@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NEK8_HUMAN: (2015-10-15 )
MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPRGPVRPAIPPPLSSVYAWGGGLGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSCCHGNTLLAVRSVTDEPVPP
Atome Classification :
(37 SA)
.........---10........20........30......-..40....-....50........60........70-------.--..-------.....80........90..--.--..--...100.......110........120--........130.......140.......150...-.-.-..160.......170.....-..--180.......190.......200.-......-210...-..---..220-.-......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEK
Y
E
R
I
R
V
---VGR
G
A
F
G
I
V
H
L
C
L
R
KAD
Q
K
L
V
I
I
K
QI
P
V
-
E
Q
M
T
K
E
E
R
-
Q
A
A
Q
N
E
C
Q
V
L
K
L
LNHP
N
V
I
E
Y
Y
E
N
F
L
-------E--D
K
-------
A
L
M
I
A
M
EYAPGG
T
L
A
E
F
I
Q
--
K
--
R
C
--
N
S
L
L
E
E
E
T
I
L
H
F
F
V
-
Q
I
L
L
A
L
H
H
V
H
T
---
H
L
I
L
HRDLKTQ
N
I
L
L
DK
H
R
M
V
V
K
IG
D
F
G
I
S
K
I
L
S-S-K-S
K
A
Y
T
V
VGTPCYIS
P
E
LCEG-KP--YNQKS
D
I
W
A
L
G
C
V
L
Y
E
L
A
S
L
K
R
A
F
-
E
A
AN
L
P
-
A
L
V
L
K
I
-MS---GTFAP-I-SDRY
S
P
E
L
R
Q
L
V
L
S
L
LSLEPAQRP
P
L
S
H
I
MAQ
P
L
C
I
R
A
L
L
N
LHTD
V
G
S
V
R
M
R
R
A
EKSVAPSNTGS
R
T
T
S
V
R
C
RGIPRGPVRPAIPP
P
L
S
S
V
Y
AWGGGLGTPLRLPMLN
T
E
V
V
QVAAGRTQKAGVTRSG
R
L
I
L
WEAPPLGAGGGSLLPGAVEQP
Q
P
Q
F
I
S
R
F
LEGQSG
V
T
I
K
H
VA
C
G
D
F
F
T
A
C
LTDR
G
I
I
M
T
FGSGSNGCLGHGSLTDIS
Q
P
T
I
V
E
A
L
L
G
Y
E
M
V
Q
V
ACGA
S
H
V
L
A
LSTER
E
L
F
A
WGRGDSGRLGLGTRESHSCPQQVPMPP
G
Q
E
A
Q
R
V
V
CGIDS
S
M
I
L
T
VPGQALACGSNR
F
N
KLGLDHLSLGEEPV
P
H
Q
Q
V
E
E
A
L
S
F
T
LLGSAPLDQEP
L
L
S
I
DLGTAH
S
A
A
V
TASG
D
C
Y
TFGSNQHGQLGTNTRRGSRAP
C
K
VQGLE
G
I
K
M
A
M
V
ACG
D
A
F
T
V
A
IGAES
E
V
YSWGKGARGRLGRRDEDAGLPRPVQLDETH
P
Y
T
V
T
S
V
S
CCHG
N
T
L
L
A
V
RSVTDEPVPP
18
PsiBlast_PDB
75.39
39%
-146
- C3 -
2JAV
1
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
-----------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
SD-------
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
-------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-
M
S
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.01
39%
-135
- C3 -
2XKF
1
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S------
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
-----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
S
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.50
39%
-139
- C3 -
2XKE
1
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
SD-------
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
--------------------
T
P
Y
Y
M
S
P
E
Q
M
N
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.47
39%
-133
- C3 -
2XNM
10
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R-------
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
-----------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
S
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
72.44
39%
-135
- C3 -
2XK7
1
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S------
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.26
39%
-133
- C3 -
2XK6
1
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
-----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S------
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
-------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.73
39%
-128
- C3 -
2W5A
5
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S----
L
H
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
----
T
-
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-
M
---
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.55
39%
-136
- C3 -
2WQO
1
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R---------
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
--------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
71.07
41%
-127
- C3 -
2W5A
5
NEK2_HUMAN
A:
[5-270]
A
E
D
Y
E
V
L
Y
T
---
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
--
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
---
R
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
-
N
V
K
L
G
D
F
G
L
A
R
I
L
-----T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-
M
---
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
70.87
39%
-130
- C3 -
2W5B
1
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S----
L
H
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
N
H
D
-
T
-
S
F
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-
M
S
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.66
39%
-133
- C3 -
2XKC
1
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S--------
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
--------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.56
39%
-133
- C3 -
2XK8
1
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S------
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
-----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.39
39%
-135
- C3 -
2XKD
1
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
SD-------
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
----------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-
M
S
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.28
39%
-130
- C3 -
2XK3
1
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S------
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
G
-----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
70.03
39%
-132
- C3 -
2XNO
13
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S------
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
-----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
70.02
39%
-126
- C3 -
2XNP
6
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S-----
H
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
G
L
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.53
39%
-129
- C3 -
2XK4
1
