@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MYLK2_HUMAN: (2015-10-15 )
MATENGAVELGIQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASEKGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGSQDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVPMTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV
Atome Classification :
(58 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......----320--.------.------...--...-330.......340........350.......360.......370.---.----------------------------------....-.380.......390.......400.......410..--.--.-.-.--.--420--........430....---.-..440.......450..--.--..--..460.......470.......480.......-490.......500.......510.......520.......530.......540.......550-..-.....--.-560.......570.......580.......590....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATEN
G
A
V
E
L
G
IQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASEKGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGSQDPGKPRVGKKAAEG
Q
A
AARRGS
P
A
F
L
HSPSCPAIISSS
E
K
L
LAKKPPSEASE
L
T
FEGVPMTHSPTDPRPA
K
A
E
E
G
K
N
I
L
A
E
S
Q
K
E
VGEKTPGQAGQAKMQGDTSRG
I
E
F
Q
AVPS
E
K
S
E
V
G
Q
A
L
C
LTAR
E
E
D
C
F
Q
I
L
DDCPPPPAPFP
H
R
M
V
E
L
RTGNVSSEFSMNSKEALGGG
K
F
G
A
V
C
T
C
M
E
KAT
G
L
K
L
A
A
K
V
I
K
KQ----TP---K------D------K
E
M
--
V
L
L
-
E
I
E
V
M
N
QLN
H
R
-
N
L
I
Q
L
Y
A
A
IETPH
E
I
V
L
F
M
E
Y
IE
G
G
E
L
F
E
R
I
V
D---E----------------------------------DYHL-
T
E
V
D
T
M
V
F
V
R
Q
I
C
D
G
I
L
F
M
H
K
M
R
V
L
H
L
DLKPE
N
I
L
C
--V--N-T-T--G--H-
L
--
V
K
I
I
D
F
G
L
ARRYNPN---E-
K
L
K
V
NFGTPEFLSPEVV--
N
--
Y
D--QISDKTD
M
W
S
M
G
V
I
T
Y
M
L
L
SGL
S
P
FLGDD
D
T
E
-
T
L
N
N
V
LSG
N
W
Y
F
D
E
E
T
F
E
A
V
S
D
E
A
K
D
F
V
S
N
L
I
V
K
D
Q
R
ARM
N
A
A
Q
C
L
A
H
P
W
L
N
N
L
A
E
K
A
K
R
C
N
--
R
R
-
L
K
S
Q
I
--
L
-
L
K
K
Y
L
M
K
R
R
WKK
N
F
I
A
V
S
A
A
N
R
F
K
K
ISSSG
A
L
M
A
LGV
1
PsiBlast_PDB
93.99
60%
-119
- C2 -
2X4F
4
MYLK4_HUMAN
A:
[65-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
----
G
M
---
K
------
D
------
K
E
E
--
V
K
N
-
E
I
S
V
M
N
Q
L
D
H
A
-
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
---
E
----------------------------------
S
Y
N
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
--
V
--
N
-
R
-
D
--
A
--
K
-
Q
--
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
---
E
-
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
--
N
--
Y
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
-
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
-----
H
K
L
H
--
S
R
-
L
S
A
Q
------------------------------------------
21
PsiBlast_CBE
92.97
60%
-123
- C2 -
2X4F
3
MYLK4_HUMAN
B:
[66-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
----
G
M
---
K
------
D
------
K
E
E
--
V
K
N
-
E
I
S
V
M
N
Q
L
D
H
A
-
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
---
E
----------------------------------
S
Y
N
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
--
V
--
N
-
R
-
D
--
A
--
K
-
Q
--
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
---
E
-
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
--
N
--
Y
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
-
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
-----
H
K
L
H
--
S
R
-
L
---------------------------------------------
119
HHSearch
92.41
61%
-123
* C2 *
2X4F
4
MYLK4_HUMAN
A:
[65-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
----
G
M
---
K
------
D
------
K
E
E
--
V
K
N
-
E
I
S
V
M
N
Q
L
D
H
A
-
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
---
E
----------------------------------
S
Y
N
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
--
V
--
N
-
R
-
D
--
A
--
K
-
Q
--
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
---
E
-
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
--
N
--
Y
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
-
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
S
R
L
S
A
--
Q
------------------------------------------------
38
PsiBlast_CBE
83.85
42%
-116
- C2 -
2Y0A
1
DAPK1_HUMAN
A:
[4-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
--
K
A
-
S
A
V
N
M
--
E
-
K
F
K
K
F
A
A
R
-----------------------------
126
HHSearch
83.37
40%
-102
- C2 -
2Y0A
1
DAPK1_HUMAN
A:
[4-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
