@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MRCKA_HUMAN: (2015-10-14 )
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQFERSPSCTPASKGRRTVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDSPRHSTASNSSNLSSPPSPASPRKTKSLSLESTDRGSWDP
Atome Classification :
(59 SA)
.........10........20........30........40........50........60........70........80........90.....---...100.......110....-.-..120.......130........140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.....-..310.......320---...-....---330.--........340...--....350-..--......360.......370.......380.......390......----.400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSG
E
V
R
L
R
Q
L
E
Q
F
I
LDGPAQTN
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
ECNNSP
L
R
R
E
K
N
I
L
E
Y
L
E
WAK
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
GRGAFG
E
V
A
V
V
K
L---KNA
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
-
E
T
A
C
F
REER
D
V
L
V-NGDN
K
W
I
T
T
L
H
Y
A
FQDDN
N
L
Y
L
V
M
D
YYVG
G
D
L
L
T
L
L
S
K
F
E
D
R
L
P
E
D
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
RDIKPD
N
I
L
MDMNG
H
I
R
L
A
D
F
G
S
C
L
K
L
M
EDGTVQSSVAVGTPDYI
S
P
E
I
L
Q
A
M
EDGKGRYGPEC
D
W
W
S
L
G
V
C
M
Y
E
M
LYGETP
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
K
E
R
FQFPAQV-TDVSE
N
A
K
D
L
I
R
R
L
I
---
C
S
R
-
E
HRL---G--Q--N
G
I
E
D
F
K
KHPFFSG--IDWDNI--RN--CEAPYIPEVSSPTDTSNFDV
D
D
D
C
LKNSETMPPPTHTAFSGHHL
P
----
F
V
G
F
T
YT
S
S
C
V
LSDR
S
C
L
R
VTAGP
T
S
L
D
L
D
V
N
V
Q
R
TLDN
N
L
A
T
E
A
Y
E
R
R
I
K
R
L
E
Q
E
K
L
E
L
S
R
K
L
Q
E
S
T
Q
T
V
Q
A
L
Q
YSTVDGPLTASKDL
E
I
K
N
L
K
E
E
I
E
K
L
R
K
Q
VT
E
S
S
H
L
E
Q
Q
L
E
E
A
N
A
V
R
Q
E
L
D
D
A
F
R
Q
I
K
A
Y
E
K
Q
I
K
T
L
Q
Q
E
R
E
D
L
N
K
E
L
V
Q
A
S
E
R
L
K
N
Q
S
K
E
L
K
D
A
H
C
Q
R
K
L
A
M
Q
E
F
M
E
I
N
E
R
L
T
E
L
H
T
Q
K
Q
K
L
A
R
H
VRD
K
E
E
E
V
D
L
V
M
Q
K
V
E
S
L
R
Q
E
L
R
R
T
E
R
A
K
K
E
L
E
V
H
T
E
A
L
A
A
E
ASK
D
R
K
L
R
E
Q
S
E
H
Y
S
K
Q
L
E
N
E
L
E
G
L
K
Q
KQISYSPGVC
S
I
E
H
Q
Q
E
I
T
K
L
K
T
D
L
E
K
K
S
I
F
Y
E
E
E
L
S
KREGI
H
A
N
E
I
K
N
L
K
K
E
LHDSEG
Q
Q
L
ALNK
E
I
M
I
L
K
D
K
L
E
K
T
R
R
E
S
Q
S
E
R
E
E
F
E
S
E
F
K
Q
Q
Y
E
RE
K
V
L
L
TEE
N
K
K
L
T
S
E
L
D
K
L
T
T
L
Y
E
NLSI
H
N
Q
Q
L
E
E
E
V
K
D
L
A
D
K
K
E
S
V
A
H
W
E
A
Q
I
T
E
I
I
Q
W
VSDEK
D
A
R
G
Y
L
Q
A
L
A
S
K
M
T
E
E
L
E
A
L
RNSSLGTRATDM
P
W
K
M
R
R
F
A
KL
D
M
S
A
R
L
E
L
Q
S
AL
D
A
E
I
R
A
K
Q
A
I
Q
E
E
L
N
K
V
K
A
S
N
I
I
T
E
C
KLKDSEK
K
N
L
E
L
L
S
E
I
E
Q
L
I
K
D
T
E
E
L
R
S
EKGIEHQDSQH
S
F
L
A
F
LNTP
T
D
A
L
D
Q
F
ERSPSCTPASKGRRTVDSTP
L
S
VHTP
T
L
RKKGCPGSTGFPPKR
K
T
H
Q
F
F
V
K
SFTT
P
T
K
C
H
Q
C
T
S
L
M
V
G
L
I
RQGCSC
E
V
CG
F
S
C
H
I
T
C
VNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKPA
G
V
K
K
G
W
Q
R
A
L
A
I
V
CD
F
K
L
F
L
Y
DIAEGKASQ
P
S
V
V
I
S
Q
V
IDMRDEEF
S
V
S
S
V
L
A
S
D
V
I
HASRKDI
P
C
I
F
R
V
T
A
S
Q
LSASNN
K
C
S
I
L
M
L
ADTENE
K
N
K
W
V
G
V
L
S
E
L
H
K
I
L
K
KNKFRDRSVYV
P
K
EAYDSTL
P
L
I
KTT
Q
A
A
A
I
I
D
H
E
R
I
ALGNEE
G
L
F
V
V
H
VTKD
E
I
I
RVGDN
K
K
I
H
Q
I
E
L
IPND
Q
L
V
A
V
I
SGRN
R
H
V
R
L
F
P
MSALDGRET
D
F
Y
K
LSETKG
C
Q
TVTSGKV
R
H
G
A
L
T
C
L
C
V
A
M
K
R
Q
V
L
C
Y
E
L
F
Q
S
K
T
RHR
K
F
K
E
I
QVPYN
V
Q
W
M
A
I
F
S
E
Q
L
C
V
G
F
QSG
F
L
RYPLNGEGN
P
Y
S
M
LHSND
H
T
L
S
F
I
AHQPM
D
A
I
C
A
V
E
ISS
K
E
Y
L
L
C
FNSIGIYTDCQGRRS
R
Q
Q
ELMWPANPSSCCYNAP
Y
L
S
V
YSEN
A
V
D
I
F
DVN
S
M
E
W
I
Q
TLPLKKVRPLNNEG
S
L
N
L
L
G
L
E
T
I
R
L
I
Y
F
KNKMAEGD
E
L
VVPETSD
N
S
R
K
Q
M
V
R
NINNK
R
R
Y
S
F
RV
P
E
E
E
R
M
Q
Q
R
R
E
M
LR
D
P
E
M
R
N
K
LISNPTNFNHIAHMGPG
D
G
I
Q
I
L
K
DLPMNPRPQES
R
T
V
F
SGSVSIPSITKSRPEPGRSMSASSGLSARSSAQN
G
S
A
L
K
R
EFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDSPRHSTASNSSNLSSPPSPASPRKT
K
S
L
SLESTDRGSWDP
1
PsiBlast_PDB
99.35
99%
-93
- C3 -
4AW2
5
MRCKA_RAT
A:
[1-416]
-
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
T
N
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
---
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
-
E
T
A
C
F
R
E
E
R
D
V
L
V
-
N
G
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
G
G
K
G
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
K
E
R
F
Q
F
P
T
Q
V
-
