@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NLK_HUMAN: (2015-10-15 )
MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
Atome Classification :
(74 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130----......----.----140-----.......150.....--.-.-160.......-170........180.......190.......200....--..--.210..--.....220..-.....230------..-......240.......250.......260.......270----..-.....280.......290-.---.--...---...300.......310.......320.......330....-----------...340...-------.----...350.......360.-..-.-..-.370---.......-..380-.......--.390....--.------------...400.......410.......420.......430.......440.......450.-......460.......470........480.......490--........500.......510.......520.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSLCGARAN
A
K
M
M
A
A
YNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVH
P
V
Q
Q
HT
S
S
A
A
A
A
A
A
A
A
A
A
A
A
A
MLNPGQQQPYFPSPAPGQAPGPAAAAP
A
Q
V
Q
A
A
A
A
A
T
V
K
A
HHHQHSHH
P
----
Q
Q
QLDI----E----PDR-----PIGYG
A
F
G
V
V
W
SVTD--P-R-DGK
R
V
A
L
K
K
M
-
P
N
-
V
F
Q
N
L
V
S
C
K
R
V
F
R
E
L
K
M
L
C
FFKHD
N
V
L
S
A
L
D
ILQP--PH--
I
D
Y
F
E
E
--
I
Y
V
V
T
E
L
M
Q
S
-
D
L
H
K
II-V------SP-QPLS
S
D
H
V
K
V
F
L
Y
Q
I
L
R
G
L
K
Y
L
H
SAGILHRDIKPG
N
L
L
V----NS-N
C
V
L
K
I
C
D
F
G
L
A
R
V
E
E
L
--
D
---
E
--
S
R
H
---
M
T
Q
E
V
V
T
Q
Y
YRA
P
E
I
LMGSRHYSN
A
I
D
I
W
S
V
G
C
I
F
A
E
L
L
G
-----------
R
R
I
L
FQAQS-------
P
----
I
Q
Q
L
D
L
I
T
D
L
LGTP
S
L
E
-
A
M
-
R
-
T
A
-CE-----GAKAHIL-RGPH--KQPSL
P
V
--
L
Y
-TLSSQ--
A
------------
T
H
E
A
V
H
L
L
C
R
M
L
VFDPSKRISA
K
D
ALAHPYLDEG
R
L
R
Y
H
T
C
M
C
K
CCFSTSTG
R
V
Y
TS-DFEPVTNPKF
D
D
T
F
E
K
N
-
L
S
S
V
R
Q
V
K
E
I
I
H
Q
F
I
L
E
QQKG---NRV
P
L
C
INP
Q
S
A
A
F
K
S
F
I
S
S
T
VAQPSEMPPSPLVWE
122
HHSearch
89.64
46%
-119
- C1 -
4IC7
1
MK07_HUMAN
A:
[58-402]
--------------------------------------------------------------------------------------------------------------------------------------------------
E
----
I
I
E
-----
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
--
R
-
L
-
T
G
Q
Q
V
A
I
K
K
I
-
P
N
-
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
--
T
V
P-
Y
G
E
F
K
S
--
V
Y
V
V
L
D
L
M
E
S
-
D
L
H
Q
I
I
-
H
------
S
S
-
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
----
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
--
S
PAE
H
--
Q
Y
F
---
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-----------
R
R
Q
L
F
P
G
K
N
-------
Y
----
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
-
V
I
-
Q
-
A
V
G
A
E
-----
R
V
R
A
Y
I
Q
-
S
L
P
P
--
R
Q
P
--
V
P
--
W
E
-
T
V
Y
P
G
--
A
------------
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
--------------------
Y
H
D
P
-
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
-
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
REG
I
R
Q
Q
I
R
------------------------------
70
PsiBlast_CBE
88.12
40%
-131
- C1 -
2QD9
1
MK14_HUMAN
A:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQNLS
P
V
G
--
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
----
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
---------------------------
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
60
PsiBlast_CBE
87.11
40%
-129
- C1 -
3MVM
1
MK14_HUMAN
B:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQNLS
P
V
----
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
-------------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---------------------------------------
45
PsiBlast_CBE
86.84
40%
-134
- C1 -
3P79
2
MK14_MOUSE
A:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQNLS
P
V
G
S
---
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
H
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
---------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
A
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
43
PsiBlast_CBE
86.84
40%
-133
- C1 -
3P7B
2
MK14_MOUSE
A:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQNLS
P
V
G
S
---
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
H
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
---------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
A
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
3
PsiBlast_PDB
86.22
43%
-123
- C1 -
4B99
1
MK07_HUMAN
A:
[48-382]
-------------------------------------------------------------------------------------------------------------------------------
V
T
F
D
V
----
G
D
E
Y
E
I
----------
I
E
-----
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
--
R
-
L
-
T
G
Q
Q
V
A
I
K
K
I
-
P
N
-
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
TV
P
Y
--
G
E
-
F
K
S
--
V
Y
V
V
L
D
L
M
E
S
-
D
L
H
Q
I
I
-
H
------
S
S
-
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
----
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
--------------QYF
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-----------
R
R
Q
L
F
P
G
K
N
-------
Y
----
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
-
V
I
-
Q
-----------
R
V
R
A
Y
I
Q
-
S
L
P
P
--
R
Q
P
-
V
P
---
W
E
-
T
V
Y
P
G
--
A
------------
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
----
A
K
Y
H
----------------
D
P
-
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
-
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
---
R
E
----------------------------------
46
PsiBlast_CBE
86.21
40%
-137
- C1 -
3P78
2
MK14_MOUSE
A:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQNLS
P
V
G
S
---
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
H
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
---------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
A
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
67
PsiBlast_CBE
85.99
40%
-127
- C1 -
3BV2
1
MK14_HUMAN
A:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
IWEV
P
E
R
YQNLS
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---------------------------------------
42
PsiBlast_CBE
85.94
40%
-133
- C1 -
3P7C
2
MK14_MOUSE
A:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQNLS
P
V
G
S
---
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
H
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
---------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
A
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
68
PsiBlast_CBE
85.76
40%
-126
- C1 -
2RG6
2
MK14_HUMAN
A:
[10-352]
----------------------------------------------------------------------------------------------------------------------------------
E
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQNLS
P
V
G
----
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
59
PsiBlast_CBE
85.47
40%
-128
- C1 -
3NWW
1
MK14_HUMAN
A:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQNLS
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
------------------------
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
L
----------------------------------
61
PsiBlast_CBE
85.34
40%
-132
- C1 -
3MVM
1
MK14_HUMAN
A:
[10-352]
----------------------------------------------------------------------------------------------------------------------------------
E
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQNLS
P
V
G
S
-----
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
-----------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
47
PsiBlast_CBE
85.33
40%
-135
- C1 -
3P5K
2
MK14_MOUSE
A:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQNLS
P
V
G
S
---
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
H
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
---------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
A
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
69
PsiBlast_CBE
84.78
40%
-125
- C1 -
2RG5
1
MK14_HUMAN
A:
[10-352]
----------------------------------------------------------------------------------------------------------------------------------
E
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQNLS
P
V
----
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
-------------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---------------------------------------
64
PsiBlast_CBE
84.77
40%
-129
- C1 -
3C5U
2
MK14_HUMAN
A:
[10-352]
----------------------------------------------------------------------------------------------------------------------------------
E
R
P
T
F
Y
R
Q
E
L
N
K
----
T
IWEV
P
E
R
YQN
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
-------------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
53
PsiBlast_CBE
84.72
40%
-125
- C1 -
4KIP
1
MK14_HUMAN
A:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQN
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
-------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
58
PsiBlast_CBE
84.16
40%
-135
- C1 -
3S4Q
1
MK14_HUMAN
A:
[10-352]
----------------------------------------------------------------------------------------------------------------------------------
E
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
-----
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
---------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
-------------------------
A
T
R
W
Y
R
A
P
E
I
M
-----
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
21
PsiBlast_CBE
84.10
43%
-111
- C1 -
4IC7
1
MK07_HUMAN
D:
[49-383]
-------------------------------------------------------------------------------------------------------------------------------
V
T
F
D
V
----
G
D
E
Y
E
I
----------
I
E
-----
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
--
R
-
L
-
T
G
Q
Q
V
A
I
K
K
I
-
P
N
-
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
TV
P
Y
--
G
E
-
F
K
S
--
V
Y
V
V
L
D
L
M
E
S
-
D
L
H
Q
I
I
-
H
------
S
S
-
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
----
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
--
S
---
P
--
A
E
H
QYF
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-----------
R
R
Q
L
F
P
G
K
N
-------
Y
----
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
-
V
I
-
Q
A
V
G
-
A
E
-----
R
V
R
A
Y
I
Q
-
S
L
P
P
--
R
Q
P
-
V
P
---
W
E
-
T
V
Y
P
G
--
A
------------
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
----
A
K
Y
H
----------------
D
P
-
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
-
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
---
R
E
G
I
R
Q
Q
I
----------------------------
52
PsiBlast_CBE
83.89
40%
-127
- C1 -
4KIP
1
MK14_HUMAN
B:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQNLS
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
------------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
102
PsiBlast_CBE
83.80
41%
-124
- C1 -
3GFE
1
MK14_HUMAN
A:
[35-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
---
D
---
E
--------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
87
PsiBlast_CBE
83.75
41%
-133
- C1 -
4F9W
4
MK14_HUMAN
A:
[52-369]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
--------------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
85
PsiBlast_CBE
83.71
41%
-133
- C1 -
4FA2
3
MK14_HUMAN
A:
[52-369]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
-------------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
L
----------------------------------
66
PsiBlast_CBE
83.69
40%
-124
- C1 -
3BV3
1
MK14_HUMAN
A:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
PT
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQNLS
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
------------------------
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
121
HHSearch
83.64
36%
-118
- C1 -
3N9X
2
?
