@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NTRK1_HUMAN: (2015-10-15 )
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
Atome Classification :
(92 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.....------.------.500.-----......510..-.....520.......530-----------.-..--..--------------..540.....-.-.-550........560.....-.-.570.......580........590.......600.......610.-.......620.-........630.......640.......650......---.-----660.......670.....-..-680.......690.......700.......710.......720.-..-....730....-...740---.-----...--.--....750.......760.......770.......780....--...790....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLRGGRRGQLGWHSWAAG
P
G
S
L
L
A
W
L
I
L
ASAGAAPCPDACCPHGSSG
L
R
CTRDGA
L
D
S
L
HHLPGA
E
N
L
T
E
L
Y
IE
N
Q
Q
H
L
Q
H
L
E
L
R
D
L
R
G
L
G
E
LR
N
L
T
I
V
K
SG
L
R
FVAPD
A
F
HFTPRL
S
R
LNL
S
F
N
A
L
E
SLSWKTVQGL
S
L
Q
E
L
VLSGNPL
H
C
S
C
A
L
R
W
L
Q
R
W
E
EEGLGGV
P
E
Q
K
LQCHGQGPLAHMPNASCGV
P
T
L
K
V
QVPNASVDVGD
D
V
L
L
R
C
Q
VEGRGL
E
Q
A
G
W
I
L
T
E
L
E
Q
S
A
T
V
M
KSGGLPSL
G
L
T
L
A
N
V
T
SDLNRK
N
V
T
C
W
AENDVG
R
A
E
V
S
V
Q
V
N
VSFP
A
S
V
Q
L
H
T
A
V
E
M
H
H
W
C
I
P
FSVDGQPAP
S
L
R
W
L
FNGSVLN
E
T
S
F
I
F
T
E
F
LEPAAN
E
T
V
R
H
G
C
LRLNQPTHVNNG
N
Y
T
L
L
AANPFG
Q
A
S
A
S
I
M
A
A
F
MDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPF
G
V
S
V
A
V
G
L
A
V
F
A
C
L
F
L
S
T
L
L
L
V
L
N
KCGRRNKFGINRP
A
V
LAPED
G
L
A
M
S
L
H
F
M
T
LGGSSLSPTEGKGSGLQ
G
H
IIEN
P
Q
Y
F
------
S
------
D
A
C
V
H
-----
H
I
KRR
D
I
V
L
K
W
-ELGEGA
F
G
K
V
F
L
A
E
C
H
N
L-----------L-PE--QD--------------
K
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
-
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
VCTE-GR
P
L
L
M
V
F
E
Y
M
RH
G
D
L
N
R
F
L
R
SHGPDA
K
L
L-A-GGEDVAPG--P-
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
ATRNCLV---G-----Q
G
L
V
V
K
IGDFGMSRDIYS-T
D
-
Y
Y
R
VGG
R
T
M
L
P
I
RWMPP
E
S
I
L
Y
R
KFTTES
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y-GK-QP
W
Y
QLSNTE
A
-
I
D
C
I
-----T-----QGR--E--LERPRAC
P
P
E
V
Y
A
I
M
R
G
C
W
QR
E
P
Q
QRH
S
I
K
D
V
H
A
R
L
Q
A
L
AQ--AP
P
V
Y
L
DVLG
22
PsiBlast_CBE
91.95
100%
-132
- C3 -
4AOJ
1
C:
[33-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
-----
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-----------
L
-
P
---
Q
D
--------------
K
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
-
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
--------------
G
--
P
-
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
------------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
A
-
I
D
C
I
-----
T
-----
Q
G
R
--
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--
A
P
P
-------
23
PsiBlast_CBE
91.77
100%
-134
- C3 -
4AOJ
1
NTRK1_HUMAN
B:
[33-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
-----
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-----------
L
-
P
-------------------
K
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
-
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
--------------
G
--
P
-
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
---------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
A
-
I
D
C
I
-----
T
-----
Q
G
R
--
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--
A
P
P
V
Y
-----
130
HHSearch
91.63
100%
-135
- C3 -
4AOJ
1
NTRK1_HUMAN
A:
[33-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
-----
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-----------
L
-
P
-------------------
K
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
-
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
-------------
P
G
--
P
-
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
A
-
I
D
C
I
-----
T
-----
Q
G
R
--
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--
A
P
P
-------
2
PsiBlast_PDB
91.63
100%
-135
- C3 -
4AOJ
1
NTRK1_HUMAN
A:
[33-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
-----
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-----------
L
-
P
-------------------
K
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
-
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
-------------
P
G
--
P
-
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
A
-
I
D
C
I
-----
T
-----
Q
G
R
--
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--
A
P
P
-------
7
PsiBlast_PDB
91.28
100%
-128
- C3 -
4PMP
1
A:
[1-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
H
-----
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-----------
L
---------------------
K
M
L
V
A
V
K
A
L
K
--------
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
