@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NTRK2_HUMAN: (2015-10-15 )
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
Atome Classification :
(92 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540-.......550.......560-----------..--..--------------....570...-.-.-.-.-580.......590...-.-...600.......-610.......620.......630..----.....---640.--.----.....650.......660.......670.......680..---.-----....690.......700.-..-....710.......720.......730.......740.......-750........760..-...-----.-----..770.........780.......790.......800.......810.--......820
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSS
W
I
R
WHG
P
A
M
A
R
L
W
G
F
C
W
L
V
V
G
F
W
R
A
A
FACPTSCKCSA
S
R
I
WCSDPSP
G
I
V
A
FPRLEPNSV
D
P
E
N
I
T
E
I
FIANQ
K
R
L
E
II
N
E
D
D
V
E
A
Y
VGLR
N
L
T
I
V
D
S
G
L
K
F
V
A
H
K
A
F
LKNSNL
Q
H
I
NF
T
R
N
K
L
T
S
L
S
R
K
H
F
R
HL
D
L
S
E
L
I
L
VGNPFTCSC
D
I
M
W
I
K
T
L
Q
E
AKSSPDTQ
D
L
Y
C
LNESSKNIPLANLQIPNCGLPSANLAAPN
L
T
V
EEG
K
S
I
T
L
S
C
S
VAGDPV
P
N
M
Y
W
D
V
G
N
L
V
S
K
H
MNETSHTQG
S
L
R
I
T
NISSDDSG
K
Q
I
S
C
V
A
E
N
LVGEDQD
S
V
N
L
T
V
H
FA
P
T
I
T
F
LESPTSDH
H
W
C
I
P
F
T
VKGNPK
P
A
L
Q
W
F
YN
G
A
I
LNES
K
Y
I
C
T
K
I
H
VTNHTEYH
G
C
LQLDNPTHMNNG
D
Y
T
L
I
AKNEYGK
D
E
K
Q
I
S
A
HFMGWPGIDDGANPNYPDV
I
Y
EDYGTAANDIGDTTNRSNEIPSTDVTDKT
G
R
E
H
L
S
V
Y
A
V
V
V
I
A
S
V
V
G
F
C
L
L
V
M
L
F
L
L
K
L
A
RHSKFGMKG
P
A
S
VISNDDDSASP
L
H
HISNGSNTPSSSEGGP
D
A
V
I
I
G
M
T
KIPVIENP
Q
Y
FGITNSQLK
P
D
T
F
V
Q
H
I
K
RH
N
I
V
L
K
R-ELGEG
A
F
G
K
V
F
L
A
E
C
Y
N
L-C-----------PE--Q
D
--------------
K
I
L
V
A
V
KTLK-D-A-S-D-
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
CVE-GD
P
L
I
M
V
F
E
Y
M
KHG
D
L
N
K
F
L
R
AHGP----
D
A
V
L
M
---AEGN--P----PTE
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
LATRNCLV---G-----E
N
L
L
V
K
IGDFGMSRDVYS-T
D
-
Y
Y
R
VGG
H
T
M
L
P
I
R
WMPPE
S
I
M
Y
R
KFTTES
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y-GK-QP
W
Y
QLSN
N
E
-
V
I
-
E
C
I
-----T-----QGR--VLQRPRT
C
P
Q
E
V
Y
E
L
M
L
G
C
WQREP
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
AKA--S
P
V
Y
L
D
ILG
1
PsiBlast_PDB
97.49
100%
-126
- C2 -
4AT3
1
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
-
C
-------------------------------
K
I
L
V
A
V
K
T
L
----
A
-
S
-
D
-
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
V
E
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
----
D
A
V
L
M
---
A
--
N
--
P
----
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
-
T
D
-
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
N
E
-
V
I
-
E
C
I
-----
T
-----
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
--
S
P
V
Y
L
D
I
L
G
2
PsiBlast_PDB
96.16
100%
-129
- C2 -
4AT4
1
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
-
C
-------------------------------
K
I
L
V
A
V
K
T
L
K
-
D
-
A
-
S
-
D
-
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
V
E
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
----
D
A
V
L
M
---
A
-----
P
----
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
-
T
D
-
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
N
E
-
V
I
-
E
C
I
-----
T
-----
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
--
S
P
V
Y
L
D
I
L
G
3
PsiBlast_PDB
94.84
100%
-124
- C2 -
4AT5
2
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
---------------------------------
K
I
L
V
A
V
K
T
L
K
-
D
-
A
-
S
-
D
-
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
V
E
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
----
D
A
V
L
M
---
A
E
G
N
--
P
----
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
-
T
D
-
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
N
E
-
V
I
-
E
C
I
-----
T
-----
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
--
S
P
V
Y
L
D
I
L
G
22
PsiBlast_CBE
89.88
73%
-124
- C2 -
4AOJ
1
C:
[33-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
-----------
P
---
Q
D
--------------
K
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
