@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NEK1_HUMAN: (2015-10-15 )
MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGEVKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGILPGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQRKREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHETGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEGEKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLETEILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSHLPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEPTANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE
Atome Classification :
(32 SA)
.........10........20...---.....30......-..40........50........60........70-.........80.......-.90..--.....----.100.......110.......120.-......130.......140.......150.......160.......170..--..---...180.......190.......200.......---210.......--220.-..---....230.......240.......250----........260-----.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEK
Y
V
R
L
Q
KIGEGSFG
K
A
I
L
V
K
ST---EDGR
Q
Y
V
I
K
EI
N
I
-
S
RMS
S
K
E
R
E
E
S
R
R
E
V
A
V
L
ANMKHP
N
I
V
Q
Y
R
E
S
F
--EENG
S
L
Y
I
V
M
D
YCEG
G
D
L
-
F
K
R
IN--AQKG
V
----
L
FQE
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
VH
D
R
K
-
I
L
H
R
DIKSQ
N
I
F
LTKDG
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
T
CIGTPYYL
S
P
E
I
--CE---NKPYNNK
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
EAG
S
M
K
---
N
L
V
L
K
I
ISGS--FP
P
V
-
S
L
---
H
YSY
D
L
R
S
L
V
S
Q
L
F
KRNPRDR
P
S
V
N
S
-----
I
L
E
K
G
F
I
A
K
R
I
-----
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
FGSQPIPAKRPASGQN
S
I
S
VM
P
A
Q
K
ITK
P
A
A
KYGIP
L
A
Y
K
KYGDKKLHEKKP
L
Q
K
H
K
Q
A
HQ
T
P
E
KRVN
T
G
E
E
R
R
K
I
S
E
E
A
A
R
K
R
R
L
E
F
I
E
K
E
K
K
Q
K
D
Q
I
I
S
L
M
K
A
E
Q
M
K
R
Q
E
K
E
R
L
E
R
I
N
R
A
R
E
Q
G
W
R
N
V
L
SAGGSGEVKA
P
F
LGSGGTIAPSSFSSRGQ
Y
E
H
Y
H
A
I
F
D
Q
M
Q
Q
Q
RAED
N
E
A
K
W
K
R
E
I
YGRGLPERGILPGVRPGFPYGAAGHHHFP
D
A
D
D
I
R
K
T
L
K
R
L
K
A
V
S
K
QANANRQK
G
Q
L
A
V
E
R
A
K
Q
V
E
E
F
L
Q
R
K
R
E
A
M
Q
N
K
ARAEG
H
M
V
Y
L
A
R
L
R
Q
I
R
L
QNF
N
E
R
Q
Q
I
K
A
K
LRGEKKEANHSEGQEG
S
E
E
A
D
M
R
R
K
K
I
E
S
L
K
A
HA
N
A
R
A
A
V
L
K
E
Q
L
E
R
K
R
K
E
A
Y
E
R
E
K
K
V
W
E
E
H
L
V
AKGVKSSDVSPPLGQHETGGS
P
S
K
Q
Q
M
R
S
V
I
S
V
T
S
A
L
K
EVGVDSSLTD
T
R
E
T
S
E
E
M
Q
K
TNNA
I
S
S
K
R
E
I
L
R
R
L
N
E
NLKAQEDEKGKQNLSD
T
F
E
I
N
VHE
D
A
K
E
H
E
K
E
KSVSS
D
R
K
K
WEAG
G
Q
L
V
I
P
L
D
E
L
T
LDTSFSTTERHTVG
E
V
I
K
LGPNGSPRRAWGKSP
T
D
S
V
L
K
I
L
G
E
A
E
L
Q
L
Q
T
E
L
LENTTIRSEISPEGEKYKPLITGE
K
K
V
Q
C
I
SHEI
N
P
S
A
IVDSPVETKSPEFSEASP
Q
M
S
L
K
LEGNLEEPD
D
L
E
T
E
I
LQEPSGTNKDESL
P
C
T
I
T
D
V
WISEEKETKETQSA
D
R
I
T
I
QENEVSED
G
V
S
S
T
V
D
Q
L
S
D
I
H
IEPGTNDSQHSKCDVDKSVQP
E
P
F
F
H
K
V
V
H
S
E
HLNLVPQ
V
Q
SVQCSPEE
S
F
AFRSHSHLPPKNKNK
N
S
L
L
I
G
LSTGLFDANNP
K
M
L
R
TCS
L
P
D
L
S
K
L
F
R
T
L
MDVPTVGDVRQDNLEIDEIEDENIKEGPSDSE
D
I
V
FEETDT
D
L
Q
E
L
Q
A
S
M
E
Q
L
L
R
EQPGEEY
S
E
E
E
E
S
V
LKNSDVEPTANGTDVADEDDNPSSESALNEEWHSDNSDGEIASEC
E
C
D
S
V
F
N
H
L
E
E
L
R
L
H
L
E
Q
EM
G
F
E
K
F
F
E
V
Y
E
K
I
K
A
I
HEDEDE
N
I
E
I
C
S
K
I
V
Q
N
I
LGN
E
H
Q
H
L
Y
A
K
I
L
H
L
V
MADGAYQEDNDE
21
PsiBlast_CBE
93.07
99%
-104
- C1 -
4B9D
2
NEK1_HUMAN
B:
[23-306]
M
E
K
Y
V
R
L
Q
K
I
G
-----
K
A
I
L
V
K
S
T
---
E
D
G
R
Q
Y
V
I
K
E
I
N
I
-
S
R
M
S
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
-
F
K
R
I
N
--
A
Q
K
G
V
----
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
--
C
E
---
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
---
N
L
V
L
K
I
I
S
G
S
--
F
P
P
V
-
S
L
---
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
-----
I
L
E
K
G
F
I
A
K
R
I
-----
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.47
99%
-105
- C1 -
4B9D
1
NEK1_HUMAN
A:
[23-306]
M
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
---
E
D
G
R
Q
Y
V
I
K
E
I
N
I
-
S
R
M
S
S
K
E
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
-
F
K
R
I
N
--
A
Q
K
G
V
----
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
--
C
E
---
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
---
N
L
V
L
K
I
I
S
G
S
--
F
P
P
V
-
S
L
---
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
-----
I
L
E
K
G
F
I
A
K
R
I
-----
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
68.67
42%
-96
- C1 -
2JAV
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID----
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
RQ
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
-----------
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
67.43
42%
-91
- C1 -
2XKF
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
RQ
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
67.23
42%
-90
- C1 -
2XNM
10
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---------
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.05
