@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NEK11_HUMAN: (2015-10-15 )
MLKFQEAAKCVSGSTAISTYPKTLIARRYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLEDKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRKLQAADEKARKLKKIVEEKYEENSKRMQELRSRNFQQLSVDVLHEKTHLKGMEEKEEQPEGRLSCSPQDEDEERWQGREEESDEPTLENLPESQPIPSMDLHELESIVEDATSDLGYHEIPEDPLVAEEYYADAFDSYCEESDEEEEEIALERPEKEIRNEGSQPAYRTNQQDSDIEALARCLENVLGCTSLDTKTITTMAEDMSPGPPIFNSVMARTKMKRMRESAMQKLGTEVFEEVYNYLKRARHQNASEAEIRECLEKVVPQASDCFEVDQLLYFEEQLLITMGKEPTLQNHL
Atome Classification :
(68 SA)
.........10........20........30........40........50........-60-........-.70........80........90........100.-------..--......110.......120.......130.......140.......150.-......160..-..----.-..----170........180.......190.......200.-----.-----.....210.......220.......230-...-....240.--.....-.250--.-.--...----..260.......270.......280.......-----290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ML
K
F
Q
E
A
A
K
CVSGSTAIST
Y
P
K
T
L
I
A
R
R
Y
V
L
Q
Q
KLGSGS
F
G
T
V
Y
L
VSDKKAKR
G
E
E
L
K
V
-
L
--
K
EISVGEL-NPNE
T
V
Q
A
N
L
E
A
Q
L
L
S
KLD
H
P
A
I
V
K
F
H
A
S
F
VE--Q-------D
N
--
F
C
I
I
T
E
YCEGR
D
L
D
D
K
I
Q
E
Y
K
Q
AGKIFP
E
N
Q
I
I
E
W
F
I
Q
L
L
L
G
V
D
Y
M
H
E
R
R
-
I
L
H
R
D
LKSK
N
V
-
F
L----K-NN----L-
L
K
I
G
D
F
G
V
S
R
L
L
MGSCDL
A
T
TLTGTPHYM
S
P
E
A
-----
L
-----
K
HQGYD
T
K
S
D
I
W
S
L
A
C
I
L
Y
E
M
C
CMNHAF-AG
S
-
N
F
L
S
I
V
L
K
--
I
VEGD-TPSL--
P
-
E
--
R
Y
P
----
K
E
L
N
A
I
M
E
S
M
LNKNPSLRPS
A
I
E
I
L
KIP
Y
L
D
E
-----
Q
L
Q
N
L
M
C
R
Y
SEMTLEDKNL
D
C
Q
K
E
A
A
H
I
I
N
A
M
Q
K
R
I
H
L
Q
T
L
R
A
L
S
E
V
Q
KMT
P
R
E
R
M
R
L
R
K
L
Q
A
A
D
E
K
A
R
K
L
K
K
I
V
E
E
K
Y
E
E
N
S
K
R
M
Q
E
L
R
SR
N
F
Q
Q
L
S
V
D
V
L
H
E
K
T
HLKG
M
E
E
K
EEQPEGRLSCSPQDE
D
E
E
R
WQGREEESDE
P
T
L
ENLPESQPIPSM
D
L
H
E
L
E
S
I
V
E
D
A
T
SDLGYHEIPEDP
L
V
A
E
E
Y
Y
A
D
A
F
D
S
Y
C
EESD
E
E
E
E
E
I
ALER
P
E
K
E
I
RNEGSQPAYRTNQQDS
D
I
E
A
L
A
R
C
L
E
N
V
LGCTSLDT
K
T
I
T
T
M
A
EDMSPGP
P
I
F
N
S
V
M
A
R
T
K
M
K
R
M
R
E
S
A
M
Q
K
L
G
T
E
V
F
E
E
V
Y
N
Y
L
K
R
A
RHQNA
S
E
A
E
I
R
E
C
L
E
K
VVPQ
A
S
D
C
F
E
V
D
Q
L
L
Y
F
E
E
Q
L
L
I
TMGKEPTLQNHL
2
PsiBlast_PDB
80.00
38%
-112
- C1 -
4B9D
1
NEK1_HUMAN
A:
[25-288]
---------------------------
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
--
K
S
T
E
D
G
R
Q
Y
-
V
-
I
--
K
E
I
N
I
S
R
M
-
S
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
--
N
-------
G
S
--
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
--
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
-
F
L
T
---
K
-
D
G
----
T
-
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
-----
C
-----
E
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
-
E
A
G
-
S
M
K
N
L
V
L
K
--
I
I
S
G
S
-
F
P
P
V
--
S
-
L
--
H
Y
S
----
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
A
K
-----
R
I
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
79.74
38%
-111
- C1 -
2W5A
5
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
-
W
--
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
-------
T
T
--
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
-
F
L
D
---
G
-
K
Q
----
N
-
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
79.37
38%
-112
- C1 -
4B9D
2
NEK1_HUMAN
B:
[25-288]
---------------------------
K
Y
V
R
L
Q
K
I
G
-----
K
A
I
L
V
--
K
S
T
E
D
G
R
Q
Y
-
V
-
I
--
K
E
I
N
I
S
R
M
-
S
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
--
N
-------
G
S
--
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
--
Q
K
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
-
F
L
T
---
K
-
D
G
----
T
-
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
-----
C
-----
E
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
-
E
A
G
-
S
M
K
N
L
V
L
K
--
I
I
S
G
S
-
F
P
P
V
--
S
-
L
--
H
Y
S
----
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
A
K
-----
R
I
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
77.49
34%
-102
- C1 -
4B9D
1
NEK1_HUMAN