-
E
-
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----
D
-------------------
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
------------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
-
A
I
-
D
C
I
-----
T
-----
Q
G
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
--
P
P
-------
5
PsiBlast_PDB
89.23
82%
-127
- C2 -
3V5Q
1
NTRK3_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
R
D
I
V
L
K
R
-
E
L
------
K
V
F
L
A
E
C
Y
N
L
-
S
-----------
P
T
--
K
D
--------------
K
M
L
V
A
V
K
A
L
----
P
-
T
-
L
-
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
G
D
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
-------------------------
E
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
A
N
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
-
T
D
-
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
F
Q
L
S
N
T
E
-
V
I
-
E
C
I
-----
T
-----
Q
G
R
--
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
--
T
P
-------
11
PsiBlast_PDB
88.90
75%
-122
- C2 -
4PMP
1
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
-------------------------------
K
M
L
V
A
V
K
A
L
K
---------
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----
D
A
K
L
L
---
A
G
G
E
DV
A
----
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
I
Y
S
-
T
D
-
Y
Y
R
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
-
A
I
-
D
C
I
-----
T
-----
Q
G
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
--
H
H
H
H
-----
130
HHSearch
88.80
76%
-128
- C2 -
4AOJ
1
NTRK1_HUMAN
A:
[33-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
-----------
P
-------------------
K
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
-
E
-
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----
D
------------------
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
-
A
I
-
D
C
I
-----
T
-----
Q
G
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
--
P
P
-------
23
PsiBlast_CBE
88.27
73%
-125
- C2 -
4AOJ
1
NTRK1_HUMAN
B:
[33-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
-----------
P
-------------------
K
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
-
E
-
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----
D
-------------------
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
---------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
-
A
I
-
D
C
I
-----
T
-----
Q
G
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
--
P
P
V
Y
-----
6
PsiBlast_PDB
88.17
73%
-128
- C2 -
4AOJ
1
NTRK1_HUMAN
A:
[33-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
-----------
P
-------------------
K
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
-
E
-
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----
D
------------------
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
-
A
I
-
D
C
I
-----
T
-----
Q
G
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
--
P
P
-------
9
PsiBlast_PDB
87.23
75%
-120
- C2 -
4YNE
2
A:
[9-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
-----------
P
----
D
--------------
K
M
L
V
A
V
K
A
L
K
-
E
---------
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----
D
A
K
L
L
---
A
G
G
E
DV
A
----
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
------
T
D
-
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
-
A
I
-
D
C
I
-----
T
-----
Q
G
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
--
P
P
V
Y
L
D
---
10
PsiBlast_PDB
86.71
75%
-116
- C2 -
4YPS
1
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
L
-
L
----------------
D
--------------
K
M
L
V
A
V
K
A
L
------
S
-
E
-
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----
D
A
K
L
L
---
A
G
G
E
DV
A
----
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
--
M
S
R
D
I
Y
S
-
T
D
-
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
-
A
I
-
D
C
I
-----
T
-----
Q
G
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
--
P
P
V
