
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
--------------------------------------
88
PsiBlast_CBE
52.15
32%
-95
- C1 -
4BF2
1
B:
[43-296]
------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-----
P
E
R
--------E-
E
I
A
L
H
K
H
L
K
H
--
K
N
I
V
Q
Y
L
G
S
F
S
E
N
--
G
F
I
K
I
F
M
E
Q
-
V
P-
G
-
G
-
S
L
S
A
L
L
R
S
----
K
----
W
-
G
---
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
-----------
E
L
G
------------
E
P
------
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-------------------------------------
87
PsiBlast_CBE
52.00
32%
-96
- C1 -
4BHN
2
B:
[43-295]
------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
-----
P
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
--
K
N
I
V
Q
Y
L
G
S
F
S
E
N
--
G
F
I
K
I
F
M
E
Q
-
V
P
-
G
-
G
-
S
L
S
A
L
L
R
S
----
K
----
W
-
G
---
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
---
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
--
Y
-----------
E
L
G
------------
E
P
------
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
E
--
S
--
M
--
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
---------------------------------------
73
PsiBlast_CBE
51.58
31%
-108
- C1 -
4EQU
2
STK10_HUMAN
B:
[22-279]
-------------------------------------------------------------------------------------------------------------------------
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
E
I
--
E
I
-
L
A
T
C
-
D
H
--
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
--
G
K
L
W
I
M
I
E
F
-
C
P-
G
-
G
-
A
V
D
A
I
M
L
E
----
L
----
D
-
R
---
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---------F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
--
H
-----------
E
L
N
------------
P
-------
M
R
V
L
L
K
I
-
A
K
S
D
P
P
T
L
L
T
--
P
--
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
----------------
57
PsiBlast_CBE
51.18
34%
-89
- C1 -
4O27
1
STK24_HUMAN
B:
[11-260]
---------------------------------------------------------------------------------------------------------------------------
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
---
T
V
L
S
Q
C
-
D
S
--
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
--
T
K
L
W
I
I
M
E
Y
-
L
--
G
---
G
G
S
A
L
D
L
L
----
E
----
P
-
G
---
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
E
F
-
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
--
S
-----------
E
L
H
------------
P
-------
M
K
V
L
F
L
I
-
P
K
N
N
P
P
T
L
E
G
--
N
----
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
----------------
67
PsiBlast_CBE
48.02
32%
-98
- C1 -
2J51
5
SLK_HUMAN
A:
[40-297]
-------------------------------------------------------------------------------------------------------------------------
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
-
V
L
A
A
A
K
V
I
D
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
--
D
I
-
L
A
S
C
-
D
H
--
P
N
I
V
K
L
L
D
A
F
Y
Y
E
--
N
N
L
W
I
L
I
E
F
C
A
--
G
-
G
-
A
V
D
A
V
M
L
E
----
L
----
E
-
R
---
P
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
--
H
-----------
E
L
N
------------
P
-------
M
R
V
L
L
K
I
-
A
K
S
E
P
P
T
L
A
Q
--
P
--
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
-----------------------
66
PsiBlast_CBE
47.66
32%
-97
- C1 -
2UV2
6
SLK_HUMAN
A:
[40-297]
-------------------------------------------------------------------------------------------------------------------------
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
-
V
L
A
A
A
K
V
I
D
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
--
D
I
-
L
A
S
C
-
D
H
--
P
N
I
V
K
L
L
D
A
F
Y
Y
E
--
N
N
L
W
I
L
I
E
F
C
A
--
G
-
G
-
A
V
D
A
V
M
L
E
----
L
----
E
-
R
---
P
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
--
H
-----------
E
L
N
------------
P
-------
M
R
V
L
L
K
I
-
A
K
S
E
P
P
T
L
A
Q
--
P
--
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
-----------------------
60
PsiBlast_CBE
46.23
34%
-94
- C1 -
4FZF
1
?
B:
[13-260]
---------------------------------------------------------------------------------------------------------------------------
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
---
T
V
L
S
Q
C
-
D
S
--
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
--
S
K
L
W
I
I
M
E
Y
-
L
--
G
---
G
G
S
A
L
D
L
L
----
R
----
A
-
G
---
P
F
D
--
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
-
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
--
S
-----------
D
M
H
------------
P
-------
M
R
V
L
F
L
I
-
P
K
N
N
P
P
T
L
V
G
--
D
----
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
----------------