A:
[24-306]
--------------------------
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
---
E
D
G
R
Q
Y
V
-
I
--
K
E
I
N
I
S
R
M
-
S
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
--
N
-------
G
S
--
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
--
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
-
F
L
T
---
K
-
D
G
----
T
-
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
-----
C
-----
E
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
-
E
A
G
-
S
M
K
N
L
V
L
K
--
I
I
S
G
S
-
F
P
P
V
--
S
-
L
--
H
Y
S
----
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
A
K
-----
R
I
E
K
F
L
S
--
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.05
37%
-108
- C1 -
2XKE
1
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
------------------
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.99
37%
-105
- C1 -
2W5A
5
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.00
37%
-103
- C1 -
2XKF
1
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
72.55
32%
-116
- C1 -
2YIR
1
CHK2_HUMAN
A:
[2-298]
-----------------
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K------------
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
----
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
72.55
37%
-101
- C1 -
2W5B
1
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
G
L
A
R
I
L
N
H
D
T
S
F
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
72.54
32%
-114
- C1 -
4BDF
3
CHK2_HUMAN
A:
[7-304]
----------------
M
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-------------
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.51
37%
-105
- C1 -
2XKD
1
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
--------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
72.02
32%
-106
- C1 -
2CN5
1
CHK2_HUMAN
A:
[7-302]
----------------
M
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K
R
------------
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
71.95
32%
-116
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[3-298]
------------------
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-------------
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
----
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
71.68
32%
-115
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[3-298]
------------------
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K--------------
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
----
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.34
37%
-98
- C1 -
2XNO
13
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
71.32
32%
-108
- C1 -
4BDI
8
CHK2_HUMAN
A:
[7-304]
----------------
M
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-----------
A
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
Q
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
71.12
32%
-110
- C1 -
2YCF
1
CHK2_HUMAN
A:
[2-298]
-----------------
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-------------
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
70.86
32%
-116
- C1 -
2YIT
1
CHK2_HUMAN
A:
[3-298]
------------------
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K------------
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
----
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.40
37%
-101
- C1 -
2WQO
1
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-------
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
------------------
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.23
37%
-103
- C1 -
2JAV
1
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
------------T-
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
G
L
A
R
I
L
-----------
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.21
37%
-103
- C1 -
2XK7
1
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
----------------
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
70.17
34%
-98
- C1 -
3MA6
1
?