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
---
C
S
R
-
E
H
R
L
---
G
--
Q
--
N
G
I
E
D
F
K
K
H
P
F
F
S
G
--
I
D
W
D
N
I
--
R
N
--
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
------------------
S
G
H
H
L
P
----
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
94.06
79%
-86
- C3 -
3TKU
3
MRCKB_HUMAN
A:
[18-431]
-
S
A
K
V
R
L
K
K
L
E
Q
L
L
L
D
G
P
W
R
-
N
E
S
A
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
---
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
-
E
T
A
C
F
R
E
E
R
D
V
L
V
-
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
-
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
---
C
S
R
-
E
R
R
L
---
G
--
Q
--
N
G
I
E
D
F
K
K
H
A
F
F
E
G
--
L
N
W
E
N
I
--
R
N
--
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
-------------------
S
G
L
H
L
P
----
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
93.98
79%
-89
- C3 -
3TKU
3
MRCKB_HUMAN
B:
[18-431]
-
S
A
K
V
R
L
K
K
L
E
Q
L
L
L
D
G
P
W
R
-
N
E
S
A
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
---
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
-
E
T
A
C
F
R
E
E
R
D
V
L
V
-
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
-
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
---
C
S
R
-
E
R
R
L
---
G
--
Q
--
N
G
I
E
D
F
K
K
H
A
F
F
E
G
--
L
N
W
E
N
I
--
R
N
--
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
-------------------
F
S
G
L
H
L
P
----
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
93.40
79%
-92
- C3 -
4UAK
2
MRCKB_HUMAN
A:
[4-418]
-
S
A
K
V
R
L
K
K
L
E
Q
L
L
L
D
G
P
W
R
-
N
E
S
A
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
---
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
-
E
T
A
C
F
R
E
E
R
D
V
L
V
-
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
-
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
---
C
S
R
-
E
R
R
L
---
G
--
Q
--
N
G
I
E
D
F
K
K
H
A
F
F
E
G
--
L
N
W
E
N
I
--
R
N
--
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
---------------
S
H
T
G
F
S
G
L
H
L
P
----
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
93.18
79%
-93
- C3 -
4UAL
2
MRCKB_HUMAN
A:
[4-418]
-
S
A
K
V
R
L
K
K
L
E
Q
L
L
L
D
G
P
W
R
-
N
E
S
A
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
---
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
-
E
T
A
C
F
R
E
E
R
D
V
L
V
-
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
---
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
--
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
-
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
---
C
S
R
-
E
R
R
L
---
G
--
Q
--
N
G
I
E
D
F
K
K
H
A
F
F
E
G
--
L
N
W
E
N
I
--
R
N
--
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
---------
I
L
P
P
--
H
T
G
F
S
G
L
H
L
P
----
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.91
79%
-89
- C3 -
3QFV
2
MRCKB_HUMAN
A:
[2-415]
-
S
A
K
V
R
L
K
K
L
E
Q
L
L
L
D
G
P
W
R
-
N
E
S
A
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
---
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
-
E
T
A
C
F
R
E
E
R
D
V
L
V
-
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
-
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
---
C
S
R
-
E
R
R
L
---
G
--
Q
--
N
G
I
E
D
F
K
K
H
A
F
F
E
G
--
L
N
W
E
N
I
--
R
N
--
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
-------------------
S
G
L
H
L
P
----
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
92.90
79%
-88
- C3 -
3QFV
3
MRCKB_HUMAN
B:
[2-415]
-
S
A
K
V
R
L
K
K
L
E
Q
L
L
L
D
G
P
W
R
-
N
E
S
A
L
S
V
E
T
L
L
D
V
L
V
C
L
Y
T
E
C
S
H
S
A
L
R
R
D
K
Y
V
A
E
F
L
E
W
A
K
P
F
T
Q
L
V
K
E
M
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
---
K
N
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
-
E
T
A
C
F
R
E
E
R
D
V
L
V
-
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
-
T
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
---
C
S
R
-
E
R
R
L
---
G
--
Q
--
N
G
I
E
D
F
K
K
H
A
F
F
E
G
--
L
N
W
E
N
I
--
R
N
--
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
------------------
G
F
S
G
L
H
L
P
----
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
80.50
48%
-79
- C3 -
2F2U
1