A:
[29-415]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
----
I
K
H
-----
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
--
K
-
N
-
T
E
K
N
V
A
I
K
K
V
-
N
R
-
M
F
E
D
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
S
D
Y
I
I
R
L
Y
D
L
I
I
P
--
D
D
--
L
L
K
F
D
E
--
L
Y
I
V
L
E
I
A
D
S
-
D
L
K
K
L
F
-
K
------
T
P
-
I
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
----
N
Q
-
D
C
S
V
K
V
C
D
F
G
L
A
R
T
I
--------------------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
----
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
-
D
L
-
K
-
N
I
N
K
P
-----
E
V
I
K
Y
I
K
-
L
F
P
H
--
R
K
P
--
I
N
--
L
K
-
Q
K
Y
P
S
--
I
------------
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
--------------------
V
R
K
K
-
K
L
E
---
T
K
K
I
I
L
P
F
D
D
W
M
V
L
S
E
T
Q
L
R
Y
I
F
L
K
E
V
Q
S
F
H
P
E
---
L
V
I
P
S
V
F
T
I
H
E
N
N
F
Y
N
N
E
------------------
63
PsiBlast_CBE
83.56
40%
-120
- C1 -
3MVL
1
MK14_HUMAN
A:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
------------------------
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
L
----------------------------------
110
PsiBlast_CBE
83.10
41%
-125
- C1 -
1YQJ
1
MK14_HUMAN
A:
[35-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
---
D
---
E
--------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
65
PsiBlast_CBE
83.09
40%
-128
- C1 -
3BX5
1
MK14_HUMAN
A:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQN
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
------------------------
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
44
PsiBlast_CBE
83.04
40%
-128
- C1 -
3P7A
2
MK14_MOUSE
A:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
P
T
F
Y
R
Q
E
L
N
K
----
T
I
W
E
V
P
E
R
YQN
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
H
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
---------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
A
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
96
PsiBlast_CBE
83.03
41%
-117
- C1 -
4LOO
1
MK14_MOUSE
A:
[30-347]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
H
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
---
D
---
E
--------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
A
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
L
----------------------------------
79
PsiBlast_CBE
82.91
41%
-134
- C1 -
3GC9
1
MK11_HUMAN
A:
[34-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
P
V
G
S
G
A
Y
G
S
V
C
S
A
Y
D
--
A
-
R
-
L
R
Q
K
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
L
I
H
A
R
R
T
Y
R
E
L
R
L
L
K
H
L
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A-
T
S
--
I
E
D
F
S
E
--
V
Y
L
V
T
T
L
M
G
A
-
D
L
N
N
I
V
-
K
------
S
--
Q
A
L
S
D
E
H
V
Q
F
L
V
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
G
I
I
H
R
D
L
K
P
S
N
V
A
V
----
N
E
-
D
S
E
L
R
I
L
D
F
G
L
A
-------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
Q
-----------
G
K
A
L
F
P
G
S
D
-------
Y
----
I
D
Q
L
K
R
I
M
E
V
V
G
T
P
S
P
E
-
V
L
A
K
-
I
S
-
S
E
-----
H
A
R
T
Y
I
-----
Q
--
S
L
P
P
M
P
Q
KD
L
S
-
S
I
F
R
G
--
A
------------
N
P
L
A
I
D
L
L
G
R
M
L
V
L
D
S
D
Q
R
V
S
A
A
E
A
L
A
H
A
Y
F
S
Q
----
Y
H
----------------
D
P
-
E
D
E
P
E
A
E
P
-
Y
D
E
S
V
E
A
K
-
E
R
T
L
E
E
W
K
E
L
T
Y
Q
E
V
L
S
F
------------------------------------------
98
PsiBlast_CBE
82.84
41%
-135
- C1 -
3ZYA
1
MK14_HUMAN
A:
[35-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
--------------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
L
----------------------------------
131
HHSearch
82.71
41%
-121
- C1 -
2B9H
1
FUS3_YEAST
A:
[14-352]
--------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
L
K
S
-----
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
--
K
-
P
-
T
G
E
I
V
A
I
K
K
I
-
E
--
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
P
--
D
S
--
F
E
N
F
N
E
--
V
Y
I
I
Q
E
L
M
Q
T
-
D
L
H
R
V
I
-
S
------
T
--
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
----
N
S
-
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
-----------------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-----------
R
R
P
I
F
P
G
R
D
-------
Y
----
R
H
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
-
R
-
C
I
E
S
P
-----
R
A
R
E
Y
I
K
-
S
L
P
M
--
Y
P
A
--
A
P
--
L
E
-
K
M
F
P
R
--
V
------------
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
-------------
D
P
---
N
D
E
P
-
E
G
E
P
I
P
P
S
F
F
E
F
D
H
Y
K
E
-
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
F
S
-------------------------------------------
62
PsiBlast_CBE
82.56
40%
-131
- C1 -
3MVL
1
MK14_HUMAN
B:
[11-352]
-----------------------------------------------------------------------------------------------------------------------------------
R
PTFY
R
Q
E
L
N
K
----
T
IWEV
P
E
R
YQNLS
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
------------------------
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
L
----------------------------------
125
HHSearch
81.97
43%
-130
- C1 -
2FST
3
MK14_HUMAN
X:
[32-358]
--------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
N
L
S
-----
P
V
