@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NUAK1_HUMAN: (2015-10-16 )
MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEVMLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKLN
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90.-...---...---.---100.......110.......120.--......130.......140....----.----------------------------------.----.150.......160.......170.......180..-..---..---.190--.........-200...---.-...210.......220..--...--..230.......240.......250.......---260.......270---...--.-----.-----..-..280........290.......300.......310----.--------.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEGAAAPVAGDRPDLGLGAPGS
P
R
E
A
VAGATAALEPRKPHG
V
K
R
H
H
H
K
H
N
L
K
H
R
Y
E
L
Q
E
T
LGKGT
Y
G
K
V
K
R
A
T
E
R
FS
G
R
V
V
A
I
K
S
I
R
K
DKIK-
D
E
Q
---
D
M
V
---
H
---
I
R
R
E
I
E
I
M
S
SLNH
P
H
I
I
S
I
Y
E
V
FE--NKD
K
I
V
I
I
M
EYASK
G
E
L
Y
D
Y
I
S
E
----
R
----------------------------------
R
----RL
S
E
R
E
T
R
H
F
F
R
Q
I
V
S
A
V
H
Y
C
H
KNG
V
V
H
R
D
L
K
L
E
N
I
-
L
L---DD---NC----
N
I
K
I
A
DF
G
L
-
S
N
L
Y
Q
K
---
D
-
K
F
L
Q
T
F
CGSPLYASPEIV--NGR--PYRGPEV
D
S
W
A
L
G
V
L
L
Y
T
L
V
YGTMPFDGF
D
H
K
---
N
L
I
R
Q
ISSGEY-----REP--T-----Q-----PS-
D
A
R
G
-
L
I
R
W
M
L
M
VNPDRR
A
T
I
E
D
I
ANH
W
W
V
NWGYK-----S--------SVCDCDALHDSES
P
L
L
A
R
I
I
D
W
HHRSTGLQAD
T
E
A
K
M
KGLAKP
T
T
S
E
V
M
L
E
R
Q
R
S
L
K
KSKKEN
D
F
AQSGQDAVPES
P
S
KLSSKR
P
K
G
I
L
K
KRSNSEHRSHSTGFIEGVVGPALP
S
T
F
K
M
E
Q
D
L
C
RTGVLLPSSPEAEVPGKLSPKQSATMP
K
K
G
I
L
K
K
T
Q
Q
RESGYYSSPERS
E
S
S
ELLDSNDVMGSSIPSPSPPD
P
A
R
VTSH
S
L
S
C
R
R
K
G
I
LKHSSKYSAGTMDPALVSPEMP
T
L
E
S
LSEPGV
P
A
E
G
L
S
RSYSRPSSVISDDSVLSSDS
F
D
L
L
DLQENR
P
A
R
Q
R
I
R
S
C
V
S
A
E
N
F
L
Q
I
QDFEGLQNRP
R
P
Q
Y
L
K
R
Y
R
N
RLADSS
F
S
L
LT
D
M
D
D
V
T
Q
V
Y
K
Q
A
L
E
I
C
SKLN
135
HHSearch
80.87
35%
-100
- C2 -
3HKO
2
?
