@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MYLK3_HUMAN: (2015-10-15 )
MSGTSKESLGHGGLPGLGKTCLTTMDTKLNMLNEKVDQLLHFQEDVTEKLQSMCRDMGHLERGLHRLEASRAPGPGGADGVPHIDTQAGWPEVLELVRAMQQDAAQHGARLEALFRMVAAVDRAIALVGATFQKSKVADFLMQGRVPWRRGSPGDSPEENKERVEEEGGKPKHVLSTSGVQSDAREPGEESQKADVLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHLPLPTKVEAKAPETPSENLRTGLELAPAPGRVNVVSPSLEVAPGAGQGASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP
Atome Classification :
(71 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540....---...550---.--.------.------...-...560.......570........580.......590.......600..-------------------------------------....-.610.......620.......630.......640..--...-.--.--650.-........660....---..-.-670.......680.....--..690.......700.......710....-...-720.......730.......740.......750.......760.......770.......-780..-...-.--.--.790--.....--...800.......810.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSGTSKESLGHGGLPGL
G
K
T
C
L
T
T
M
D
T
K
L
N
M
L
N
E
K
V
D
Q
L
L
H
F
Q
E
D
V
T
E
K
L
Q
S
M
C
R
D
M
G
H
L
E
R
G
L
H
R
L
EASRAPGPGGADGVPHIDTQAG
W
P
E
V
L
E
L
V
R
A
M
Q
Q
D
A
A
QH
G
A
R
L
E
A
L
F
R
M
V
A
A
V
D
R
A
I
A
L
VGAT
F
Q
K
S
K
V
A
D
F
L
M
QGRVPWRRGSPGDS
P
E
E
N
K
E
R
V
E
EEGGKP
K
H
V
L
STSGVQSDAREPG
E
E
S
Q
K
A
D
V
L
E
G
T
A
E
RLPPIRASGLGA
D
P
A
Q
A
VVSPGQGDGVPGPAQAFPGHLPLPTKVEAKAPETP
S
E
N
L
R
TGLELAPAPG
R
V
N
V
VSPS
L
E
VAPGAGQGASSSRPD
P
E
P
L
EEGTRLTPGPGPQCPGPPGLPAQARATHSGGETP
P
R
I
S
I
H
I
Q
EMDTPG
E
M
L
MTGRGSLGPTLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTP
E
G
A
R
ELSPLQESSSPGGV
K
A
E
E
E
Q
RAGAEPGTRPSLARSDDNDHEV
G
A
L
G
L
QQGKSPGAGNPE
P
E
Q
D
C
AARAP
V
R
A
E
A
V
RRMPPGAEA
G
S
V
V
L
DDSPAPPAPFE
H
R
V
V
S
V
K
ETSIS
A
G
Y
E
V
C
Q
H
EVLGGGRFG
Q
V
H
R
CTEKSTGL
P
L
A
A
K
I
I
---
K
VKS-----A--K------
D
------
R
E
D
-
V
K
N
E
I
N
I
M
N
Q
LSH
V
-
N
L
I
Q
L
Y
D
A
F
ESKH
S
C
T
L
V
M
E
YVD
G
G
E
L
F
D
R
ITDE-------------------------------------KYHL-
T
E
L
D
V
V
L
F
T
R
Q
I
C
E
G
V
H
Y
L
H
Q
H
Y
I
L
H
L
DLKPE
N
I
L
C
--VNQ-T--G--
H
--
Q
-
I
K
I
I
D
F
G
L
ARRYKPR---
E
K
-
L
-
K
V
NFGTPEFLAPEVV
N
Y
E
--
F
VSFP
T
D
M
W
S
V
G
V
I
T
Y
M
L
L
SGL
S
P
F
LGET-DA
E
-
T
M
N
F
I
V
N
C
SWDFD
A
D
T
F
E
G
L
S
E
E
A
K
D
F
V
S
R
L
L
V
K
EKSC
R
M
S
A
T
Q
C
L
K
H
E
W
L
NNLPAKA
S
R
-
S
K
-
T
R
-
L
K
S
-
Q
--
L
--
L
L
Q
---
K
Y
I
A
Q
--
R
K
W
K
K
H
F
Y
V
V
T
A
A
N
R
L
RKFPTSP
116
HHSearch
86.76
70%
-111
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[65-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
---
K
T
R
G
-----
M
--
K
------
D
------
K
E
E
-
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
-
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
-------------------------------------
S
Y
N
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
--
V
N
R
-
D
--
A
--
K
--
Q
-
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
---
E
K
-
L
-
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
-
D
A
E
-
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
S
R
L
-
S
A
-
Q
------------------------------------------------
1
PsiBlast_PDB
84.42
64%
-111
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[65-348]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
---
K
T
R
G
-----
M
--
K
------
D
------
K
E
E
-
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
-
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
-------------------------------------
S
Y
N
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
--
V
N
R
-
D
--
A
--
K
--
Q
-
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
---
E
K
-
L
-
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
-
D
A
E
-
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
S
R
L
-
S
A
-
Q
------------------------------------------------
21
PsiBlast_CBE
83.50
64%
-114
- C1 -
2X4F
3
MYLK4_HUMAN
B:
[66-348]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
---
K
T
R
G
-----
M
