@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PAK1_HUMAN: (2015-10-16 )
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH
Atome Classification :
(96 SA)
.........10........20........30........40........50........60........70........80........90........100...----....110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300...---.---.--..310..-.....320-.......330....--...340.......350......----------------------.-----360---------------....----.....370.......380.......390.......400-.--........410...-----...--.420.......430.....-----.--.440---.........450.......460.......470.......480..--...-------..490.......500.......510.......520-..--......530.......540...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSNNGLDIQDKPPAPPMRNT
S
T
M
IGAGSKDAGTLNHGSKPLPPN
P
E
E
K
K
K
K
D
R
F
Y
R
S
ILPGDKTNK
K
K
EKERPEISLPSDFE
H
T
I
H
V
GFDAVTGEFTG
M
P
E
Q
W
A
R
----
L
L
Q
TSNIT
K
S
E
QKK
N
P
Q
A
V
L
D
V
L
E
F
YNSKKTSNSQ
K
Y
M
SFTDKSAEDYNSSN
A
L
N
V
K
AVSETPAVPPVSEDEDDDDDDATPPPVIAPRPE
H
T
K
S
V
Y
T
R
SVIEPLPVTPTRDVATSPISPTENNTTP
P
D
A
LTRN
T
E
K
Q
KKKPKM
S
D
E
E
I
L
E
K
L
R
S
I
V
SVGD
P
K
K
K
Y
T
R
F
E
K
IGQGASG
T
V
Y
T
A
M
DVATGQ
E
V
A
I
K
Q
MNLQQ---Q---
P
--
K
K
E
L
I
I
N
-
E
I
L
V
M
REN-KNP
N
I
V
N
Y
L
D
S
Y
LV--
G
D
E
L
W
V
V
M
E
Y
LAGG
S
L
T
D
V
V
T
E
----------------------
T
-----C-----------------MDE
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
HSN
Q
V
I
H
R
DIKSD
N
I
L
L
GMD---G--
S
V
K
L
TDF
G
F
C
AQIT-----PEQ--SKRSTMVGTPYWM
A
P
E
V
V
T-----R--KA-----YGPKV
D
I
W
S
L
G
I
M
A
I
E
MIEGEPPYLNENP
L
R
A
L
Y
L
I
ATNGTPEL--Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
KRG
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
ATKNNH
118
HHSearch
92.62
100%
-110
- C1 -
3FXZ
1
?
A:
[1-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
---
Q
---
P
--
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
11
PsiBlast_PDB
92.39
99%
-110
- C1 -
3FXZ
1
?
A:
[1-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
---
Q
---
P
--
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
15
PsiBlast_PDB
91.80
99%
-110
- C1 -
4O0R
1
PAK1_HUMAN
A:
[1-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
---
Q
---
P
--
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
--
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
14
PsiBlast_PDB
91.68
98%
-115
- C1 -
3Q4Z
1
PAK1_HUMAN
A:
[4-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
I
I
V
S
V
G
D
P
K
-----
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
Q
M
N
L
-------------
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
H
29
PsiBlast_CBE
91.22
99%
-111
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[2-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-------
P
--
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
16
PsiBlast_PDB
89.95
99%
-107
- C1 -
4O0T
1
PAK1_HUMAN
A:
[3-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
---
Q
---
P
--
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
--
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
8
PsiBlast_PDB
89.93
98%
-108
- C1 -
4EQC
1
PAK1_HUMAN
A:
[2-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
T
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
---
Q
---
P
--
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
12
PsiBlast_PDB
89.17
99%
-108
- C1 -
3FY0
1
PAK1_HUMAN
A:
[1-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
---
Q
---
P
--
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
28
PsiBlast_CBE
89.16
99%
-112
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[8-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-------
P
--
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
1
PsiBlast_PDB
88.08
100%
-117
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[8-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-------------
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
--------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
2
PsiBlast_PDB
87.84
100%
-118
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[3-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
------------
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
--------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
------
27
PsiBlast_CBE
87.56
99%
-110
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[8-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
---
Q
---
P
--
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
---------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
26
PsiBlast_CBE
87.14
100%
-118
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[8-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-------------
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
--------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-----
23
PsiBlast_CBE
85.42
100%
-119
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[5-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-------------
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
--------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
------
32
PsiBlast_CBE
83.53
98%
-117
- C1 -
4P90
1
PAK1_HUMAN
B:
[9-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-----------------
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
------------------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
25
PsiBlast_CBE
81.10
100%
-110
- C1 -
4ZJI
1
?