G
----
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
--------------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
-----------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
S
S
E
-----
S
A
R
N
Y
I
Q
-
S
L
T
Q
--
M
P
K
--
M
N
--
F
A
-
N
V
F
I
G
--
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
--------------------
Y
H
D
P
-
D
D
E
P
V
A
D
-
P
Y
D
Q
S
L
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
86
PsiBlast_CBE
81.82
41%
-133
- C1 -
4F9Y
6
MK14_HUMAN
A:
[52-369]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
------------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
L
----------------------------------
99
PsiBlast_CBE
81.50
41%
-125
- C1 -
3U8W
1
MK14_HUMAN
A:
[35-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
---
D
---
E
--------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
100
PsiBlast_CBE
81.02
41%
-130
- C1 -
3LHJ
1
MK14_HUMAN
A:
[35-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
---------------------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
-----------------------------------
127
HHSearch
80.94
38%
-131
- C1 -
3TTJ
1
MK10_HUMAN
A:
[65-400]
--------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
N
L
K
-----
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
D
--
A
-
V
-
L
D
R
N
V
A
I
K
K
L
-
S
R
-
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
P
--
Q
K
T-
L
E
E
F
Q
D
--
V
Y
L
V
M
E
L
M
D
A
-
N
L
C
Q
V
I
-
Q
------
M
---
E
L
D
H
E
R
M
S
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
----
K
S
-
D
C
T
L
K
I
L
D
F
G
L
A
--------------
S
F
M
---
M
----
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
-----------
H
K
I
L
F
P
G
R
D
-------
Y
----
I
D
Q
W
N
K
V
I
E
Q
L
G
T
P
C
P
E
-
F
M
-
K
-
K
L
-
Q
P
-----
T
V
R
N
Y
V
E
-
N
R
P
K
--
Y
A
G
--
L
T
--
F
P
-
K
L
F
P
D
--
S
LFPADS
E
H
N
K
L
K
A
S
Q
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
--------------------
W
Y
D
P
A
E
V
E
A
P
P
------------
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
M
N
-------------------------------------------
81
PsiBlast_CBE
80.60
41%
-122
- C1 -
3GC8
1
MK11_HUMAN
A:
[34-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
P
V
G
S
G
A
Y
G
S
V
C
S
A
Y
D
--
A
-
R
-
L
R
Q
K
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
L
I
H
A
R
R
T
Y
R
E
L
R
L
L
K
H
L
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A-
T
S
--
I
E
D
F
S
E
--
V
Y
L
V
T
T
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
A
L
S
D
E
H
V
Q
F
L
V
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
G
I
I
H
R
D
L
K
P
S
N
V
A
V
----
N
E
-
D
S
E
L
R
I
L
D
F
G
L
A
R
--
Q
A
--
D
---
E
----
E
---
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
Q
-----------
G
K
A
L
F
P
G
S
D
-------
Y
----
I
D
Q
L
K
R
I
M
E
V
V
G
T
P
S
P
E
-
V
L
A
K
-
I
S
-
S
E
-----
H
A
R
T
Y
I
-----
Q
--
S
L
P
P
M
P
Q
KD
L
S
-
S
I
F
R
G
--
A
------------
N
P
L
A
I
D
L
L
G
R
M
L
V
L
D
S
D
Q
R
V
S
A
A
E
A
L
A
H
A
Y
F
S
Q
----
Y
H
----------------
D
P
-
E
D
E
P
E
A
E
P
-
Y
D
E
S
V
E
A
K
-
E
R
T
L
E
E
W
K
E
L
T
Y
Q
E
V
L
S
F
K
-----------------------------------------
78
PsiBlast_CBE
80.31
41%
-127
- C1 -
3GC9
1
MK11_HUMAN
B:
[34-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
P
V
G
S
G
A
Y
G
S
V
C
S
A
Y
D
--
A
-
R
-
L
R
Q
K
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
L
I
H
A
R
R
T
Y
R
E
L
R
L
L
K
H
L
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A-
T
S
--
I
E
D
F
S
E
--
V
Y
L
V
T
T
L
M
G
A
-
D
L
N
N
I
V
-
K
------
S
--
Q
A
L
S
D
E
H
V
Q
F
L
V
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
G
I
I
H
R
D
L
K
P
S
N
V
A
V
----
N
E
-
D
S
E
L
R
I
L
D
F
G
L
A
R
-----------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
Q
-----------
G
K
A
L
F
P
G
S
D
-------
Y
----
I
D
Q
L
K
R
I
M
E
V
V
G
T
P
S
P
E
-
V
L
A
K
-
I
S
-
S
E
-----
H
A
R
T
Y
I
-----
Q
--
S
L
P
P
M
P
Q
KD
L
S
-
S
I
F
R
G
--
A
------------
N
P
L
A
I
D
L
L
G
R
M
L
V
L
D
S
D
Q
R
V
S
A
A
E
A
L
A
H
A
Y
F
S
Q
----
Y
H
----------------
D
P
-
E
D
E
P
E
A
E
P
-
Y
D
E
S
V
E
A
K
-
E
R
T
L
E
E
W
K
E
L
T
Y
Q
E
V
L
S
F
K
-----------------------------------------
101
PsiBlast_CBE
79.68
41%
-128
- C1 -
3ITZ
1
MK14_HUMAN
A:
[35-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
--
T
-
K
-
T
G
L
R
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
--
A
R
S-
L
E
E
F
N
D
--
V
Y
L
V
T
H
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
---
D
---
E
--------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
-
L
L
-
K
-
K
I
-
S
S
-----
E
S
A
R
N
Y
I
-
Q
S
L
T
--
Q
M
P
K
M
N
F
--
A
N
-
V
F
I
G
---
A
------------
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----
Y
H
----------------
D
P
-
D
D
E
P
V
A
D
P
-
Y
D
Q
S
F
E
S
R
-
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
P
---
P
L
----------------------------------
33
PsiBlast_CBE
79.52
46%
-126
- C1 -
4H3P
1
MK01_HUMAN
D:
[33-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
DH-------------------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
R
---------------------------------------------------------
129
HHSearch
78.84
38%
-125
- C1 -
4QNY
1
?