--
K
------
D
------
K
E
E
-
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
-
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
-------------------------------------
S
Y
N
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
--
V
N
R
-
D
--
A
--
K
--
Q
-
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
---
E
K
-
L
-
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
-
D
A
E
-
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
S
R
L
-----------------------------------------------------
24
PsiBlast_CBE
72.52
42%
-99
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[4-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
Q
-----
S
--
R
------
A
SRRGVC
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
-
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
-
Q
-------------------------------------
K
E
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
-
N
--
I
--
P
I
P
H
-
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
--
P
V
D
T
Q
Q
-
A
M
-
V
R
-
R
E
S
-
V
--
V
--
N
L
E
---
N
F
K
K
Q
Y
V-----------------------
8
PsiBlast_PDB
72.47
42%
-99
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[6-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
Q
-----
S
--
R
ASR
R
G
V
S
------
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
-
Q
-------------------------------------
K
E
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
-
N
--
I
--
P
I
P
H
-
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
--
P
V
D
N
Q
Q
-
A
M
-
V
R
-
R
E
S
-
V
--
V
--
N
L
E
---
N
F
R
K
Q
YV-----------------------
28
PsiBlast_CBE
71.82
42%
-101
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[6-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
Q
-----
S
--
R
ASR
R
G
V
S
------
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
-
Q
-------------------------------------
K
E
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
-
N
--
I
--
P
I
P
H
-
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
--
P
V
D
N
Q
Q
-
A
M
-
V
R
-
R
E
S
-
V
--
V
--
N
L
E
---
N
F
R
K
Q
Y
V-----------------------
26
PsiBlast_CBE
71.36
42%
-101
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[6-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
Q
-----
S
--
R
ASRRGV
S
------
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
-
Q
-------------------------------------
K
E
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
-
N
--
I
--
P
IP
H
-
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
--
P
V
D
N
Q
Q
-
A
M
-
V
R
-
R
E
S
-
V
--
V
--
N
L
E
---
N
F
R
K
Q
YV-----------------------
27
PsiBlast_CBE
70.79
42%
-100
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[6-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
Q
-----
S
--
R
ASRRGV
S
------
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
-
Q
-------------------------------------
K
E
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
-
N
--
I
--
P
IP
H
-
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
--
P
V
D
N
Q
Q
-
A
M
-
V
R
-
R
E
S
-
V
--
V
--
N
L
E
---
N
F
R
K
Q
YV-----------------------
6
PsiBlast_PDB
70.56
42%
-101
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[4-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
Q
-----
S
--
R
------
A
SRRGVC
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
-
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
-
Q
-------------------------------------
K
E
S
L
-
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
K
-
N
--
I
--
P
I
P
H
-
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
--
P
V
D
T
Q
Q
-
A
M
-
V
R
-
R
E
S
-
V
--
V
--
N
L
E
---
N
F
K
K
Q
Y
V-----------------------
42
PsiBlast_CBE
65.15
46%
-108
- C1 -
4TXC
7
DAPK1_HUMAN
A:
[36-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
------------------------------------------------------------
128
HHSearch
64.60
34%
-106
- C1 -
3Q5I
1
?
