@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NEK5_HUMAN: (2015-10-15 )
MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHMLICRAGAPASRHAGKVVQKCKIQKVRFQGKCPPRSRISVPIKRNAILHRNEWRPPAGAQKARSIKMIERPKIAAVCGHYDYYYAQLDMLRRRAHKPSYHPIPQENTGVEDYGQETRHGPSPSQWPAEYLQRKFEAQQYKLKVEKQLGLRPSSAEPNYNQRQELRSNGEEPRFQELPFRKNEMKEQEYWKQLEEIRQQYHNDMKEIRKKMGREPEENSKISHKTYLVKKSNLPVHQDASEGEAPVQMEFRSCCPGWSAMARSWLTATSASQDIEKDLKQMRLQNTKESKNPEQKYKAKKGVKFEINLDKCISDENILQEEEAMDIPNETLTFEDGMKFKEYECVKEHGDYTDKAFEKLHCPEAGFSTQTVAAVGNRRQWDGGAPQTLLQMMAVADITSTCPTGPDSESVLSVSRQEGKTKDPYSPVLILM
Atome Classification :
(41 SA)
.........10........20........30.....-...40-........-.---50........60........70-.--...-------.....80........90..--.---.--------------.----------------------...100.......110........120.-......130...---....140........150...----....160.......170......--.180.........190.......200..-.-..-..210.......--220.-.-..---..-.230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
K
Y
D
V
I
K
A
I
GQGAFG
K
A
Y
LAKGKSDSK
H
C
V
I
K
EIN-FEKM--PIQEKEAS-K---K
E
V
I
L
L
EKMKHPN
I
V
A
F
F
N
SF--Q--EN
G
-------
R
L
F
I
V
M
E
YCD
G
G
D
L
M
K
R
I
N
--
R
---Q--------------R----------------------G
V
L
FSED
Q
I
L
G
W
F
V
-
Q
I
S
L
G
L
K
H
I
H
D
R
K
-
I
L
H
R
DIKA
Q
N
I
F
---LSKN
G
-
M
V
A
KLG
D
F
G
I
A
R
V
L
N----N
S
M
E
L
A
R
T
CIGTPYYL
S
P
E
I
CQN--KP--YNNKT
D
I
W
S
L
G
C
V
L
Y
E
L
C
TLKHPF-E-GN-
N
L
Q
Q
L
V
L
K
I
C
Q
A
--HFAP-I-SP---
G
F
-
S
R
E
L
H
S
L
I
S
Q
L
F
QVSPRDR
P
S
I
N
S
I
L
K
R
P
F
L
E
N
L
I
P
K
YL
T
P
E
V
I
Q
E
EFS
H
M
L
I
CRAGAPA
S
R
H
A
G
K
V
V
Q
K
CK
I
Q
K
V
R
F
QGKCPPRS
R
I
SVPIKR
N
A
I
LHRNEWRPPAGA
Q
K
A
R
S
I
K
MIERP
K
I
A
A
VCGH
Y
D
Y
Y
Y
A
Q
L
D
M
L
R
R
RAHKPSYHPIPQENTG
V
E
DYGQETRHGPS
P
S
Q
W
P
A
E
Y
L
Q
R
K
F
E
A
Q
Q
Y
K
L
K
V
E
K
QLGLRPSSAEPN
Y
N
Q
R
Q
E
L
R
SNGEEP
R
F
Q
ELPFRK
N
E
M
K
E
Q
E
Y
W
K
Q
L
E
E
I
R
Q
Q
Y
H
N
D
M
K
E
I
R
K
KMGREPEENSKIS
H
K
T
Y
L
V
KKSNLPVHQDASEGEA
P
V
Q
M
E
F
R
SCCP
G
W
S
A
M
A
R
S
W
L
TATS
A
S
Q
D
I
E
K
D
L
K
Q
M
R
L
QNTKESK
N
P
E
Q
K
Y
KAKKG
V
K
F
E
I
N
L
D
KCISD
E
N
IL
Q
E
E
E
AMDIPNE
T
L
T
F
EDGMK
F
K
E
Y
E
C
V
K
EHGD
Y
T
D
K
A
F
E
K
LHCPEAGFST
Q
T
V
AAVGNRRQWDGG
A
P
Q
T
L
L
Q
M
M
A
V
A
D
I
TSTCPTGPD
S
E
S
V
L
S
V
S
RQEGKTKDPYS
P
V
L
I
LM
21
PsiBlast_CBE
86.95
62%
-115
- C2 -
4B9D
2
NEK1_HUMAN
B:
[23-306]
M
E
K
Y
V
R
L
Q
K
I
G
-----
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
-
I
S
R
M
--
S
S
K
E
R
E
E
S
-
R
---
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
--
E
N
G
-------
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
--
A
---
Q
--------------
K
----------------------
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
-
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
---
L
T
K
D
G
-
T
V
-
Q
L
G
D
F
G
I
A
R
V
L
N
----
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
N
--
K
P
--
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
-
E
-
A
G
-
S
M
K
N
L
V
L
K
I
I
S
G
--
S
F
P
P
-
V
-
S
L
---
H
Y
-
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.43
62%
-117
- C2 -
4B9D
1
NEK1_HUMAN
A:
[23-306]
M
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
-
I
S
R
M
--
S
S
K
E
R
E
E
S
-
R
---
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
--
E
N
G
-------
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
--
A
---
Q
--------------
K
----------------------
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
-
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
---
L
T
K
D
G
-
T
V
-
Q
L
G
D
F
G
I
A
R
V
L
N
----
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
N
--
K
P
--
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
-
E
-
A
G
-
S
M
K
N
L
V
L
K
I
I
S
G
--
S
F
P
P
-
V
-
S
L
---
H
Y
-
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
HHSearch
84.50
57%
-117
- C2 -
4B9D
1
NEK1_HUMAN
A:
[23-306]
M
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
-
I
S
R
M
--
S
S
K
E
R
E
E
S
-
R
---
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
--
E
N
G
-------
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
--
A
---
Q
--------------
K
----------------------
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
-
Q
I
C
L
A
L
K
H
V
H
D
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
---
L
T
K
D
G
-
T
V
-
Q
L
G
D
F
G
I
A
R
V
L
N
----
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
N
--
K
P
--
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
-
E
-
A
G
-
S
M
K
N
L
V
L
K
I
I
S
G
--
S
F
P
P
-
V
-
S
L
---
H
Y
-
