@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NEK4_HUMAN: (2015-10-15 )
MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAESNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELATISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQPENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLGSSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKRREQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSSRSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRLSSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDSKESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVEVLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMNF
Atome Classification :
(38 SA)
.........10........20........30......-.---.40...-----.....-50--.........60...-.....-----.70.-.---.---..--------...80........90......--..--100-........110.......120....-...130.......140.---......150.......160.......170......---.-----180.......190.......200......-.210--.......-220---....-..----.-230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPL
A
A
Y
C
Y
L
R
V
VGKGSYG
E
V
T
L
V
K
HRRD
G
K
Q
Y
V
I
K
K
L-N---LRNA
S
S
-----
R
E
R
R
A
-
A
---
E
Q
E
A
Q
L
L
S
QL-KHP-
N
I
V
T
Y
-----KESW-E---G---GD--------
G
L
L
Y
I
V
M
G
FCEG
G
D
L
Y
R
K
L
K
E
--QK--GQ--LL
P
E
N
Q
V
V
E
W
F
V
Q
I
A
M
A
L
Q
Y
L
H
E
K
H
-
I
L
H
R
DLKTQ
N
V
F
L
T
RT
N
---
I
I
K
VG
D
L
G
I
A
R
V
L
E
N
HC
D
M
A
S
T
LIGTPYYM
S
P
E
L
F---S-----NKPYNYKS
D
V
W
A
L
G
C
C
V
Y
E
M
A
T
L
K
H
AF
N
A
-
K
D
M
N
--
S
L
V
Y
R
I
I
-EGK---LPPM-PR----D-Y
S
P
E
L
A
E
L
I
R
T
M
L
SKRPEE
R
P
S
V
R
S
I
L
R
Q
P
Y
I
K
R
Q
I
S
F
F
L
E
A
T
K
IKTSKNNIKNGDSQSK
P
F
A
T
V
VSGEAESNH
E
V
IHPQPLSSEG
S
Q
T
Y
I
M
GEGKCLSQEKPRASGLLKSP
A
S
L
K
A
H
T
C
K
Q
D
LSNTT
E
L
A
T
I
S
S
V
N
I
D
I
LPAKGRDSVSDGFVQENQP
R
Y
LDASNELGGIC
S
I
S
Q
V
E
E
E
M
L
QDNTKSSAQPEN
L
I
PMWSSDIVTGEKNEPVK
P
L
Q
P
L
I
K
EQKPKDQSLALSPKLEC
S
G
T
I
L
A
HS
N
L
R
L
LGSSDSPAS
A
S
RVA
G
I
T
G
VCH
H
A
Q
D
QVA
G
E
C
I
IEKQGRIHPDLQPHNSGSEP
S
L
S
R
Q
R
R
Q
K
R
R
E
Q
T
E
HR
G
E
K
R
Q
V
R
R
D
L
F
A
FQESPPRFLPSHPI
V
G
K
V
DVTS
T
Q
K
E
AENQ
R
R
V
V
TGSVSSSRSSEMSSSKDRPL
S
A
R
E
R
R
R
L
K
Q
S
Q
E
E
M
SSSGPS
V
R
K
A
S
L
SVAGPGKPQEEDQPL
P
A
R
RLSSDC
S
V
T
Q
E
R
K
Q
I
H
CL
S
E
D
ELSSSTSSTDKSDGDYGEGKGQT
N
E
I
N
A
L
V
Q
L
M
T
Q
T
LKLDSKESCEDVPVAN
P
V
S
E
F
K
L
H
R
K
YR
D
T
L
I
LHG
K
V
A
E
E
A
E
E
I
H
F
K
EL
P
S
A
IMP
G
S
E
K
I
R
R
L
V
E
V
L
R
T
D
V
I
R
G
L
G
V
Q
L
L
E
Q
V
Y
D
L
L
EE
E
D
E
F
D
R
E
V
R
L
R
E
HMGEKY
T
T
Y
S
V
K
A
R
Q
L
K
F
F
E
ENMNF
21
PsiBlast_CBE
79.92
50%
-110
- C1 -
4B9D
2
NEK1_HUMAN
B:
[26-288]
-----
Y
V
R
L
Q
K
I
G
-----
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
-
N
---
I
S
R
M
S
S
-----
K
E
R
E
E
-
S
---
R
R
E
V
A
V
L
A
N
M
-
K
H
P
-
N
I
V
Q
Y
-----
R
E
S
F
-
E
---
E
----
N
--------
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
--
Q
K
--
G
V
--
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
---
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
---
E
-----
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
-
G
S
M
K
--
N
L
V
L
K
I
I
-
S
G
S
---
F
P
P
V
-
S
L
----
H
-
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
76.63
45%
-101
- C1 -
4B9D
1
NEK1_HUMAN
A:
[23-306]
--
M
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
-
N
---
I
S
R
M
S
S
-----