A:
[27-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
K
K
E
G
K
I
G
E
S
Y
F
K
V
--
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
---
K
K
----------
K
------
F
------
H
E
E
-
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
-
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
--------------------------------------
R
H
K
F
-
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
--
E
N
K
-
N
--
S
L-
L
--
N
-
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
---
Y
K
-
L
-
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
K
---
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
-
D
Q
D
-
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
K
Y
A
N
N
I
N
K
-
S
D
-
Q
K
-
T
L
C
-
G
A
L
S
--
N
M
R
---
K
F
E
G
S
--
Q
K
L
A
Q
A
A
I
L
F
I
G
S
K
L
T
T
L
E
E
R
K
E
20
PsiBlast_PDB
63.61
46%
-109
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
-
S
R
-
K
A
-
S
A
V
-
N
--
M
--
E
K
F
---
K
K
F
A
A
--
R
----------------------
17
PsiBlast_PDB
63.32
46%
-110
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[19-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
-
S
R
-
K
A
-
S
A
V
-
N
--
M
--
E
K
F
---
K
K
F
A
A
--
A
K
---------------------
71
PsiBlast_CBE
63.23
41%
-108
- C1 -
3LM0
2
ST17B_HUMAN
A:
[37-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
---
K
K
R
R
R----
G
--
Q
------
D
C-----
R
A
E
-
I
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
-------------------------------------
L
A
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
SS
I
Y
P
-
L
--
G
-----
D
-
I
K
I
V
D
F
G
M
S
R
K
I
--------------
M
G
T
P
E
Y
L
A
P
E
I
L
N
Y
D
--
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
-
N
Q
E
-
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
Q
W
D
F
E
N
L
F
-
H
P
--------------------------------------------------
60
PsiBlast_CBE
63.11
46%
-103
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------
137
HHSearch
63.02
35%
-104
- C1 -
3F3Z
5
?
A:
[6-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
N
Q
Y
Y
T
L
--
E
N
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
---
P
K
Y
F
-----
V
--
E
------
D
------
V
D
R
-
F
K
Q
E
I
E
I
M
K
S
L
D
H
P
-
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
K
--------------------------------------
R
V
F
-
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
--
L
T
D
S
P
--
D
--
S
--
P
-
L
K
L
I
D
F
G
L
A
A
R
F
K
P
G
---
K
M
-
M
-
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
E
G
---
L
Y
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
A
P
T
-
D
S
E
-
V
M
L
K
I
R
E
G
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
A
L
E
H
E
W
F
E
K
Q
L
S
S
S
P
R
-
N
L
-
L
------------------------------------------------
124
HHSearch
62.99
43%
-93
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[4-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
SSRRGV
S
------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
--------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
-
S
R
-
K
A
S
A
V
N
-
M
--
E
--
K
F
K
---
K
F
A
A
R
-------------------------
16
PsiBlast_PDB
62.94
44%
-96
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[17-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--
P
K
D
T
Q
Q
-
A
L
-
S
R
-
K
A
S
-
A
--
V
--
N
M
E
---
K
F
K
K
F
--
A
A
R
--------------------
54
PsiBlast_CBE
62.63
46%
-112
- C1 -
4UV0
1
?
A:
[19-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
-
S
R
-
K
A
-
C
A
V
-
N
--
M
--
E
K
F
---
K
K
F
A
A
--
R
----------------------
69
PsiBlast_CBE
62.11
46%
-102
- C1 -
3GU8
1
DAPK1_HUMAN
A:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
----------------------------------------------------------
59
PsiBlast_CBE
62.04
46%
-107
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-----------------------------------------------------------
126
HHSearch
62.00
38%
-112
* C1 *
3LIJ
1
?