A:
[29-286]
----------------
I
-------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
-
I
--
S
K
R
Q
V
K
Q
K
-
T
D
K
E
S
L
L
R
--
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
-------
G
Y
--
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
-
I
V
H
R
D
L
K
P
E
N
L
-
L
L
ESKS
K
-
D
A
----
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
-
S
K
K
M
K
D
K
I
-
G
T
A
Y
Y
I
A
P
E
V
-----
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
-
N
E
Y
D
I
L
K
K
--
V
E
K
G
K
Y
T
F
E
L
--
P
-
Q
W
K
K
V
S
----
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.98
37%
-105
- C1 -
2XK8
1
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
----
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
69.89
32%
-113
- C1 -
4BDC
2
CHK2_HUMAN
A:
[8-304]
-----------------
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-------------
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
69.67
32%
-115
- C1 -
2YCS
1
CHK2_HUMAN
A:
[2-298]
-----------------
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-------------
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
----
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
69.48
37%
-104
- C1 -
2XK6
1
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
-----
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
-----------------
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
69.38
32%
-109
- C1 -
4BDK
4
CHK2_HUMAN
A:
[9-304]
------------------
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
SK-----------
A
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EE
D
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
69.18
37%
-102
- C1 -
2XNM
10
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-----
R
D
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
G
L
A
R
I
L
---------
F
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
69.08
32%
-116
- C1 -
2YCR
1
CHK2_HUMAN
A:
[3-298]
------------------
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-------------
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
----
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
K
P
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
68.93
32%
-117
- C1 -
4BDJ
1
CHK2_HUMAN
A:
[9-304]
------------------
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-------------
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
68.79
32%
-114
- C1 -
4BDE
5
CHK2_HUMAN
A:
[7-304]
----------------
M
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-----------
A
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
68.72
32%
-116
- C1 -
4BDG
2
CHK2_HUMAN
A:
[7-304]
----------------
M
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-------------
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
68.34
32%
-114
- C1 -
4BDB
10
CHK2_HUMAN
A:
[7-304]
----------------
M
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K------------
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
68.33
32%
-119
- C1 -
4BDD
4
CHK2_HUMAN
A:
[7-304]
----------------
M
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-------------
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EE
D
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
68.32
32%
-109
- C1 -
2XM9
1
CHK2_HUMAN
A:
[9-304]
------------------
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K----------
P
A
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
68.28
37%
-100
- C1 -
2XNP
6
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---
H
R
D
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
67.94
32%
-111
- C1 -
2WTD
4
CHK2_HUMAN
A:
[8-304]
-----------------
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K----------
P
A
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
67.41
32%
-109
- C1 -
2WTC
1
CHK2_HUMAN
A:
[9-304]
------------------
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K----------
P
A
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V
--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
E
VS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
67.24
32%
-106
- C1 -
4A9T
4
CHK2_HUMAN
A:
[7-304]
----------------
M
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K----------
P
A
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
E
VS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
67.17
32%
-111
- C1 -
2WTJ
5
CHK2_HUMAN
A:
[7-304]
----------------
M
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K----------
P
A
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
67.11
34%
-93
- C1 -
3MA6
1
?