SSRRGV
S
------
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
--------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
--
D
-
R
-
N
VP
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
--
K
A
S
A
V
N
M
E
--
K
-
F
K
K
F
A
A
R
------------------------------
53
PsiBlast_CBE
82.25
42%
-106
- C2 -
3GU5
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
13
PsiBlast_PDB
82.07
42%
-113
- C2 -
2W4K
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
--
K
A
-
S
A
V
N
M
--
E
-
K
F
K
K
F
A
A
R
-----------------------------
10
PsiBlast_PDB
81.96
42%
-106
- C2 -
3DFC
1
DAPK1_HUMAN
B:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
41
PsiBlast_CBE
81.91
42%
-102
- C2 -
2W4J
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
------------------------------------------------------------
12
PsiBlast_PDB
81.84
42%
-114
- C2 -
4B4L
3
DAPK1_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
--
K
A
-
S
A
V
N
M
--
E
-
K
F
K
K
F
A
A
A
K
----------------------------
54
PsiBlast_CBE
81.78
42%
-104
- C2 -
3GU4
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
45
PsiBlast_CBE
81.62
42%
-105
- C2 -
3EHA
1
DAPK1_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
------------------------------------
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
18
PsiBlast_PDB
81.29
42%
-101
- C2 -
3F5U
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
52
PsiBlast_CBE
80.73
42%
-104
- C2 -
3GU6
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
16
PsiBlast_PDB
80.63
41%
-114
- C2 -
4TXC
7
DAPK1_HUMAN
A:
[21-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
------------------------------------------------------------
43
PsiBlast_CBE
80.60
42%
-105
- C2 -
4YO4
1
DAPK1_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
E
K
--------------------------------------------------------
19
PsiBlast_PDB
80.53
42%
-113
- C2 -
2YAK
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-----------------------------------------------------------
46
PsiBlast_CBE
80.52
42%
-107
- C2 -
3EH9
1
DAPK1_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRGVS-
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
------------------------------------
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
51
PsiBlast_CBE
80.33
42%
-105
- C2 -
3GU7
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
42
PsiBlast_CBE
79.88
42%
-106
- C2 -
4YPD
1
DAPK1_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
K
-------------------------------------------------------
64
PsiBlast_CBE
79.86
42%
-108
- C2 -
3GUB
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
----------------------------------------------------------
65
PsiBlast_CBE
79.78
42%
-108
- C2 -
3GU8
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
----------------------------------------------------------
23
PsiBlast_CBE
79.76
40%
-106
- C2 -
2CKE
1
DAPK2_HUMAN
D:
[18-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
S
---
R
ASRRGV
S
------
R
E
E
--
I
E
R
-
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---
K
----------------------------------
E
-
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
--
D
-
K
-
N
--
I
--
P
-
I
PH
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
M
V
R
--
R
E
-
S
V
V
N
L
--
E
N
F
R
K
Q
Y
V
-------------------------------
49
PsiBlast_CBE
79.53
42%
-107
- C2 -
1IG1
1
DAPK1_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
134
HHSearch
79.33
33%
-102
- C2 -
3NYV
1
?
A:
[20-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
A
I
F
S
D
R
Y
K
G
Q
--
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
V
KQK
T
------
D
------
K
E
S
--
L
L
R
-
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
-----------------------------------
K
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
--
S
-
K
-
S
K-
D
--
A
-
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
--
G
---
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
-----
D
VP
S
L
-
D
N
A
I
L
--
N
-
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
48
PsiBlast_CBE
79.11
42%
-107
- C2 -
1JKK
1
DAPK1_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
F
-----------------------------------------------------------
17
PsiBlast_PDB
79.10
42%
-112
- C2 -
4UV0
1
?
