@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OXSR1_HUMAN: (2015-10-16 )
MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
Atome Classification :
(83 SA)
.........10........20-----........30........40.--.......50........60.....-...-70.........80....------....90........100.......110......--.120.......130.......-140..-......150....-...160.......170.......180-...-....190......----.----200--...----......210.......220.......230---...-..-...------------.240.......250.......260.......270.......280.......290..-......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSEDSSALPWSINRD
D
Y
E
L
Q
E
-----
V
IGS
G
A
T
A
V
V
Q
A
A
YCAPKK
E
K
--
V
A
I
K
RI
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q-C-HHP
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
LSGG
S
V
L
D
I
I
K
H
I
V
AKGEHKSGVL--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K-N-G
Q
I
-
H
R
D
VKAG
N
I
L
LGE-DG
S
V
Q
I
A
D
FG
V
S
A
F
LATGGD
I
T
R
N
K
V
-
R
K
T-FVGTPCWM
A
P
E
V
M
----
E
----
Q
----
V
RG----YDFK
A
D
I
W
SFG
I
T
A
I
E
LATGAAPYHKY-----PP
M
-
K
V
-
L
M
L
------------
T
LQNDPPSLETGV
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
QKDPEKR
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-AK
N
K
E
F
L
Q
E
K
T
LQRAP
T
I
S
E
R
A
K
K
V
R
RVPGSSGRLHKTEDGGWEWSDDEFDEE
S
E
E
G
K
A
A
I
S
Q
LRSP
R
V
K
ESISNSELFPTTDP
V
G
T
L
L
Q
V
P
E
Q
I
S
A
HLPQP
A
G
QIATQP
T
Q
VSLPPTAE
P
A
K
T
A
Q
A
L
SSGSGSQETK
I
P
I
S
L
V
L
R
L
RNSKKELN
D
I
R
F
E
FTPGR
D
T
A
E
G
V
S
Q
E
L
I
S
A
GLVDG
R
D
L
V
I
V
A
A
N
L
Q
K
I
V
EEPQSN
R
S
V
T
F
K
LASGVEGSDIPDDG
K
L
I
G
F
A
Q
L
SIS
3
PsiBlast_PDB
89.10
100%
-117
- C2 -
3DAK
1
OXSR1_HUMAN
A:
[1-290]
-----
S
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
--
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
-------------
V
G
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
R
G
----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
88.65
100%
-114
- C2 -
3DAK
1
OXSR1_HUMAN
C:
[2-290]
------
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
--
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
---------
T
-
F
V
G
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
R
G
----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
87.90
100%
-113
- C2 -
3DAK
1
OXSR1_HUMAN
D:
[2-290]
------
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
--
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
I
T
R
N
-------
F
V
G
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
R
G
----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
87.77
100%
-114
- C2 -
3DAK
1
OXSR1_HUMAN
B:
[1-290]
-----
S
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
--
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
--------------
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
R
G
----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
86.40
100%
-110
- C2 -
2VWI
1
OXSR1_HUMAN
D:
[6-298]
-----
S
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
--
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
----------
T
-
F
V
G
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
R
G
----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
K
N
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
83.53
85%
-106
- C2 -
5D9H
1
?
B:
[10-309]
------
A
V
G
W
P
I
C
R
D
A
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
--
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
G
E
H
K
N
G
V
L
--
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
-
N
-
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
V
T
R
N
---------
G
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
R
G
----
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
T
L
E
T
G
V
E
D
K
E
M
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
-
F
Q
K
-
A
K
N
R
E
Y
L
I
E
K
L
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.88
85%
-108
- C2 -
5D9H
1
?
