@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NTRK3_HUMAN: (2015-10-16 )
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
Atome Classification :
(86 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540-.......550.....----------..560-----------..--...-...570...-.-.-.-.580..---.....590...-.-...600.......-610.......620.......630-....----.....640.......650..----.....660.......670.......680.....---.-----.690.......700.......710.......720.......730.......740.......750.......760....-..-.770.....-..-780.-----.-----..--.--..790.......800.......810.......820.......830........
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDVSLCPAKC
S
F
W
R
I
F
L
L
G
S
V
W
L
D
Y
V
G
S
V
L
ACPANCVCSKTEINCRRPDDG
N
L
F
P
L
LEGQDSGNSNG
N
A
S
I
N
I
T
DISRN
I
T
S
I
H
IENWRSLHTL
N
A
V
D
M
E
L
Y
T
G
L
Q
K
L
T
IKNSGLRSIQPRAFAKNP
H
L
R
Y
I
NLSSN
R
L
T
T
L
S
W
Q
L
F
Q
T
L
S
L
R
E
L
Q
L
EQNFFNCSC
D
I
R
W
M
Q
L
W
Q
EQGEAKLNSQ
N
L
Y
C
INADGSQ
L
P
L
F
R
MNISQCDLP
E
I
S
V
S
H
V
N
L
T
V
REGD
N
A
V
I
T
CNGSGSPLP
D
V
D
W
I
V
T
G
L
Q
SINTHQTNL
N
W
T
N
V
H
A
I
N
L
T
L
V
N
V
TSEDN
G
F
T
L
T
C
IAENVVGMSNA
S
V
A
L
T
V
YYPPRVVSLEE
P
E
L
R
L
E
H
C
I
E
F
V
VRGNPP
P
T
L
H
W
LHNGQPLRES
K
I
I
H
V
E
Y
YQEGEISE
G
C
L
L
FNKPTHYNNG
N
Y
T
L
I
AKNPLGTANQTINGHFLKEPFPESTD
N
F
I
L
F
DEVSPTP
P
I
T
V
THKPEEDTFG
V
S
I
A
V
G
L
A
A
F
A
C
V
L
L
V
V
L
F
V
M
I
N
KYGRRSKFGMKG
P
V
A
V
I
SGEEDSASP
L
H
H
I
NHGITTPSSLDAGP
D
T
V
V
I
G
M
T
RIPVIEN
P
Q
Y
F
R
QGHNCHKP
D
T
Y
V
Q
H
I
K
RR
D
I
V
L
K
R-ELGEGA
F
G
K
V
F
L
A
E
C----------YNL-S-----------PT--KD
K
-
M
L
V
A
V
KALK-D-P-
T
-
L
A
A
R
K
D
---
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
GVCGD-GD
P
L
I
M
V
F
E
Y
M
KHG
D
L
N
K
F
L
R
---AHGP----
D
A
M
I
L
VDGQPRQAKGEL
G
L
S
----
Q
M
L
H
I
A
S
Q
I
AS
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
LATRNCLV---G-----
A
N
L
L
V
K
IGDFGMSRDVYST
D
Y
Y
R
L
FNPSGN
D
F
C
I
W
C
EVGG
H
T
M
L
P
I
R
WMPPE
S
I
M
Y
R
KFTTES
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y-GK-Q
P
W
F
QLSN
T
-
E
V
-
I
E
C
I
-----T-----QG--R--VLERPRV
C
P
K
E
V
Y
D
V
M
L
G
C
W
QR
E
P
Q
QRL
N
I
K
E
I
Y
K
I
L
H
A
LGKAT-
P
I
Y
L
D
ILG
2
PsiBlast_PDB
96.87
95%
-134
- C5 -
3V5Q
1
NTRK3_HUMAN
A:
[8-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
Q
H
I
K
R
R
D
I
V
L
K
R
-
E
L
------
K
V
F
L
A
E
C
----------
Y
N
L
-
S
-----------
P
T
--
K
D
K
-
M
L
V
A
V
K
A
L
----
P
-
T
-
L
A
A
R
K
D
---
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
G
D
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
---
A
H
G
P
-------------------
E
L
G
L
S
----
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
A
N
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
D
Y
Y
R
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
F
Q
L
S
N
T
-
E
V
-
I
E
C
I
-----
T
-----
Q
G
--
R
--
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
T
-
P
-------
5
PsiBlast_PDB
93.61
78%
-120
- C5 -
4AT5
2
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
Y
N
L
-------------------
K
-
I
L
V
A
V
K
T
L
K
-
D
-
A
-
S
-
D
N
A
R
K
D
---
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
V
E
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
---
A
H
G
P
----
D
A
V
L
M
A
E
G
N
P
---
P
T
E
L
T
Q
S
----
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
--------------
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
N
-
E
V
-
I
E
C
I
-----
T
-----
Q
G
--
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
-
P
V
Y
L
D
I
L
G
3
PsiBlast_PDB
93.44
78%
-125
- C5 -
4AT3
1
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
Y
N
L
-
C
-----------------
K
-
I
L
V
A
V
K
T
L
----
A
-
S
-
D
N
A
R
K
D
---
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
V
E
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
---
A
H
G
P
----
D
A
V
L
M
A
--
N
P
---
P
T
E
L
T
Q
S
----
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
T
D
Y
Y
R
--------------
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
N
-
E
V
-
I
E
C
I
-----
T
-----
Q
G
--
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
-
P
V
Y
L
D
I
L
G
4
PsiBlast_PDB
92.71
78%
-125
- C5 -
4AT4
1
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
Y
N
L
-
C