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
76.78
42%
-110
- C2 -
2W5A
5
NEK2_HUMAN
A:
[5-271]
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
--
I
DR
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
---
G
T
K
------------
E
----------------------
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
G
L
A
R
I
L
-------
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
M
---
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.03
41%
-111
- C2 -
2W5A
5
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
G
L
A
R
I
L
-------
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
M
---
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.32
41%
-117
- C2 -
2XKE
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
----------------------
T
P
Y
Y
M
S
P
E
Q
M
N
--------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.07
41%
-113
- C2 -
2XKF
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
-------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
S
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.05
41%
-115
- C2 -
2XKD
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
------------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
M
S
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.96
41%
-111
- C2 -
2XNM
10
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
-----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
G
L
A
R
I
L
-------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
---
S
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
73.82
41%
-119
- C2 -
2JAV
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID-------------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
D-----
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
G
L
A
R
I
L
---------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
M
S
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
72.73
41%
-111
- C2 -
2XK7
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
--------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
--------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.22
41%
-108
- C2 -
2W5B
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
--
L
H
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
G
L
A
R
I
L
N
----
H
D
T
S
F
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
M
S
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.18
41%
-112
- C2 -
2XK8
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
-------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
--------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.09
41%
-108
- C2 -
2XNO
13
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
-------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.84
41%
-111
- C2 -
2WQO
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
-------
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
----------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
71.44
41%
-107
- C2 -
2XNP
6
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
---
H
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
G
L
-----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
71.32
41%
-105
- C2 -
2XNN
6
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
G
------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.30
41%
-107
- C2 -
2XK3
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
G
-------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.74
41%
-109
- C2 -
2XK6
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
-----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
---------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.65
41%
-108
- C2 -
2XK4
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
R
D
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
F
G
L
-----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
M
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.85
41%
-105
- C2 -
2XKC
1
NEK2_HUMAN
A:
[6-271]
-
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
-
Y
G
S
M
--
T
E
A
E
K
Q
M
L
-
V
---
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--------------
R
----------------------
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
K
P
A
N
V
F
---
L
D
G
K
Q
-
N
V
-
K
L
G
D
----------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
-
A
F
-
S
Q
K
E
L
A
G
K
I
R
E
G
--
K
F
R
R
-
I
-
P
Y
---
R
Y
-
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
66.77
36%
-109
- C2 -