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S------
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
G
L
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-
M
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
68.97
39%
-130
- C3 -
2XNN
7
NEK2_HUMAN
A:
[6-272]
-
E
D
Y
E
V
L
Y
T
---
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
-
G
S
M
T
E
A
E
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-------
D
RT
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
K
E
--
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
-
Q
L
T
L
A
L
K
E
C
H
R
R
S------
R
D
L
K
P
A
N
V
F
L
D
G
-
K
Q
N
V
K
L
G
D
F
G
----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
-----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
-
T
A
F
S
Q
K
-
E
L
A
G
K
I
-
R
E
---
G
K
F
R
R
-
I
-
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
66.45
40%
-139
- C3 -
2WQN
1
NEK7_HUMAN
A:
[38-288]
-------
K
K
---
I
G
R
G
Q
F
S
E
V
Y
R
A
A
C
L
L
D
G
V
P
V
A
L
K
K
V
Q
I
F
D
L
M
D
A
K
A
R
-
A
D
C
I
K
E
I
D
L
L
K
Q
L
N
H
P
N
V
I
K
Y
Y
A
S
F
I
-------
E
--
D
N
-------
E
L
N
I
V
L
E
L
A
D
A
G
D
L
S
R
M
I
K
H
F
K
--
K
Q
--
K
R
L
I
P
E
R
T
V
W
K
Y
F
V
-
Q
L
C
S
A
L
E
H
M
H
S
---
R
R
V
M
H
R
D
I
K
P
A
N
V
F
I
T
A
-
T
G
V
V
K
L
G
D
L
--------------------
T
P
Y
Y
M
S
P
E
R
I
H
E
-
N
G
--
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
Y--
M
N
L
Y
-
S
L
C
K
K
I
-
E
Q
---
C
D
Y
P
P
-
L
P
S
D
H
Y
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
P
D
V
T
Y
V
Y
D
V
A
K
R
M
H
A
C
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
59.12
33%
-123
- C3 -
1ZY4
1
GCN2_YEAST
A:
[6-287]
-
S
D
F
E
E
I
A
V
---
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
----
H
T
E
E
K
L
-
S
T
I
L
S
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
-------
E
--
R
R
N
F
VK
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
L
I
H
--
S
--
E
---
N
L
N
Q
Q
R
D
E
Y
W
R
L
F
R
-
Q
I
L
E
A
L
S
Y
I
H
S
---
Q
G
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
-
N
V
K
I
G
D
F
G
L
A
K
N
V
H
-
R
------------
A
M
Y
V
A
T
E
V
L
D
G
T
G
H
--
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
---
P
F
-
S
T
G
M
E
R
-
V
N
I
L
K
K
-
L
R
SVS
I
E
F
P
P
D
F
-
D
D
N
K
M
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
K
H
Q
D
E
V
I
K
E
A
L
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
55.69
31%
-124
- C3 -
3COK
1
PLK4_HUMAN
A:
[8-267]
-
E
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
-
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
-------
D
--
S
N
-------
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
--
N
--
R
V
--
K
P
F
S
E
N
E
A
-
R
H
F
M
H
-
Q
I
I
T
G
M
L
Y
L
H
S
---
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
-
M
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
---------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-
D
T
D
T
V
K
------
V
-
V
L
---
A
D
Y
-
E
-
M
-
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
54.87
31%
-121
- C3 -
4YUR
1
PLK4_HUMAN
A:
[10-269]
-
E
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
-
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
-------
D
--
S
N
-------
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
--
N
--
R
V
--
K
P
F
S
E
N
E
A
-
R
H
F
M
H
-
Q
I
I
T
G
M
L
Y
L
H
S
---
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
-
M
N
I
K
I
A
D
F
--------------------------------------
G
L
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
T
V
K
-
N
T
L
N
K
V
-
V
L
---
A
D
Y
E
--
M
-
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
54.83
31%
-122
- C3 -
4JXF
2
PLK4_HUMAN
A:
[4-264]
-
E
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
-
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
-------
D
--
S
N
-------
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
--
N
--
R
V
--
K
P
F
S
E
N
E
A
-
R
H
F
M
H
-
Q
I
I
T
G
M
L
Y
L
H
S
---
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
-
M
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
-
M
P
H
-
E
----------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-----
V
K
-
N
T
L
N
K
V
-
V
L
---
A
D
Y
E
--
M
-
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
53.69
31%
-117
- C3 -
4BIC
2
B:
[26-267]
--------
V
---
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
-
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
-------
E
--
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
--
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
---
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
-
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
---
K
V
H
P
E
-
I
-
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
53.62
31%
-117
- C3 -
4BIC
2
M3K5_HUMAN
A:
[26-267]
--------
V
---
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
-----
S
-
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
-------
E
--
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
--
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
---
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-
G
-------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
-
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
---
K
V
H
P
E
-
I
-
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
53.39
31%
-120
- C3 -
4BIE
2
M3K5_HUMAN
A:
[26-267]
--------
V
---
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
---------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
-------
E
--
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
--
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
---
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-
G
-------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
-
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
---
K
V
H
P
E
-
I
-
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
52.54
31%
-116
- C3 -
4BIB
1
B:
[26-267]