B:
[29-286]
----------------
I
-------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
-
I
--
S
K
R
Q
V
K
Q
--
T
D
K
E
S
L
L
R
--
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
-------
G
Y
--
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
-
I
V
H
R
D
L
K
P
E
N
L
-
L
L
ESKS
K
-
D
A
----
N
-
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
M
K
D
K
I
-
G
T
A
Y
Y
I
A
P
E
V
-----
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
-
N
E
Y
D
I
L
K
K
--
V
E
K
G
K
Y
T
F
E
L
--
P
-
Q
WK
K
V
S
----
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
66.98
32%
-116
- C1 -
4BDH
4
CHK2_HUMAN
A:
[8-304]
-----------------
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-------------
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EE
D
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
66.89
32%
-107
- C1 -
2WTI
3
CHK2_HUMAN
A:
[8-304]
-----------------
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K----------
P
A
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
66.56
32%
-107
- C1 -
4A9U
10
CHK2_HUMAN
A:
[7-304]
----------------
M
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K---------
D
P
A
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
66.43
32%
-115
* C1 *
4BDA
8
CHK2_HUMAN
A:
[7-304]
----------------
M
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-------------
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.32
37%
-99
- C1 -
2XKC
1
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
------------------
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
65.96
37%
-95
- C1 -
2XNN
7
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
G
--------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
65.81
37%
-99
- C1 -
2XK3
1
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
----
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
G
---------------
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.78
34%
-103
- C1 -
2WQN
1
NEK7_HUMAN
A:
[34-291]
----------------------------
F
R
I
E
K
K
I
G
R
G
Q
F
S
E
V
Y
----
R
A
A
C
L
L
D
G
V
P
V
A
L
--
K
K
V
Q
I
F
D
L
M
D
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
N
H
P
N
V
I
K
Y
Y
A
S
F
I
E
--
D
-------
N
E
--
L
N
I
V
L
E
L
A
D
A
G
D
L
S
R
M
I
K
H
F
K
K
Q
K
R
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
R
R
-
V
M
H
R
D
I
K
P
A
N
V
-
F
I
T
---
A
-
T
G
----
V
-
V
K
L
G
D
L
------------------
T
P
Y
Y
M
S
P
E
R
-----
I
-----
H
E
N
G
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
-
Y
--M
N
L
Y
S
L
C
K
K
--
I
E
Q
C
D
-
Y
P
P
L
--
P
S
D
--
H
Y
S
----
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
P
D
V
T
Y
V
Y
D
V
A
K
R
M
H
-----
A
C
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
65.67
32%
-111
- C1 -
4A9S
1
CHK2_HUMAN
A:
[9-304]
------------------
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K----------
P
A
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
64.78
32%
-108
- C1 -
4A9R
2
CHK2_HUMAN
A:
[8-304]
-----------------
S
V
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K----------
P
A
L
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EED
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
-----
L
V
S
V--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
64.48
37%
-97
- C1 -
2XK4
1
NEK2_HUMAN
A:
[5-273]
-------------------------
A
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
-----
Q
K
I
R
R
K
S
D
G
K
I
-
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
--
R
-------
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
-
F
L
D
G--
K
-
Q
N
----
V
--
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
-----
M
-----
N
R
M
--
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
-
S
Q
K
E
L
A
G
K
--
I
R
E
G
K
-
F
R
R
I
--
P
-
Y
--
R
Y
S
----
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
-----
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
64.14
31%
-81
- C1 -
4USF
1
?
B:
[24-276]
----------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
-
I
--
D
T
K
S
E
E
E
L
-
E
-----
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
-------
N
N
--
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
E
R
P
---
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
-
I
I
H
R
D
L
K
A
G
N
I
L
F
T
----
L
-
D
G
----
D
-
I
K
L
A
D
F
G
V
S
A
K
N
---------
F
I
G
T
P
Y
W
M
A
P
E
V
-----
V
MCETS
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
-
H
E
L
-
N
P
M
R
V
L
L
K
--
I
A
K
S
E
-
P
P
T
L
AQ
P
-
S
--
R
W
S
----
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
-----
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
63.87
32%
-114
- C1 -
2CN8
1
CHK2_HUMAN
A:
[10-301]
-------------------
Y
P
K
A
L
-
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-
I
S
K-------------
N
V
E
T
E
I
E
--
I
L
K
K
L
N
H
P
C
I
I
K
I
K
-
N
F
F
D
--
A
-------
E
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
-
L
L
----
S
-
S
Q
EE
D
C
L
-
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
-----
L
V
S
V
--
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-
I
C
L
S
G
Y
P
P
-
F
S
E
-
H
---
V
S
L
K
D
Q
I
T
S
G
K
-
Y
N
F
I
--
P
-
E
--
V
W
A
EVS
E
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
61.43
31%
-88
- C1 -
3DBE
1
?
A:
[22-275]
--------------------
P
R
T
M
--
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
-
V
--
P
K
S
M
L
--
L
-
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
--
D
-------
D
F
--
V
Y
V
V
L
E
I
C
R
R
R
S
L
----
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
-
V
I
H
R
D
L
K
L
G
N
L
-
F
L
----
N
-
D
D
----
M
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
E
R
K
K
D
L
---
P
N
Y
I
A
P
E
V
-----
L
-----
C
K
K
G
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-
E
T
S
-
C
L
K
E
T
Y
I
R
--
I
K
K
N
E
-
Y
-
S
V
--
P
-
R
--
H
I
N
----
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
-----
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
60.95
31%
-86
- C1 -
3D5X
1
?