K
E
R
E
E
-
S
---
R
R
E
V
A
V
L
A
N
M
-
K
H
P
-
N
I
V
Q
Y
-----
R
E
S
F
-
E
---
E
----
N
--------
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
--
Q
K
--
G
V
--
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
---
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
---
E
-----
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
-
G
S
M
K
--
N
L
V
L
K
I
I
-
S
G
S
---
F
P
P
V
-
S
L
----
H
-
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.69
40%
-113
- C1 -
2XKD
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
--------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.28
40%
-111
- C1 -
2W5A
5
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
71.03
42%
-106
- C1 -
2W5A
5
NEK2_HUMAN
A:
[6-273]
---
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
-
I
---
D
R--
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
--
G
T
K
E
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
71.03
40%
-110
- C1 -
2XKF
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
70.98
40%
-103
- C1 -
2W5B
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
A
R
I
L
N
H
D
T
S
F
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.85
40%
-109
- C1 -
2XK6
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
-----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
-----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.76
40%
-109
- C1 -
2XK7
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.59
40%
-110
- C1 -
2XK8
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.44
40%
-112
- C1 -
2JAV
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
------------------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
A
R
I
L
-----------
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
M
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.04
40%
-106
- C1 -
2XNM
10
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
A
R
I
L
---------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
-
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
69.95
40%
-114
- C1 -
2XKE
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
------------------
T
P
Y
Y
M
S
P
E
Q
M
---
N
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.59
40%
-104
- C1 -
2XNP
6
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
69.51
40%
-103
- C1 -
2XNO
13
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.91
40%
-104
- C1 -
2XKC
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
------------------
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
68.87
40%
-109
- C1 -
2WQO
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-------
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
------------------
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.10
40%
-106
- C1 -
2XK4
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
M
--
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
68.05
40%
-107
- C1 -
2XK3
1
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
G
---------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
65.95
40%
-101
- C1 -
2XNN
6
NEK2_HUMAN
A:
[8-271]
-----
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
-
D
---
Y
G
S
M
T
E
-----
A
E
K
Q
M
-
L
---
V
S
E
V
N
L
L
R
E
L
-
K
H
P
-
N
I
V
R
Y
-----
Y
D
R
I
I
D
---
R
---