--------
V
---
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
-
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
-------
E
--
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
--
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
---
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
-----------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
-
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
---
K
V
H
P
E
-
I
-
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
52.16
31%
-120
- C3 -
4BF2
1
B:
[42-283]
--------
V
---
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
-------
E
--
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
--
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
---
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
-
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
---
K
V
H
P
E
-
I
-
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
51.98
32%
-107
- C3 -
2A19
1
E2AK2_HUMAN
B:
[11-269]
-
M
D
F
K
E
I
E
L
---
I
G
S
G
G
F
G
Q
V
F
K
A
K
H
R
I
D
G
K
T
Y
V
I
K
R
V
K
Y
-
N
N
-------
E
K
A
E
R
E
V
K
A
L
A
K
L
D
H
V
N
I
V
H
Y
N
G
C
W
D
G
F
D
YDRS
K
--
T
K
-------
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
E
Q
W
I
E
--
K
--
R
R
--
G
E
K
L
D
K
V
L
A
L
E
L
F
E
-
Q
I
T
K
G
V
D
Y
I
H
S
---
K
K
L
I
N
R
D
L
K
P
S
N
I
F
L
V
D
T
K
-
Q
V
K
I
G
D
F
G
L
V
T
S
L
K
-
N
-
D
-
G
K
R
T
R
S
K
G
T
L
R
Y
M
S
P
E
Q
I
S
S
-
Q
D
--
Y
G
K
E
V
D
L
Y
A
L
G
L
I
L
A
E
L
L
H
V
C
D
T
A
-
F
E
T
--
S
-
K
F
F
T
D
L
-
R
D
---
G
I
----
I
-
S
D
I
F
D
K
K
E
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
L
T
V
W
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
51.77
31%
-112
- C3 -
4BHN
2
B:
[42-283]
--------
V
---
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
-
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
-------
E
--
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
--
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
---
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
-
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
---
K
V
H
P
E
-
I
-
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
51.28
31%
-116
- C3 -
4BID
1
B:
[26-267]
--------
V
---
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
-
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
-------
E
--
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
--
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
---
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
-----------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
-
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
---
K
V
H
P
E
-
I
-
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
50.96
31%
-121
- C3 -
4BID
1
M3K5_HUMAN
A:
[26-267]
--------
V
---
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
---------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
-------
E
--
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
--
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
---
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
-
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
---
K
V
H
P
E
-
I
-
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
50.79
31%
-113
- C3 -
4BIB
3
M3K5_HUMAN
A:
[26-267]
--------
V
---
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
---------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
-------
E
--
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
--
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
---
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
-
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
---
K
V
H
P
E
-
I
-
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
50.79
31%
-114
- C3 -
4BIE
2
B:
[26-267]
--------
V
---
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
-------
E
--
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
--
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
---
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
-
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
---
K
V
H
P
E
-
I
-
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
50.58
31%
-121
- C3 -
4BF2
2
M3K5_HUMAN
A:
[42-283]
--------
V
---
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
-----------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
-------
E
--
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
--
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
---
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
-
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
---
K
V
H
P
E
-
I
-
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
49.43
32%
-111
- C3 -
2CLQ
1
M3K5_HUMAN
A:
[29-270]
--------
V
---
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
D
S
----
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
-------
E
--
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
--
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
---
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-
G
------
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
-
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
---
K
V
H
P
E
-
I
-
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
48.70
32%
-112
- C3 -
2CLQ
1
B:
[29-270]
--------
V
---
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
-
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
-------
E
--
N
G
-------
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
--
S
--
K
W
--
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
---
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
-
G
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
-
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
---
K
V
H
P
E
-
I
-
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------