A:
[22-335]
------------------------------------------------
L
E
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q--
K
---
D
V
E
---
R
---
I
K
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
--
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
----
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
-
L
F
---
S
T
---
N
K
SF--
E
I
K
L
V
D
F
G
L
-
S
K
E
F
Y
K
LNN
G
-------
A
G
T
P
Y
F
V
A
P
E
V
L
--
N
T
T
NE
S
Y
-
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
---
D
T
I
S
Q
V
L
N
K
K
L
-----
C
F
E
--
N
PNYNV
L
-----
S
P
-
L
A
R
D
-
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
D
-----
K
--------
I
Y
K
M
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
79.73
37%
-85
- C2 -
4CZU
3
CIPKN_ARATH
B:
[12-295]
-----------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
---
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
----------------------------------
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
---
D
A
---
N
G
----
A
L
K
V
S
D
F
G
L
-
S
A
L
P
Q
Q
VRE
D
-
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
---
S
L
Y
K
K
I
F
K
A
E
F
-----
T
C
P
--
P
-----
W
-----
F
S
A
S
A
K
K
-
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
-----
A
PKFE------
D
D
V
D
A
I
F
D
D
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
79.08
38%
-80
- C2 -
4CZT
4
CIPKN_ARATH
D:
[12-306]
-----------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
---
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
----------------------------------
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
---
D
A
---
N
G
----
A
L
K
V
S
D
F
G
L
-
S
A
L
P
Q
Q
VRE
D
-
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
---
S
L
Y
K
K
I
F
K
A
E
F
-----
T
C
P
--
P
-----
W
-----
F
S
A
S
A
K
K
-
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
-----
A
P
K
F
E
N
A
DV
S
L
D
D
V
D
A
I
F
D
D
S
----
N
L
V
V
E
--
R
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
79.02
38%
-84
- C2 -
4CZT
2
CIPKN_ARATH
B:
[12-295]
-----------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
---
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
----------------------------------
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
---
D
A
---
N
G
----
A
L
K
V
S
D
F
G
L
-
S
A
L
P
Q
Q
VRE
D
-
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
---
S
L
Y
K
K
I
F
K
A
E
F
-----
T
C
P
--
P
-----
W
-----
F
S
A
S
A
K
K
-
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
-----
A
P
K
F
E------
D
D
V
D
A
I
F
D
D
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
78.85
47%
-99
- C2 -
3AQV
1
AAPK2_HUMAN
A:
[13-264]
------------------------------------------------------
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
-
S
L
D
---
V
V
G
---
K
---
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
--
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
----
H
----------------------------------
G
----
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
---
D
A
---
H
M
----
N
A
K
I
A
D
F
G
L
-
S
N
M
M
S
D
---
G
-
E
F
L
------
P
N
Y
A
A
P
E
V
I
--
S
G
R
--
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
---
T
L
F
K
K
I
R
G
G
V
F
-----
Y
I
P
--
E
-----
Y
-----
L
N
-
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
-----
S
--------
Y
L
F
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
78.56
37%
-85
- C2 -
4CZU
3
CIPKN_ARATH
C:
[12-294]
-----------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
---
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
----------------------------------
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
---
D
A
---
N
G
----
A
L
K
V
S
D
F
G
L
-
S
A
L
P
Q
Q
VRE
D
-
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
---
S
L
Y
K
K
I
F
K
A
E
F
-----
T
C
P
--
P
-----
W
-----
F
S
A
S
A
K
K
-
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
-----
A
P
K
F
E
N
ADV-----
D
A
I
F
D
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
78.51
38%
-88
- C2 -
4CZT
3
CIPKN_ARATH
C:
[12-295]
-----------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
---
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
----------------------------------
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
---
D
A
---
N
G
----
A
L
K
V
S
D
F
G
L
-
S
A
L
P
Q
Q
VRE
D
-
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
---
S
L
Y
K
K
I
F
K
A
E
F
-----
T
C
P
--
P
-----
W
-----
F
S
A
S
A
K
K
-
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
-----
A
P
K
F
E
N
ADV
S
L
D
D
V
D
A
I
F
D
D
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
77.50
34%
-95
- C2 -
4TXC
7
DAPK1_HUMAN
A:
[21-294]
-----------------------------------------
T
V
--
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
---
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
----------------------------------
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