------
12
PsiBlast_PDB
82.43
75%
-122
- C2 -
4PMT
1
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
------------------
D
--------------
K
M
L
V
A
V
K
A
L
--------------
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----
D
A
K
L
L
---
A
G
G
E
DV
A
----
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
--
S
R
D
I
Y
S
-
T
D
-
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
-
A
I
-
D
C
I
-----
T
-----
Q
G
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
--
H
H
H
H
-----
134
HHSearch
79.31
49%
-119
- C2 -
4BKJ
10
DDR1_HUMAN
A:
[7-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
P
-
Q
DLVSLDFPLNV
R
K
--
G
H
--------------
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
-
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
----
E
D
------------------
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
-
Q
P
F
G
Q
L
T
D
E
Q
-
V
I
-
E
N
A
-----
G
E
F
F
R
D
Q
G
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
--
T
V
-------
18
PsiBlast_PDB
78.10
47%
-117
- C2 -
4BKJ
10
DDR1_HUMAN
A:
[9-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---------------
P
--
Q
D
LVSLDFPLNVRKG
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
-
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
----
E
D
-----------------
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
-
V
I
-
E
N
A
G
E
F
F
R
D
-----
Q
G
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
--
T
V
-------
25
PsiBlast_CBE
77.95
47%
-107
- C2 -
3ZOS
3
B:
[9-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---------------
P
--
Q
D
LVSLDFPLNVRKG
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
-
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
----
E
D
K
------------Q
G
--
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
-
V
I
-
E
N
A
G
E
F
F
R
D
-----
Q
G
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
--
T
V
-------
24
PsiBlast_CBE
77.82
47%
-113
- C2 -
4BKJ
10
B:
[9-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---------------
P
--
Q
D
LVSLDFPLNVRKG
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
-
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
----
E
D
K
------------G---
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
-
V
I
-
E
N
A
G
E
F
F
R
D
-----
Q
G
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
--
T
V
-------
17
PsiBlast_PDB
76.94
47%
-111
- C2 -
3ZOS
4
DDR1_HUMAN
A:
[9-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---------------
P
--
Q
D
LVSLDFP
L
N
V
R
KG
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
-
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
----
E
D
-------------AAQ
G
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
-
V
I
-
E
N
A
G
E
F
F
R
D
-----
Q
G
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
--
T
V
-------
15
PsiBlast_PDB
75.97
47%
-120
- C2 -
5BVW
1
?
A:
[18-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
--------------------H-------------
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
-
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
----
E
D
K
----------------
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
----
L
Y
A
-
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
-
V
I
-
E
N
A
G
E
F
F
R
D
-----
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
-----------
27
PsiBlast_CBE
75.79
44%
-111
- C2 -
3ETA
1
INSR_HUMAN
A:
[12-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H
14
PsiBlast_PDB
75.76
47%
-116
- C2 -
5BVK
1
?
A:
[18-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
--------------------H-------------
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
-
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
----
E
D
K
----------------
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
-
V
I
-
E
N
A
G
E
F
F
R
D
-----
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
-----------
16
PsiBlast_PDB
75.72
47%
-120
- C2 -
5BVN
1
?
