@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NEK10_HUMAN: (2015-10-15 )
MPDQDKKVKTTEKSTDKQQEITIRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNSMTKSEPAIRAGGHRARGQWHESTEAVELENFSINYKNERNFSKHPQRKLFQEIFTALVKNRLISREWVNRAPSIHFLRVLICLRLLMRDPCYQEILHSLGGIENLAQYMEIVANEYLGYGEEQHTVDKLVNMTYIFQKLAAVKDQREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLAESQECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAEPQVKEQVKLYEGIPVLLSLLHSDHLKLLWSIVWILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDHSSIGSLSSANAAGRIQQLHLSEDLSPREIQENTFSLQAACCAALTELVLNDTNAHQVVQENGVYTIAKLILPNKQKNAAKSNLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFEIFIDIGHYVRDISAYEELVSKLNLLVEDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKLTSVVGTILYSCPEVLKSEPYGEKADVWAVGCILYQMATLSPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTISRCLTPDAEARPDIVEVSSMISDVMMKYLDNLSTSQLSLEKKLERERRRTQRYFMEANRNTVTCHHELAVLSHETFEKASLSSSSSGAASLKSELSESADLPPEGFQASYGKDEDRACDEILSDDNFNLENAEKDTYSEVDDELDISDNSSSSSSSPLKESTFNILKRSFSASGGERQSQTRDFTGGTGSRPRPALLPLDLLLKVPPHMLRAHIKEIEAELVTGWQSHSLPAVILRNLKDHGPQMGTFLWQASAGIAVSQRKVRQISDPIQQILIQLHKIIYITQLPPALHHNLKRRVIERFKKSLFSQQSNPCNLKSEIKKLSQGSPEPIEPNFFTADYHLLHRSSGGNSLSPNDPTGLPTSIELEEGITYEQMQTVIEEVLEESGYYNFTSNRYHSYPWGTKNHPTKR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590....--...600.......610.......620.......630.......640.......-650.......660---.......670......-.680.......690.......700.......710.......720.......730.......740.....---..750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPDQDKKVKTTEKSTDKQ
Q
E
I
T
IR
D
Y
S
D
L
K
R
L
R
C
L
L
NVQSSKQQLPAINFDSAQNSMTKSEP
A
I
RAGGHRARGQWHEST
E
A
V
E
L
E
N
F
S
I
N
YKNERNFSK
H
P
Q
R
K
L
F
Q
E
I
F
T
A
L
V
KNRLI
S
R
E
W
VNRAP
S
I
H
F
L
R
V
L
I
C
L
R
L
L
MRDP
C
Y
Q
E
I
L
H
SLG
G
I
E
N
L
A
Q
Y
M
E
I
V
A
N
E
YLGYGE
E
Q
H
T
V
D
K
L
V
N
M
T
Y
I
F
Q
K
L
A
A
V
K
DQR
E
W
VTTSG
A
H
K
T
L
V
N
L
LGAR
D
T
N
V
L
L
G
S
L
L
A
L
A
S
L
A
E
S
Q
E
C
R
E
K
I
S
E
L
N
I
V
E
N
L
L
M
I
L
H
E
Y
D
L
L
S
K
R
L
T
A
E
L
L
R
L
LCAEP
Q
V
K
E
Q
V
K
L
YE
G
I
P
V
L
L
S
L
L
H
S
D
H
L
K
L
L
W
S
I
V
W
I
L
V
Q
V
CEDPET
S
V
E
I
R
I
W
G
G
I
K
Q
L
L
H
I
LQGDR
N
F
V
SDHSSIGSLSSANAAG
R
I
Q
Q
L
HLSEDL
S
P
R
E
I
Q
E
N
T
F
S
L
Q
A
A
C
C
A
A
L
T
E
L
V
LNDT
N
A
H
Q
V
V
Q
ENG
V
Y
T
I
A
K
L
ILPNKQK
N
A
A
K
S
N
L
L
Q
C
Y
A
F
R
A
L
R
F
L
F
SMERNR
P
L
F
K
R
LF
P
T
D
L
F
E
I
F
I
D
I
G
H
Y
V
R
D
I
S
A
Y
E
E
L
V
S
K
L
N
L
L
V
E
D
E
L
K
Q
I
A
E
N
I
E
S
INQNKA
P
L
K
Y
IG
N
Y
A
I
L
D
HLGSG
A
F
G
C
V
Y
K
V
R
KHSGQ
N
L
L
A
M
K
E
VNLHNPAFGKDKKD
R
D
S
S
V
R
N
I
V
S
E
L
T
I
I
K
E
QLYH
P
N
I
V
R
Y
Y
K
T
F
LE--ND
R
L
Y
I
V
M
E
L
IEGAP
L
G
E
H
F
S
S
L
K
E
K
H
H
H
F
T
E
E
R
L
W
K
I
F
I
Q
L
C
L
A
L
R
Y
L
H
K
E
K
-
R
I
V
HRDLTPNNIM---LGDKD
K
V
T
V
TDFGL
A
K
-
Q
K
QEN
S
K
L
T
S
V
V
G
T
I
L
Y
S
C
P
E
V
LKSEPYGEKA
D
V
W
A
V
G
C
I
L
Y
Q
M
ATLSPPFYS
T
N
M
L
S
L
A
T
K
I
V
E
A
V
YE---PVPE
G
I
Y
S
E
K
V
T
D
T
I
S
R
CLTPDAEARP
D
I
V
E
V
S
S
M
I
S
D
V
M
M
K
Y
L
D
NLS
T
S
Q
L
S
L
E
K
K
L
E
R
E
R
R
R
T
Q
R
Y
F
M
EANR
N
T
V
T
C
H
H
E
L
A
V
L
S
H
E
T
F
E
K
ASLSSSSS
G
A
A
S
L
K
S
E
L
S
ESADLPPEGFQASYGKD
E
D
R
A
C
D
E
I
LSDDNFNLENAEKDTYSEVDDELDISDNSSSSSSSP
L
K
E
S
T
F
N
I
L
K
R
S
FSASGGERQSQTRDFTGGTGSRPRPALL
P
L
D
L
L
L
KV
P
P
H
M
L
R
A
H
I
K
E
I
E
A
E
L
V
TGWQSHS
L
P
A
V
I
L
R
N
L
K
DHGPQM
G
T
F
L
W
QASAGI
A
V
S
Q
R
K
V
R
Q
I
S
D
P
I
Q
Q
I
L
I
Q
L
H
K
I
I
Y
I
TQL
P
P
A
L
H
H
N
L
K
R
R
V
I
E
R
F
K
K
S
L
F
SQQSNPC
N
L
K
S
E
I
K
K
L
SQGSPEPIEPNFFTAD
Y
H
L
L
HRSSGGNSLSPNDPTGLP
T
S
I
E
LEEGI
T
Y
E
Q
M
Q
T
V
I
E
E
V
L
E
ESGYYNFTSN
R
Y
HSYPWGTKNHPTKR
18
PsiBlast_PDB
74.48
33%
-95
- C2 -
2JAV
1
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
----
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D------
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
-----------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.74
33%
-93
- C2 -
2XK6
1
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