-----------------
K
-
I
L
V
A
V
K
T
L
K
-
D
-
A
-
S
-
D
N
A
R
K
D
---
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
V
E
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
---
A
H
G
P
----
D
A
V
L
M
A
---
P
---
P
T
E
L
T
Q
S
----
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
--------------
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
N
-
E
V
-
I
E
C
I
-----
T
-----
Q
G
--
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
-
P
V
Y
L
D
I
L
G
128
HHSearch
92.31
76%
-129
- C5 -
4AOJ
1
NTRK1_HUMAN
A:
[33-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------
C
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
H
N
L
-
L
-----------
P
-----
K
-
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
-
E
S
A
R
Q
D
---
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
---
S
H
G
P
----
D
------------
P
G
P
L
G
L
G
----
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
------------------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
-
E
A
-
I
D
C
I
-----
T
-----
Q
G
--
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
-
P
-------
6
PsiBlast_PDB
90.76
70%
-129
- C5 -
4AOJ
1
NTRK1_HUMAN
A:
[33-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
H
N
L
-
L
-----------
P
-----
K
-
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
-
E
S
A
R
Q
D
---
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
---
S
H
G
P
----
D
------------
P
G
P
L
G
L
G
----
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
------------------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
-
E
A
-
I
D
C
I
-----
T
-----
Q
G
--
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
-
P
-------
22
PsiBlast_CBE
90.72
70%
-126
- C5 -
4AOJ
1
C:
[33-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
H
N
L
-
L
-----------
P
---
Q
D
K
-
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
-
E
S
A
R
Q
D
---
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
---
S
H
G
P
----
D
-------------
G
P
L
G
L
G
----
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
------------------------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
-
E
A
-
I
D
C
I
-----
T
-----
Q
G
--
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
-
P
-------
9
PsiBlast_PDB
90.44
72%
-121
- C5 -
4YNE
2
A:
[9-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
H
N
L
-
L
-----------
P
----
D
K
-
M
L
V
A
V
K
A
L
K
-
E
--------
R
Q
D
---
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
---
S
H
G
P
----
D
A
K
L
L
A
G
G
E
D
-
V
A
P
G
P
L
G
L
G
----
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
-----
T
D
Y
Y
------------------
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
-
E
A
-
I
D
C
I
-----
T
-----
Q
G
--
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
-
P
V
Y
L
D
---
23
PsiBlast_CBE
90.42
70%
-129
- C5 -
4AOJ
1
NTRK1_HUMAN
B:
[33-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
H
N
L
-
L
-----------
P
-----
K
-
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
-
E
S
A
R
Q
D
---
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
---
S
H
G
P
----
D
-------------
G
P
L
G
L
G
----
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
---------------------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
-
E
A
-
I
D
C
I
-----
T
-----
Q
G
--
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
-
P
V
Y
-----
11
PsiBlast_PDB
90.12
73%
-123
- C5 -
4PMP
1
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
H
N
L
-
L
-----------------
K
-
M
L
V
A
V
K
A
L
K
--------
S
A
R
Q
D
---
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
---
S
H
G
P
----
D
A
K
L
L
A
G
G
E
D
-
V
A
P
G
P
L
G
L
G
----
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
I
Y
S
T
D
Y
Y
R
--------------
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
-
E
A
-
I
D
C
I
-----
T
-----
Q
G
--
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
-
H
H
H
-----
10
PsiBlast_PDB
88.17
72%
-119
- C5 -
4YPS
1
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
---
G
K
V
F
L
A
E
C
----------
H
N
L
-
L
----------------
D
K
-
M
L
V
A
V
K
A
L
------
S
-
E
S
A
R
Q
D
---
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
---
S
H