42%
-95
- C1 -
2XKE
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
RQ
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
------------------
T
P
Y
Y
M
S
P
E
Q
--
M
N
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
67.03
42%
-92
- C1 -
2XKD
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
RQ
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
--------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
66.18
42%
-87
- C1 -
2XK6
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
-----
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
RQ
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
-----------------
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
65.76
42%
-88
- C1 -
2W5A
5
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
65.74
38%
-95
- C1 -
2WQN
1
NEK7_HUMAN
A:
[38-295]
-------
K
K
I
G
R
G
Q
F
S
E
V
Y
R
A
A
C
L
---
L
D
G
V
P
V
A
L
K
K
V
Q
I
F
D
L
M
D
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
N
H
P
N
V
I
K
Y
Y
A
S
F
--
I
E
D
N
E
L
N
I
V
L
E
L
A
D
A
G
D
L
-
S
R
M
I
K
H
F
K
K
Q
K
R
----
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
R
R
-
V
M
H
R
D
I
K
P
A
N
V
F
I
T
A
T
G
V
V
K
L
G
D
L
------------------
T
P
Y
Y
M
S
P
E
R
--
I
H
---
E
N
G
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
Y
---
M
N
L
Y
-
S
L
C
K
K
I
E
Q
C
D
--
Y
P
P
L
P
S
D
---
H
Y
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
P
D
V
T
Y
-----
V
Y
D
---
V
A
K
R
M
-----
H
A
C
T
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.45
42%
-91
- C1 -
2WQO
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
RQ
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-------
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
------------------
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
65.21
42%
-86
- C1 -
2XNO
13
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
64.97
42%
-88
- C1 -
2W5B
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
RQ
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
N
H
D
T
S
F
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
64.02
42%
-88
- C1 -
2XK7
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
----------------
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
63.70
42%
-85
- C1 -
2XNP
6
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.29
42%
-86
- C1 -
2XK3
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
---------------
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.86
42%
-87
- C1 -
2XK4
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
M
--
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.72
42%
-90
- C1 -
2XK8
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
RQ
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
61.64
42%
-85
- C1 -
2XKC
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
RQ
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
------------------
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
61.33
42%
-84
- C1 -
2XNN
6
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
---
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
-
A
S
V
I
T
----
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
--------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
--
F
R
R
I
-
P
Y
---
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
L
E
H
H
-----
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
50.75
31%
-74
- C1 -
4EJN
3
AKT1_HUMAN
A:
[147-423]
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
-
E
V
I
V
------------
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
--
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
-
F
F
H
L
S
--
R
E
R
------
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-----
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
--
L
E
---
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
-------
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
50.51
31%
-66
- C1 -
5AJQ
2
STK10_HUMAN
A:
[24-291]
---------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
E
------
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--
L
D
R
G
L
------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
------
F
I
G
T
P
Y
W
M
A
P
E
V
VM
C
E
TMK
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
---
R
V
L
L
K
-
I
A
K
S
--
D
P
P
T
-
L
L
TPS
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
-----
L
L
E
H
P
F
V
S
S
I
T
-----
S
N
K
A
L
R
E
L
V
A
E
A
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
48.27
31%
-77
- C1 -
3O96
1
AKT1_HUMAN
A:
[150-426]
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
-
E
V
I
V
A
---------
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
--
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
-
F
F
H
L
S
--
R
E
R
------