L
L
-
A
-
G
G
E
D
V
A
P
G
--
P
-
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
I
Y
S
-
T
D
-
Y
Y
R
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
A
-
I
D
C
I
-----
T
-----
Q
G
R
--
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--
A
H
H
H
H
-----
5
PsiBlast_PDB
90.94
100%
-126
- C3 -
4YNE
2
A:
[9-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
-----
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-----------
L
-
P
----
D
--------------
K
M
L
V
A
V
K
A
L
K
-
E
--------
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
L
L
-
A
-
G
G
E
D
V
A
P
G
--
P
-
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
------
T
D
-
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
A
-
I
D
C
I
-----
T
-----
Q
G
R
--
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--
A
P
P
V
Y
L
D
---
6
PsiBlast_PDB
89.90
100%
-124
- C3 -
4YPS
1
A:
[9-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
-----
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
L
-----------
L
------
D
--------------
K
M
L
V
A
V
K
A
L
------
S
-
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
L
L
-
A
-
G
G
E
D
V
A
P
G
--
P
-
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
--
M
S
R
D
I
Y
S
-
T
D
-
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
A
-
I
D
C
I
-----
T
-----
Q
G
R
--
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--
A
P
P
V
------
8
PsiBlast_PDB
89.65
100%
-130
- C3 -
4PMT
1
A:
[1-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
H
-----
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
------------------
D
--------------
K
M
L
V
A
V
K
A
L
-------------
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
L
L
-
A
-
G
G
E
D
V
A
P
G
--
P
-
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
--
S
R
D
I
Y
S
-
T
D
-
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
A
-
I
D
C
I
-----
T
-----
Q
G
R
--
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--
A
H
H
H
H
-----
10
PsiBlast_PDB
86.02
75%
-123
- C3 -
4AT3
1
A:
[4-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
-----
H
I
K
R
H
N
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
-----------
C
---------------------
K
I
L
V
A
V
K
T
L
----
A
-
S
-
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
V
E
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
-
A
---
N
--
P
P
T
--
E
-
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
-
T
D
-
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
N
E
V
-
I
E
C
I
-----
T
-----
Q
G
R
--
V
--
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
--
A
S
P
V
Y
L
D
I
L
G
11
PsiBlast_PDB
85.66
75%
-126
- C3 -
4AT4
1
A:
[4-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
-----
H
I
K
R
H
N
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
-----------
C
---------------------
K
I
L
V
A
V
K
T
L
K
-
D
-
A
-
S
-
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
V
E
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
-
A
------
P
P
T
--
E
-
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
-
T
D
-
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
N
E
V
-
I
E
C
I
-----
T
-----
Q
G
R
--
V
--
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
--
A
S
P
V
Y
L
D
I
L
G
12
PsiBlast_PDB
85.53
75%
-120
- C3 -
4AT5
2
A:
[4-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
-----
H
I
K
R
H
N
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
---------------------------------
K
I
L
V
A
V
K
T
L
K
-
D
-
A
-
S
-
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
V
E
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
-
A
-
E
G
N
--
P
P
T
--
E
-
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
-
T
D
-
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
N
E
V
-
I
E
C
I
-----
T
-----
Q
G
R
--
V
--
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
--
A
S
P
V
Y
L
D
I
L
G
13
PsiBlast_PDB
84.48
76%
-129
- C3 -
3V5Q
1
NTRK3_HUMAN
A:
[9-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
-----
H
I
K
R
R
D
I
V
L
K
R
-
E
L
------
K
V
F
L
A
E
C
Y
N
L
-----------
S
-
P
T
--
K
D
--------------
K
M
L
V
A
V
K
A
L
----
P
-
T
-
L
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
G
D
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
------------------
E
-
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
A
N
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
-
T
D
-
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
F
Q
L
S
N
T
E
V
-
I
E
C
I
-----
T
-----
Q
G
R
--
V
--
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
--
A
T
P
-------
72