G
P
----
D
A
K
L
L
A
G
G
E
D
-
V
A
P
G
P
L
G
L
G
----
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
--
M
S
R
D
I
Y
S
T
D
Y
Y
R
--------------
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
-
E
A
-
I
D
C
I
-----
T
-----
Q
G
--
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
-
P
V
------
12
PsiBlast_PDB
87.10
73%
-125
- C5 -
4PMT
1
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
H
N
L
------------------
D
K
-
M
L
V
A
V
K
A
L
-------------
D
---
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
---
S
H
G
P
----
D
A
K
L
L
A
G
G
E
D
-
V
A
P
G
P
L
G
L
G
----
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
Q
G
L
V
V
K
I
G
D
F
--
S
R
D
I
Y
S
T
D
Y
Y
R
--------------
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
Y
Q
L
S
N
T
-
E
A
-
I
D
C
I
-----
T
-----
Q
G
--
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
-
H
H
H
-----
21
PsiBlast_CBE
86.53
94%
-82
- C5 -
4YMJ
4
B:
[8-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
Q
H
I
K
R
R
D
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
Y
N
L
-
S
-----------
P
T
--
K
D
K
-
M
L
V
A
V
K
A
L
K
-
D
-
P
-
T
-
L
A
A
R
K
D
---
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
G
D
-
G
-
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
---
A
H
G
P
------------------
G
E
L
G
L
S
----
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
A
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
-----------------
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
F
Q
L
S
N
T
-
E
V
-
I
E
C
I
-----
T
-----
Q
G
--
R
--
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
T
-
P
I
Y
-----
1
PsiBlast_PDB
84.72
94%
-83
- C5 -
4YMJ
4
NTRK3_HUMAN
A:
[8-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
Q
H
I
K
R
R
D
I
V
L
K
R
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
Y
N
L
-
S
-----------
P
T
--
K
D
K
-
M
L
V
A
V
K
A
L
K
-
D
-
P
-
T
-
L
A
A
R
K
D
---
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
G
D
-
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
---
A
H
G
P
------------------
G
E
L
G
L
S
----
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
A
N
L
L
V
K
I
G
D
F
G
---
D
V
Y
S
T
D
Y
Y
R
-----------------
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
-
Q
P
W
F
Q
L
S
N
T
-
E
V
-
I
E
C
I
-----
T
-----
Q
G
--
R
--
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
T
---------
134
HHSearch
80.68
47%
-119
- C5 -
4BKJ
10
DDR1_HUMAN
A:
[7-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
----------
D
S
P
-
Q
DLVSLDFPLNV
R
K
--
G
H
P
-
L
L
V
A
V
K
I
L
R
-
P
D
A
-
T
-
K
N
A
R
N
D
---
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
---
A
H
Q
L
----
E
D
------------
P
T
I
S
Y
P
----
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
------------------
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
-
Q
P
F
G
Q
L
T
D
E
-
Q
V
-
I
E
N
A
-----
G
E
F
F
R
D
Q
G
RQ
V
--
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
-
V
-------
20
PsiBlast_PDB
78.69
43%
-122
- C5 -
5BVW
1
?
A:
[18-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
DS------------------------------
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
---
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
---
A
H
Q
L
----
E
D
K
---------------
P
T
IS
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
----
L
Y
A
G
D
Y
Y
R
--------------
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
-
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
--
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
----------
29
PsiBlast_CBE
78.62
43%
-120
- C5 -
4BKJ
10
DDR1_HUMAN
A:
[9-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
SPQDLVSLD
F
P
L
-
N
-----------
V
R
--
K
G
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
---
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
---
A
H
Q
L
----
E
D
----------------
P
T
IS
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
------------------
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
-
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
--
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
-
V
-------
19
PsiBlast_PDB
78.49
43%
-118
- C5 -
5BVK
1
?