ROCK2_BOVIN
B:
[12-400]
------
Q
R
K
L
E
A
L
I
R
D
P
R
S
P
I
N
-----
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
L
C
F
P
E
D
--
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
Q
H
P
F
F
K
N
DQ
W
N
W
D
N
I
--
R
E
--
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
--------
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
I
G
F
T
Y
Y
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.44
48%
-82
- C3 -
4YVC
1
ROCK1_HUMAN
A:
[6-402]
-
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-------
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
-------
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
R
R
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
80.16
48%
-79
- C3 -
5BML
1
ROCK1_HUMAN
B:
[5-402]
M
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
---
E
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
80.06
48%
-84
- C3 -
2F2U
1
ROCK2_BOVIN
A:
[12-400]
------
Q
R
K
L
E
A
L
I
R
D
P
R
S
P
I
N
-----
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
L
C
F
P
E
D
--
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
Q
H
P
F
F
K
N
DQ
W
N
W
D
N
I
--
R
E
--
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
-----
V
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
I
G
F
T
Y
Y
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
79.89
48%
-77
- C3 -
2H9V
1
ROCK2_BOVIN
A:
[10-400]
----
S
R
Q
R
K
L
E
A
L
I
R
D
P
R
S
P
I
N
-----
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
L
C
F
P
E
D
--
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
Q
H
P
F
F
K
N
DQ
W
N
W
D
N
I
--
R
E
--
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
----------
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
I
G
F
T
Y
Y
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
79.61
49%
-81
- C3 -
4L6Q
1
ROCK2_HUMAN
B:
[12-400]
------
Q
R
K
L
E
A
L
I
R
D
P
R
S
P
I
N
-----
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
L
C
F
P
E
D
--
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
DQ
W
H
W
D
N
I
--
R
E
--
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
D
D
---
V
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
I
G
F
T
Y
Y
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
79.41
48%
-78
- C3 -
3D9V
1
ROCK1_HUMAN
B:
[5-402]
M
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
79.40
48%
-77
- C3 -
2ETR
1
ROCK1_HUMAN
B:
[5-402]
M
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
79.40
48%
-83
- C3 -
5BML
1
ROCK1_HUMAN
A:
[6-402]
-
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
----
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
-----
E
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
R
R
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
79.28
48%
-81
- C3 -
2ETR
1
ROCK1_HUMAN
A:
[6-402]
-
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
R
R
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
79.24
48%
-79
- C3 -
2ETK
1
ROCK1_HUMAN
B:
[5-402]
M
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.09
48%
-79
- C3 -
2ESM
1
ROCK1_HUMAN
A:
[6-402]
-
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
R
R
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
78.97
48%
-80
- C3 -
4YVC
1
ROCK1_HUMAN
B:
[5-402]
M
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
------
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
78.74
48%
-82
- C3 -
2ETK
1
ROCK1_HUMAN
A:
[6-402]
-
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
R
R
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
78.66
48%
-78
- C3 -
2ESM
1
ROCK1_HUMAN
B:
[5-402]
M
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
78.60
49%
-84
- C3 -
4L6Q
1
ROCK2_HUMAN
A:
[12-400]
------
Q
R
K
L
E
A
L
I
R
D
P
R
S
P
I
N
-----
V
E
S
L
L
D
G
L
N
S
L
V
L
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
R
G
L
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
L
C
F
P
E
D
--
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
DQ
W
H
W
D
N
I
--
R
E
--
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
D
D
---
V
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
I
G
F
T
Y
Y