A:
[31-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
G
H
L
S
E
M
Y
Q
R
V
--
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
---
R
K
----------
S
------
S
------
N
S
K
-
L
L
E
E
V
A
V
L
K
L
L
D
H
P
-
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
--------------------------------------
R
M
K
F
-
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
E
K-
D
--
A
--
L
-
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
---
K
K
-
M
-
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K
K
---
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
-
D
Q
E
-
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
M
C
S
K
K
E
S
-
L
P
-
S
L
-
A
N
A
-
I
--
E
--
N
M
R
---
K
F
Q
N
S
--
Q
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
S
Q
E
E
T
K
E
63
PsiBlast_CBE
61.49
42%
-97
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[17-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--
P
K
D
T
Q
Q
-
A
L
-
S
R
-
K
A
S
-
A
--
V
--
N
M
E
K
F
K
K
F
A
A
R
-------------------------
133
HHSearch
61.16
34%
-99
- C1 -
3HKO
2
?
A:
[25-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
K
Y
H
L
K
--
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
---
N
K
N
K
I
R
Q-----
K
------
D
------
V
E
R
-
I
K
T
E
V
R
L
M
K
K
L
H
H
P
-
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
-
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
--
S
T
N
-
K
--
S
--
F
--
E
-
I
K
L
V
D
F
G
L
S
K
E
F
Y
K
L
NNG--------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
NE
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
-
D
A
D
-
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
D
K
I
Y
K
-
M
S
--------------------------------------------------
48
PsiBlast_CBE
61.07
46%
-100
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[16-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRGVS-
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
53
PsiBlast_CBE
60.64
46%
-102
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
130
HHSearch
60.24
34%
-92
- C1 -
3NYV
1
?
A:
[23-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
S
D
R
Y
K
G
Q
--
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
VKQ--
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--------------------------------------
K
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
K-
D
--
A
--
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
----D
V
P
-
S
L
-
D
N
A
-
I
--
L
--
N
I
R
---
Q
F
Q
G
T
--
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
47
PsiBlast_CBE
60.20
46%
-99
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[16-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
-
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
84
PsiBlast_CBE
60.15
38%
-104
- C1 -
4MXA
1
?
A:
[34-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
-
V
D
-
V
P
-
S
L
D
-
N
--
A
--
I
L
N
---
I
R
Q
F
Q
--
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
121
HHSearch
59.99
31%
-90
- C1 -
3C0I
1
CSKP_HUMAN
A:
[23-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
--
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
---
D
V
A
K
F
T
S
SP
G
--
L
------
S
------
T
E
D
-
L
K
R
E
A
S
I
C
H
M
L
K
H
P
-
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
----------------------------------
G
F
V
Y
-
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
S
K
-
E
N-
S
--
A
--
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
---
G
L
-
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
--
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
--
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
-
I
H
-
L
P
--
E
T
-
V
--
E
--
Q
L
R
---
K
F
N
A
R
--
R
K
---------------------
97
PsiBlast_CBE
59.81
38%
-105
- C1 -
3UPX
1
?
A:
[33-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
V
P
S
L
-
D
N
-
A
I
-
L
N
I
-
R
--
Q
--
F
Q
G
---
T
Q
K
L
A
--
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
68
PsiBlast_CBE
59.66
46%
-101
- C1 -
3GUB
1
DAPK1_HUMAN
A:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
----------------------------------------------------------
70
PsiBlast_CBE
59.55
41%
-108
- C1 -
3LM5
1
ST17B_HUMAN
A:
[37-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
---
K
K
R
R
R----
G
--
Q
------
D
C-----
R
A
E
-
I
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
-------------------------------------
L
-
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
SS
I
Y
P
-
L
--
G
-----
D
-
I
K
I
V
D
F
G
M
S
R
K
I
--------------
M
G
T
P
E
Y
L
A
P
E
I
L
N
Y
D
--
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
-
N
Q
E
-
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
Q
W
D
F
E
N
L
------------------------------------------------------
131
HHSearch
59.49
34%
-94
- C1 -
3MWU
1
?