T
N
--------
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
--
R
Q
--
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
G
--------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
---
N
-----
R
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
-
F
S
Q
K
--
E
L
A
G
K
I
R
-
E
G
K
---
F
R
R
I
-
P
Y
----
R
-
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
64.15
40%
-100
- C1 -
2WQN
1
NEK7_HUMAN
A:
[40-288]
-----------
I
G
R
G
Q
F
S
E
V
Y
R
A
A
C
L
L
D
G
V
P
V
A
L
K
K
V
-
Q
---
I
F
D
L
M
D
-----
A
K
A
R
A
D
C
---
I
K
E
I
D
L
L
K
Q
L
-
N
H
P
-
N
V
I
K
Y
-----
Y
A
S
F
-
I
---
E
----
D
--------
N
E
L
N
I
V
L
E
L
A
D
A
G
D
L
S
R
M
I
K
H
--
F
K
--
K
Q
KR
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
R
R
-
V
M
H
R
D
I
K
P
A
N
V
F
I
T
A
T
G
---
V
V
K
L
G
D
L
------------------
T
P
Y
Y
M
S
P
E
R
I
---
H
-----
E
N
G
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
Y
----
M
N
L
Y
S
L
C
K
K
I
E
-
Q
C
D
---
Y
P
P
L
-
P
S
----
D
H
Y
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
P
D
V
T
Y
V
Y
D
V
A
K
R
M
H
A
C
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
57.02
31%
-103
- C1 -
3COK
1
PLK4_HUMAN
A:
[18-267]
----------
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
-
D
K
K
A
M
Y
K
A
G
M
-----
V
Q
R
---
V
---
Q
N
E
V
K
I
H
C
Q
L
-
K
H
P
-
S
I
L
E
L
-----
Y
N
Y
F
-
E
---
D
---
S
N
---------
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
---
N
R
--
V
K
--
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
-
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
---
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
-
D
T
V
K
-------
V
V
-
L
A
D
---
Y
-
E
M
-
P
S
----
F
-
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
56.94
31%
-84
- C1 -
4B6L
1
PLK3_HUMAN
A:
[15-265]
---------
R
L
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
P
Q
---
S
R
V
A
K
P
-----
H
Q
R
E
K
-
I
---
L
N
E
I
E
L
H
R
D
L
-
Q
H
R
-
H
I
V
R
F
-----
S
H
H
F
-
E
---
D
---
A
D
--------
N
I
-
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
I
W
K
A
--
R
H
--
T
L
--
L
E
P
E
--
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
R
G
-
I
L
H
R
D
L
K
L
G
N
F
F
I
T
E
N
M
---
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
P
E
Q
R
K
K
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
---
L
-----
R
Q
G
H
G
P
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
P
F
E
T
-
A
D
L
K
--
E
-
T
Y
R
C
I
-
K
Q
V
---
H
Y
T
L
-
P
A
----
S
-
L
S
L
P
A
R
Q
L
L
A
A
I
L
R
A
S
P
R
D
R
P
S
I
D
Q
I
L
R
H
D
F
F
T
K
G
Y
T
P
D
R
L
P
I
S
S
C
V
T
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
56.37
31%
-102
- C1 -
4OBO
2
M4K4_HUMAN
A:
[22-292]
-
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
---
V
T
-------------
E
-
I
---
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
-
N
I
A
T
Y
-----
Y
G
A
F
-
I
K
K
S-----
D
--------
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
--
T
K
--
G
N
--
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
---
E
V
K
L
V
D
F
G
-----------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
CDENP
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
-
M
H
P
M
--
R
A
L
F
L
I
P
-
R
N
P
---
P
P
R
L
K
S
K
----
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
56.36
32%
-84
- C1 -
4ZK5
2
?