2WQN
1
NEK7_HUMAN
A:
[31-288]
L
A
N
F
R
I
E
K
K
I
G
R
G
Q
F
S
E
V
Y
R
A
A
C
L
L
D
G
V
P
V
A
L
K
K
V
Q
I
F
D
L
M
--
D
A
K
A
R
A
D
C
-
I
---
K
E
I
D
L
L
K
Q
L
N
H
P
N
V
I
K
Y
Y
A
S
F
--
I
--
E
D
N
-------
E
L
N
I
V
L
E
L
A
D
A
G
D
L
S
R
M
I
K
H
F
K
---
K
--------------
Q
----------------------
K
R
L
I
P
E
R
T
V
W
K
Y
F
V
-
Q
L
C
S
A
L
E
H
M
H
S
R
R
-
V
M
H
R
D
I
K
P
A
N
V
F
---
I
T
A
T
G
-
V
V
-
K
L
G
D
L
----------------------
T
P
Y
Y
M
S
P
E
R
I
H
E
--
N
G
--
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
-
Y
---M
N
L
Y
S
L
C
K
K
I
E
Q
C
--
D
Y
P
P
-
L
P
S
D
---
H
Y
-
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
P
D
V
T
Y
V
Y
D
V
A
K
R
M
H
A
C
T
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
66.71
30%
-91
- C2 -
3HKO
2
?
A:
[26-337]
-
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
-
K
N
K
I
R
Q--
K
D
V
E
R
I
-
K
---
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
--
E
--
D
E
Q
-------
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
--
V
---
F
I
DDSTG
K
C
A
M
D
V
V
K
T
QICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
-
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
-
I
C
H
R
D
I
K
P
E
N
F
L
---
F
S
T
N
K
S
F
E
I
K
L
V
D
F
G
L
S
K
E
F
Y
KLNN
G
--------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
TN
E
S
--
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
-
P
-
G
V
-
N
D
A
D
T
I
S
Q
V
L
N
K
--
K
L
C
F
-
E
-
N
P
NYN
V
L
-
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
D
K
I
Y
K
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
63.98
33%
-98
- C2 -
4BIC
2
B:
[26-280]
--------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------
P
E
R
----
S
-
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
--
S
--
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
---
K
--------------
W
----------------------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
-
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-------------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
--
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
-
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
F
--
K
V
H
P
E
I
-
P
E
---
S
M
-
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
63.43
33%
-99
- C2 -
4BF2
1
B:
[42-295]
--------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------
P
E
R
----------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
--
S
--
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
---
K
--------------
W
----------------------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
-
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-------------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
--
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
-
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
F
--
K
V
H
P
E
I
-
P
E
---
S
M
-
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
63.09
33%
-102
- C2 -
4BF2
2
M3K5_HUMAN
A:
[42-295]
--------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------
P
E
-----------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
--
S
--
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
---
K
--------------
W
----------------------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
-
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
--
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
-
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
F
--
K
V
H
P
E
I
-
P
E
---
S
M
-
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
62.67
34%
-98
- C2 -
2CLQ
1
B:
[29-283]
--------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------
P
E
R
----
S
-
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
--
S
--
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
---
K
--------------
W
----------------------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
-
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
--
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
-
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
F
--
K
V
H
P
E
I
-
P
E
---
S
M
-
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
62.19
33%
-99
- C2 -
4BIC
2
M3K5_HUMAN
A:
[26-280]
--------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------
P
E
-----
S
-
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
--
S
--
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
---
K
--------------
W
----------------------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