A:
[22-275]
--------------------
P
R
T
M
--
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
-
V
--
P
K
S
M
L
--
L
-
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
--
D
-------
D
F
--
V
Y
V
V
L
E
I
C
R
R
R
S
L
----
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
-
V
I
H
R
D
L
K
L
G
N
L
-
F
L
----
N
-
D
D
----
M
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
E
R
K
K
D
-------
I
A
P
E
V
-----
L
-----
C
K
K
G
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-
E
T
S
-
C
L
K
E
T
Y
I
R
--
I
K
K
N
E
-
Y
-
S
V
--
P
-
R
--
H
I
N
----
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
-----
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
59.99
32%
-100
- C1 -
2J7T
1
STK10_HUMAN
A:
[17-280]
------------------------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
---
T
G
A
L
A
A
-
A
--
K
V
I
E
-------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
-------
G
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
---
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
-
L
M
T
---
L
-
E
G
----
D
-
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
-----
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
-
H
E
L
-
N
P
M
R
V
L
L
K
--
I
A
K
S
D
-
P
P
T
L
LT
P
-
S
--
K
W
S
----
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-----
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
58.26
31%
-89
- C1 -
3DBC
1
?
A:
[38-291]
--------------------
P
R
T
M
--
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
-
V
--
P
K
S
M
L
--
L
-
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
--
D
-------
D
F
--
V
Y
V
V
L
E
I
C
R
R
R
S
L
----
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
-
V
I
H
R
D
L
K
L
G
N
L
-
F
L
----
N
-
D
D
----
M
D
V
K
I
G
D
F
G
L
A
T
K
I
------------------------------------
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-
E
T
S
-
C
L
K
E
T
Y
I
R
--
I
K
K
N
E
-
Y
-
S
V
--
P
-
R
--
H
I
N
----
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
-----
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
58.18
31%
-77
- C1 -
5AJQ
2
STK10_HUMAN
A:
[24-286]
----------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
-
I
--
E
---
E
E
E
L
-
E
-----
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
-------
G
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
--
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
-
L
M
----
T
L
E
G
----
D
-
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
------
F
I
G
T
P
Y
W
M
A
P
E
V
VMCET
M
-----
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
-
H
E
L
-
N
P
M
R
V
L
L
K
--
I
A
K
S
D
-
P
P
T
L
LT
P
-
S
--
K
W
S
----
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-----
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
56.70
31%
-68
- C1 -
4AOT
1
STK10_HUMAN
B:
[27-289]
----------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
-
I
--
E
T
K
S
E
E
E
L
-
E
-----
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
-------
G
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
--
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
-
L
M
----
T
L
E
G
----
D
-
I
R
L
A
D
F
G
V
S
A
K
-----------
I
G
T
P
Y
W
M
A
P
E
V
VM------------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
-
H
E
L
-
N
P
M
R
V
L
L
K
--
I
A
K
S
D
-
P
P
T
L
LT
P
-
S
--
K
W
S
----
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-----
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
56.44
30%
-90
- C1 -
2A19
1
E2AK2_HUMAN
B:
[8-268]
-----------------------
R
F
G
M
D
F
K
E
I
E
L
I
G
S
G
G
F
G
Q
V
F
K
A
K
H
R
I
---
D
G
K
T
Y
V
-
I
--
K
R
V
K
Y
N
-----
N
E
--
K
A
E
R
E
V
K
A
L
A
K
L
D
H
V
N
I
V
H
Y
N
G
C
W
D
G
--
F
D
YDRSK
T
K
C
--
L
F
I
Q
M
E
F
C
D
K
G
T
L
E
Q
W
I
E
K
R
R
--
G
E
K
L
D
K
V
L
A
L
E
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
-
L
I
N
R
D
L
K
P
S
N
I
-
F
L
V---
D
-
T
K
----
Q
-
V
K
I
G
D
F
G
L
V
T
S
L
K
N
D
G
-
K
R
T
R
S
K
G
T
L
R
Y
M
S
P
E
Q
-----
I
-----
S
S
Q
D
Y
G
K
E
V
D
L
Y
A
L
G
L
I
L
A
E
L
L
H
V
C
D
T
A
F
E
T
S
-
K
F
F
T
D
-----
L
R
----
D
G
I
I
--
S
-
D
--
I
F
D
----
K
K
E
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
L
T
V
W
K
-----
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
55.98
31%
-75
- C1 -
4O27
1
STK24_HUMAN
B:
[12-254]
--------------------------------
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
-
I
---
D
L
E
E
A
E
D
-
E
I
E
D
I
Q
Q
---
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
-------
T
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