A:
[10-308]
------
A
V
G
W
P
I
C
R
D
A
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
--
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
G
E
H
K
N
G
V
L
--
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
-
N
-
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
V
T
R
---------
V
G
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
R
G
----
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
T
L
E
T
G
V
--
K
E
M
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
-
F
Q
K
-
A
K
N
R
E
Y
L
I
E
K
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
82.33
100%
-119
- C2 -
2VWI
1
OXSR1_HUMAN
B:
[9-292]
--------
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
--
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
--------------
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
R
G
----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
S
L
E
T
G
-----
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
64.59
40%
-98
- C2 -
4OBO
2
M4K4_HUMAN
A:
[18-303]
--------
S
L
R
D
P
A
G
I
F
E
L
V
E
-----
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
--
A
A
I
K
V
M
D
V
T
-------
E
I
K
L
E
I
N
M
-
L
K
K
-
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SD----
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
------
T
K
G
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
-----------------
R
N
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
DENP
D
A
T
----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-----
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
--------
K
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
-
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
63.45
40%
-104
- C2 -
4ZY6
1
PAK1_HUMAN
B:
[20-278]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
-------------
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
62.94
40%
-108
- C2 -
4ZJI
1
PAK1_HUMAN
A:
[21-279]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
K
Q
M
N
L
------
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
-------
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
62.31
44%
-98
- C2 -
4FZD
1
STK26_HUMAN
B:
[14-272]
--------------------
E
-----
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
------
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
Q
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-----
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
62.24
40%
-106
- C2 -
4ZJI
1
PAK1_HUMAN
B:
[21-279]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
K
Q
M
N
L
Q
------
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
-------
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
61.64
40%
-99
- C2 -
4ZY5
2
PAK1_HUMAN
B:
[20-278]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
K
Q
M
N
L
Q
Q
--
P
K
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.59
46%
-92
- C2 -
2XIK
2
STK25_HUMAN
A:
[27-283]
---------------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
--
V
A
I
K
I
I
D
L
E
E
A
E
-
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
---------
P
G
P
L
--
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
R
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
-----
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
S
P
P
T
L
E
G
---------
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
61.35
40%
-103
- C2 -
4P90
1
PAK1_HUMAN
B:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
K
Q
M
N
L
----------
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
-----------------
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
61.23
40%
-108
- C2 -
4ZJJ
1
PAK1_HUMAN
B:
[21-279]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
K
Q
M
N
L
------
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-------------
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
61.13
40%
-97
- C2 -
4O0R
1
PAK1_HUMAN
A:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
------
Q
I
T
P
E
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
60.69
40%
-104
- C2 -
4ZJJ
1
PAK1_HUMAN
A:
[21-279]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
K
Q
M
N
L
Q
-----
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-------------
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
60.48
31%
-97
- C2 -
3EQC
2
MP2K1_HUMAN
A:
[27-332]
--------
V
G
E
L
K
D
D
D
F
E
K
I
S
-----
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
--
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
------
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
--------
A
G
R
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
-
K
I
M
-
H
R
D
V
K
P
S
N
I
L
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
-------
S
M
-
A
----
V
G
T
R
S
Y
M
S
P
E
R
L
----
Q
----
G
-----
T
H
----
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
-----
D
A
K
-
E
L
E
L
M
F
GCPMA
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
-
I
K
R
-
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
60.37
48%
-93
* C2 *
3A7I
1
STK24_HUMAN
A:
[19-286]
-----------
D
P
E
E
L
F
T
K
L
E
-----
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
-----
Q
I
K
-
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
Y
---------
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
60.30
37%
-106
- C2 -
4OBQ
2
M4K4_HUMAN
A:
[26-296]
----------------
F
E
L
V
E
-----
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
--
A
A
I
K
V
M
D
V
------------
E
I
N
M
-
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
T
------
K
G
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
-----------------
N
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-----
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
-
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
60.28
34%
-100
- C2 -
4USF
1
?
A:
[12-282]
-----------
L
N
P
E
D
F
--
W
E
-----
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
-
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
-------
E
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
--
K
------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E------------
R
P
----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
-
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
60.26
40%
-99
- C2 -
4ZY4
2
PAK1_HUMAN
B:
[20-278]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
K
Q
M
N
L
Q
Q
--
P
K
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
60.00
44%
-100
- C2 -
3GGF
1
STK26_HUMAN
B:
[29-287]
--------------------
E
-----
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
D
F
G
V
A
----------------
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
Q
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-----
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
60.00
46%
-101
- C2 -
4NZW
1
STK25_HUMAN
B:
[28-284]
---------------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
---------
P
G
P
L
--
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
R
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
---------------
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
-----
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
S
P
P
T
L
E
G
---------
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
59.87
40%
-105
- C2 -
4ZJJ
1
PAK1_HUMAN
D:
[21-279]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
--
V
A
I
K
Q
M
N
L
----
P
K
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
--
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
---------
P
E
Q
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
HHSearch
59.69
44%
-94
- C2 -
3FXZ
1
?