A:
[5-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
--
K
A
-
C
A
V
N
M
--
E
-
K
F
K
K
F
A
A
R
-----------------------------
36
PsiBlast_CBE
78.94
42%
-111
- C2 -
1WVY
1
DAPK1_HUMAN
A:
[4-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------
30
PsiBlast_CBE
78.87
40%
-110
- C2 -
2YAA
1
DAPK2_MOUSE
B:
[18-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
S
---
R
------
A
SRRGVC
R
E
E
--
I
E
R
-
E
V
S
I
L
R
Q
V
L
H
P
-
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---
K
----------------------------------
E
-
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
--
D
-
K
-
N
--
I
--
P
-
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
--
R
E
-
S
V
V
N
L
--
E
N
F
K
K
Q
Y
V
-------------------------------
34
PsiBlast_CBE
78.60
42%
-119
- C2 -
3ZXT
1
DAPK1_HUMAN
B:
[7-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
RRGVS-
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
-------------------------------------
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
--------------
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------
63
PsiBlast_CBE
78.38
41%
-114
- C2 -
2XUU
1
DAPK1_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
--
K
A
-
S
A
V
N
M
--
E
-
K
F
K
K
F
A
A
R
-----------------------------
47
PsiBlast_CBE
78.33
42%
-107
- C2 -
1JKL
1
DAPK1_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
35
PsiBlast_CBE
77.97
42%
-123
- C2 -
3ZXT
1
DAPK1_HUMAN
A:
[7-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
-----------------
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR--
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
----------------
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------
24
PsiBlast_CBE
77.93
40%
-107
- C2 -
2CKE
1
DAPK2_HUMAN
C:
[18-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
S
---
R
ASRRGV
S
------
R
E
E
--
I
E
R
-
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---
K
----------------------------------
E
-
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
--
D
-
K
-
N
--
I
--
P
-
I
PH
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
M
V
R
--
R
E
-
S
V
V
N
L
--
E
N
F
R
K
Q
Y
V
-------------------------------
32
PsiBlast_CBE
77.39
42%
-130
- C2 -
3ZXT
1
DAPK1_HUMAN
D:
[7-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------------------VS----
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
-------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
--------------
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------
6
PsiBlast_PDB
77.21
40%
-109
- C2 -
2CKE
1
DAPK2_HUMAN
A:
[18-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
S
---
R
ASR
R
G
V
S
------
R
E
E
--
I
E
R
-
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---
K
----------------------------------
E
-
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
--
D
-
K
-
N
--
I
--
P
-
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
M
V
R
--
R
E
-
S
V
V
N
L
--
E
N
F
R
K
Q
Y
V
-------------------------------
33
PsiBlast_CBE
77.11
42%
-121
- C2 -
3ZXT
1
DAPK1_HUMAN
C:
[5-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---
K
----------------------------------
E
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
--
K
--
P
-
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
---------------
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------
136
HHSearch
77.03
33%
-107
- C2 -
3HKO
2
?