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
78.52
48%
-82
- C3 -
4YVE
1
ROCK1_HUMAN
A:
[6-402]
-
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
------
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
R
R
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.35
48%
-79
- C3 -
3D9V
1
ROCK1_HUMAN
A:
[6-402]
-
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
R
R
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.93
48%
-76
- C3 -
2V55
1
ROCK1_HUMAN
A:
[6-402]
-
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
------
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
R
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
77.54
48%
-79
- C3 -
4YVE
1
ROCK1_HUMAN
B:
[5-402]
M
S
F
E
T
R
F
E
K
M
D
N
L
L
R
D
P
K
S
E
V
N
S
D
C
-----
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
---
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
-
D
S
A
F
F
W
E
E
R
D
I
M
A
-
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-
Q
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
--
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
---
T
D
R
-
E
V
R
L
---
G
--
R
--
N
G
V
E
E
I
K
R
H
L
F
F
K
N
DQ
W
A
W
E
T
L
--
R
D
--
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
-----
E
E
E
T
F
P
I
P
--
K
A
F
V
G
N
Q
L
P
----
F
V
G
F
T
Y
Y
S
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
70.69
34%
-71
- C3 -
1O6K
1
AKT2_HUMAN
A:
[1-333]
----------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
-
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
------
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
---
K
K
D
-
P
K
Q
R
LGG
G
--
P
--
S
D
A
K
E
V
M
E
H
R
F
F
L
S
--
I
N
W
Q
D
V
V
Q
K
K
--
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
-----------
Q
R
T
H
----
F
P
Q
F
D
Y
S
A
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
70.62
34%
-73
* C3 *
2X39
1
AKT2_HUMAN
A:
[6-340]
----------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
-
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
------
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
---
K
K
D
-
P
K
Q
R
LGG
G
--
P
--
S
D
A
K
E
V
M
E
H
R
F
F
L
S
--
I
N
W
Q
D
V
V
Q
K
K
--
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
------------
Q
E
M
----
F
E
D
F
D
Y
I
A
D
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
70.44
34%
-70
- C3 -
1O6L
1
AKT2_HUMAN
A:
[1-335]
----------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
-
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
------
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
---
K
K
D
-
P
K
Q
R
LGG
G
--
P
--
S
D
A
K
E
V
M
E
H
R
F
F
L
S
--
I
N
W
Q
D
V
V
Q
K
K
--
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
------------
Q
E
M
----
F
E
D
F
D
Y
I
A
D
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
70.33
34%
-71
- C3 -
2JDO
2
AKT2_HUMAN
A:
[6-340]
----------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
-
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
------
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
---
K
K
D
-
P
K
Q
R
LGG
G
--
P
--
S
D
A
K
E
V
M
E
H
R
F
F
L
S
--
I
N
W
Q
D
V
V
Q
K
K
--
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
--------------
M
----
F
E
D
F
D
Y
I
A
D
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
70.11
34%
-70
- C3 -
2JDR
1
AKT2_HUMAN
A:
[6-340]
----------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
-
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
------
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
---
K
K
D
-
P
K
Q
R
LGG
G
--
P
--
S
D
A
K
E
V
M
E
H
R
F
F
L
S
--
I
N
W
Q
D
V
V
Q
K
K
--
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
------------
Q
E
M
----
F
E
D
F
D
Y
I
A
D
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
69.99
34%
-71
- C3 -
3E8D
1
AKT2_HUMAN
A:
[1-333]
----------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
-
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
------
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
---
K
K
D
-
P
K
Q
R
LGG
G
--
P
--
S
D
A
K
E
V
M
E
H
R
F
F
L
S
--
I
N
W
Q
D
V
V
Q
K
K
--
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