A:
[18-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
--------------------H-------------
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
-
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
----
E
D
K
----------------
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
-
G
D
-
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
-
V
I
-
E
N
A
G
E
F
F
R
D
-----
Q
G
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
-----------
65
PsiBlast_CBE
75.46
42%
-114
- C2 -
4CNH
2
B:
[24-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
------------------
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
S
-
Y
-----
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
45
PsiBlast_CBE
75.46
43%
-115
- C2 -
1I44
1
A:
[9-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H
43
PsiBlast_CBE
74.60
44%
-122
- C2 -
3EKK
1
A:
[14-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
--------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H
26
PsiBlast_CBE
74.53
44%
-111
- C2 -
3ETA
1
B:
[12-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H
49
PsiBlast_CBE
74.42
43%
-112
- C2 -
3LW0
2
IGF1R_HUMAN
A:
[7-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
-
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
----
P
S
---
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
36
PsiBlast_CBE
74.41
44%
-116
- C2 -
3NW5
1
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
M
-------
E
N
N
--
P
V
L
A
-
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
140
HHSearch
74.24
40%
-116
- C2 -
4CKJ
16
A:
[20-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
N
L
V
L
G
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
-----------
G
R
--
A
G
--------------
Y
T
T
V
A
V
K
M
L
K
-
E
-
N
A
S
-
P
-
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
----
V
-------------------
R
A
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
-
E
D
-
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
-
N
P
Y
P
G
I
P
P
E
R
-
L
F
-
N
L
L
-----
K
-----
T
G
H
--
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
--
R
R
-------
48
PsiBlast_CBE
74.12
43%
-112
- C2 -
3LW0
3
IGF1R_HUMAN
B:
[7-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
-
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
----
P
S
---
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
46
PsiBlast_CBE
74.09
43%
-110
- C2 -
3LW0
2
D:
[7-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
-
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
----
P
S
---
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
30
PsiBlast_CBE
73.96
44%
-110
- C2 -
4IBM
1
?
A:
[13-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H
98
PsiBlast_CBE
73.57
43%
-113
- C2 -
1IR3
1
A:
[4-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
F
V
P
D
E
W
--
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H
47
PsiBlast_CBE
73.50
43%
-112
- C2 -
3LW0
3
IGF1R_HUMAN
C:
[7-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
-
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
----
P
S
---
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
57
PsiBlast_CBE
73.46
42%
-121
- C2 -
4DCE
1
B:
[31-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
----
E
V
Y
E
G
Q
V
S
--------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
-----------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
99
PsiBlast_CBE
73.27
43%
-114
- C2 -
1GAG
1
A:
[4-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
F
V
P
D
E
W
--
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H
133
HHSearch
73.17
42%
-109
- C2 -
3L9P
4
A:
[65-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
-------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
---------
P
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
---
T
CPG--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
35
PsiBlast_CBE
73.13
44%
-114
- C2 -
3NW6
1
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
M
-------
E
N
N
--
P
VLA-
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
91
PsiBlast_CBE
72.89
43%
-115
- C2 -
3BU5
1
A:
[13-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
---
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H
31
PsiBlast_CBE
72.79
44%
-115
- C2 -
3I81
1
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
-
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
--------
E
N
N
--
P
V
L
A
-
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
135
HHSearch
72.76
39%
-114
- C2 -
3CBL
3
A:
[111-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
H
E
D
L
V
L
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
-------------------
D
--------------
N
T
L
V
A
V
K
S
C
R
-
E
-
T
L
P
-
P
-
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
P
N
I
V
R
L
I
G
V
C
T
Q
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
-------------------------
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
-----
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
-
G
V
-
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
-
G
A
-
S
P
Y
P
N
L
S
N
Q
Q
-
T
R
-
E
F
V
-----
E
-----
K
G
G
--
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
--
H
--------
141
HHSearch
72.71
38%
-114
- C2 -
3TT0
1
FGFR1_HUMAN
A:
[65-353]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
-----------
K
D
KP
N
R
--------------
V
T
K
V
A
V
K
M
L
K
-
S
D
A
-
T
-
E
-
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
----
P
G
L
E
Y
SYN
P
S
H
N
--
P
----
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
-
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
-
S
P
Y
P
G
V
P
V
E
E
-
L
F
-
K
L
L
-----
K
-----
E
G
H
--
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
----
42
PsiBlast_CBE
72.58
44%
-112
- C2 -
3EKN
1
A:
[14-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H
138
HHSearch
72.51
36%
-110
- C2 -
1T46
1
?