A:
[18-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
DS------------------------------
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
---
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
---
A
H
Q
L
----
E
D
K
---------------
P
T
IS
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
--------------
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
-
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
--
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
----------
27
PsiBlast_CBE
78.29
43%
-120
- C5 -
5BVN
1
?
A:
[18-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
DS------------------------------
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
---
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
---
A
H
Q
L
----
E
D
K
---------------
P
T
IS
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
--------------
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
-
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
--
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
----------
137
HHSearch
78.21
36%
-115
- C5 -
1T46
1
?
A:
[19-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
----------
Y
G
L
-
I
-----------
K
S
--
D
A
A
-
M
T
V
A
V
K
M
L
K
-
P
-
S
A
H
-
L
T
E
R
E
A
---
L
M
S
E
L
K
V
L
S
Y
L
G
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
---
R
K
R
D
----
S
F
------------
L
A
L
D
L
E
----
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
-----
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
--------------
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
-
S
P
Y
P
G
M
P
V
D
-
S
K
F
Y
K
M
I
-----
K
-----
E
G
--
F
--
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
S
-
T
N
------
28
PsiBlast_CBE
78.14
43%
-117
- C5 -
4BKJ
10
B:
[9-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
SPQDLVSLD
F
P
L
-
N
-----------
V
R
--
K
G
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
---
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
---
A
H
Q
L
----
E
D
K
--------------
G
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
------------------
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
-
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
--
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
-
V
-------
30
PsiBlast_CBE
78.04
43%
-110
- C5 -
3ZOS
3
B:
[9-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
SPQDLVSLD
F
P
L
-
N
-----------
V
R
--
K
G
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
---
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
---
A
H
Q
L
----
E
D
K
-------------
Q
G
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
--------------
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
-
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
--
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
-
V
-------
31
PsiBlast_CBE
78.02
43%
-114
- C5 -
3ZOS
4
DDR1_HUMAN
A:
[9-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
SPQDLVSLD
F
P
L
-
N
-----------
V
R
--
K
G
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
-
K
N
A
R
N
D
---
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
---
A
H
Q
L
----
E
D
------------
A
A
Q
G
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
--------------
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
-
C
R
A
Q
P
F
G
Q
L
T
D
E
-
Q
V
-
I
E
N
A
G
E
F
F
R
D
-----
Q
G
--
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
-
V
-------
132
HHSearch
77.69
39%
-118
- C5 -
3CBL
3
A:
[111-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
H
E
D
L
V
L
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
----------
R
-------------------
A
D
N
-
T
L
V
A
V
K
S
C
R
-
E
-
T
-
L
P
P
D
L
K
A
K
---
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
P
N
I
V
R
L
I
G
V
C
T
Q
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
---
T
E
G
-------------------
A
R
L
R
V
K
----
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
-----
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
-
A
-------------
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
-
G
A
-
S
P
Y
P
N
L
S
N
Q
-
Q
T
-
R
E
F
V
-----
E
-----
K
G
--
G
--
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
---------
38
PsiBlast_CBE
77.14
39%
-110
- C5 -
3EKN
1
A:
[8-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
--
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
----------
R
D
I
-
I
-----------
K
G
--
E
A
E
-
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
A
------
E
N
N
P
G
R
P
P
P
T
L
Q
----
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
K
F
V
-----
M
-----
D
G
--
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
-
F
P
E
V
S
F
F
H
133
HHSearch
77.09
41%
-114
* C5 *
4CLJ
1
A:
[26-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
---------------------
P
-
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
---
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
----
R
P
---------
S
Q
P
S
S
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
---
T
CPG--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
57
PsiBlast_CBE
77.06
39%
-106