-
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
--
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
-
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
F
--
K
V
H
P
E
I
-
P
E
---
S
M
-
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
62.07
34%
-96
- C2 -
2CLQ
1
M3K5_HUMAN
A:
[29-283]
--------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------
P
E
R
D
S
----
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
--
S
--
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
---
K
--------------
W
----------------------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
-
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----
G
-----
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
--
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
-
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
F
--
K
V
H
P
E
I
-
P
E
---
S
M
-
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
61.84
33%
-100
- C2 -
4BID
1
B:
[26-280]
--------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------
P
E
R
----
S
-
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
--
S
--
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
---
K
--------------
W
----------------------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
-
G
V
L
K
I
S
D
F
G
T
S
K
R
L
-------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
--
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
-
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
F
--
K
V
H
P
E
I
-
P
E
---
S
M
-
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
61.67
33%
-99
- C2 -
4BIE
2
M3K5_HUMAN
A:
[26-280]
--------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------
P
E
--------LH-
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
--
S
--
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
---
K
--------------
W
----------------------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
-
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----
G
------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
--
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
-
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
F
--
K
V
H
P
E
I
-
P
E
---
S
M
-
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
61.66
33%
-98
- C2 -
4BIE
2
B:
[26-280]
--------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------
P
E
R
-------L
H
-
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
--
S
--
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
---
K
--------------
W
----------------------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
-
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
--
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
-
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
F
--
K
V
H
P
E
I
-
P
E
---
S
M
-
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
61.60
33%
-104
- C2 -
4BID
1
M3K5_HUMAN
A:
[26-280]
--------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------
P
E
--------L
H
-
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
--
S
--
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
---
K
--------------
W
----------------------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
-
G
V
L
K
I
S
D
F
G
T
S
K
R
------------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
--
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
-
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
F
--
K
V
H
P
E
I
-
P
E
---
S
M
-
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
61.25
33%
-98
- C2 -
4BIB
1
B:
[26-280]
--------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------
P
E
R
----
S
-
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
--
S
--
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
---
K
--------------
W
----------------------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
-
G
V
L
K
I
S
D
F
G
T
S
K
R
L
-------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
--
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
-
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
F
--
K
V
H
P
E
I
-
P
E
---
S
M
-
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
60.89
31%
-110
- C2 -
4FG7
1
KCC1A_HUMAN
A:
[18-276]
-
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
--------------
S
M
E
---
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
--
E
--
S
G
G
-------
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