PsiBlast_CBE
76.55
41%
-120
- C3 -
4CNH
2
B:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
-------------
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
S
-
Y
-----
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
87
PsiBlast_CBE
76.15
41%
-120
- C3 -
4FOB
1
A:
[51-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
--------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
-------------
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
-------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
84
PsiBlast_CBE
75.88
41%
-124
- C3 -
2XB7
1
A:
[16-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
----------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
135
HHSearch
75.80
48%
-120
- C3 -
4BKJ
10
DDR1_HUMAN
A:
[7-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
P
QDLVSLDFPLN
V
-
R
K
--
G
H
--------------
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
-------------
P
--
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
-
Q
P
F
G
Q
L
T
D
E
Q
V
-
I
E
N
A
-----
G
E
F
F
R
D
Q
G
R
QV
Y
--
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
--
N
T
V
-------
51
PsiBlast_CBE
75.73
40%
-111
- C3 -
4MKC
3
A:
[50-349]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
AG
K
T
S
S
------
I
S
D
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
--------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
74
PsiBlast_CBE
75.61
41%
-119
- C3 -
4CMU
1
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
73
PsiBlast_CBE
75.57
41%
-123
- C3 -
4CNH
1
ALK_HUMAN
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
------
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
76
PsiBlast_CBE
75.49
41%
-119
- C3 -
4CMO
1
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
86
PsiBlast_CBE
75.47
41%
-120
- C3 -
4FOC
1
A:
[51-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
--------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
62
PsiBlast_CBE
75.31
40%
-112
- C3 -
3LCS
3
A:
[30-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
FAG
K
T
S
S
------
I
S
D
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
-----------
P
-
N
D
--
P
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
64
PsiBlast_CBE
75.29
41%
-118
- C3 -
4FOD
2
A:
[31-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
--------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
65
PsiBlast_CBE
75.19
41%
-125
- C3 -
4DCE
1
B:
[31-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
----
E
V
Y
E
G
Q
V
S
--------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
-----------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
71
PsiBlast_CBE
75.18
41%
-123
- C3 -
4CTB
1
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
---
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
77
PsiBlast_CBE
75.16
41%
-118
- C3 -
4CLI
1
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
63
PsiBlast_CBE
75.02
41%
-121
- C3 -
4FNW
2
A:
[25-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
----
G
E
V
Y
E
G
Q
V
S
--------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
L
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
67
PsiBlast_CBE
74.83
41%
-119
- C3 -
4CD0
1
A:
[39-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
83
PsiBlast_CBE
74.72
41%
-127
- C3 -
2XBA
1
A:
[16-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
-------
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
69
PsiBlast_CBE
74.69
41%
-120
- C3 -
4FNZ
1
A:
[25-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
-------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
-----------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
52
PsiBlast_CBE
74.66
40%
-111
- C3 -
3L9P
4
A:
[50-349]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
AG
K
T
S
S
------
I
S
D
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
-------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
48
PsiBlast_CBE
74.64
45%
-116
- C3 -
5BVK
1
?
A:
[18-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
--------------------H-------------
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
---------------
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
R
--
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
--
N
---------
136
HHSearch
74.58
43%
-116
- C3 -
4CLJ
1
A:
[26-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
---
T
CPG--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
82
PsiBlast_CBE
74.56
41%
-121
- C3 -
2YFX
1
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
47
PsiBlast_CBE
74.56
45%
-121
- C3 -
5BVN
1
?