- C5 -
3LW0
3
IGF1R_HUMAN
B:
[3-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
-----------------
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
58
PsiBlast_CBE
76.78
39%
-105
- C5 -
3LW0
2
IGF1R_HUMAN
A:
[3-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
-----------------
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
55
PsiBlast_CBE
76.64
39%
-104
- C5 -
3LW0
2
D:
[3-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
-----------------
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
56
PsiBlast_CBE
76.53
39%
-105
- C5 -
3LW0
3
IGF1R_HUMAN
C:
[3-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
-----------------
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
34
PsiBlast_CBE
76.51
40%
-109
- C5 -
3ETA
1
B:
[12-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
----------
R
D
I
-
I
-----------
K
G
--
E
A
E
-
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
A
----
E
N
N
P
--
G
R
P
P
P
T
L
Q
----
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
K
F
V
-----
M
-----
D
G
--
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
-
F
P
E
V
S
F
F
H
143
HHSearch
76.37
38%
-118
- C5 -
2PVF
1
A:
[32-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
-----------
K
D
KP----
V
T
V
A
V
K
M
L
K
-
D
-
D
A
T
-
E
K
D
L
S
D
---
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
---
A
R
R
P
----
P
G
M
E
Y
S
Y
--------
Q
M
T
F
K
----
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
--------------
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
-
S
P
Y
P
G
I
P
V
E
-
E
L
-
F
K
L
L
-----
K
-----
E
G
--
H
--
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T--------
136
HHSearch
76.30
39%
-118
- C5 -
4CKJ
16
A:
[20-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
N
L
V
L
G
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
----------
F
H
L
-
K
-----------
G
R
--
A
G
Y
-
T
T
V
A
V
K
M
L
K
-
E
-
N
A
S
-
P
S
E
L
R
D
---
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
---
E
S
R
K
----
V
-------------
R
A
L
T
M
G
----
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
--------------
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
-
N
P
Y
P
G
I
P
P
E
-
R
L
-
F
N
L
L
-----
K
-----
T
G
--
H
--
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
R
-
R
-------
146
HHSearch
76.29
37%
-112
- C5 -
2I1M
1
A:
[43-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
N
N
L
Q
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
----------
F
G
L
-
G
-----------
K
E
--
D
A
V
-
L
K
V
A
V
K
M
L
K
-
S
-
T
-
A
H
A
D
E
K
E
A
---
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
---
R
K
S
R
V
L
ET
D
-------------
S
T
A
S
T
R
----
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
-----
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
--------------
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
-
N
P
Y
P
G
I
L
V
N
S
K
F
-
Y
K
L
V
-----
K
-----
D
G
--
Y
--
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
E
D
-
R
R
E
R
----
40
PsiBlast_CBE
76.28
40%
-109
- C5 -
1I44
1
A:
[9-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
----------
R
D
I
-
I
-----------
K
G
--
E
A
E
-
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
A
----
E
N
N
P
--
G
R
P
P
P
T
L
Q
----
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
------------------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
K
F
V
-----
M
-----
D
G
--
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
-
F
P
E
V
S
F
F
H
131
HHSearch
76.24
41%
-111
- C5 -
3L9P
4
A:
[66-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
G
-------------------
S
P
-
L
Q
V
A
V
K
T
L
P
-
E
-
V
C
S
-
E
Q
D
E
L
D
---
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
----
R
P
---------
S
Q
P
S
S
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
---
T
CPG--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
--------------
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
61
PsiBlast_CBE
76.04
38%
-117
- C5 -
4DCE
1
B:
[17-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
----
E
V
Y
E
G
Q
V
----------
S
--------------------
S
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
-----------------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
141
HHSearch
75.89
36%
-119
- C5 -
2XIR
1
A:
[23-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
K
L
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
----------
F
G
I
-
D
-----------
K
T
--
A
T
C
-
R
T
V
A
V
K
M
L
K
-
E
-
G
A
T
-
H
S
E
H
R
A
---
L
M
S
E
L
K
I
L
I
H
I
-
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
---
S
K
R
N
----
E
F
V
P
Y
-------
Y
K
D
F
L
T
L
E
----
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
---
S
-----
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
--------------
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
-
S
P
Y
P
G
V
K
I
D
E
E
F
-
C
R
R
L
-----
K
-----
E
G
--
T
--
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
-
A
-------
35
PsiBlast_CBE
75.63
40%
-109
- C5 -
3ETA
1
INSR_HUMAN
A:
[12-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
----------
R
D
I
-
I