---
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
F
---
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
---
E
T
L
A
N
V
S
A
V
N
Y
-----
E
F
E
--
D
-----
E
YFSNT
S
A
-
L
A
K
D
-
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
77.09
36%
-96
- C2 -
2Y0A
1
DAPK1_HUMAN
A:
[7-276]
------------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
RGV
S
R
E
---
D
---
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
----------------------------------
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
-
M
L
---
L
D
---
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
F
---
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
---
E
T
L
A
N
V
S
A
V
N
Y
-----
E
F
E
--
D
EYFSN
T
-----
S
A
-
L
A
K
D
-
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
-----
Q
--------
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
76.98
37%
-79
- C2 -
4CZU
3
CIPKN_ARATH
D:
[12-306]
-----------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
---
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
----------------------------------
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
---
D
A
---
N
G
----
A
L
K
V
S
D
F
G
L
-
S
A
L
P
Q
Q
VRE
D
-
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
---
S
L
Y
K
K
I
F
K
A
E
F
-----
T
C
P
--
P
-----
W
-----
F
S
A
S
A
K
K
-
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
-----
A
PKFENADV
S
L
D
D
V
D
A
I
F
D
D
S
----
N
L
V
V
E
--
R
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
76.86
35%
-104
- C2 -
4BDF
3
CHK2_HUMAN
A:
[7-285]
-------------------------------------------
M
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------
N
---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
----
N
----------------------------------
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
SSQ
E
E
---
D
C
----
L
I
K
I
T
D
F
G
H
-
S
K
I
L
G
E
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
H
R
TQV
S
L
K
D
Q
I
T
S
G
K
Y
-----
N
F
I
--
P
-----
E
VWAEV
S
E
-
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
-----
K
--------
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
76.68
35%
-110
- C2 -
4BDD
4
CHK2_HUMAN
A:
[7-285]
-------------------------------------------
M
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------
N
---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
----
N
----------------------------------
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
SSQ
E
E
---
D
C
----
L
I
K
I
T
D
F
G
H
-
S
K
I
L
-----
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
H
R
TQV
S
L
K
D
Q
I
T
S
G
K
Y
-----
N
F
I
--
P
-----
E
VWAEV
S
E
-
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
-----
K
--------
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
76.56
37%
-80
- C2 -
4CZU
3
CIPKN_ARATH
A:
[12-302]
-----------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
---
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
----------------------------------
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
---
D
A
---
N
G
----
A
L
K
V
S
D
F
G
L
-
S
A
L
P
Q
Q
VRE
D
-
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
---
S
L
Y
K
K
I
F
K
A
E
F
-----
T
C
P
--
P
-----
W
-----
F
S
A
S
A
K
K
-
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
-----
A
PKFEN-----
D
D
V
D
A
I
F
D
D
S
G
E
S
K
N
L
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
76.46
38%
-79
- C2 -
4CZT
3
CIPKN_ARATH
A:
[12-297]
-----------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
---
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
----------------------------------
G
----
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
---
D
A
---
N
G
----
A
L
K
V
S
D
F
G
L
-
S
A
L
P
Q
Q
VRE
D
-
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
---
S
L
Y
K
K
I
F
K
A
E
F
-----
T
C
P
--
P
-----
W
-----
F
S
A
S
A
K
K
-
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
-----
A
P
K
F
E
NV--
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
75.91
35%
-97
- C2 -
4I6B
1
PLK2_HUMAN
A:
[29-296]
-----------------------------------------------------
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
-
K
P
H
---
Q
R
E
---
K
---
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
--
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
----
R
----------------------------------
K
----
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
-
F
I
---
N
E
---
S
M
----
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
---
E
-
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
--
N
K
Q
--
G
H
-
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
---
E
T
Y
R
S
I
R
E
A
R
Y
-----
T
M
P
--
S
-----
S
L----
L
A
-
P
A
K
H
-
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
PDRLS
S
--------
S
C
C
H
T
V
P
D
F
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
75.47
34%
-93
- C2 -
3MA6
1
?