---
V
---
E
--------------
K
----------------------
G
-
F
Y
T
E
R
D
A
S
R
L
I
F
-
Q
V
L
D
A
V
K
Y
L
H
D
L
G
-
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
D
S
-
K
I
M
-
I
S
D
F
G
L
S
K
M
E
D
----
P
G
---------
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
----
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
-
D
E
-
N
D
A
K
L
F
E
Q
I
L
K
A
--
E
Y
E
F
-
D
-
S
P
YWD
D
I
-
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
60.82
33%
-98
- C2 -
4BIB
3
M3K5_HUMAN
A:
[26-280]
--------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------
P
E
--------L
H
-
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
--
S
--
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
---
K
--------------
W
----------------------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
-
G
V
L
K
I
S
D
F
G
T
S
K
R
------------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
--
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
-
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
F
--
K
V
H
P
E
I
-
P
E
---
S
M
-
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
59.95
33%
-96
- C2 -
4BHN
2
B:
[42-295]
--------
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
--------
P
E
R
----
S
-
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
--
S
--
E
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
---
K
--------------
W
----------------------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
-
I
V
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
-
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
--
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
-
L
G
-
E
P
Q
A
A
M
F
K
V
G
M
F
--
K
V
H
P
E
I
-
P
E
---
S
M
-
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
58.23
32%
-98
- C2 -
4YUR
1
PLK4_HUMAN
A:
[12-268]
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
-
K
K
A
M
Y
-
K
A
G
M
V
Q
R
V
-
Q
---
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
--
E
--
D
S
N
-------
Y
V
Y
L
V
L
E
M
C
H
N
G
E
-
M
N
R
Y
L
--
K
---
N
--------------
R
----------------------
V
K
P
F
S
E
N
E
A
R
H
F
M
H
-
Q
I
I
T
G
M
L
Y
L
H
S
H
G
-
I
L
H
R
D
L
T
L
S
N
L
L
---
L
T
R
N
--
M
N
I
K
I
A
D
F
-----------------------------------------
G
L
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
------
T
V
K
N
T
L
N
K
V
V
L
A
--
D
Y
E
----
M
P
---
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
57.90
32%
-98
- C2 -
3COK
1
PLK4_HUMAN
A:
[10-266]
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
-
K
K
A
M
Y
-
K
A
G
M
V
Q
R
V
-
Q
---
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
--
E
--
D
S
N
-------
Y
V
Y
L
V
L
E
M
C
H
N
G
E
-
M
N
R
Y
L
--
K
---
N
--------------
R
----------------------
V
K
P
F
S
E
N
E
A
R
H
F
M
H
-
Q
I
I
T
G
M
L
Y
L
H
S
H
G
-
I
L
H
R
D
L
T
L
S
N
L
L
---
L
T
R
N
--
M
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-
D
-
T
D
-
T
V
K
-----
V
V
L
A
--
D
Y
E
----
M
P
---
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
HHSearch
56.64
31%
-99
- C2 -
1ZY4
1
GCN2_YEAST
A:
[6-288]
-
S
D
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
-
H
-----
T
E
E
K
L
S
T
I
-
L
---
S
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
--
L
--
E
R
R
N
F
VK
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
L
I
H
--
S
------------------
E
----------------------
N
L
N
Q
Q
R
D
E
Y
W
R
L
F
R
-
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
-
I
I
H
R
D
L
K
P
M
N
I
F
---
I
D
E
S
R
-
N
V
-
K
I
G
D
F
G
L
A
K
N
V
H
----
R
-----------
A
M
Y
V
A
T
E
V
L
D
G
T-
G
H
--
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
---
P
F
-
S
T
G
M
-
E
R
V
N
I
L
K
K
L
R
S
V
SI
E
F
P
P
D
F
-
D
D
---
N
K
-
M
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
K
H
Q
D
E
V
I
K
E
A
L
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
55.37
32%
-99
- C2 -
4JXF
2
PLK4_HUMAN
A:
[6-262]
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
-
K
K
A
M
Y
-
K
A
G
M
V
Q
R
V
-
Q
---
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
--
E
--
D
S
N
-------
Y
V
Y
L
V
L
E
M
C
H
N
G
E
-
M
N
R
Y
L
--
K
---
N
--------------
R
----------------------
V
K
P
F
S
E
N
E
A
R
H
F
M
H
-
Q
I
I
T
G
M
L
Y
L
H
S
H
G
-
I
L
H
R
D
L
T
L
S
N
L
L
---
L
T
R
N
--
M
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
----
M
P
H
E
-----------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-------
V
K
N
T
L
N
K
V
V
L
A
--
D
Y
E
----
M
P
---
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------