A:
[24-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
-----
I
I
G
A
G
S
Y
G
V
V
I
R
A
R
D
--
T
K
S
-
D
N
R
L
V
A
M
K
R
V
-
N
K
E
I
F
E
E
V
I
L
A
K
R
I
L
R
E
I
K
L
L
A
H
F
N
D
D
N
I
I
G
L
R
N
I
L
T
P
--
E
D
--
P
E
N
F
D
H
--
F
Y
I
V
M
D
I
M
E
T
-
D
L
K
Q
V
L
-
R
------
S
G
-
Q
E
L
T
E
A
H
I
Q
F
F
I
Y
Q
A
L
R
A
L
H
I
I
H
S
A
G
V
I
H
R
D
I
T
P
A
N
I
L
V
----
N
T
-
N
C
D
L
K
I
C
D
F
G
L
A
K
E
E
-----------
G
E
Y
---
M
T
D
Y
V
T
M
R
W
Y
R
A
P
E
L
V
M
E
D
K
D
Y
S
A
Q
I
D
V
W
G
I
G
C
I
L
G
E
L
L
G
-----------
S
R
P
L
F
Q
G
K
D
-------
R
----
V
N
Q
L
D
K
I
V
D
V
I
G
T
P
S
E
E
-
D
I
-
N
-
S
V
G
S
S
-----
A
A
Q
K
Y
L
K
-
K
K
S
H
--
R
P
Q
--
A
D
--
W
R
-
Q
R
Y
P
T
--
A
------------
S
P
E
A
L
D
L
L
R
H
M
L
V
F
N
P
K
R
R
I
T
V
L
Q
A
M
R
H
P
F
L
E
Q
--------------------
L
H
D
D
-------
Y
A
L
F
R
F
D
-------
T
I
V
D
V
K
R
A
I
Y
E
E
S
V
K
F
------------------------------------------
130
HHSearch
78.53
36%
-109
- C1 -
4O2Z
1
?
A:
[30-377]
----------------------------------------------------------------------------------------------------------------------------
D
F
K
V
Y
N
V
S
----
G
S
P
F
E
V
P
SK
Y
T
----
L
L
K
-----
I
L
G
M
G
A
Y
G
I
A
C
S
C
L
D
--
G
-
D
-
T
G
E
K
V
S
I
K
K
C
-
R
D
-
V
F
R
D
V
E
D
G
K
R
V
L
R
E
I
D
M
M
R
F
F
H
H
E
N
L
L
N
V
V
N
I
L
P
P
--
L
K
RE
Y
H
S
F
E
D
--
V
Y
V
V
T
P
L
M
D
V
-
D
M
N
V
V
L
-
R
------
S
R
-
Q
V
L
E
E
S
H
M
Q
Y
F
V
Y
Q
I
L
R
G
L
K
Y
L
H
S
A
N
V
A
H
R
D
L
K
P
A
N
L
V
T
----
N
I
-
S
C
E
L
K
I
I
D
F
G
L
S
R
S
--
V
------
P
--
Y
S
E
---
L
T
D
Y
V
I
T
R
W
Y
R
P
P
E
L
L
L
E
N
T
N
Y
S
T
A
V
D
I
W
S
V
G
C
I
F
A
E
M
Y
N
-----------
R
K
P
V
F
P
G
R
N
-------
T
----
M
D
Q
L
R
M
I
A
Q
H
I
G
K
P
P
A
S
-
I
V
-
E
-
H
---
R
-----
E
A
L
E
K
L
N
-
E
L
P
D
--
G
S
L
---
N
--
I
P
-
K
L
V
P
G
LA
G
------------
N
T
E
G
I
D
F
L
S
K
M
W
T
L
D
P
S
K
R
P
T
A
A
D
M
L
A
H
P
Y
L
A
H
--------------------
L
H
D
E
-
E
D
E
P
T
C
P
C
P
F
L
W
A
H
E
S
T
-
P
M
G
V
S
E
L
R
R
A
F
W
A
D
I
V
D
Y
N
P
----------------------------------------
132
HHSearch
78.46
43%
-111
- C1 -
4QTB
16
MK03_HUMAN
A:
[46-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
-----
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
D
--
H
-
V
-
R
K
T
R
V
A
I
K
K
I
-
S
P
--
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
A
--
S
T
--
L
E
A
M
R
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
S
--
Q
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
I
A
D
P
--
E
---
H
DH
T
G
F
---
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
I
N
M
-----
K
A
R
N
Y
L
Q
-
S
L
P
S
--
K
T
K
--
V
A
--
W
A
-
K
L
F
P
K
--
S
------------
D
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
--------------------
Y
Y
D
P
-
T
D
E
P
V
A
E
E
P
F
T
F
A
M
E
L
D
-
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
Q
P
G
---------------------------------------
18
PsiBlast_PDB
77.46
46%
-132
- C1 -
5BUJ
1
?