A:
[19-282]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
R
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
---------
T
C
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
-----
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
59.47
44%
-99
- C2 -
3GGF
1
STK26_HUMAN
A:
[29-287]
--------------------
E
-----
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
D
F
G
V
A
---------------
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
Q
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-----
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
59.36
45%
-95
- C2 -
4O27
1
STK24_HUMAN
B:
[12-270]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
Q
I
K
R
N
E
------
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
58.91
37%
-97
- C2 -
4ZK5
2
?
A:
[26-296]
----------------
F
E
L
V
E
-----
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
--
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
I
K
L
--
E
I
N
M
-
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
T
------
K
G
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
---------------
N
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
E
N
PDAT
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-----
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
-
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
58.64
40%
-96
- C2 -
4ZY6
1
PAK1_HUMAN
A:
[20-278]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
K
-------
Q
P
K
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
58.49
40%
-103
- C2 -
4ZJI
1
?
C:
[21-279]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
--
V
A
I
K
Q
M
N
------
K
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
----------
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
58.46
45%
-93
- C2 -
3A7H
1
STK24_HUMAN
A:
[28-286]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
Q
I
K
R
N
-----
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
58.41
45%
-92
- C2 -
3A7J
1
STK24_HUMAN
A:
[28-286]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
Q
I
K
R
N
-----
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
58.27
40%
-95
- C2 -
4O0T
1
PAK1_HUMAN
A:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
------
Q
I
T
P
E
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
57.99
40%
-105
- C2 -
4ZJI
1
?
D:
[21-279]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
K
Q
M
N
------
K
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
--------
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
57.94
32%
-103
- C2 -
3ALN
1
MP2K4_HUMAN
A:
[14-294]
------
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
G
-----
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
--
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
-
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
------
G
D
C
W
I
C
M
E
L
M
S
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
---
L
D
D
V
I
--
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
-
N
L
K
I
I
-
H
R
D
I
K
P
S
N
I
L
L
D
R
-
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
---------------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
-------------
T
Q
------------
V
V
K
G
D
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
-
I
L
M
-
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
57.69
37%
-97
- C2 -
4OBP
2
M4K4_HUMAN
A:
[26-296]
----------------
F
E
L
V
E
-----
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
--
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
I
K
L
--
E
I
N
M
-
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SD----
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
T
------
K
G
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
---------------
N
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
E
N
PDAT
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-----
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
-
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
57.69
40%
-97
- C2 -
4ZY4
1
PAK1_HUMAN
A:
[20-278]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
--
V
A
I
K
-----
Q
-
Q
P
K
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
-----
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
57.49
37%
-101
- C2 -
4RVT
2
M4K4_HUMAN
A:
[28-298]
----------------
F
E
L
V
E
-----
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
--
A
A
I
K
V
M
D
V
T
----
E
E
I
K
L
--
E
I
N
M
-
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
T
------
K
G
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
-----------------
N
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-----
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
-
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
57.21
37%
-93
- C2 -
4U45
1
M4K4_HUMAN
A:
[26-296]
----------------
F
E
L
V
E
-----
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
--
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
I
K
L
--
E
I
N
M
-
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPD--
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
T
------
K
G
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
---------------
N
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-----
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
-
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
57.20
40%
-104
- C2 -
4ZJJ
1
PAK1_HUMAN
C:
[21-279]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
--
V
A
I
K
Q
M
N
L
Q
----
K
K
E
L
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
------------
E
Q
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
-----------
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
57.15
37%
-93
- C2 -
4U44
2
M4K4_HUMAN
A:
[26-296]
----------------
F
E
L
V
E
-----
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
--
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
I
K
L
--
E
I
N
M
-
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SHD---
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
T
------
K
G
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
----------------
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
E
N
PDAT
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-----
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
-
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
57.02
34%
-92
- C2 -
4USF
1
?
B:
[12-282]
-----------
L
N
P
E
D
F
--
W
E
-----
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
-
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
-------
E
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
--
K
N
--------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCET
S
----
K
----
D
R
P
----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
-
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
56.98
44%
-91
- C2 -
4FZA
3
STK26_HUMAN
B:
[14-272]
--------------------
E
-----
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
Q
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-----
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
55.52
37%
-90
- C2 -
4U43
1
M4K4_HUMAN
A:
[26-296]
----------------
F
E
L
V
E
-----
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
--
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
I
K
L
--
E
I
N
M
-
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
T
------
K
G
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
-----------------
N
T
-
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
E
N
PDAT
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-----
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
-
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
55.44
35%
-90
- C2 -
4USD
1
?