-----------
K
G
--
E
A
E
-
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
A
----
E
N
N
P
--
G
R
P
P
P
T
L
Q
----
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
K
F
V
-----
M
-----
D
G
--
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
-
F
P
E
V
S
F
F
H
39
PsiBlast_CBE
75.56
39%
-116
- C5 -
3EKK
1
A:
[6-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
V
P
D
E
W
--
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
----------
R
D
I
-
I
-----------
K
G
--
E
A
E
-
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
A
------
E
N
N
P
G
R
P
P
P
T
L
Q
----
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
--------------------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
K
F
V
-----
M
-----
D
G
--
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
-
F
P
E
V
S
F
F
H
64
PsiBlast_CBE
75.50
38%
-114
- C5 -
4CTB
1
A:
[9-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
---
F
G
E
V
Y
E
G
Q
V
--------------------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
139
HHSearch
75.11
37%
-116
- C5 -
3TT0
1
FGFR1_HUMAN
A:
[65-351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
-----------
K
D
KP
N
R
V
-
T
K
V
A
V
K
M
L
K
-
S
-
D
A
T
-
E
K
D
L
S
D
---
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
---
A
R
R
P
----
P
G
L
E
Y
S
Y
N
P
S
H
N
P
E
E
Q
L
S
S
K
----
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
------------
N
--
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
-
S
P
Y
P
G
V
P
V
E
-
E
L
-
F
K
L
L
-----
K
-----
E
G
--
H
--
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-
S
N
Q
E
----
69
PsiBlast_CBE
75.10
38%
-110
- C5 -
4CMO
1
A:
[9-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------------------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
67
PsiBlast_CBE
74.95
38%
-109
- C5 -
4CMU
1
A:
[9-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------------------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
66
PsiBlast_CBE
74.90
38%
-116
- C5 -
4CNH
1
ALK_HUMAN
A:
[10-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
------
E
V
Y
E
G
Q
V
----------
S
---------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
41
PsiBlast_CBE
74.68
39%
-103
- C5 -
3I81
1
A:
[6-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
-----
E
N
N
P
V
L
A
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
-------------------
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
70
PsiBlast_CBE
74.66
38%
-110
- C5 -
4CLI
1
A:
[9-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------------------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
90
PsiBlast_CBE
74.49
38%
-115
- C5 -
2XB7
1
A:
[3-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
---------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
-
S
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
----------------------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
87
PsiBlast_CBE
74.36
38%
-110
- C5 -
4ANQ
1
A:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
--------------------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
--------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
65
PsiBlast_CBE
74.36
38%
-108
- C5 -
4CNH
2
B:
[9-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
---------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
---
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
Y
-------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
140
HHSearch
74.33
41%
-115
- C5 -
3ZBF
1
A:
[30-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
E
K
L
T
L
R
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
----------
V
D
I
L
G
-----------
V
G
--
S
G
E
-
I
K
V
A
V
K
T
L
K
-
K
-
G
-
S
T
D
Q
E
K
I
E
---
F
L
K
E
A
H
L
M
S
K
F
-
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
L
-
N
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
---
K
A
R
M
----
A
---------
T
F
Y
G
P
L
L
T
L
V
----
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
---
S
VKDYT
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
--------------------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
-
G
H
-
Q
P
Y
P
A
H
S
N
L
-
D
V
-
L
N
Y
V
-----
Q
-----
T
G
--
G
--
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
-
L
N
S
I
Y
K
S
R
42
PsiBlast_CBE
74.30
39%
-102
- C5 -
3NW7
1
A:
[8-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
----
M
E
N
N
P
V
L
A
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
71
PsiBlast_CBE
74.29
38%
-110
- C5 -
4CCU
1
A:
[9-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
--------------------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
78
PsiBlast_CBE
74.18
38%
-112
- C5 -
2YFX
1
A:
[9-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
--------------------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
88
PsiBlast_CBE
74.17
38%
-111
- C5 -
4ANS
1
A:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
--------------------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
--------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
37
PsiBlast_CBE
74.08
39%
-101
- C5 -
4IBM
1
?