A:
[26-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
Y
H
L
--
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q-----
K
------
D
------
V
E
R
--
I
K
T
-
E
V
R
L
M
K
K
L
H
H
P
-
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
D
D
STG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
-
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
--
S
--
T
-
N
-
K
--
S
--
F
-
E
--
I
K
L
V
D
F
G
L
S
K
E
F
Y
K
L
NNG-------
A
G
T
P
Y
F
V
A
P
E
V
L
--
N
--
T
T
NE
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
D
-
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
D
K
I
Y
K
M
S
---------------------------------------------------
25
PsiBlast_CBE
76.72
40%
-109
- C2 -
2CKE
1
DAPK2_HUMAN
B:
[18-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
S
---
R
ASR
R
G
V
S
------
R
E
E
--
I
E
R
-
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---
K
----------------------------------
E
-
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
--
D
-
K
-
N
--
I
--
P
-
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
M
V
R
--
R
E
-
S
V
V
N
L
--
E
N
F
R
K
Q
Y
V
-------------------------------
72
PsiBlast_CBE
75.78
40%
-117
- C2 -
3LM0
2
ST17B_HUMAN
A:
[25-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
N
N
F
Y
I
L
T
S
K
E
-
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
----
R
R
---
G
------
Q
DC----
R
A
E
--
I
L
H
-
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
---
E
----------------------------------
L
A
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
SS
I
--
Y
-
P
-
L
--
G
--
D
----
I
K
I
V
D
F
G
M
S
R
K
I
-------------
M
G
T
P
E
Y
L
A
P
E
I
L
--
N
--
Y
D
--
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
N
Q
E
-
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
Q
W
D
F
E
N
L
F
H
P
---------------------------------------------------
50
PsiBlast_CBE
75.70
42%
-105
- C2 -
1P4F
1
DAPK1_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
T
---
K
------
S
SRRGVS
R
E
D
--
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
----------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
DR
N
-
V
-
P
-------
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
----------------------------------------------------------
9
PsiBlast_PDB
75.39
40%
-109
- C2 -
2YAA
1
DAPK2_MOUSE
A:
[18-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
S
---
R
------
A
SRRGVC
R
E
E
--
I
E
R
-
E
V
S
I
L
R
Q
V
L
H
P
-
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
---
K
----------------------------------
E
-
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
--
D
-
K
-
N
--
I
--
P
-
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
--
R
E
-
S
V
V
N
L
--
E
N
F
K
K
Q
Y
V
-------------------------------
131
HHSearch
75.30
33%
-117
- C2 -
3Q5I
1
?
A:
[26-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
R
K
K
E
G
K
I
G
E
S
Y
F
K
V
--
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
----------
K
------
F
------
H
E
E
--
I
Y
N
-
E
I
S
L
L
K
S
L
D
H
P
-
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
--------------------------------------
R
H
K
F
-
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
--
E
--
N
-
K
-
N
--
S
L-
L
-
N
--
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
---
Y
-
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
--
K
--
K
---
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
D
Q
D
-
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
K
Y
A
N
N
I
N
K
S
D
--
Q
K
-
T
L
C
G
A
L
S
N
-
M
R
K
F
E
G
S
Q
K
L
A
Q
A
A
I
L
F
I
G
S
K
L
T
T
L
E
E
R
K
E
L
T
D
I
F
K
K
133
HHSearch
75.16
36%
-98
- C2 -
2W4O
1
KCC4_HUMAN
A:
[50-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
D
F
F
E
V
E
--
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
----------------------------------
I
G
V
L
L
R
L
S
H
P
-
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
---
K
----------------------------------
G
-
Y
Y
-
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
A
--
T
-
P
-
A
P-
D
--
A
-
P
--
L
K
I
A
D
F
--------------------
G
T
P
G
Y
C
A
P
E
I
L
--
R
--
G
C
--
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
A
A
---
N
F
V
--
H
M
-
D
T
A
Q
K
--
K
-
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
----------------
139
HHSearch
74.45
34%
-112
- C2 -
3F3Z
5
?
A:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
N
Q
Y
Y
T
L
--
E
N
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
P
K
Y
----
F
V
---
E
------
D
------
V
D
R
--
F
K
Q
-
E
I
E
I
M
K
S
L
D
H
P
-
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
---
K
-----------------------------------
R
V
F
-
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
--
L
--
T
-
D
S
P
--
D
--
S
-
P
--
L
K
L
I
D
F
G
L
A
A
R
F
K
P
G
---
K
-
M
M
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
--
E
--
G
---
L
Y
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
A
P
T
D
S
E
-
V
M
L
K
I
R
E
G
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
A
L
E
H
E
W
F
E
K
Q
L
S
S
S
P
R
N
L
--
L
------------------------------------------------
71
PsiBlast_CBE
74.36
40%
-118
- C2 -
3LM5
1
ST17B_HUMAN
A:
[25-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
N
N
F
Y
I
L
T
S
K
E
-
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
----
R
R
---
G
------
Q
DC----
R
A
E
--
I
L
H
-
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
---
E
----------------------------------
L
-
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
SS
I
--
Y
-
P
-
L
--
G
--
D
----
I
K
I
V
D
F
G
M
S
R
K
I
-------------
M
G
T
P
E
Y
L
A
P
E
I
L
--
N
--
Y
D
--
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
N
Q
E
-
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
Q
W
D
F
E
N
L
------------------------------------------------------
89
PsiBlast_CBE
74.13
35%
-106
- C2 -
3MA6
1
?