B:
[16-290]
--------------
D
P
N
E
V
W
E
-----
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
----------------------
G
T
P
Y
W
M
A
P
E
V
V
MC-------------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
-
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
54.74
35%
-91
- C2 -
5AJQ
2
STK10_HUMAN
A:
[13-287]
--------------
D
P
N
E
V
W
E
-----
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
T
--------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MC--
E
----
T
----
M
K
D
TP--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
-
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
54.47
33%
-94
- C2 -
2CLQ
1
M3K5_HUMAN
A:
[18-284]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
--
I
A
I
K
E
I
P
-
E
R
D
S
---
Q
P
L
H
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----
G
------
E
T
-
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
G---
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GE
P
Q
A
A
M
F
-
K
V
-
G
M
F
------------
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
54.45
35%
-86
- C2 -
4AOT
1
STK10_HUMAN
A:
[16-290]
--------------
D
P
N
E
V
W
E
-----
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
--------------------
G
T
P
Y
W
M
A
P
E
V
V
M--------------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
-
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
53.64
33%
-96
- C2 -
4BF2
2
M3K5_HUMAN
A:
[31-296]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
--
I
A
I
K
E
I
P
E
-----------
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------------
E
E
-
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
G---
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GE
P
Q
A
A
M
F
-
K
V
-
G
M
F
------------
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
53.50
44%
-90
- C2 -
4FZF
1
?
B:
[14-272]
--------------------
E
-----
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
Q
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-----
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
53.18
35%
-89
- C2 -
4AOT
1
STK10_HUMAN
B:
[16-290]
--------------
D
P
N
E
V
W
E
-----
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
GA
L
A
A
A
K
V
I
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
-------------
I
G
T
P
Y
W
M
A
P
E
V
V
M----------------P---
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
-
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
52.99
33%
-89
- C2 -
4BIB
3
M3K5_HUMAN
A:
[15-280]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
--
I
A
I
K
E
I
P
-
E
--------
L
H
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
--------------
E
E
-
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
G---
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GE
P
Q
A
A
M
F
-
K
V
-
G
M
F
------------
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
52.45
33%
-91
- C2 -
4BIE
2
M3K5_HUMAN
A:
[15-281]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
--
I
A
I
K
E
I
P
-
E
--------
L
H
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----
G
-------
E
-
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
G---
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GE
P
Q
A
A
M
F
-
K
V
-
G
M
F
------------
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
52.39
33%
-94
- C2 -
4BID
1
M3K5_HUMAN
A:
[15-280]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
--
I
A
I
K
E
I
P
-
E
--------
L
H
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
--------------
E
E
-
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
G---
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GE
P
Q
A
A
M
F
-
K
V
-
G
M
F
------------
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
52.07
33%
-94
- C2 -
4BIB
1
B:
[15-281]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
--
I
A
I
K
E
I
P
-
E
R
----
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
----------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
G---
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GE
P
Q
A
A
M
F
-
K
V
-
G
M
F
------------
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
52.07
31%
-106
- C2 -
3ALN
1
MP2K4_HUMAN
B:
[17-288]
---------
W
D
F
T
A
E
D
L
K
D
L
G
-----
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
--
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
-
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
------
G
D
C
W
I
C
M
E
L
M
S
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
L
D
---
D
V
I
--
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
-
N
-
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
-
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
--------------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
---------------------------------
D
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
-
I
L
M
-
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
51.90
33%
-94
- C2 -
4BIE
2
B:
[15-282]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
--
I
A
I
K
E
I
P
-
E
R
-------
L
H
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
G---
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GE
P
Q
A
A
M
F
-
K
V
-
G
M
F
------------
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
51.81
33%
-93
- C2 -
4BIC
2
M3K5_HUMAN
A:
[15-281]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
--
I
A
I
K
E
I
P
-
E
-----
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----
G
-------
E
-
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
G---
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GE
P
Q
A
A
M
F
-
K
V
-
G
M
F
------------
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
50.87
33%
-95
- C2 -
4BHN
2
B:
[31-295]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
--
I
A
I
K
E
I
P
E
R
----
S
Q
-
P
L
H
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
G---
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GE
P
Q
A
A
M
F
-
K
V
-
G
M
F
------------
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
50.55
34%
-82
- C2 -
2UV2
6
SLK_HUMAN
A:
[33-303]
-----------
L
N
P