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
--------------
P
E
Y
L
A
P
E
V
--
L
E
---
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
-------
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
ED
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
46.63
31%
-62
- C1 -
4BC6
2
STK10_HUMAN
A:
[19-286]
---------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
E
T
-
K
--
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
--
D
A
I
M
--
L
E
L
D
R
----
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
---
R
V
L
L
K
-
I
A
K
S
--
D
P
P
T
-
L
L
TPS
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
-----
L
L
E
H
P
F
V
S
S
I
T
-----
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
45.69
31%
-62
- C1 -
4USD
1
?
B:
[27-294]
---------
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
E
T
-
K
--
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--
L
D
R
G
L
------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
---------------
G
T
P
Y
W
M
A
P
E
V
VM
C
-------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
---
R
V
L
L
K
-
I
A
K
S
--
D
P
P
T
-
L
L
TPS
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
-----
L
L
E
H
P
F
V
S
S
I
T
-----
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
45.56
31%
-59
- C1 -
4AOT
1
STK10_HUMAN
B:
[27-294]
---------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
E
T
-
K
--
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--
L
D
R
G
L
------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
-----------
I
G
T
P
Y
W
M
A
P
E
V
VM-------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
---
R
V
L
L
K
-
I
A
K
S
--
D
P
P
T
-
L
L
TPS
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
-----
L
L
E
H
P
F
V
S
S
I
T
-----
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
45.18
31%
-60
- C1 -
4AOT
1
STK10_HUMAN
A:
[27-294]
---------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
E
T
-
K
--
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--
L
D
R
G
L
------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-------------
G
T
P
Y
W
M
A
P
E
V
VM--------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
---
R
V
L
L
K
-
I
A
K
S
--
D
P
P
T
-
L
L
TPS
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
-----
L
L
E
H
P
F
V
S
S
I
T
-----
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
42.00
32%
-73
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[33-272]
------
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
TRP
D
S
G
H
L
Y
A
M
K
V
L
-------------------
I
L
A
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
--
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
-
F
T
R
L
S
----
K
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
------------
G
T
V
E
Y
M
A
P
E
V
--
V
N
---
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
M
----
P
Q
-
F
L
-----
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
-----
D
G
A
E
E
I
K
R
H
V
F
-----
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
40.92
31%
-60
- C1 -
2J7T
1
STK10_HUMAN
A:
[27-294]
---------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--
L
D
R
G
L
------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
---
R
V
L
L
K
-
I
A
K
S
--
D
P
P
T
-
L
L
TPS
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
-----
L
L
E
H
P
F
V
S
S
I
T
-----
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
40.01
31%
-58
- C1 -
4EQU
2
STK10_HUMAN
B:
[27-294]
---------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--
L
D
R
G
L
------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
--------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
---
R
V
L
L
K
-
I
A
K
S
--
D
P
P
T
-
L
L
TPS
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
-----
L
L
E
H
P
F
V
S
S
I
T
-----
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
38.94
31%
-58
- C1 -
4USE
1
?
A:
[27-294]
---------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
E
T
-
K
--
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--
L
D
R
G
L
------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
-------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
---
R
V
L
L
K
-
I
A
K
S
--
D
P
P
T
-
L
L
TPS
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
-----
L
L
E
H
P
F
V
S
S
I
T
-----
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
37.98
31%
-61
- C1 -
4USE
1
?
B:
[27-294]
---------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
-----
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
--
L
D
R
G
L
------
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
---
R
V
L
L
K
-
I
A
K
S
--
D
P
P
T
-
L
L
TPS
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
-----
L
L
E
H
P
F
V
S
S
I
T
-----
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------