B:
[29-292]
-------------------------------------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
-
T
---
D
K
E
---
S
---
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
----
R
----------------------------------
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
---
E
S
KSK
D
A
----
N
I
R
I
I
D
F
G
L
-
S
T
H
F
E
A
---
S
-
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
---
D
I
L
K
K
V
E
K
G
K
Y
TFELP
Q
W
K
--
K
-----
V
-----
S
E
-
S
A
K
D
-
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
75.36
35%
-96
- C2 -
4I6F
1
PLK2_HUMAN
A:
[29-296]
-----------------------------------------------------
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
-
K
P
H
---
Q
R
E
---
K
---
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
--
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
----
R
----------------------------------
K
----
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
-
F
I
---
N
E
---
S
M
----
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
---
E
-
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
--
N
K
Q
--
G
H
-
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
---
E
T
Y
R
S
I
R
E
A
R
Y
-----
T
M
P
--
S
-----
S
L----
L
A
-
P
A
K
H
-
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
PDRLS
S
--------
S
C
C
H
T
V
P
D
F
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
75.19
34%
-98
- C2 -
4B4L
3
DAPK1_HUMAN
A:
[7-277]
----------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
---
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
----------------------------------
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
---
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
F
---
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
---
E
T
L
A
N
V
S
A
V
N
Y
-----
E
F
E
--
D
-----
E
YFSNT
S
A
-
L
A
K
D
-
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
-----
Q
--------
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
75.01
35%
-100
- C2 -
4I6H
1
PLK2_HUMAN
A:
[29-296]
-----------------------------------------------------
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
-
K
P
H
---
Q
R
E
---
K
---
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
--
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
----
R
----------------------------------
K
----
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
-
F
I
---
N
E
---
S
M
----
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
---
E
-
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
--
N
K
Q
--
G
H
-
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
---
E
T
Y
R
S
I
R
E
A
R
Y
-----
T
M
P
--
S
-----
S
L----
L
A
-
P
A
K
H
-
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
PDRLS
S
--------
S
C
C
H
T
V
P
D
F
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
74.86
35%
-100
- C2 -
4BDG
2
CHK2_HUMAN
A:
[7-285]
-------------------------------------------
M
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------
N
---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
----
N
----------------------------------
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
SSQ
E
E
---
D
C
----
L
I
K
I
T
D
F
G
H
-
S
K
I
L
G
E
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
H
R
TQV
S
L
K
D
Q
I
T
S
G
K
Y
-----
N
F
I
--
P
-----
E
VWAEV
S
E
-
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
-----
K
--------
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
74.68
34%
-93
- C2 -
3MA6
1
?
A:
[29-292]
-------------------------------------------------
I
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
K
T
---
D
K
E
---
S
---
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
--
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
----
R
----------------------------------
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
---
E
S
KSK
D
A
----
N
I
R
I
I
D
F
G
L
-
S
T
H
F
E
----
S
-
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
----
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
---
D
I
L
K
K
V
E
K
G
K
Y
TFEL
P
Q
W
K
--
K
-----
V
-----
S
E
-
S
A
K
D
-
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
74.64
35%
-103
- C2 -
4BDK
4
CHK2_HUMAN
A:
[9-285]
---------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------
A
L
---
N
---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
----
N
----------------------------------
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
SSQ
E
E
---
D
C
----
L
I
K
I
T
D
F
G
H
-
S
K
I
L
G
E
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
H
R
TQV
S
L
K
D
Q
I
T
S
G
K
Y
-----
N
F
I
--
P
-----
E
VWAEV
S
E
-
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
-----
K
--------
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
74.57
35%
-97
- C2 -
4I5P
1
PLK2_HUMAN
A:
[29-296]
-----------------------------------------------------
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
-
K
P
H
---
Q
R
E
---
K
---
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
--
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
----
R
----------------------------------
K
----
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
-
F
I
---
N
E
---
S
M
----
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
---
E
-
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
--
N
K
Q
--
G
H
-
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
---
E
T
Y
R
S
I
R
E
A
R
Y
-----
T
M
P
--
S
-----
S
L----
L
A
-
P
A
K
H
-
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
PDRLS
S
--------
S
C
C
H
T
V
P
D
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
74.51
35%
-92
- C2 -
4I5M
1
PLK2_HUMAN
A:
[29-296]
-----------------------------------------------------
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
-
K
P
H
---
Q
R
E
---
K
---
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
--
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
----
R