A:
[18-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
--------------------H-------------
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
---------------
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
R
--
Q
VY
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
--
N
---------
81
PsiBlast_CBE
74.48
41%
-117
- C3 -
4CLJ
1
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
88
PsiBlast_CBE
74.37
41%
-121
- C3 -
4ANQ
1
A:
[39-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
133
HHSearch
74.36
42%
-109
- C3 -
3L9P
4
A:
[50-348]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
------
F
AG
K
T
S
S
I
S
D
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
-------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
---
T
CPG--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
89
PsiBlast_CBE
74.35
41%
-124
- C3 -
4FNY
1
A:
[25-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
-----------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
24
PsiBlast_CBE
74.35
76%
-80
- C3 -
4YMJ
4
B:
[9-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
-----
H
I
K
R
R
D
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
-----------
S
-
P
T
--
K
D
--------------
K
M
L
V
A
V
K
A
L
K
-
D
-
P
-
T
-
L
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
G
D
-
G
-
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
---------------
G
--
E
-
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
A
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
-
T
D
-
Y
Y
R
---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
F
Q
L
S
N
T
E
V
-
I
E
C
I
-----
T
-----
Q
G
R
--
V
--
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
--
A
T
P
I
Y
-----
70
PsiBlast_CBE
74.31
41%
-122
- C3 -
4CTC
1
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
----
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
91
PsiBlast_CBE
74.26
41%
-120
- C3 -
4ANS
1
A:
[39-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
66
PsiBlast_CBE
74.23
41%
-120
- C3 -
4DCE
1
ALK_HUMAN
A:
[31-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
-------------------
P
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
----------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
61
PsiBlast_CBE
74.17
40%
-107
- C3 -
3LCT
3
A:
[27-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
AG
K
T
S
S
------
I
S
D
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
-----------
P
-
N
D
--
P
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
137
HHSearch
74.15
40%
-118
- C3 -
3CBL
3
A:
[111-375]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
H
E
D
L
V
L
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
-------------------
D
--------------
N
T
L
V
A
V
K
S
C
R
-
E
-
T
L
P
-
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
P
N
I
V
R
L
I
G
V
C
T
Q
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
----------------
A
--
R
-
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
-----
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
-
G
V
-
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
-
G
A
-
S
P
Y
P
N
L
S
N
Q
Q
T
-
R
E
F
V
-----
E
-----
K
G
G
--
R
--
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
--
R
H
--------
85
PsiBlast_CBE
74.15
41%
-117
- C3 -
4TT7
5
A:
[15-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
----
G
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
-------------
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
S
---
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
78
PsiBlast_CBE
74.07
41%
-119
- C3 -
4CCU
1
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
29
PsiBlast_CBE
74.05
42%
-116
- C3 -
3LW0
3
IGF1R_HUMAN
B:
[11-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
46
PsiBlast_CBE
73.99
45%
-121
- C3 -
5BVW
1
?
A:
[18-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
--------------------H-------------
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
---------------
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
----
L
Y
A
-
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
R
--
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
--
N
---------
43
PsiBlast_CBE
73.91
45%
-116
- C3 -
4BKJ
10
DDR1_HUMAN
A:
[9-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---------------
P
--
Q
D
LVSLDFPLNVRKG
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
----------------
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
R
--
Q
VY
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
--
N
T
V
-------
42
PsiBlast_CBE
73.54
45%
-112
- C3 -
4BKJ
10
B:
[9-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---------------
P
--
Q
D
LVSLDFPLNVRKG
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
------------
G
--
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
R
--
Q
VY
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
--
N
T
V
-------
68
PsiBlast_CBE
73.50
41%
-119
- C3 -
3AOX
5
A:
[41-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
----
G
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
----------
Q
P
S
--
S
-
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
V
-
L
E
F
V
-----
T
-----
S
G
G
--
R
--
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
--
D
P
D
V
I
N
T
A
L
P
30
PsiBlast_CBE
73.48
42%
-118
- C3 -
3LW0
2
IGF1R_HUMAN
A:
[11-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
28
PsiBlast_CBE
73.44
42%
-116
- C3 -
3LW0
3
IGF1R_HUMAN
C:
[11-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
27
PsiBlast_CBE
73.23
42%
-114
- C3 -
3LW0
2
D:
[11-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
143
HHSearch
73.15
37%
-119
- C3 -
2PVF
1
A:
[31-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-----------
D
-
K
D
KP-----------------
V
T
V
A
V
K
M
L
K
-
D
D
A
-
T
-
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
-
S
Y----------
Q
-
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
-
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
-
S
P
Y
P
G
I
P
V
E
E
L
-
F
K
L
L
-----
K
-----
E
G
H
--
R
--
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
LT
T
---------
145
HHSearch
73.13
37%
-114
- C3 -
1T46
1
?
