@TOME V2.3
(Nov 2016)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NUAK2_HUMAN: (2015-10-16 )
MESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAEGVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVSGDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPSGAVSEDSILSSESFDQLDLPERLPEPPLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPLGDSCFSLTDCQEVTATYRQALRVCSKLT
Atome Classification :
(41 SA)
.........10........20........30........40........50........60........70..-.-......80........-90.---...---....100.......110.......120...-------......130.......140.----.---------------.----------------.--------..-.150.......160.......170.......180......----..190.......200---.---.---.....210.......220..--.....230.......240.......250....-...260......-.270.-----..-----.-....-.----280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MES
L
V
F
ARRSGPTP
S
A
A
E
L
A
R
P
L
A
E
G
L
IKS
P
K
P
L
M
K
K
Q
A
V
K
R
H
H
H
K
H
N
L
R
H
R
Y
E
F
L
E
T
LGKGTY
G
K
V
K
K
A
-RE-S-S
G
R
L
V
A
I
K
S
I
R
K
DKIK-
D
E
Q
---
D
L
M
---
H
I
R
R
E
I
E
I
M
S
SLNH
P
H
I
I
A
I
H
E
V
FE--NSS-------
K
I
V
I
V
M
E
YASRG
D
L
Y
D
Y
I
S
E
----
R
---------------
Q
----------------
Q
--------
L
S
-
E
R
E
A
R
H
F
F
R
Q
I
V
S
A
V
H
Y
C
H
QN
R
V
V
H
R
DL
K
L
E
N
I
-
L
LDANG----
N
I
K
I
A
DF
G
L
S
N
L
Y
HQ---
G
---
K
---
F
L
Q
T
F
CGSPLYASPEIVNGK--PYTGPEVDS
W
S
L
G
V
L
L
Y
I
LVHGTMPFDGHD
H
K
-
I
L
V
K
QISNGAYR-EP--P-----KP-----S-
D
A
C
G
-
L
----
I
R
W
L
L
MVNPTRR
A
T
L
E
D
V
A
SH
W
W
V
NWGYATRVGEQEAPHEGGHPGS
D
S
A
R
A
S
M
A
D
W
L
R
RSS
R
P
L
L
E
N
G
A
K
V
C
S
F
F
K
QHAPGGGSTTPG
L
E
R
Q
H
S
L
K
K
SRKE
N
D
M
A
Q
S
LHSDTADDTAHRPGKSNLKL
P
K
G
I
L
K
K
K
VSASAEGVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESG
E
L
LDAG
D
V
F
VSGDPKEQKPPQAS
G
L
L
L
HRK
G
I
L
K
LNGKFSQ
T
A
L
E
LAAPTTFG
S
L
D
ELAPPRPLARASRPSGAVSEDSILSSESFDQLD
L
P
E
RLPEPPLRGCVSVDNLTGLEEPPSEG
P
G
S
C
L
R
R
W
RQDPLGDSCFSL
T
D
C
Q
E
V
T
A
T
Y
R
Q
A
L
R
V
C
S
KLT
139
HHSearch
84.15
35%
-107
- C2 -
3HKO
2
?
A:
[23-335]
-----------------------------------------------
E
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
-
I
E
-
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q--
K
---
D
V
E
---
R
I
K
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
--
D
E
Q
-------
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
----
F
I
DDSTG
K
C
A
M
D
V
V
KT
Q
ICPC
P
E
C
N
E
E
A
I
N
G
SI-F
R
E
S
L
D
F
V
Q
R
-
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
-
L
F
S
T
N
K
SF--
E
I
K
L
V
D
F
G
L
S
K
E
F
Y
K
LNN
G
------------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
NE
S
Y
-
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
-
D
T
I
S
Q
V
L
N
K
K
L
C
-
F
E
--
N
PNYNV
L
S
-----
P
-
L
A
R
D
-
L
----
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
D
K
I
Y
K
M
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
80.07
37%
-102
- C2 -
4TXC
7
DAPK1_HUMAN
A:
[25-294]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
79.33
37%
-102
- C2 -
3GU7
1
DAPK1_HUMAN
A:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
79.18
37%
-104
- C2 -
3DFC
1
DAPK1_HUMAN
B:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
K
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
SRE
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
PKP-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
AKDF
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
79.09
46%
-109
- C2 -
3AQV
1
AAPK2_HUMAN
A:
[13-264]
----------------------------------------------------
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
-
L
-
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
-
S
L
D
---
V
V
G
---
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
--
T
P
T
-------
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
----
H
---------------
G
----------------
R
--------
V
E
-
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
----
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
---
G
---
E
---
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
--
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
-
T
L
F
K
K
I
R
G
G
V
F
Y
-
I
P
--
E
-----
Y
L
-----
N
-
R
S
V
A
T
L
----
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
F
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
78.90
37%
-100
- C2 -
3F5U
1
DAPK1_HUMAN
A:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
78.75
37%
-105
- C2 -
3EHA
1
DAPK1_HUMAN
A:
[5-274]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
--------------------------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
78.69
37%
-103
- C2 -
3EH9
1
DAPK1_HUMAN
A:
[5-274]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
----
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
--------------------------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
78.56
37%
-105
- C2 -
4B4L
3
DAPK1_HUMAN
A:
[8-277]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
78.41
37%
-100
- C2 -
1JKL
1
DAPK1_HUMAN
A:
[5-274]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
78.21
37%
-101
- C2 -
2W4J
1
DAPK1_HUMAN
A:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
78.02
37%
-106
- C2 -
3GUB
1
DAPK1_HUMAN
A:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
77.82
37%
-102
- C2 -
2Y0A
1
DAPK1_HUMAN
A:
[7-276]
----------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
-