A:
[5-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
V
P
D
E
W
--
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
----------
R
D
I
-
I
-----------
K
G
--
E
A
E
-
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
A
------
E
N
N
P
G
R
P
P
P
T
L
Q
----
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
K
F
V
-----
M
-----
D
G
--
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
-
F
P
E
V
S
F
F
H
60
PsiBlast_CBE
73.71
38%
-109
- C5 -
4FOD
2
A:
[16-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
--------------------
S
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
---------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
63
PsiBlast_CBE
73.50
38%
-114
- C5 -
4CTC
1
A:
[10-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
----
G
E
V
Y
E
G
Q
V
--------------------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
----------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
97
PsiBlast_CBE
73.46
38%
-108
- C5 -
1RQQ
1
B:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
--
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
----------
R
D
I
-
I
-----------
K
G
--
E
A
E
-
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
A
------
E
N
N
P
G
R
P
P
P
T
L
Q
----
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
--------------
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
K
F
V
-----
M
-----
D
G
--
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
-
F
P
E
V
S
F
F
H
76
PsiBlast_CBE
73.45
38%
-111
- C5 -
4CD0
1
A:
[25-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
---------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
62
PsiBlast_CBE
73.43
38%
-112
- C5 -
4DCE
1
ALK_HUMAN
A:
[16-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
----------
S
-------------------
P
S
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
----------------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
98
PsiBlast_CBE
73.35
38%
-108
- C5 -
1RQQ
1
INSR_HUMAN
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
--
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
----------
R
D
I
-
I
-----------
K
G
--
E
A
E
-
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
A
------
E
N
N
P
G
R
P
P
P
T
L
Q
----
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
--------------
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
K
F
V
-----
M
-----
D
G
--
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
-
F
P
E
V
S
F
F
H
81
PsiBlast_CBE
73.31
38%
-102
- C5 -
3LCT
3
A:
[27-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
G
M
-
P
-----------
N
D
--
P
S
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
--------------
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
51
PsiBlast_CBE
73.30
39%
-111
- C5 -
3QQU
1
IGF1R_HUMAN
B:
[4-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
-------------------
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
47
PsiBlast_CBE
73.22
39%
-102
- C5 -
4D2R
1
A:
[1-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
----
M
E
N
N
P
V
L
A
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
83
PsiBlast_CBE
73.17
38%
-112
- C5 -
4FOC
1
A:
[36-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
--------------------
S
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
36
PsiBlast_CBE
73.11
39%
-105
- C5 -
4IBM
1
?
B:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
--
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
----------
R
D
I
-
I
-----------
K
G
--
E
A
E
-
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
----
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
A
------
E
N
N
P
G
R
P
P
P
T
L
Q
----
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
K
F
V
-----
M
-----
D
G
--
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
-
F
P
E
V
S
F
F
H
44
PsiBlast_CBE
73.10
39%
-103
- C5 -
3NW5
1
A:
[6-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
----
M
E
N
N
P
V
L
A
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
82
PsiBlast_CBE
73.06
38%
-107
- C5 -
3LCS
3
A:
[30-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
G
M
-
P
-----------
N
D
--
P
S
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
--------------
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
92
PsiBlast_CBE
73.05
38%
-112
- C5 -
3BU5
1
A:
[10-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
--
E
V
S
R
E
K
I
T
L
L
R
-
E
L
G
Q
G
---
M
V
Y
E
G
N
A
----------
R
D
I
-
I
-----------
K
G
--
E
A
E
-
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
-
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
A
------
E
N
N
P
G
R
P
P
P
T
L
Q
----
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
--------------
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
K
F
V
-----
M
-----
D
G
--
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
-
F
P
E
V
S
F
F
H
99
PsiBlast_CBE
72.96
39%
-114
- C5 -
4TT7
5
A:
[15-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
----
G
E
V
Y
E
G
Q
V
----------
S
---------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
---
P
S
-
S
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
--
R
--------------
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
89
PsiBlast_CBE
72.93
38%
-117
- C5 -
2XBA
1
A:
[3-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
-------
V
Y
E
G
Q
V
----------
S
---------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
-
S
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
------------------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
49
PsiBlast_CBE
72.75
39%
-107
- C5 -
3QQU
1
D:
[4-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
----
M
-----
L
A
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
84
PsiBlast_CBE
72.72
38%
-110
- C5 -
4FOB
1
A:
[36-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
--------------------
S
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
---
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
--------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
45
PsiBlast_CBE
72.54
39%
-102
- C5 -
2OJ9
1
A:
[6-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
------------
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
43
PsiBlast_CBE
72.48
39%
-103
- C5 -
3NW6
1
A:
[7-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
----
M
E
N
N
P
V
L
A
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
79
PsiBlast_CBE
72.47
38%
-108
- C5 -
3AOX
5
A:
[26-312]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
----
G
E
V
Y
E
G
Q
V
----------
S
---------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
---------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
46
PsiBlast_CBE
72.12
39%
-105
- C5 -
1JQH
1
IGF1R_HUMAN
B:
[7-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
-----------------
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
-------
Y
Y
R
--------------
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
142
HHSearch
72.08
36%
-121
- C5 -
1U59
1
A:
[5-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
----------
R
--------------------
K
Q
-
I
D
V
A
I
K
V
L
K
-
Q
-
G
-
T
E
K
A
D
T
E
E
---
M
M
R
E
A
Q
I
M
H
Q
L
-
D
-
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
-
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
---
G
K
-------------------
R
E
E
I
P
V
S
----
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
---
V
-----
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
D
D
S
Y
Y
T
-------------
A
R
S
A
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
-
G
Q
-
K
P
Y
K
K
M
K
G
P
-
E
V
-
M
A
F
I
-----
E
-----
Q
G
--
K
--
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
-
A
S
K
V
E
G
H
H
85
PsiBlast_CBE
71.99
38%
-120
- C5 -
4FNY
1
A:
[20-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
---
G
E
V
Y
E
G
Q
V
----------
S
G
--------------------
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
-----
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
------------------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
52
PsiBlast_CBE
71.93
39%
-111
- C5 -
3QQU
1
IGF1R_HUMAN
A:
[6-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
------------------
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
74
PsiBlast_CBE
71.82
38%
-104
- C5 -
4MKC
3
A:
[50-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
--
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
--------------------
S
P
-
L
Q
V
A
V
K
T
L
----
P
-
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
---
E
T
R
P
------------
R
P
S
Q
P
S
S
-
L
A
M
L
----
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-----
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
--------------
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
-
M
P
Y
P
S
K
S
N
Q
-
E
V
-
L
E
F
V
-----
T
-----
S
G
--
G
--
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
-
D
V
I
N
T
A
L
P
50
PsiBlast_CBE
71.74
39%
-106
- C5 -
3QQU
1
IGF1R_HUMAN
C:
[4-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
----
M
----
V
L
A
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
54
PsiBlast_CBE
71.47
40%
-124
- C5 -
4CSV
1
?
A:
[7-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
-
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
----------
R
N
Y
-
N
-------------------
I
E
V
A
V
K
T
L
K
-
E
-
G
-
T
-
M
S
V
-
E
E
---
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
P
N
L
V
Q
L
Y
G
V
C
T
K
-
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C----
V
----
N
A
Q
A
L
L
D
---------------------
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-----
E
N
N
V
V
K
V
A
D
F
G
--------------------
F
------------
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
-
V
P
Y
P
G
M
S
G
S
-
E
V
-
I
E
Q
V
-----
E
-----
R
G
--
Y
--
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
---
T
L
H
A
L
E
T
M
F
-
L
-------
32
PsiBlast_CBE
71.34
39%
-109
- C5 -
3LVP
2
IGF1R_HUMAN
A:
[39-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
-
V
-----------
K
D
--
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
-
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
---
S
L
R
P
----
E
----
M
E
--
P
V
L
A
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
---------------------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
-
Q
P
Y
Q
G
L
S
N
E
-
Q
V
-
L
R
F
V
-----
M
-----
E
G
--
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
-
F
R
E
V
S
F
Y
Y
53
PsiBlast_CBE
70.60
40%
-122
- C5 -
4UEU
1
?
A:
[7-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
-
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
----------
R
N
Y
-
N
-------------------
I
E
V
A
V
K
T
L
K
-
E
-
G
-
T
-
M
S
V
-
E
E
---
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
P
N
L
V
Q
L
Y
G
V
C
T
K
-
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
DCE
G
H
T
V
----
N
A
Q
A
L
L
D
---------------------
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-----
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-------------
A
K
F
------------
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
-
V
P
Y
P
G
M
S
G
S
-
E
V
-
I
E
Q
V
-----
E
-----
R
G
--
Y
--
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
---
T
L
H
A
L
E
T
M
F
---------