A:
[17-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
F
A
E
R
Y
N
I
V
--
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
---
N
K
A
S
AK---
N
--
K
------
D
------
T
S
T
-
I
L
R
E
V
E
L
L
K
K
L
D
H
P
-
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--------------------------------------
K
R
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
E
S
K
-
E
K-
D
--
C
--
D
-
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
---------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
---
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
-
E
Y
D
-
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
-
L
E
S
A
M
--
T
--
N
I
R
---
Q
F
Q
A
E
--
K
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
T
L
D
E
T
K
Q
43
PsiBlast_CBE
59.40
46%
-98
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
106
PsiBlast_CBE
59.36
38%
-97
- C1 -
3MA6
1
?
A:
[39-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
-
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
---------------------------------------------------------
44
PsiBlast_CBE
59.36
46%
-96
- C1 -
4YPD
1
DAPK1_HUMAN
A:
[16-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
K
-------------------------------------------------------
86
PsiBlast_CBE
59.16
38%
-103
- C1 -
4WG5
1
?
A:
[33-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
-
V
D
-
V
P
-
S
L
D
-
N
--
A
--
I
L
N
---
I
R
Q
F
Q
--
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
102
PsiBlast_CBE
58.87
38%
-105
- C1 -
3N51
3
?
A:
[33-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
-
V
D
-
V
P
-
S
L
D
-
N
--
A
--
I
L
N
---
I
R
Q
F
Q
--
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
91
PsiBlast_CBE
58.86
38%
-103
- C1 -
4M84
1
?
A:
[33-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
-
V
D
-
V
P
-
S
L
D
-
N
--
A
--
I
L
N
---
I
R
Q
F
Q
--
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
64
PsiBlast_CBE
58.78
46%
-99
- C1 -
3GU7
1
DAPK1_HUMAN
A:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
51
PsiBlast_CBE
58.59
46%
-98
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[16-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
85
PsiBlast_CBE
58.58
38%
-104
- C1 -
4MX9
1
?
A:
[34-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
-
V
D
-
V
P
-
S
L
D
-
N
--
A
--
I
L
N
---
I
R
Q
F
Q
--
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
66
PsiBlast_CBE
58.54
46%
-99
- C1 -
3GU5
1
DAPK1_HUMAN
A:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
65
PsiBlast_CBE
58.54
46%
-100
- C1 -
3GU6
1
DAPK1_HUMAN
A:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
76
PsiBlast_CBE
58.21
38%
-106
- C1 -
4IHP
1
?
A:
[56-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
-
V
P
-
S
L
-
D
N
A
-
I
--
L
--
N
I
R
---
Q
F
Q
G
T
--
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
62
PsiBlast_CBE
58.13
46%
-97
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
------------------------------------------------------------
129
HHSearch
57.98
33%
-96
- C1 -
4QOX
1
CDPK4_PLAF7
A:
[75-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
E
Q
Y
K
G
I
--
K
I
L
G
K
G
S
F
G
E
V
I
L
S
R
D
K
H
T
G
H
E
Y
A
I
K
V
I
---
S
K
K
H
VKR--
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
E
L
L
K
M
L
D
H
I
-
N
I
M
K
L
Y
E
F
F
E
D
N
N
Y
Y
Y
L
V
S
D
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--------------------------------------
K
R
F
-
Y
E
I
D
A
A
R
I
I
K
Q
I
L
S
G
I
T
Y
M
H
K
N
N
V
V
H
R
D
L
K
P
E
N
I
L
L
--
E
T
K
-
N
---ED
M
--
I
-
I
K
I
I
D
F
G
L
S
T
H
F
E
Y
S
----------
K
I
G
T
A
Y
Y
I
A
P
D
V
L
H
G
T
---
Y
D
E
K
C
D
I
W
S
C
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
S
N
-
E
Y
D
-
I
L
K
K
V
E
A
G
K
Y
T
F
D
L
P
Q
F
K
K
I
S
D
K
A
K
D
L
I
K
K
M
L
M
Y
T
S
A
V
R
I
S
A
R
D
A
L
E
H
E
W
I
K
M
M
T
S
K
--------
L
-
E
L
S
-
I
--
A
--
N
I
R
---
Q
F
Q
S
T
--
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
T
I
D
E
T
K
E
94
PsiBlast_CBE
57.86
38%
-106
- C1 -
3V5P
1
?