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
RGV
S
R
E
---
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
-
M
L
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
-
F
E
--
D
EYFSN
T
S
-----
A
-
L
A
K
D
-
F
----
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
77.81
37%
-102
- C2 -
1IG1
1
DAPK1_HUMAN
A:
[5-274]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
77.45
37%
-102
- C2 -
3GU6
1
DAPK1_HUMAN
A:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
77.30
37%
-103
- C2 -
4YPD
1
DAPK1_HUMAN
A:
[5-274]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
77.29
37%
-100
- C2 -
3GU5
1
DAPK1_HUMAN
A:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
77.16
37%
-103
- C2 -
3GU8
1
DAPK1_HUMAN
A:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
PK
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
77.10
37%
-98
- C2 -
1JKK
1
DAPK1_HUMAN
A:
[5-274]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
76.87
37%
-99
- C2 -
3GU4
1
DAPK1_HUMAN
A:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
P
Q
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
76.86
37%
-102
- C2 -
4YO4
1
DAPK1_HUMAN
A:
[5-274]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
76.68
37%
-103
- C2 -
2W4K
1
DAPK1_HUMAN
A:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
76.63
37%
-102
- C2 -
1WVY
1
DAPK1_HUMAN
A:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
76.08
37%
-102
- C2 -
2XUU
1
DAPK1_HUMAN
A:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
76.07
37%
-101
- C2 -
2YAK
1
DAPK1_HUMAN
A:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
74.71
42%
-97
- C2 -
4CZU
3
CIPKN_ARATH
A:
[12-272]
---------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
-
R
N
V
E
-
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
---------------
G
----------------
R
--------
L
K
-
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
D
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
---
V
---
R
EDG
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
T
-
C
P
--
P
-----
W
F
-----
S
A
S
A
K
K
-
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
D
D
V
D
A
I
F
D
D
S
G
E
S
K
N
L
V
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
74.32
37%
-110
- C2 -
3ZXT
1
DAPK1_HUMAN
D:
[7-275]
----------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
---------------
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
-----------------------------------------------
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
PK
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-------------------
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
74.31
43%
-97
- C2 -
4CZT
3
CIPKN_ARATH
A:
[12-272]
---------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
-
R
N
V
E
-
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
---------------
G
----------------
R
--------
L
K
-
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
D
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
---
V
---
R
EDG
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
T
-
C
P
--
P
-----
W
F
-----
S
A
S
A
K
K
-
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
V
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
72.91
42%
-105
- C2 -
4CZU
3
CIPKN_ARATH
C:
[12-272]
---------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
-
R
N
V
E
-
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
---------------
G
----------------
R
--------
L
K
-
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
D
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
---
V
---
R
EDG
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
T
-
C
P
--
P
-----
W
F
-----
S
A
S
A
K
K
-
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
D
A
I
F
D
D
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
72.87
42%
-102
- C2 -
4CZU
3
CIPKN_ARATH
B:
[12-272]
---------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
-
R
N
V
E
-
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
---------------
G
----------------
R
--------
L
K
-
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
D
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
---
V
---
R
EDG
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
T
-
C
P
--
P
-----
W
F
-----
S
A
S
A
K
K
-
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
72.72
43%
-102
- C2 -
4CZT
2
CIPKN_ARATH
B:
[12-272]
---------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
-
R
N
V
E
-
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
---------------
G
----------------
R
--------
L
K
-
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
D
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
---
V
---
R
EDG
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
T
-
C
P
--
P
-----
W
F
-----
S
A
S
A
K
K
-
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
72.65
37%
-111
- C2 -
3ZXT
1
DAPK1_HUMAN
C:
[6-275]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
--------------------
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
72.65
43%
-97
- C2 -
4CZT
4
CIPKN_ARATH
D:
[12-272]
---------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
-
R
N
V
E
-
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
---------------
G
----------------
R
--------
L
K
-
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
D