A:
[19-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-----------
I
-
K
S
--
D
A
--------------
A
M
T
V
A
V
K
M
L
K
-
P
-
S
A
H
-
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
-------------
L
--
A
-
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
-----
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
-
D
S
-
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
-
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
-----
K
-----
E
G
F
--
R
--
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
--
E
S
T
N
------
44
PsiBlast_CBE
73.04
45%
-106
- C3 -
3ZOS
3
B:
[9-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---------------
P
--
Q
D
LVSLDFPLNVRKG
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
-----------
Q
G
--
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
R
--
Q
VY
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
--
N
T
V
-------
19
PsiBlast_PDB
72.87
41%
-115
- C3 -
3I81
1
A:
[14-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
E
-------
N
N
P
V
L
A
--
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
25
PsiBlast_CBE
72.74
41%
-114
- C3 -
1JQH
1
IGF1R_HUMAN
B:
[6-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
Y
V
P
D
EW
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
---------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
9
PsiBlast_PDB
72.69
76%
-79
- C3 -
4YMJ
4
NTRK3_HUMAN
A:
[9-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
-----
H
I
K
R
R
D
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
-----------
S
-
P
T
--
K
D
--------------
K
M
L
V
A
V
K
A
L
K
-
D
-
P
-
T
-
L
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
G
D
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
---------------
G
--
E
-
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
A
N
L
L
V
K
I
G
D
F
G
---
D
V
Y
S
-
T
D
-
Y
Y
R
---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
F
Q
L
S
N
T
E
V
-
I
E
C
I
-----
T
-----
Q
G
R
--
V
--
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
--
A
T
--------
139
HHSearch
72.61
39%
-119
- C3 -
4CKJ
16
A:
[19-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
K
N
L
V
L
G
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-----------
K
-
G
R
--
A
G
--------------
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
-
S
-
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
--------------
R
--
A
-
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
-
E
D
-
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
-
N
P
Y
P
G
I
P
P
E
R
L
-
F
N
L
L
-----
K
-----
T
G
H
--
R
--
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
--
K
R
R
-------
38
PsiBlast_CBE
72.57
41%
-114
- C3 -
3NW5
1
A:
[14-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
E
-------
N
N
P
V
L
A
--
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
37
PsiBlast_CBE
72.44
41%
-114
- C3 -
3NW6
1
A:
[14-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
E
-------
N
N
P
V
L
A
--
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
115
PsiBlast_CBE
72.40
42%
-121
- C3 -
3BU5
1
A:
[13-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
---
M
V
Y
E
G
N
A
R
D
I
-----------
I
-
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
---------
E
N
N
P
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
K
F
V
-----
M
-----
D
G
G
--
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
--
P
S
F
P
E
V
S
F
F
H
45
PsiBlast_CBE
72.40
45%
-110
- C3 -
3ZOS
4
DDR1_HUMAN
A:
[9-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---------------
P
--
Q
D
LVSLDFP
L
N
V
R
KG
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
----------
A
A
Q
G
--
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
R
--
Q
VY
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
--
N
T
V
-------
36
PsiBlast_CBE
72.36
41%
-115
- C3 -
3NW7
1
A:
[14-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
E
-------
N
N
P
V
L
A
--
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