A:
[18-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
N
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
-----------
K
S
--
D
A
--------------
A
M
T
V
A
V
K
M
L
K
-
P
-
S
A
H
-
L
-
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
----
S
F
------------------
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
-----
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
-
D
S
-
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
-
S
P
Y
P
G
M
P
V
D
S
-
K
F
Y
K
M
I
-----
K
-----
E
G
F
--
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
--
S
T
N
------
34
PsiBlast_CBE
72.38
44%
-113
- C2 -
3NW7
1
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
M
-------
E
N
N
--
P
V
L
A
-
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
96
PsiBlast_CBE
72.12
43%
-109
- C2 -
1RQQ
1
B:
[13-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H
29
PsiBlast_CBE
72.11
44%
-108
- C2 -
4IBM
1
?
B:
[13-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
----
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H
149
HHSearch
72.05
37%
-110
- C2 -
2I1M
1
A:
[43-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
N
N
L
Q
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
-----------
K
E
--
D
A
--------------
V
L
K
V
A
V
K
M
L
K
-
S
-
T
A
H
-
A
-
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
S
R
V
L
ET
D
-------------------
S
T
A
S
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
-----
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
-
D
S
-
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
-
N
P
Y
P
G
I
L
V
N
S
K
F
Y
-
K
L
V
-----
K
-----
D
G
Y
--
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
E
--
D
R
R
E
R
----
136
HHSearch
72.00
42%
-111
* C2 *
4CLJ
1
A:
[26-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
---------
P
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
---
T
CPG--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
97
PsiBlast_CBE
71.92
43%
-109
- C2 -
1RQQ
1
INSR_HUMAN
A:
[13-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H
4
PsiBlast_PDB
71.91
82%
-85
- C2 -
4YMJ
4
NTRK3_HUMAN
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
R
D
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
-
S
-----------
P
T
--
K
D
--------------
K
M
L
V
A
V
K
A
L
K
-
D
-
P
-
T
-
L
-
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
G
D
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
------------------------
G
E
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
A
N
L
L
V
K
I
G
D
F
G
---
D
V
Y
S
-
T
D
-
Y
Y
R
---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
F
Q
L
S
N
T
E
-
V
I
-
E
C
I
-----
T
-----
Q
G
R
--
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
--
T
--------
146
HHSearch
71.77
36%
-112
- C2 -
2XIR
1
A:
[23-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
K
L
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
-----------
K
T
--
A
T
--------------
C
R
T
V
A
V
K
M
L
K
-
E
-
G
A
T
-
H
-
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
-
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
----
E
F
V
P
Y
---------
Y
----
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
---
S
-----
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
-
D
P
-
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
-
S
P
Y
P
G
V
K
I
D
E
E
F
C
-
R
R
L
-----
K
-----
E
G
T
--
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
--
N
A
-------
60
PsiBlast_CBE
71.76
42%
-118
- C2 -
2XB7
1
A:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
----------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
58
PsiBlast_CBE
71.73
42%
-116
- C2 -
4DCE
1
ALK_HUMAN
A:
[31-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
-------------------
P
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
----------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
40
PsiBlast_CBE
71.69
44%
-115
- C2 -
3QQU
1
IGF1R_HUMAN
B:
[4-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
-
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-------------------------
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
150
HHSearch
71.57
37%
-115
- C2 -
2PVF
1
A:
[32-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
-----------
K
D
KP-----------------
V
T
V
A
V
K
M
L
K
-
D
-
D
A
T
-
E
-
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
----
P
G
M
E
Y
---
S
Y
-----------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
-
I
D
-
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
-
S
P
Y
P
G
I
P
V
E
E
-
L
F
-
K
L
L
-----
K
-----
E
G
H
--
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
TT---------
63
PsiBlast_CBE
71.40
42%
-115
- C2 -
4CTC
1
A:
[24-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
----
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
56
PsiBlast_CBE
71.37
42%
-111
- C2 -
4FOD
2
A:
[31-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
--------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
88
PsiBlast_CBE
71.28
41%
-114
- C2 -
4ANS
1
A:
[39-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
83
PsiBlast_CBE
71.27
42%
-114
- C2 -
4FOB
1
A:
[51-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
--------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
------------------
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
-------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
139
HHSearch
71.25
42%
-111
- C2 -
3ZBF
1
A:
[31-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
E
K
L
T
L
R
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
D
I
L
G
-----------
V
G
--
S
G
--------------
E
I
K
V
A
V
K
T
L
K
-
K
-
G
-
S
T
D
-
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
L
-
N
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
----
A
---------
T
F