A:
[22-293]
-
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
---
V
---
T
E
-----
D
E
E
E
E
-
I
---
K
L
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
-
P
---
G
---
H
D
--------
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
--
T
K
--
G
N
--
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
---
E
V
K
L
V
D
F
G
V
S
A
---------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
CDENP
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
--
E
G
A
P
P
L
-
C
D
M
H
--
P
M
R
A
L
F
L
-
I
P
R
---
N
P
P
--
P
R
LKSK
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
56.35
31%
-103
- C1 -
4A9U
10
CHK2_HUMAN
A:
[18-285]
-----
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-
S
---
K
-------------
D
P
-
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
H
P
-
C
I
I
K
I
-----
K
N
F
F
-
D
---
A
---
E
D
----------
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--
N
K
--
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
ED
C
L
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
-----
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
T
-
S
G
K
YNF
I
P
E
V
-
W
A
----
E
-
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
56.18
32%
-81
- C1 -
4U44
2
M4K4_HUMAN
A:
[22-293]
-
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
---
V
---
T
E
-----
D
E
E
E
E
-
I
---
K
L
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
----------
H
D
--------
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
--
T
K
--
G
N
--
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
---
E
V
K
L
V
D
F
G
V
S
A
----------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
CDENP
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
--
E
G
A
P
P
L
-
C
D
M
H
--
P
M
R
A
L
F
L
-
I
P
R
---
N
P
P
--
P
R
LKSK
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
56.07
31%
-98
- C1 -
4A9T
4
CHK2_HUMAN
A:
[18-285]
-----
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
-
S
---
K
--------------
P
-
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
H
P
-
C
I
I
K
I
-----
K
N
F
F
-
D
---
A
---
E
D
----------
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
--
N
K
--
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
-
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
ED
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
-----
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
--
S
L
K
D
Q
I
T
-
S
G
K
YNF
I
P
E
V
-
W
A
----
E
-
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
55.73
31%
-97
- C1 -
4YUR
1
PLK4_HUMAN
A:
[20-269]
----------
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
-
D
K
K
A
M
Y
K
A
G
M
-----
V
Q
R
---
V
---
Q
N
E
V
K
I
H
C
Q
L
-
K
H
P
-
S
I
L
E
L
-----
Y
N
Y
F
-
E
---
D
---
S
N
---------
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
---
N
R
--
V
K
--
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
-
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
---
N
I
K
I
A
D
F
-----------------------------------------
G
L
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
T
V
K
--
N
T
L
N
K
V
V
-
L
A
D
---
Y
-
E
M
-
P
S
----
F
-
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
55.68
32%
-79
- C1 -
4U45
1
M4K4_HUMAN
A:
[22-293]
-
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
---
V
---
T
E
-----
D
E
E
E
E
-
I
---
K
L
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
-
P
--------
D
--------
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
--
T
K
--
G
N
--
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
---
E
V
K
L
V
D
F
G
V
S
A
---------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
CDENP
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
--
E
G
A
P
P
L
-
C
D
M
H
--
P
M
R
A
L
F
L
-
I
P
R
---
N
P
P
--
P
R
LKSK
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
55.31
35%
-77
- C1 -
2A19
1
E2AK2_HUMAN
B:
[12-269]
----
D
F
K
E
I
E
L
I
G
S
G
G
F
G
Q
V
F
K
A
K
H
R
I
D
G
K
T
Y
V
I
K
R
V
-
K
---
Y
N
N
-----------
E
K
-
A
---
E
R
E
V
K
A
L
A
K
L
-
D
H
V
-
N
I
V
H
Y
-----
N
G
C
W
-
D
---
G
---
F
D
YDRSK
T
--
K
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
E
Q
W
I
E
K
--
R
R
--
G
E
--
K
L
D
K
V
L
A
L
E
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
-
L
I
N
R
D
L
K
P
S
N
I
F
L
V
D
T
K
---
Q
V
K
I
G
D
F
G
L
V
T
S
L
K
N
D
G
K
-
R
T
R
S
K
G
T
L
R
Y
M
S
P
E
Q
I
---
S
-----
S
Q
D
Y
G
K
E
V
D
L
Y
A
L
G
L
I
L
A
E
L
L
H
V
C
D
T
A
F
E
---
T
S
--
K
F
F
T
D
L
R
-
D
G
I
---
I
----
S
D
----
I
-
F
D
K
K
E
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
L
T
V
W
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
55.14
32%
-82
- C1 -
4U43
1
M4K4_HUMAN
A:
[22-293]
-