A:
[33-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
V
P
S
L
-
D
N
-
A
I
-
L
N
I
-
R
--
Q
--
F
Q
G
---
T
Q
K
L
A
--
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
45
PsiBlast_CBE
57.65
46%
-95
- C1 -
4YO4
1
DAPK1_HUMAN
A:
[16-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
E
K
--------------------------------------------------------
99
PsiBlast_CBE
57.60
38%
-104
- C1 -
3T3U
5
?
A:
[33-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
-
V
D
-
V
P
-
S
L
D
-
N
--
A
--
I
L
N
---
I
R
Q
F
Q
--
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
103
PsiBlast_CBE
57.51
38%
-104
- C1 -
3I7B
4
?
A:
[33-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
-
V
D
-
V
P
-
S
L
D
-
N
--
A
--
I
L
N
---
I
R
Q
F
Q
--
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
57
PsiBlast_CBE
57.47
46%
-111
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
RRGVS-
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
--
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
---------------
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------
100
PsiBlast_CBE
57.39
38%
-102
- C1 -
3SXF
3
?
A:
[33-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
-
V
D
-
V
P
-
S
L
D
-
N
--
A
--
I
L
N
---
I
R
Q
F
Q
--
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
67
PsiBlast_CBE
57.23
46%
-96
- C1 -
3GU4
1
DAPK1_HUMAN
A:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
50
PsiBlast_CBE
56.81
46%
-97
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[16-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
F
-----------------------------------------------------------
135
HHSearch
56.78
32%
-95
- C1 -
4MVF
2
CDPK2_PLAFK
A:
[54-347]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
K
Y
I
I
D
--
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
E
E
---
K
K
D
R
-----
L
--
K
------
N
------
I
N
R
-
F
F
Q
E
I
E
I
M
K
K
L
D
H
P
-
N
I
V
K
L
Y
E
T
Y
E
N
D
N
Y
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
S
I
I
E
--------------------------------------
N
G
S
F
-
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
F
--
Q
S
E
-
N
K-
D
--
S
--
L
-
L
K
I
I
D
F
G
L
S
K
N
L
----------------------------
K
---
Y
D
K
K
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
Y
------------------
C
F
Y
E
N
D
W
G
S
I
S
S
D
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
T
I
E
E
A
L
N
H
P
W
I
T
Q
M
T
K
S
--
H
----
V
E
-
L
S
S
-
T
--
L
L
K
N
L
K
---
N
F
K
K
E
--
N
E
L
K
K
I
A
L
T
I
I
A
K
H
L
C
D
V
E
I
N
N
L
87
PsiBlast_CBE
56.64
38%
-105
- C1 -
4WG4
1
?
A:
[33-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
D
V
P
S
-
L
D
-
N
A
-
I
L
N
-
I
--
R
--
Q
F
Q
---
G
T
Q
K
L
--
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
90
PsiBlast_CBE
56.61
38%
-101
- C1 -
4ONA
1
?