A:
[29-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
D
R
Y
--
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
V
---
K
QKT---
D
------
K
E
S
--
L
L
R
-
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
--
S
-
K
-
S
--
K
--
D
-
A
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
-
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
GT
Y
D
--
E
---
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
---------------------------------------------------------
106
PsiBlast_CBE
73.33
35%
-109
- C2 -
3N51
3
?
A:
[22-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
F
S
D
R
Y
--
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
V
---
K
QKT---
D
------
K
E
S
--
L
L
R
-
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
--
S
-
K
-
S
--
K
--
D
-
A
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
GT
Y
D
--
E
---
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
V
D
--
V
P
-
S
L
D
N
A
--
I
-
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
127
HHSearch
71.91
32%
-88
- C2 -
3SOA
1
KCC2A_HUMAN
A:
[7-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
T
E
E
Y
Q
L
--
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
----
K
L
SA-
R
------
D
------
H
Q
K
--
L
E
R
-
E
A
R
I
C
R
L
L
K
H
P
-
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---
R
----------------------------------
E
-
Y
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
--
A
--
S
-
K
L
K
--
G
--
A
-
A
--
V
K
L
A
D
F
G
L
A
I
E
V
E
G
E
---
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
D
--
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
---
H
R
-
Q
E
T
V
D
--
C
-
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
N
F
S
V
R
K
Q
E
I
I
K
V
T
E
Q
73
PsiBlast_CBE
71.75
34%
-121
- C2 -
3LIJ
1
?
A:
[15-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
Q
--
G
D
L
Q
A
T
P
G
M
F
----
I
T
S
K
K
G
H
L
S
E
M
Y
Q
R
V
K
K
--
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
----------
S
------
S
------
N
S
K
--
L
L
E
-
E
V
A
V
L
K
L
L
D
H
P
-
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
---
R
-----------------------------------
M
K
F
-
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
--
S
-
K
-
E
--
K
--
D
A
L
--
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
---
K
-
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
--
R
KK
Y
D
--
E
---
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
-
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
M
C
S
K
K
E
S
L
P
--
S
L
-
A
N
A
I
E
--
N
-
M
R
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
S
Q
E
E
T
K
E
L
T
D
I
F
R
H
88
PsiBlast_CBE
71.74
35%
-102
- C2 -
3MA6
1
?
B:
[29-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
D
R
Y
--
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
V
---
K
QT----
D
------
K
E
S
--
L
L
R
-
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
--
S
-
K
-
S
--
K
--
D
-
A
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
GT
Y
D
--
E
---
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
----------------------------------------------------------
132
HHSearch
70.53
33%
-105
- C2 -
4QOX
1
CDPK4_PLAF7
A:
[74-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
N
E
Q
Y
K
G
I
--
K
I
L
G
K
G
S
F
G
E
V
I
L
S
R
D
K
H
T
G
H
E
Y
A
I
K
V
I
S
K
K
----
H
V
KRK
T
------
D
------
K
E
S
--
L
L
R
-
E
V
E
L
L
K
M
L
D
H
I
-
N
I
M
K
L
Y
E
F
F
E
D
N
N
Y
Y
Y
L
V
S
D
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
-----------------------------------
K
R
F
-
Y
E
I
D
A
A
R
I
I
K
Q
I
L
S
G
I
T
Y
M
H
K
N
N
V
V
H
R
D
L
K
P
E
N
I
L
L
--
E
--
T
-
K
-
N
---ED
M
-
I
--
I
K
I
I
D
F
G
L
S
T
H
F
E
Y
S
---------
K
I
G
T
A
Y
Y
I
A
P
D
V
L
--
H
--
G
---
T
Y
D
E
K
C
D
I
W
S
C
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
S
N
E
Y
D
-
I
L
K
K
V
E
A
G
K
Y
T
F
D
L
P
Q
F
K
K
I
S
D
K
A
K
D
L
I
K
K
M
L
M
Y
T
S
A
V
R
I
S
A
R
D
A
L
E
H
E
W
I
K
M
M
T
S
K
--------
L
-
E
L
S
I
A
--
N
-
I
R
Q
F
Q
S
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
T
I
D
E
T
K
E
L
T
K
I
F