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
---
V
---
T
E
-----
D
E
E
E
E
-
I
---
K
L
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
-
P
---
G
---
H
D
--------
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
--
T
K
--
G
N
--
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
---
E
V
K
L
V
D
F
G
V
-----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
CDENP
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
--
E
G
A
P
P
L
-
C
D
M
H
--
P
M
R
A
L
F
L
-
I
P
R
---
N
P
P
--
P
R
LKSK
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
54.15
32%
-84
- C1 -
4OBP
2
M4K4_HUMAN
A:
[22-293]
-
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
---
V
---
T
E
-----
D
E
E
E
E
-
I
---
K
L
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
GAFI
K
K
S
-----------
D
--------
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
--
T
K
--
G
N
--
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
---
E
V
K
L
V
D
F
G
V
S
A
---------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
CDENP
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
--
E
G
A
P
P
L
-
C
D
M
H
--
P
M
R
A
L
F
L
-
I
P
R
---
N
P
P
--
P
R
LKSK
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
53.30
31%
-97
- C1 -
4JXF
2
PLK4_HUMAN
A:
[14-264]
----------
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
-
D
K
K
A
M
Y
K
A
G
M
-----
V
Q
R
---
V
---
Q
N
E
V
K
I
H
C
Q
L
-
K
H
P
-
S
I
L
E
L
-----
Y
N
Y
F
-
E
---
D
---
S
N
---------
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
---
N
R
--
V
K
--
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
-
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
---
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
M
P
H
E
---------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-----
V
K
--
N
T
L
N
K
V
V
-
L
A
D
---
Y
-
E
M
-
P
S
----
F
-
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
51.58
32%
-86
- C1 -
4RVT
2
M4K4_HUMAN
A:
[24-295]
-
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
---
V
---
T
---------
E
E
-
I
---
K
L
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
-
P
---
G
---
H
D
--------
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
--
T
K
--
G
N
--
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
---
E
V
K
L
V
D
F
G
V
-----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
CDENP
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
--
E
G
A
P
P
L
-
C
D
M
H
--
P
M
R
A
L
F
L
-
I
P
R
---
N
P
P
--
P
R
LKSK
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
51.51
32%
-86
- C1 -
4OBQ
2
M4K4_HUMAN
A:
[22-293]
-
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
-
D
---
V
----------------------
E
I
N
M
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
-
P
---
G
---
H
D
--------
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
--
T
K
--
G
N
--
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
---
E
V
K
L
V
D
F
G
V
-----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
CDENP
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
--
E
G
A
P
P
L
-
C
D
M
H
--
P
M
R
A
L
F
L
-
I
P
R
---
N
P
P
--
P
R
LKSK
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
50.60
31%
-69
- C1 -
3F61
1
PKNB_MYCTU
A:
[19-292]
----------
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
D
H
R
D
V
A
V
K
V
L
-
R
---
A
D
L
A
R
D
P
S
F
Y
L
R
F
R
R
--------
E
A
Q
N
A
A
A
L
-
N
H
P
-
A
I
V
A
V
-----
Y
D
T
G
-
E
---
A
E
T
P
A
G
--------
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
-
R
D
I
V
H
--
T
E
--
G
P
--
M
T
P
K
-
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
-
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
---
A
V
K
V
M
D
F
G
I
A
----------------
A
Q
Y
L
S
P
E
Q
A
---
R
-----
G
D
S
V
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
G
E
P
P
F
T
G
-
D
S
P
D
--
S
V
A
Y
Q
H
V
R
E
D
P
---
I
P
P
S
-
A
R
HE--
G
-
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
V
L
T
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
48.67
32%
-105
- C1 -
2A19
1
E2AK2_HUMAN
C:
[16-267]
--------
I
E
L
I
G
S
G
G
F
G
Q
V
F
K
A
K
H
R
I
D
G
K
T
Y
V
I
K
R
V
-
K
---
Y
N
N
E
K
------------
A
---
E
R
E
V
K
A
L
A
K
L
-
D
H
V
-
N
I
V
H
Y
-----
N
G
C
W
-
D
---
G
---
F
D
YDPETSK
T
K
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
---------------------
L
A
L
E
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
-
L
I
N
R
D
L
K
P
S
N
I
F
L
V
D
T
K
---
Q
V
K
I
G
D
F
G
L
V
--------------------------------------
G
K
E
V
D
L
Y
A
L
G
L
I
L
A
E
L
--
L
----------------------
G
I
---
I
S
D
I
---------
F
D
K
K
E
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
L
T
V
W
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------