--
Y
----
G
P
L
L
T
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
---
S
VKDYT
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
--------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
-
G
H
-
Q
P
Y
P
A
H
S
N
L
D
-
V
L
-
N
Y
V
-----
Q
-----
T
G
G
--
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
--
F
L
N
S
I
Y
K
S
R
82
PsiBlast_CBE
71.22
42%
-115
- C2 -
4FOC
1
A:
[51-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
--------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
89
PsiBlast_CBE
71.21
43%
-108
- C2 -
2Z8C
1
A:
[4-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
P
D
E
W
--
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H
55
PsiBlast_CBE
71.17
42%
-115
- C2 -
4FNZ
1
A:
[25-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
-------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
-----------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
84
PsiBlast_CBE
71.05
41%
-120
- C2 -
4FNY
1
A:
[25-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
----------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
21
PsiBlast_CBE
70.89
82%
-85
- C2 -
4YMJ
4
B:
[9-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
R
D
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
-
S
-----------
P
T
--
K
D
--------------
K
M
L
V
A
V
K
A
L
K
-
D
-
P
-
T
-
L
-
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
G
D
-
G
-
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
------------------------
G
E
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
A
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
-
T
D
-
Y
Y
R
---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
F
Q
L
S
N
T
E
-
V
I
-
E
C
I
-----
T
-----
Q
G
R
--
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
--
T
P
I
Y
-----
37
PsiBlast_CBE
70.81
44%
-114
- C2 -
2OJ9
1
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
------------------
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
69
PsiBlast_CBE
70.75
42%
-112
- C2 -
4CMO
1
A:
[24-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
59
PsiBlast_CBE
70.33
42%
-122
- C2 -
2XBA
1
A:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
-------
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
66
PsiBlast_CBE
70.23
42%
-118
- C2 -
4CNH
1
ALK_HUMAN
A:
[24-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
------
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
38
PsiBlast_CBE
70.15
44%
-114
- C2 -
3QQU
1
D:
[4-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
-
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
M
-------------LA--
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
71
PsiBlast_CBE
70.05
42%
-112
- C2 -
4CCU
1
A:
[24-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
64
PsiBlast_CBE
70.04
42%
-117
- C2 -
4CTB
1
A:
[24-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
---
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
87
PsiBlast_CBE
70.02
41%
-114
- C2 -
4ANQ
1
A:
[39-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
33
PsiBlast_CBE
69.85
44%
-115
- C2 -
1JQH
1
IGF1R_HUMAN
B:
[11-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
-
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-----------------------
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
---------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
62
PsiBlast_CBE
69.78
42%
-110
- C2 -
4TT7
5
A:
[15-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
----
G
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
------------------
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
S
---
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
67
PsiBlast_CBE
69.74
42%
-112
- C2 -
4CMU
1
A:
[24-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
147
HHSearch
69.72
36%
-116
- C2 -
1U59
1
A:
[5-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
--------------------
K
--------------
Q
I
D
V
A
I
K
V
L
K
-
Q
-
G
-
T
E
K
-
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
-
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
-------------------------
E
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
---
V
-----
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
-
D
D
S
Y
Y
T
A
R
S
A
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
-
G
Q
-
K
P
Y
K
K
M
K
G
P
E
-
V
M
-
A
F
I
-----
E
-----
Q
G
K
--
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
--
L
A
S
K
V
E
G
H
H
61
PsiBlast_CBE
69.70
42%
-112
- C2 -
4CD0
1
A:
[39-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
70
PsiBlast_CBE
69.67
42%
-112
- C2 -
4CLI
1
A:
[24-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
81
PsiBlast_CBE
69.66
42%
-115
- C2 -
2YFX
1
A:
[24-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
------------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
74
PsiBlast_CBE
69.38
42%
-107
- C2 -
4MKC
3
A:
[65-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
--------------------
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
44
PsiBlast_CBE
69.12
44%
-111
- C2 -
4D2R
1
A:
[5-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
-
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
M
-------
E
N
N
--
P
V
L
A
-
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
76
PsiBlast_CBE
69.04
42%
-111
- C2 -
3AOX
5
A:
[41-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
----
G
E
V
Y
E
G
Q
V
S
-----------------------------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
41
PsiBlast_CBE
68.98
44%
-117
- C2 -
3QQU
1
IGF1R_HUMAN
A:
[6-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
-
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
------------------------
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
119
PsiBlast_CBE
68.47
43%
-116
- C2 -
4CSV
1
?