----
P
G
P
L
-
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
-
L
L
S
---
E
-
H
G
----
E
-
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
-----
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
-
S
E
L
-
H
P
M
K
V
L
F
L
--
I
P
K
N
N
-
P
P
T
L
--
E
-
G
--
N
Y
S
----
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-----
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
53.59
31%
-69
- C1 -
4AOT
1
STK10_HUMAN
A:
[27-289]
----------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
-
I
--
E
T
K
S
E
E
E
L
-
E
-----
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
-------
G
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
--
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
-
L
M
----
T
L
E
G
----
D
-
I
R
L
A
D
F
G
V
S
A
-------------
G
T
P
Y
W
M
A
P
E
V
VM-------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
-
H
E
L
-
N
P
M
R
V
L
L
K
--
I
A
K
S
D
-
P
P
T
L
LT
P
-
S
--
K
W
S
----
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-----
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
52.25
31%
-80
- C1 -
4EQU
2
STK10_HUMAN
B:
[27-289]
----------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
-
I
--
E
----
E
E
L
-
E
-----
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
-------
G
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
--
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
-
L
M
----
T
L
E
G
----
D
-
I
R
L
A
D
F
G
V
S
A
K
N
L
--------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
-----
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
-
H
E
L
-
N
P
M
R
V
L
L
K
--
I
A
K
S
D
-
P
P
T
L
LT
P
-
S
--
K
W
S
----
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-----
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
50.91
31%
-76
- C1 -
4USD
1
?
B:
[27-289]
----------------------------------
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
-
I
--
E
T
K
S
E
E
E
L
-
E
-----
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
-------
G
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
--
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
-
L
M
----
T
L
E
G
----
D
-
I
R
L
A
D
F
G
V
---------------
G
T
P
Y
W
M
A
P
E
V
VMC------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
-
H
E
L
-
N
P
M
R
V
L
L
K
--
I
A
K
S
D
-
P
P
T
L
LT
P
-
S
--
K
W
S
----
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-----
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
50.78
31%
-77
- C1 -
4BC6
2
STK10_HUMAN
A:
[19-281]
----------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
-
I
--
E
T
K
S
E
E
E
L
-
E
-----
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
-------
G
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
--
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
-
L
M
----
T
L
E
G
----
D
-
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
-----
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
-
H
E
L
-
N
P
M
R
V
L
L
K
--
I
A
K
S
D
-
P
P
T
L
LT
P
-
S
--
K
W
S
----
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-----
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
48.53
31%
-74
- C1 -
4USE
1
?
B:
[27-289]
----------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
-
I
--
E
----
E
E
L
-
E
-----
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
----------------
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
--
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
-
L
M
----
T
L
E
G
----
D
-
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
-----
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
-
H
E
L
-
N
P
M
R
V
L
L
K
--
I
A
K
S
D
-
P
P
T
L
LT
P
-
S
--
K
W
S
----
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-----
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
48.11
31%
-71
- C1 -
4USE
1
?
A:
[27-289]
----------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
-
I
--
E
T
K
S
E
E
E
L
-
E
-----
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
-------
G
K
--
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
--
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
-
L
M
----
T
L
E
G
----
D
-
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
-------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
-----
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
-
H
E
L
-
N
P
M
R
V
L
L
K
--
I
A
K
S
D
-
P
P
T
L
LT
P
-
S
--
K
W
S
----
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-----
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------