E
D
F
--
W
E
-----
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
-
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
-------
E
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
--
K
N
T
R
T
I
Q
R
----
R
D
S
-
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CET
S
----
K
----
D
R
P
----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
-
D
S
N
K
P
I
R
E
L
I
A
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
50.36
37%
-88
- C2 -
2J7T
1
STK10_HUMAN
A:
[17-292]
------------
P
N
E
V
W
E
I
V
G
-----
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
--
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-------
D
R
G
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
-----
L
Q
K
------
I
G
T
P
Y
W
M
A
P
E
V
V
----
M
C
E
T
M
K
----
D
T
P
----
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
-
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
50.33
33%
-88
- C2 -
4BID
1
B:
[15-281]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
--
I
A
I
K
E
I
P
-
E
R
----
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
----------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
G---
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GE
P
Q
A
A
M
F
-
K
V
-
G
M
F
------------
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
50.23
34%
-82
- C2 -
2J51
5
SLK_HUMAN
A:
[33-303]
-----------
L
N
P
E
D
F
--
W
E
-----
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
-
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
-------
E
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
--
K
N
T
R
T
I
Q
R
----
R
D
S
-
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CET
S
----
K
----
D
R
P
----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
-
D
S
N
K
P
I
R
E
L
I
A
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
50.13
33%
-91
- C2 -
4BIC
2
B:
[15-282]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
--
I
A
I
K
E
I
P
-
E
R
----
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------------
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
G---
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GE
P
Q
A
A
M
F
-
K
V
-
G
M
F
------------
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
49.77
33%
-94
- C2 -
4BF2
1
B:
[31-297]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
--
I
A
I
K
E
I
P
E
R
----------
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------------
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
G---
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GE
P
Q
A
A
M
F
-
K
V
-
G
M
F
------------
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
49.55
33%
-94
- C2 -
2CLQ
1
B:
[18-284]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
--
I
A
I
K
E
I
P
-
E
R
----
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
G---
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GE
P
Q
A
A
M
F
-
K
V
-
G
M
F
------------
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
49.01
35%
-88
- C2 -
4EQU
2
STK10_HUMAN
B:
[16-290]
--------------
D
P
N
E
V
W
E
-----
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
----------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
--
E
----
T
----
M
K
D
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
-
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
48.98
35%
-89
- C2 -
4EQU
2
STK10_HUMAN
A:
[16-290]
--------------
D
P
N
E
V
W
E
-----
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
-----------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
--
E
----
T
----
M
K
D
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
-
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
47.60
31%
-92
- C2 -
3ALO
1
MP2K4_HUMAN
A:
[17-288]
---------
W
D
F
T
A
E
D
L
K
D
L
G
-----
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
--
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
-
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
------
G
D
C
W
I
C
M
E
L
M
S
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
L
D
---
D
V
I
--
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
-
N
-
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
-
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
V
D
S
I
A
K
T
R
D
--------
A
G
C
R
P
Y
M
A
P
E
R
I
----
D
P---------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
-----
N
S
V
F
D
Q
-
L
T
Q
------------
V
V
K
G
D
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
-
I
L
M
-
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
45.65
35%
-76
- C2 -
4USE
1
?
A:
[16-290]
--------------
D
P
N
E
V
W
E
-----
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
T
L
Q
---------
T
P
Y
W
M
A
P
E
V
V
M
C
--
E
----
T
----
M
K
D
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
-
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
43.62
35%
-78
- C2 -
4USE
1
?
B:
[16-290]
--------------
D
P
N
E
V
W
E
-----
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-----------
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
T
L
Q
K
--------
T
P
Y
W
M
A
P
E
V
V
M
C
--
E
----
T
----
M
K
D
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
-
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
42.19
45%
-48
- C2 -
4QML
2
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
42.07
45%
-50
- C2 -
4QMS
2
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
40.19
45%
-48
- C2 -
4QMN
1
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
40.17
45%
-49
- C2 -
4QMU
2
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
39.82
45%
-49
- C2 -
4QMO
3
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
39.33
45%
-52
- C2 -
4QMQ
3
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
38.72
45%
-49
- C2 -
4QMT
2
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
38.28
45%
-47
- C2 -
4QMP
2
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
37.65
45%
-47
- C2 -
4QMM
3
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
--
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
-----
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------