A:
[7-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
-
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
---------------------------------
N
I
E
V
A
V
K
T
L
K
-
E
-
G
-
T
-
M
-
S
V
-
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
P
N
L
V
Q
L
Y
G
V
C
T
K
-
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
---------------
C
-------------
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-----
E
N
N
V
V
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
-
V
P
Y
P
G
M
S
G
S
E
-
V
I
-
E
Q
V
-----
E
-----
R
G
Y
--
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
------------
79
PsiBlast_CBE
68.39
42%
-105
- C2 -
3LCS
3
A:
[42-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
-
P
-----------
N
D
--
P
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
143
HHSearch
68.03
34%
-116
- C2 -
4FYO
1
A:
[12-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
---------------
M
K
--
K
V
--------------
V
K
T
V
A
V
K
I
L
--------
P
-
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
-
N
P
Y
I
V
R
M
I
G
I
C
E
--
A
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
--------------------------
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
---
V
-----
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
-
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
-
G
Q
-
K
P
Y
R
G
M
K
G
S
E
-
V
T
-
A
M
L
-----
E
-----
K
G
E
--
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
--
V
V
N
E
G
H
H
--
39
PsiBlast_CBE
67.99
44%
-113
- C2 -
3QQU
1
IGF1R_HUMAN
C:
[4-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
-
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
M
-------------VLA-
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
78
PsiBlast_CBE
67.56
42%
-102
- C2 -
3LCT
3
A:
[42-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
-
P
-----------
N
D
--
P
S
--------------
P
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
-
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----
R
P
---------
S
--
Q
----
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
G
-
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
E
-
V
L
-
E
F
V
-----
T
-----
S
G
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
--
P
D
V
I
N
T
A
L
P
20
PsiBlast_PDB
67.46
43%
-117
- C2 -
3LVP
2
IGF1R_HUMAN
A:
[39-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
-----------
K
D
--
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
-
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
M
-------
E
----
P
VLA-
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
---------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
R
F
V
-----
M
-----
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
--
G
F
R
E
V
S
F
Y
Y
118
PsiBlast_CBE
61.21
43%
-111
- C2 -
4UEU
1
?
A:
[7-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
-
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
---------------------------------
N
I
E
V
A
V
K
T
L
K
-
E
-
G
-
T
-
M
-
S
V
-
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
P
N
L
V
Q
L
Y
G
V
C
T
K
-
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
---------------
C
E
G
H
--
T
-------
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-----
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
-
V
P
Y
P
G
M
S
G
S
E
-
V
I
-
E
Q
V
-----
E
-----
R
G
Y
--
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-------------
86
PsiBlast_CBE
55.96
43%
-80
- C2 -
4XLV
1
?
A:
[35-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
-----------
K
G
--
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
E
A
E
-
N
---
N
P
G
R
--
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
-
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
-
V
L
-
K
F
V
-----
M
-----
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
--
S
F
P
E
V
S
F
F
H