A:
[32-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
-----------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
----------------------------------------------------------
16
PsiBlast_PDB
77.08
46%
-131
- C1 -
5BUE
1
?
A:
[32-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
-----------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
----------------------------------------------------------
80
PsiBlast_CBE
77.04
41%
-122
- C1 -
3GC8
1
MK11_HUMAN
B:
[34-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
P
V
G
S
G
A
Y
G
S
V
C
S
A
Y
D
--
A
-
R
-
L
R
Q
K
V
A
V
K
K
L
-
S
R
-
P
F
Q
S
L
I
H
A
R
R
T
Y
R
E
L
R
L
L
K
H
L
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A-
T
S
--
I
E
D
F
S
E
--
V
Y
L
V
T
T
L
M
G
A
-
D
L
N
N
I
--
V
------
K
C
-
Q
A
L
S
D
E
H
V
Q
F
L
V
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
G
I
I
H
R
D
L
K
P
S
N
V
A
V
----
N
E
-
D
S
E
L
R
I
L
D
F
G
L
A
R
--
Q
A
--
D
---
E
----
E
---
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
Q
-----------
G
K
A
L
F
P
G
S
D
-------
Y
----
I
D
Q
L
K
R
I
M
E
V
V
G
T
P
S
P
E
-
V
L
A
K
-
I
S
-
S
E
-----
H
A
R
T
Y
I
-----
Q
--
S
L
P
P
M
P
Q
KD
L
S
-
S
I
F
R
G
--
A
------------
N
P
L
A
I
D
L
L
G
R
M
L
V
L
D
S
D
Q
R
V
S
A
A
E
A
L
A
H
A
Y
F
S
Q
----
Y
H
----------------
D
P
-
E
D
E
P
E
A
E
P
-
Y
D
E
S
V
E
A
K
-
E
R
T
L
E
E
W
K
E
L
T
Y
Q
E
V
L
S
F
K
-----------------------------------------
11
PsiBlast_PDB
76.92
46%
-132
- C1 -
3I60
1
MK01_HUMAN
A:
[51-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
----------------------------------------------------------
5
PsiBlast_PDB
76.86
46%
-125
- C1 -
4QTA
8
MK01_HUMAN
A:
[32-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
----------------------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
----------------------------------------------------------
7
PsiBlast_PDB
76.21
46%
-118
- C1 -
2OJG
1
MK01_HUMAN
A:
[51-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
DH
D
---
H
--
T
G
F
---
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
E
L
D
D
L
P
K
E
-
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
--------------------------------------------------------------
17
PsiBlast_PDB
76.05
46%
-118
- C1 -
5BUI
1
?