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
---
V
---
R
EDG
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
T
-
C
P
--
P
-----
W
F
-----
S
A
S
A
K
K
-
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
72.50
43%
-107
- C2 -
4CZT
3
CIPKN_ARATH
C:
[12-272]
---------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
-
R
N
V
E
-
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
---------------
G
----------------
R
--------
L
K
-
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
D
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
---
V
---
R
EDG
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
T
-
C
P
--
P
-----
W
F
-----
S
A
S
A
K
K
-
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
72.04
37%
-98
- C2 -
1P4F
1
DAPK1_HUMAN
A:
[5-274]
---------------------------------------------
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
--------------------------------------------------
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P---
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
---
G
---
N
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
70.50
42%
-95
- C2 -
4CZU
3
CIPKN_ARATH
D:
[12-272]
---------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
-
R
N
V
E
-
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
---
M
I
A
---
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
--
S
K
T
-------
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
---------------
G
----------------
R
--------
L
K
-
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
D
A
N
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
---
V
---
R
EDG
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
K
I
F
K
A
E
F
T
-
C
P
--
P
-----
W
F
-----
S
A
S
A
K
K
-
L
----
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
70.10
37%
-105
- C2 -
3ZXT
1
DAPK1_HUMAN
B:
[7-275]
----------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
-
R
---
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
-----------------------------------------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-------------------
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
----
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
68.52
37%
-106
- C2 -
3ZXT
1
DAPK1_HUMAN
A:
[7-275]
----------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
-
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------R
E
-
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
--
N
K
T
-------
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
K
---------------
E
----------------
S
--------
L
T
-
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
V
PK
P
-
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---------------------
E
F
V
A
P
E
I
V
N
Y
E
--
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
--
E
-----
Y
F
-----
S
-
N
T
S
A
-
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
65.39
32%
-104
- C2 -
2W5A
5
NEK2_HUMAN
A:
[6-273]
--------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
-
R
R
-
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
--
E
A
---
E
K
Q
---
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
DR
T
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---------------
Q
----------------
Y
--------
L
D
-
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-
L
H
R
D
L
K
P
A
N
V
-
F
L
D
G
K
Q
----
N
V
K
L
G
D
F
G
L
A
R
I
L
------T--
S
---
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
---
Y
-
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
-
E
L
A
G
K
I
R
E
G
K
F
R
-
R
I
--
P
YR---
Y
S
-----
D
-
E
L
N
E
-
I
----
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
61.42
30%
-107
- C2 -
1ZY4
1
GCN2_YEAST
A:
[6-288]
--------------------------------------------------
S
D
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
-
R
N
-
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
-----
T
E
E
---
K
L
S
---
T
I
L
S
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
--
E
R
R
N
F
VK
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
L
I
H
S
----
E
---------------
N
----------------
L
--------
N
Q
Q
R
D
E
Y
W
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
I
I
H
R
D
L
K
P
M
N
I
-
F
I
D
E
S
R
----
N
V
K
I
G
D
F
G
L
A
K
N
V
H
R
-------------------
A
M
Y
V
A
T
E
V
L
D
G
T
--
G
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
--
P
F
S
T
G
M
E
R
V
-
N
I
L
K
K
L
R
S
V
S
I
E
-
F
P
--
P
-----
D
F
DDNKM
K
-
V
E
K
K
-
I
----
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
K
H
Q
D
E
V
I
K
E
A
L
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
55.47
30%
-92
- C2 -
2YEX
8
CHK1_HUMAN
A:
[5-266]
------------------------------------------------
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
-
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
-
D
-----
C
P
E
---
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
--
E
G
N
-------
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
----
D
---------------
I
----------------
G
--------
M
P
-
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
-
L
L
D
E
R
D
----
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
---
N
N
R
E
R
---
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
--
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
WK
K
-----
I
D
-----
S
-
A
P
L
A
-
L
----
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------