39
PsiBlast_CBE
72.28
41%
-115
- C3 -
2OJ9
1
A:
[14-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-----------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
54
PsiBlast_CBE
71.96
43%
-125
- C3 -
3EKK
1
A:
[14-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-----------
I
-
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
---------
E
N
N
P
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
--------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
K
F
V
-----
M
-----
D
G
G
--
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
--
P
S
F
P
E
V
S
F
F
H
41
PsiBlast_CBE
71.82
41%
-112
- C3 -
4D2R
1
A:
[9-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
E
-------
N
N
P
V
L
A
--
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
20
PsiBlast_PDB
71.81
44%
-113
- C3 -
3ETA
1
INSR_HUMAN
A:
[12-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-----------
I
-
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
---------
E
N
N
P
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
K
F
V
-----
M
-----
D
G
G
--
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
--
P
S
F
P
E
V
S
F
F
H
59
PsiBlast_CBE
71.74
43%
-117
- C3 -
1I44
1
A:
[13-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-----------
I
-
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
---------
E
N
N
P
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
K
F
V
-----
M
-----
D
G
G
--
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
--
P
S
F
P
E
V
S
F
F
H
26
PsiBlast_CBE
71.63
44%
-113
- C3 -
3ETA
1
B:
[12-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-----------
I
-
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
---------
E
N
N
P
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
K
F
V
-----
M
-----
D
G
G
--
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
--
P
S
F
P
E
V
S
F
F
H
31
PsiBlast_CBE
71.59
41%
-115
- C3 -
3QQU
1
D:
[8-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
------------
L
A
--
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
49
PsiBlast_CBE
71.57
44%
-111
- C3 -
4IBM
1
?
B:
[13-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-----------
I
-
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
----
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
---------
E
N
N
P
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
K
F
V
-----
M
-----
D
G
G
--
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
--
P
S
F
P
E
V
S
F
F
H
112
PsiBlast_CBE
71.56
42%
-118
- C3 -
1IR3
1
A:
[13-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-----------
I
-
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
---------
E
N
N
P
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
K
F
V
-----
M
-----
D
G
G
--
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
--
P
S
F
P
E
V
S
F
F
H
18
PsiBlast_PDB
71.40
41%
-118
- C3 -
3LVP
2
IGF1R_HUMAN
A:
[39-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEW-
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
E
---------
P
V
L
A
--
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
---------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
113
PsiBlast_CBE
71.22
42%
-119
- C3 -
1GAG
1
A:
[13-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-----------
I
-
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
---------
E
N
N
P
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
K
F
V
-----
M
-----
D
G
G
--
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
--
P
S
F
P
E
V
S
F
F
H
34
PsiBlast_CBE
71.11
41%
-118
- C3 -
3QQU
1
IGF1R_HUMAN
A:
[8-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-------------------
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
33
PsiBlast_CBE
71.05
41%
-118
- C3 -
3QQU
1
IGF1R_HUMAN
B:
[8-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
---------------------
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
50
PsiBlast_CBE
71.03
44%
-111
- C3 -
4IBM
1
?