---------------H---
F
P
Q
F
D
Y
S
A
S
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
69.67
34%
-71
- C3 -
3E8D
1
AKT2_HUMAN
B:
[1-333]
----------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
-
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
------
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
---
K
K
D
-
P
K
Q
R
LGG
G
--
P
--
S
D
A
K
E
V
M
E
H
R
F
F
L
S
--
I
N
W
Q
D
V
VQ
K
K
--
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
----------------QRTH
F
P
Q
F
D
Y
S
A
S
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
69.37
34%
-72
- C3 -
2XH5
1
AKT2_HUMAN
A:
[6-340]
----------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
-
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
------
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
---
K
K
D
-
P
K
Q
R
LGG
G
--
P
--
S
D
A
K
E
V
M
E
H
R
F
F
L
S
--
I
N
W
Q
D
V
VQ
K
K
--
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
------------
Q
E
M
----
F
E
D
F
D
Y
I
A
D
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
69.04
36%
-68
- C3 -
2OJF
1
KAPCA_BOVIN
E:
[30-329]
---------------------------------------------------------
K
W
E
N
P
-----
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
-
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
----
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
------
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q--
V
D
L
-
T
K
R
F
---
G
NL
K
--
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
A
I
YQ
R
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
68.71
36%
-68
- C3 -
2F7E
1
KAPCA_BOVIN
E:
[30-329]
---------------------------------------------------------
K
W
E
N
P
-----
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
-
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
----
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
------
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q--
V
D
L
-
T
K
R
F
---
G
NL
K
--
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
A
I
YQ
R
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
68.61
34%
-70
- C3 -
2UW9
1
AKT2_HUMAN
A:
[6-340]
----------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
-
E
V
A
H
T
V
T
E
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
------
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
---
K
K
D
-
P
K
Q
R
LGG
G
--
P
--
S
D
A
K
E
V
M
E
H
R
F
F
L
S
--
I
N
W
Q
D
V
V
Q
K
K
--
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
--
D
D
E
F
T
A
Q
S
I
T
------------
Q
E
M
----
F
E
D
F
D
Y
I
A
D
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
67.93
36%
-66
- C3 -
2F7X
1
KAPCA_BOVIN
E:
[30-329]
---------------------------------------------------------
K
W
E
N
P
-----
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
-
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
----
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
------
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q--
V
D
L
-
T
K
R
F
---
G
NL
K
--
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
A
I
YQ
R
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
67.02
39%
-78
- C3 -
2R5T
1
SGK1_HUMAN
A:
[39-320]
---------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
H
-----
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
------
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q--
K
D
R
-
T
K
R
L
---
G
A-
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
--
I
N
W
D
D
L
--
I
N
KK
I
T
P
P
F
N
P
N
V
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
66.85
36%
-70
- C3 -
2OH0
1
KAPCA_BOVIN
E:
[30-329]
---------------------------------------------------------
K
W
E
N
P
-----
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
-
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
----
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
------
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q--
V
D
L
-
T
K
R
F
---
G
NL
K
--
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
A
I
YQ
R
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
66.35
35%
-58
- C3 -
4L43
1
KS6B1_HUMAN
A:
[14-344]