K
K
69
PsiBlast_CBE
69.25
34%
-104
- C2 -
2JC6
1
KCC1D_HUMAN
C:
[27-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
----
A
-----------------------
S
I
E
N
E
I
A
V
L
R
K
I
K
H
E
-
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---
K
----------------------------------
G
F
Y
--
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
--
S
-
Q
-
D
--
E
--
E
-
S
K-
I
M
I
S
------------------------
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
G
D
T
A
L
N
K
N
I
H
--
E
S
-
V
S
A
Q
I
-----
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
--------------------
138
HHSearch
69.04
35%
-125
- C2 -
4MVF
2
CDPK2_PLAFK
A:
[52-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
K
L
E
D
K
Y
I
I
D
--
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
E
E
K
K
D
----
R
L
---
K
------
N
------
I
N
R
--
F
F
Q
-
E
I
E
I
M
K
K
L
D
H
P
-
N
I
V
K
L
Y
E
T
Y
E
N
D
N
Y
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
S
I
I
E
--------------------------------------
N
G
S
F
-
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
F
--
Q
--
S
-
E
-
N
K-
D
--
S
-
L
--
L
K
I
I
D
F
G
L
S
K
N
L
----------------------------------
K
Y
D
K
K
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
Y
-----------------
C
F
Y
E
N
D
W
G
S
I
S
S
D
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
T
I
E
E
A
L
N
H
P
W
I
T
Q
M
T
K
S
H
V
E
L
S
--
S
T
-
L
L
K
N
L
--
K
-
N
F
K
K
E
N
E
L
K
K
I
A
L
T
I
I
A
K
H
L
C
D
V
E
I
N
N
L
R
N
I
F
I
A
L
D
V
70
PsiBlast_CBE
68.44
34%
-104
- C2 -
2JC6
1
KCC1D_HUMAN
A:
[27-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
----
A
--------------------
S
--
S
I
E
N
E
I
A
V
L
R
K
I
K
H
E
-
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---
K
----------------------------------
G
F
Y
--
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
--
S
-
Q
-
D
--
E
--
E
-
S
K
-
I
M
I
S
------------------------
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
G
D
T
A
L
N
K
N
I
H
--
E
S
-
V
S
A
Q
I
-----
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
--------------------
77
PsiBlast_CBE
68.14
38%
-111
- C2 -
3IGO
8
?
A:
[30-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
----
S
A
---
K
------
N
------
K
-
T
S
T
I
L
R
-
E
V
E
L
L
K
K
L
D
H
P
-
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
---
R
----------------------------------
K
-
R
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
--
S
-
K
-
E
--
K
--
D
-
C
D
-
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
---
T
--------
T
A
Y
Y
I
A
P
E
V
L
R
G
T
--
Y
D
--
E
---
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
-
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
I
S
--
D
L
-
P
S
L
E
S
--
A
-
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
L
T
E
I
78
PsiBlast_CBE
68.02
37%
-108
- C2 -
2WEI
1
?
A:
[30-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
----
S
A
---
K
------
N
------
K
D
T
S
T
I
L
R
-
E
V
E
L
L
K
K
L
D
H
P
-
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
---
R
----------------------------------
K
-
R
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
--
S
-
K
-
E
--
K
--
D
-
C
D
-
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
---
T
-
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
--
Y
D
--
E
---
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
-
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
--------------------------------------------------------
130
HHSearch
65.94
30%
-100
- C2 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
K
T
F
I
F
M
--
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
-------------------------
S
--
L
E
N
-
E
I
A
V
L
K
K
I
K
H
E
-
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---
R
-----------------------------------
G
V
Y
-
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
L
--
T
P
E
-
E
--
N
--
S
-
K
--
I
M
I
T
D
F
G
L
S
K
M
E
Q
N
G
-----
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
D
I
Y
--
P
S
-
V
S
L
Q
-----
I
Q
K
N
F
A
K
S
-----------------------------