-----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
-----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.34
33%
-97
- C2 -
2XKF
1
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.15
33%
-89
- C2 -
2XK4
1
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
--
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.82
33%
-91
- C2 -
2XNO
12
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.56
33%
-95
- C2 -
2XKD
1
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D------
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
--------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
71.47
33%
-90
- C2 -
2XNP
5
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
H
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.24
33%
-91
- C2 -
2XK3
1
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
G
---------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.06
33%
-96
- C2 -
2XK7
1
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.56
33%
-93
- C2 -
2XK8
1
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
70.31
33%
-91
- C2 -
2WQO
1
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
--------
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.04
33%
-90
- C2 -
2XNN
6
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
G
--------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.98
33%
-91
- C2 -
2XNM
10
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
------
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.82
33%
-92
- C2 -
2XKC
1
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-------
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
69.81
33%
-95
- C2 -
2XKE
1
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D------
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
------------------
T
P
Y
Y
M
S
P
E
Q
M
N
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.55
33%
-88
- C2 -
2W5A
5
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---
L
H
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
68.29
33%
-86
- C2 -
2W5B
1
NEK2_HUMAN
A:
[7-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--------
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---
L
H
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
N
H
D
T
S
F
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
---
R
I
P
Y
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
63.69
33%
-89
- C2 -
4FG7
1
KCC1A_HUMAN
A:
[20-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
-------
C
I
A
--------
S
M
E
N
E
I
A
V
L
H
K
I
K
----
H
P
N
I
V
A
L
D
D
I
Y
E
S
--
G
G
H
L
Y
L
I
M
Q
L
V
S
G
---
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
-
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
D
S
K
I
M
I
S
D
F
G
L
S
K
-
M
E
D
P
G
--------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
FDS
P
Y
W
D
D
I
-
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
59.98
31%
-80
- C2 -
2X81
1
AURKA_HUMAN
A:
[13-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
---
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
-------
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
---
A
P
L
G
T
V
Y
R
E
L
-
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
-------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
-
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
---
T
F
P
D
F
V
-
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
57.83
31%
-75
- C2 -
2WTW
1
AURKA_HUMAN
A:
[14-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
-------
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
---
A
P
R
G
E
V
Y
K
E
L
-
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
-
H
-
A
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
-
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
---
T
F
P
D
F
V
-
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------