----------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
-
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
------------
G
T
I
E
Y
M
A
P
E
I
L
--
M
R
S
G
H
N
R
---
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
--
K
C
K
L
N
L
P
P
Y
L
-
T
---
Q
E
A
R
D
L
L
K
K
L
L
KRN
A
A
S
-
R
L
G
A
---
G
--
P
--
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
--
I
N
W
E
E
L
L
A
R
K
--
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
--
D
S
K
F
T
R
Q
T
P
V
----------
S
A
N
Q
V
----
F
L
G
F
A
Y
V
A
P
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
66.26
35%
-67
- C3 -
2UZU
1
KAPCA_BOVIN
E:
[15-314]
---------------------------------------------------------
K
W
E
N
P
-----
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
-
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
----
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
------
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q--
V
D
L
-
T
K
R
F
---
G
NL
K
--
D
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
A
I
YQ
R
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
66.06
39%
-74
- C3 -
3HDM
1
SGK1_HUMAN
A:
[39-320]
---------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
H
-----
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
------
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q--
K
D
R
-
T
K
R
L
---
G
A-
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
--
I
N
W
D
D
L
--
I
N
KK
I
T
P
P
F
N
P
N
V
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
66.05
39%
-61
- C3 -
4NW6
1
KS6A3_HUMAN
A:
[32-322]
----------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
-
R
-
D
R
V
R
T
K
M
E
R
D
I
L
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
-
K
E
S
I
D
H
E
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
----
L
S
P
E
A
Q
S
L
L
R
M
L
F
---
K
R
N
P
A
N
R
L
---
G
--
A
GP
D
G
V
E
E
I
K
R
H
S
F
F
S
T
--
I
D
W
N
K
L
Y
R
R
E
--
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
66.05
36%
-73
- C3 -
2F7Z
1
KAPCA_BOVIN
E:
[30-329]
---------------------------------------------------------
K
W
E
N
P
-----
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
-
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
----
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
------
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q--
V
D
L
-
T
K
R
F
---
G
NL
K
--
N
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
A
I
YQ
R
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
65.99
35%
-71
- C3 -
2UZT
1
KAPCA_BOVIN
A:
[15-314]
---------------------------------------------------------
K
W
E
N
P
-----
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
-
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
----
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
------
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q--
V
D
L
-
T
K
R
F
---
G
NL
K
--
D
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
A
I
Y
Q
R
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
65.92
34%
-69
- C3 -
4L46
1
KS6B1_HUMAN
A:
[14-346]
----------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
-
D
T
A
H
T
K
A
E
R
N
I
L
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
-----
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
P
Y
----
L
T
Q
E
A
R
D
L
L
K
K
L
L
---
K
R
N
A
A
S
R
L
GA-
G
--
P
--
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
--
I
N
W
E
E
L
L
A
R
K
--
V
E
P
P
F
K
P
L
---
E
E
D
V
S
Q
F
--
D
S
K
F
T
R
Q
T
P
V
-------------
Q
V
----
F
L
G
F
T
Y
V
A
P
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
65.85
35%
-67
- C3 -
2UZW
1
KAPCA_BOVIN
E:
[15-314]
---------------------------------------------------------
K
W
E
N
P
-----
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
-
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
----
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
------
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q--
V
D
L
-
T
K
R
F
---
G
NL
K
--
D
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
A
I
YQ
R
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
65.81
39%
-63
- C3 -
5D9L
2
?