A:
[32-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
DH
D
------------------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
----------------------------------------------------------
73
PsiBlast_CBE
75.76
46%
-121
- C1 -
4N4S
1
MK01_RAT
A:
[30-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
L
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
A
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
L
D
F
G
L
A
R
V
A
D
P
D---------------
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
----------------------------------------------------------
19
PsiBlast_PDB
75.67
46%
-129
- C1 -
4FV6
2
MK01_HUMAN
A:
[31-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
-----------------------------------------------------------
20
PsiBlast_PDB
75.58
46%
-126
- C1 -
4O6E
1
MK01_HUMAN
A:
[39-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
E
L
D
D
L
P
K
E
K
-
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
---------------------------------------------------------------
10
PsiBlast_PDB
75.57
46%
-136
- C1 -
3I5Z
1
MK01_HUMAN
A:
[51-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
----------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
-----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
-----------------------------------------------------------
77
PsiBlast_CBE
75.07
46%
-116
- C1 -
4H3Q
1
MK01_HUMAN
A:
[33-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
S
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
DH
D
---
H
--
T
G
F
---
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
G
-
I
N
L----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
R
S
--------------------------------------------------------
72
PsiBlast_CBE
74.94
46%
-124
- C1 -
4N4S
1
MK01_RAT
B:
[30-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
L
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
A
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
L
D
F
G
L
A
R
V
A
D
P
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
----------------------------------------------------------
34
PsiBlast_CBE
74.82
46%
-123
- C1 -
4H3P
1
MK01_HUMAN
A:
[33-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
DH---------------
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
R
---------------------------------------------------------
9
PsiBlast_PDB
74.49
46%
-120
- C1 -
2OJJ
1
MK01_HUMAN
A:
[51-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
DH
D
---
H
--
T
G
F
---
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
----------------------------------------------------------
8
PsiBlast_PDB
74.23
46%
-118
- C1 -
2OJI
1
MK01_HUMAN
A:
[51-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
DH
D
---
H
--
T
G
F
---
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
----------------------------------------------------------
14
PsiBlast_PDB
73.50
46%
-120
- C1 -
4FMQ
1
MK01_HUMAN
A:
[33-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
DH
D
---
H
--
T
G
F
---
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
----------------------------------------------------------
74
PsiBlast_CBE
73.40
46%
-117
- C1 -
4I5H
1
MK01_RAT
A:
[30-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
L
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
A
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
L
D
F
G
L
A
R
V
A
D
P
---------------
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
D
L
P
K
E
K
L
K
E
-
L
I
F
E
E
T
A
R
F
Q
P
G
Y
-----------------------------------------------------------------
36
PsiBlast_CBE
73.07
46%
-121
- C1 -
1GOL
1
MK01_RAT
A:
[35-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
L
-
N
K
V
R
V
A
I
R
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
DH
D
---
H
--
T
G
F
---
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
R
S
--------------------------------------------------------
25
PsiBlast_CBE
73.00
46%
-116
- C1 -
3ERK
1
MK01_RAT
A:
[35-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
L
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
DH
D
---
H
--
T
G
F
---
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
-----------------------------------------------------------
82
PsiBlast_CBE
72.56
41%
-130
- C1 -
4QNY
2
?
B:
[25-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
-----
I
I
G
A
G
S
Y
G
V
V
I
R
A
R
D
--
T
-
K
S
D
N
R
L
V
A
M
K
R
V
N
K
E
-
I
F
E
E
V
I
L
A
K
R
I
L
R
E
I
K
L
L
A
H
F
N
D
D
N
I
I
G
L
R
N
I
L
T
P
--
E
D
--
P
E
N
F
D
H
--
F
Y
I
V
M
D
I
M
E
T
-
D
L
K
Q
V
L
-
R
------
S
G
-
Q
E
L
T
E
A
H
I
Q
F
F
I
Y
Q
A
L
R
A
L
H
I
I
H
S
A
G
V
I
H
R
D
I
T
P
A
N
I
L
V
----
N
T
-
N
C
D
L
K
I
C
D
F
G
L
A
K
-
E
E
N
--
D
---
Q
----
Y
---
M
T
D
Y
V
T
M
R
W
Y
R
A
P
E
L
V
M
E
D
K
D
Y
S
A
Q
I
D
V
W
G
I
G
C
I
L
G
E
L
L
G
-----------
S
R
P
L
F
Q
G
K
D
-------
R
----
V
N
Q
L
D
K
I
V
D
V
I
G
T
P
S
E
E
-
D
I
-
N
-
S
V
-
G
S
-----
S
A
A
Q
K
Y
L
-
K
K
K
S
--
H
R
P
Q
A
D
W
--
R
Q
-
R
Y
P
T
---
A
------------
S
P
E
A
L
D
L
L
R
H
M
L
V
F
N
P
K
R
R
I
T
V
L
Q
A
M
R
H
P
F
L
E
Q
L
H
D
D
A
D
D
Y
A
L
F
R
F
D
E
K
T
I
V
D
V
K
R
A
-
I
Y
E
E
S
V
K
F
----------------------------------------------------------------------
35
PsiBlast_CBE
72.11
46%
-124
- C1 -
3TEI
1
MK01_HUMAN
A:
[33-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
DH---------------
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
Y
----------------------------------------------------------
31
PsiBlast_CBE
69.93
46%
-113
- C1 -
1WZY
1
MK01_HUMAN
A:
[39-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
DH
D
---
H
--
T
G
F
---
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
-----------------------------------------------------------
32
PsiBlast_CBE
69.13
46%
-112
- C1 -
1TVO
1
MK01_HUMAN
A:
[31-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
--
N
-
V
-
N
K
V
R
V
A
I
K
K
I
--
S
-
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
--
P
T
--
I
E
Q
M
K
D
--
V
Y
I
V
Q
D
L
M
E
T
-
D
L
Y
K
L
L
-
K
------
T
--
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
----
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
DH
D
---
H
--
T
G
F
---
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
-----------
N
R
P
I
F
P
G
K
H
-------
Y
----
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
-
D
L
-
N
-
C
I
-
I
N
L
----
K
A
R
N
Y
L
L
-
S
L
P
H
--
K
N
-
K
V
P
---
W
N
-
R
L
F
P
N
--
A
------------
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
K
F
D
M
E
L
D
D
L
P
-
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
-
G
-----------------------------------------------------------
143
HHSearch
65.41
35%
-128
- C1 -
4F6U
10
CDK8_HUMAN
A:
[26-342]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
-----
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
KD
G
-
K
-
D
D
K
D
Y
A
L
K
Q
I
-
E
G
-
T
----
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
--
H
A
-----
D
R
K
--
V
W
L
L
F
D
Y
A
E
H
-
D
L
W
H
I
I
-
K
F
H
R
A
S
K---
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
E
-
R
G
R
V
K
I
A
D
M
G
F
-------------------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-----------
S
E
P
I
F
H
C
R
Q
-------
E
NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
-
D
W
-
E
-
D
I
-
K
K
MPE
H
S
T
L
M
K
D
F
R
-
R
N
T
Y
--
T
N
C
S
L
I
K
--
Y
M
E
K
H
K
V
K
--
P
------------
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
---------------------------------------------------------------------------------
139
HHSearch
64.89
33%
-118
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[15-303]
--------------------------------------------------------------------------------------------------------------------------------------------------
E
----
I
L
G
-----
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
--
K
-
E
-
T
H
E
I
V
A
I
K
K
F
-
K
--------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
--
R
-------
G
K
--
L
Y
L
V
F
E
Y
V
E
K
-
N
M
L
E
L
L
E
E
------
M
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
----
S
H
-
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
---------------------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-----------
G
Q
P
L
F
P
G
E
S
-------
E
----
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
-
Q
M
-
K
-
L
F
-
Y
S
-----
N
P
R
F
H
G
L
-
R
F
P
A
V
N
H
P
Q
S
L
E
----
R
-
R
Y
L
G
I
--
L
------------
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
----------------------------------------------------------------------------------------------------
128
HHSearch
64.23
30%
-106
- C1 -
3EB0
3
?
A:
[10-371]
--------------------------------------------------------------------------------------------------------------------------------------------------
S
----
L
G
K
-----
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
--
I
-
E
-
S
G
K
R
F
A
L
K
K
V
-
L
Q
-------
D
P
R
Y
K
N
R
E
L
D
I
M
K
V
L
D
H
V
N
I
I
K
L
V
D
Y
F
Y
T
--
T
--------
N
K
Y
L
N
V
I
M
E
Y
V
P
D
-
T
L
H
K
V
L
-
K
S
F
I
R
--
S
G
-
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
----
N
S
K
D
N
T
L
K
L
C
D
F
G
S
A
K
K
L
I
P
--
S
-------
E
P
---
S
V
A
Y
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
-----------
G
K
P
L
F
S
G
E
T
-------
S
----
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
K
E
-
Q
M
-
I
-
R
M
-
N
P
-----
H
Y
----
V
-
R
F
P
T
--
L
K
A
--
K
D
--
W
R
-
K
I
L
P
E
G-
T
------------
P
S
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
S
--------------------------
I
P
Q
L
F
N
F
S
P
Y
E
L
-
S
I
I
P
G
N
V
L
N
R
I
L
P
K
----------------------------------------------
140
HHSearch
63.45
36%
-108
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-297]
--------------------------------------------------------------------------------------------------------------------------------------------------
E
----
K
L
D
-----
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
--
K
-
N
-
T
N
Q
I
V
A
I
K
K
I
-----------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
G
H
--
K
-------
S
N
--
I
S
L
V
F
D
F
M
E
T
-
D
L
E
V
I
I
-
K
------
D
N
S
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
----
D
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
------
P
--
N
R
A
---
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-----------
R
V
P
F
L
P
G
D
S
-------
D
----
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
-
Q
W
-
P
-
D
M
-
C
S
-----
L
P
D
-
Y
-
V
-
T
F
K
S
--
F
P
G
--
I
P
--
L
H
-
H
I
F
S
A
--
A
------------
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
P
T
P
G
C
Q
L
P
R
P
N
-----------------------------------------------------------------------------------------
147
HHSearch
57.09
30%
-104
* C1 *
4AGU
1
CDKL1_HUMAN
A:
[7-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
-----
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
--
R
-
D
-
T
G
Q
I
V
A
I
K
K
F
-
L
E
-
S
E
D
-
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
--
K
-------
R
R
--
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
-
R
------
Y
Q
-
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
----
T
K
-
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
-----------------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-----------
G
V
P
L
W
P
G
K
S
-------
D
----
V
D
Q
L
Y
L
I
R
K
T
L
G
D
L
I
P
R
-
H
Q
-
Q
-
V
F
-
S
T
-----
N
--
Q
Y
F
S
G
V
K
I
P
--
D
P
E
D
M
E
P
--
L
E
-
L
K
F
P
N
--
I
------------
S
Y
P
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
-----------------------------------------------------------------------------------------------------