----------------------------------
K
----
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
-
F
I
---
N
E
---
S
M
----
E
L
K
V
G
D
F
G
L
A
A
R
L
E
---------------
T
P
N
Y
L
S
P
E
V
L
--
N
K
Q
--
G
H
-
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
---
E
T
Y
R
S
I
R
E
A
R
Y
-----
T
M
P
--
S
-----
S
L----
L
A
-
P
A
K
H
-
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
PDRLS
S
--------
S
C
C
H
T
V
P
D
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
73.79
35%
-110
- C2 -
4BDE
5
CHK2_HUMAN
A:
[7-285]
-------------------------------------------
M
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------
A
L
---
N
---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
----
N
----------------------------------
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
SSQ
E
E
---
D
C
----
L
I
K
I
T
D
F
G
H
-
S
K
I
L
-----
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
H
R
TQV
S
L
K
D
Q
I
T
S
G
K
Y
-----
N
F
I
--
P
-----
E
VWAEV
S
E
-
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
-----
K
--------
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
73.69
35%
-101
- C2 -
4BDI
8
CHK2_HUMAN
A:
[7-285]
-------------------------------------------
M
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------
A
L
---
N
---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
----
N
----------------------------------
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
SSQ
E
E
---
D
C
----
L
I
K
I
T
D
F
G
H
-
S
K
I
L
G
E
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
H
R
TQV
S
L
K
D
Q
I
T
S
G
K
Y
-----
N
F
I
--
P
-----
E
VWAEV
S
E
-
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
-----
K
--------
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
Q
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
73.53
35%
-95
- C2 -
2XUU
1
DAPK1_HUMAN
A:
[6-275]
-----------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
---
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
----------------------------------
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
R
---
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
-
A
H
K
I
D
F
---
G
-
N
E
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
--
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
---
E
T
L
A
N
V
S
A
V
N
Y
-----
E
F
E
--
D
-----
E
YFSNT
S
A
-
L
A
K
D
-
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
-----
Q
--------
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
73.52
34%
-88
- C2 -
2WEI
1
?
A:
[10-280]
----------------------------------------
G
R
E
N
L
Y
F
Q
G
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-
N
-
K
---
D
T
S
---
T
---
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
--
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
----
R
----------------------------------
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
---
E
S
KEK
D
C
----
D
I
K
I
I
D
F
G
L
-
S
T
C
F
Q
Q
---
N
-
T
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
T
----
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
---
D
I
L
K
R
V
E
T
G
K
Y
AFDLP
Q
W
R
--
T
-----
I
-----
S
D
-
D
A
K
D
-
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
-----
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
73.08
35%
-107
- C2 -
4BDH
4
CHK2_HUMAN
A:
[8-285]
--------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------
N
---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
----
N
----------------------------------
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
SSQ
E
E
---
D
C
----
L
I
K
I
T
D
F
G
H
-
S
K
I
L
G
E
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
H
R
TQV
S
L
K
D
Q
I
T
S
G
K
Y
-----
N
F
I
--
P
-----
E
VWAEV
S
E
-
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
-----
K
--------
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
72.46
35%
-107
- C2 -
4BDJ
1
CHK2_HUMAN
A:
[9-285]
---------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------
N
---
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
--
A
E
D
-
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
----
N
----------------------------------
K
----
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
SSQ
E
E
---
D
C
----
L
I
K
I
T
D
F
G
H
-
S
K
I
L
-
E
---
T
-
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
--
E
H
R
TQV
S
L
K
D
Q
I
T
S
G
K
Y
-----
N
F
I
--
P
-----
E
VWAEV
S
E
-
K
A
L
D
-
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
-----
K
--------
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
72.40
31%
-98
- C2 -
2W5A
5
NEK2_HUMAN
A:
[6-273]
----------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--
E
A
---
E
K
Q
---
M
---
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
----------------------------------
Q
----
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-
L
H
R
D
L
K
P
A
N
V
-
F
L
---
D
G
---
K
Q
----
N
V
K
L
G
D
F
G
L
-
A
R
I
L
------T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
--
N
R
M
---
Y
-
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
---
E
L
A
G
K
I
R
E
G
K
F
-----
R
R
I
--
P
YR---
Y
-----
S
D
-
E
L
N
E
-
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
-----
H
--------
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
66.15
32%
-86
- C2 -
2YEX
8
CHK1_HUMAN
A:
[5-266]
--------------------------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
-
D
C
-----
P
E
---
N
---
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
--
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
----
D
----------------------------------
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
-
L
L
---
D
E
---
R
D
----
N
L
K
I
S
D
F
G
L
-
A
T
V
F
R
Y
NN
R
E
-
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
--
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C--
Q
E
Y
S
D
W
K
E
K
K
T
Y----
L
N
P
WK
K
-----
I
-----
D
S
-
A
P
L
A
-
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------