A:
[32-322]
----------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
-
R
-
D
R
V
R
T
K
M
E
R
D
I
L
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
-
K
E
------------
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
----
L
S
P
E
A
Q
S
L
L
R
M
L
F
---
K
R
N
P
A
N
R
L
---
G
--
A
GP
D
G
V
E
E
I
K
R
H
S
F
F
S
T
--
I
D
W
N
K
L
Y
R
R
E
--
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
65.58
39%
-61
- C3 -
4NW5
1
KS6A3_HUMAN
A:
[32-322]
----------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
-
R
-
D
R
V
R
T
K
M
E
R
D
I
L
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
-
K
E
S
I
D
H
E
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
----
L
S
P
E
A
Q
S
L
L
R
M
L
F
---
K
R
N
P
A
N
R
L
---
G
--
A
GP
D
G
V
E
E
I
K
R
H
S
F
F
S
T
--
I
D
W
N
K
L
Y
R
R
E
--
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
65.38
34%
-72
- C3 -
4L42
1
KS6B1_HUMAN
A:
[14-344]
----------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
-
D
T
A
H
T
K
A
E
R
N
I
L
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
-
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
P
Y
----
L
T
Q
E
A
R
D
L
L
K
K
L
L
---
K
R
N
A
A
S
R
L
GA-
G
--
P
--
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
--
I
N
W
E
E
L
L
A
R
K
--
V
E
P
P
F
K
-------------------------------------
E
M
----
F
R
D
F
E
Y
I
A
D
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
65.16
39%
-71
- C3 -
3HDN
1
SGK1_HUMAN
A:
[39-316]
---------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
T
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
H
-----
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
------
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q--
K
D
R
-
T
K
R
L
---
G
A-
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
--
I
N
W
D
D
L
--
I
N
KK
I
T
P
P
F
N
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
65.04
39%
-73
- C3 -
5D9K
2
?
A:
[32-322]
----------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
-
R
-
D
R
V
R
T
K
M
E
R
D
I
L
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
-
K
------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
----
L
S
P
E
A
Q
S
L
L
R
M
L
F
---
K
R
N
P
A
N
R
L
---
G
--
A
GP
D
G
V
E
E
I
K
R
H
S
F
F
S
T
--
I
D
W
N
K
L
Y
R
R
E
--
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
64.85
35%
-57
- C3 -
4L44
1
KS6B1_HUMAN
A:
[14-344]
----------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
-
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
-----
H
T
F
C
-
G
T
I
E
Y
M
A
P
E
I
L
--
M
R
S
G
H
N
R
---
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
--
K
C
K
L
N
L
P
P
Y
L
-
T
---
Q
E
A
R
D
L
L
K
K
L
L
KRN
A
A
S
-
R
L
G
A
---
G
--
P
--
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
--
I
N
W
E
E
L
L
A
R
K
--
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
---
D
S
K
F
T
R
Q
T
----------
S
E
S
A
N
Q
V
----
F
L
G
F
A
Y
V
A
P
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
64.65
39%
-72
- C3 -
5D9K
2
?
B:
[32-322]
----------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
-
R
-
D
R
V
R
T
K
M
E
R
D
I
L
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
-
K
E
-----------
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
----
L
S
P
E
A
Q
S
L
L
R
M
L
F
---
K
R
N
P
A
N
R
L
---
G
--
A
GP
D
G
V
E
E
I
K
R
H
S
F
F
S
T
--
I
D
W
N
K
L
Y
R
R
E
--
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
64.12
39%
-69
- C3 -
3G51
1
KS6A3_MOUSE
A:
[26-304]
----------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
-
R
-
D
---------
I
L
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
-
K
E
S
I
-----------
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
----
L
S
P
E
A
Q
S
L
L
R
M
L
F
---
K
R
N
P
A
N
R
L
---
G
--
A
GP
D
G
V
E
E
I
K
R
H
S
F
F
S
T
--
I
D
W
N
K
L
Y
R
R
E
--
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
62.61
39%
-64
- C3 -
4NUS
1
KS6A3_HUMAN
A:
[32-322]
----------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
-
A
T
L
K
V
-
R
-
D
R
V
R
T
K
M
E
R
D
I
L
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
-
K
E
S
I
D
H
E
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
T
M
T
M
I
L
--
K
A
K
L
G
M
P
Q
F
----
L
S
P
E
A
Q
S
L
L
R
M
L
F
---
K
R
N
P
A
N
R
L
---
G
--
A
GP
D
G
V
E
E
I
K
R
H
S
F
F
S
T
--
I
D
W
N
K
L
Y
R
R
E
--
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
33.62
35%
40
- C3 -
2UZV
1
KAPCA_BOVIN
A:
[15-314]
---------------------------------------------------------
K
W
E
N
P
-----
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
-
Q
I
E
H
T
L
N
E
K
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
----
K
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
------
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q--
V
D
L
-
T
K
R
F
---
G
NL
K
--
D
G
V
N
D
I
K
N
H
K
W
F
A
T
--
T
D
W
I
A
I
Y
Q
R
K
--
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------