A:
[33-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
-----
K
--
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
-
V
D
-
V
P
-
S
L
D
-
N
--
A
--
I
L
N
---
I
R
Q
F
Q
--
G
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
T
S
Q
D
E
T
49
PsiBlast_CBE
56.60
46%
-98
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[16-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
--------------------------------------------------------
52
PsiBlast_CBE
56.57
46%
-99
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[16-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
----------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP------
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
-
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
----------------------------------------------------------
125
HHSearch
56.51
33%
-79
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
T
E
E
Y
Q
L
F
--
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
---
N
T
K
K
-----
L
SA
R
------
D
------
H
Q
K
-
L
E
R
E
A
R
I
C
R
L
L
K
H
P
-
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-------------------------------------
E
-
Y
Y
-
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
--
A
S
K
L
K
--
G
--
A
--
A
-
V
K
L
A
D
F
G
L
A
I
E
V
E
G
E
---
Q
Q
A
W
-
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
--
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
-
M
--
H
R
-
Q
E
T
-
V
--
D
--
C
L
K
---
K
F
N
A
R
--
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
N
F
S
V
R
K
Q
E
58
PsiBlast_CBE
55.93
46%
-110
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
----------------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
--VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
-----------------
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------
55
PsiBlast_CBE
55.93
46%
-113
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----------------------VS----
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
---------------
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------
134
HHSearch
54.91
38%
-94
- C1 -
2W4O
1
KCC4_HUMAN
A:
[50-346]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
D
F
F
E
V
E
--
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
---
K
K
--------------------------------
I
G
V
L
L
R
L
S
H
P
-
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
-------------------------------------
G
-
Y
Y
-
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
A
T
P
-
A
P-
D
--
A
--
P
-
L
K
I
A
D
F
---------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
--
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
-
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
A
A
N
F
----
V
-
H
M
-
D
T
A
-
Q
--
K
--
K
L
Q
---
E
F
N
A
R
--
R
K
L
K
A
A
V
K
A
V
V
A
S
S
---------
56
PsiBlast_CBE
54.50
46%
-114
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[17-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
-----
T
--
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-
E
-------------------------------------
K
E
S
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
R
-
N
VP
K
--
P
--
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
----------------
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------------------------------------
72
PsiBlast_CBE
53.32
35%
-95
- C1 -
2JC6
1
KCC1D_HUMAN
C:
[28-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
---
P
K
K
A
-------------------------S
I
E
N
E
I
A
V
L
R
K
I
K
H
E
-
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-------------------------------------
G
F
Y
--
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
S
Q
-
D
--
E
--
E
S-
K
-
I
M
I
S
-------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
G
D
T
A
L
N
K
N
-
I
H
-
E
S
-
V
S
A
-
Q
------
I
R
---
K
N
F
A
K
--
S
K
W
R
Q
A
F
N
A
T
-------------
105
PsiBlast_CBE
52.72
38%
-94
- C1 -
3MA6
1
?
B:
[39-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
KR
Q
V
K
Q
--------
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-------------------------------------
K
-
R
F
-
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
E
S
K
-
S
--
K
--
D
A
-
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
D
-
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
----------------------------------------------------------
132
HHSearch
52.36
35%
-91
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[6-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
K
T
F
I
F
M
--
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
---
K
K
S
-------------------------
S
-
L
E
N
E
I
A
V
L
K
K
I
K
H
E
-
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
--------------------------------------
G
V
Y
-
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
L
T
P
E
E
--
N
--
S
--
K
-
I
M
I
T
D
F
G
L
S
K
M
E
Q
N
G
----
I
-
M
-
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
-
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
D
-
I
Y
-
P
S
-
V
S
L
-------
Q
I
Q
---
K
N
F
A
K
--
S
----------------------
83
PsiBlast_CBE
52.23
38%
-92
- C1 -
2W4O
1
KCC4_HUMAN
A:
[61-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
---
K
--
K
------------------------------
I
G
V
L
L
R
L
S
H
P
-
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
-------------------------------------
G
Y
Y
--
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
A
T
P
-
A
--
P
--
D
--
A
P
L
K
I
A
D
F
---------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
--
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
-
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
A
A
N
F
V
H
-
M
D
-
T
----
A
-
Q
--
K
--
K
L
Q
---
E
F
N
A
R
--
R
K
L
K
A
A
V
K
A
V
V
A
S
S
---------
73
PsiBlast_CBE
51.82
35%
-95
- C1 -
2JC6
1
KCC1D_HUMAN
A:
[28-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
---
P
K
K
A
------------------------
S
S
I
E
N
E
I
A
V
L
R
K
I
K
H
E
-
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-------------------------------------
G
F
Y
--
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
S
Q
-
D
--
E
--
E
S
-
K
-
I
M
I
S
-------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
S
K
-
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
G
D
T
A
L
N
K
N
-
I
H
-
E
S
-
V
S
A
-
Q
------
I
R
---
K
N
F
A
K
--
S
K
W
R
Q
A
F
N
A
T
-------------