A:
[13-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-----------
I
-
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
---------
E
N
N
P
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
K
F
V
-----
M
-----
D
G
G
--
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
--
P
S
F
P
E
V
S
F
F
H
140
HHSearch
71.01
41%
-119
* C3 *
3ZBF
1
A:
[30-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
E
K
L
T
L
R
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
D
I
-----------
L
G
V
G
--
S
G
--------------
E
I
K
V
A
V
K
T
L
K
-
K
-
G
S
T
-
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
L
-
N
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
A
T
----------
F
Y
G
P
--
L
-
L
T
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
---
S
VKDYT
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
--------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
-
G
H
-
Q
P
Y
P
A
H
S
N
L
D
V
-
L
N
Y
V
-----
Q
-----
T
G
G
--
R
--
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
--
F
F
L
N
S
I
Y
K
S
R
32
PsiBlast_CBE
70.98
41%
-113
- C3 -
3QQU
1
IGF1R_HUMAN
C:
[8-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-----------
V
-
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
-----------
V
L
A
--
P
-
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
R
F
V
-----
M
-----
E
G
G
--
L
--
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
--
P
G
F
R
E
V
S
F
Y
Y
144
HHSearch
70.95
39%
-112
- C3 -
3TT0
1
FGFR1_HUMAN
A:
[65-353]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----------
D
-
K
D
KP
N
R
--------------
V
T
K
V
A
V
K
M
L
K
-
S
D
A
-
T
-
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
S
Y
-
N
P
S
H
N
P
E
E
--
Q
-
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
-
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
-
S
P
Y
P
G
V
P
V
E
E
L
-
F
K
L
L
-----
K
-----
E
G
H
--
R
--
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
--
L
T
S
N
Q
E
----
53
PsiBlast_CBE
70.92
43%
-116
- C3 -
3EKN
1
A:
[14-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-----------
I
-
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
---------
E
N
N
P
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
K
F
V
-----
M
-----
D
G
G
--
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
--
P
S
F
P
E
V
S
F
F
H
120
PsiBlast_CBE
70.76
42%
-114
- C3 -
1RQQ
1
B:
[13-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-----------
I
-
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
---------
E
N
N
P
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
K
F
V
-----
M
-----
D
G
G
--
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
--
P
S
F
P
E
V
S
F
F
H
148
HHSearch
70.11
38%
-117
- C3 -
2XIR
1
A:
[23-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
K
L
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-----------
D
-
K
T
--
A
T
--------------
C
R
T
V
A
V
K
M
L
K
-
E
-
G
A
T
-
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
-
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
--------
Y
K
D
--
F
-
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
---
S
-----
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
-
D
P
-
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
-
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
-----
K
-----
E
G
T
--
R
--
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
--
A
N
A
-------
111
PsiBlast_CBE
69.45
42%
-113
- C3 -
2Z8C
1
A:
[10-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-----------
I
-
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
---------
E
N
N
P
G
RP
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
K
F
V
-----
M
-----
D
G
G
--
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
--
P
S
F
P
E
V
S
F
F
H
142
HHSearch
69.13
36%
-118
- C3 -
1U59
1
A:
[5-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
--------------------
K
--------------
Q
I
D
V
A
I
K
V
L
K
-
Q
-
G
-
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
-
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
-
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
----------------
E
--
E
-
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
---
V
-----
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
-
D
D
S
Y
Y
T
A
R
S
A
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
-
G
Q
-
K
P
Y
K
K
M
K
G
P
E
V
-
M
A
F
I
-----
E
-----
Q
G
K
--
R
--
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
--
S
L
A
S
K
V
E
G
H
H
146
HHSearch
67.31
34%
-117
- C3 -
4FYO
1
A:
[12-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
---------------
M
K
--
K
V
--------------
V
K
T
V
A
V
K
I
L
--------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
-
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
-
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
-------------------
H
-
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
---
V
-----
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
-
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
-
G
Q
-
K
P
Y
R
G
M
K
G
S
E
V
-
T
A
M
L
-----
E
-----
K
G
E
--
R
--
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
H
H
--
150
HHSearch
66.47
33%
-113
- C3 -
4OTW
1
A:
[8-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
I
F
K
E
T
E
L
R
K
L
K
-
V
L
G
S
G
V
F
G
T
V
H
K
G
V
W
I
P
------------
E
-
G
E
--
S
I
--------------
K
I
P
V
C
I
K
V
I
E
-
D
-
K
-
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
-
D
-
H
A
H
I
V
R
L
L
G
L
C
P
G
-
S
-
S
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
R
----------------
G
--
A
-
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
---
K
-----
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
-
D
----------
K
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
-
G
A
-
E
P
Y
A
G
L
R
L
A
E
V
-
P
D
L
L
-----
E
-----
K
G
E
--
R
--
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
R
M
A
R
--
D
P
P
R
Y
L
V
I
K
-
110
PsiBlast_CBE
62.08
42%
-85
- C3 -
4XLV
1
?
A:
[35-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-----------
I
-
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
-
P
-
G
R
P
-------
P
-
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
-
L
K
F
V
-----
M
-----
D
G
G
--
Y
--
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
--
P
S
F
P
E
V
S
F
F
H