C:
[4-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
-------------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
24
PsiBlast_CBE
80.43
100%
-110
- C1 -
4ZJI
1
?
D:
[7-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-------------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
----------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
117
HHSearch
80.17
46%
-96
- C1 -
4FIE
1
PAK4_HUMAN
A:
[46-422]
---------------------------------------------------------------------------------------------------------------------------
R
P
K
P
L
V
D
-----------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
------
21
PsiBlast_CBE
80.09
100%
-120
- C1 -
4ZJJ
1
PAK1_HUMAN
D:
[6-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
E
K
L
R
S
I
V
S
V
---
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
Q
M
N
L
---------
P
--
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
----
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
F
C
---------
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
33
PsiBlast_CBE
78.67
40%
-102
- C1 -
4FIE
1
PAK4_HUMAN
B:
[46-417]
---------------------------------------------------------------------------------------------------------RPKP
L
V
D
-----------------------------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
------
18
PsiBlast_PDB
78.52
40%
-102
- C1 -
4FIE
1
PAK4_HUMAN
A:
[46-417]
---------------------------------------------------------------------------------------------------------RPKP
L
V
D
-----------------------------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
------
51
PsiBlast_CBE
77.74
52%
-108
- C1 -
2F57
1
PAK7_HUMAN
A:
[24-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
D
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
D
---
G
--
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
L
P
-----
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
P
P
L
Q
A
M
R
R
I
R
D
S
L
P
P
R
V
--
K
D
L
-------
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
-
L
-
K
L
--
A
G
P
P
S
C
I
V
P
L
M
R
Q
---------
22
PsiBlast_CBE
77.29
100%
-111
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[5-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
Q
-----------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
----
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
------------
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---------
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
44
PsiBlast_CBE
76.54
53%
-104
- C1 -
2X4Z
3
A:
[4-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
------
19
PsiBlast_PDB
75.75
52%
-108
- C1 -
2CDZ
1
PAK4_HUMAN
A:
[11-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
--
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
------
119
HHSearch
75.58
52%
-100
- C1 -
4JDI
1
PAK4_HUMAN
A:
[55-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
-------
34
PsiBlast_CBE
75.31
52%
-103
- C1 -
4JDI
1
PAK4_HUMAN
A:
[55-340]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
-------
53
PsiBlast_CBE
75.21
49%
-103
- C1 -
4KS8
1
A:
[3-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
--
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
S
Q
----------------------
V
-----
R
-----------------
L
N
E
E
----
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
-----
K
D
V
--
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
S
L
-----
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
P
P
K
L
--
K
N
S
-------
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
-
L
-
L
Q
--
T
G
L
P
E
C
L
V
P
L
I
-----------
50
PsiBlast_CBE
74.63
52%
-100
- C1 -
2F57
1
B:
[24-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
D
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
D
---
G
--
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
L
P
-----
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
P
P
L
Q
A
M
R
R
I
R
D
S
L
P
P
R
V
--
K
D
L
-------
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
-
L
-
K
L
--
A
G
P
P
S
C
I
V
P
L
M
R
Q
Y
R
H
------
39
PsiBlast_CBE
74.22
52%
-101
- C1 -
4FIF
1
PAK4_HUMAN
B:
[52-340]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
-------
41
PsiBlast_CBE
74.07
52%
-102
- C1 -
2Q0N
7
PAK4_HUMAN
A:
[8-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
R
-----
20
PsiBlast_PDB
73.80
52%
-104
- C1 -
2J0I
4
PAK4_HUMAN
A:
[12-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
-------
120
HHSearch
73.45
49%
-103
- C1 -
4KS7
2
A:
[4-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
--
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
S
Q
----------------------
V
-----
R
-----------------
L
N
E
E
----
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
-----
K
D
V
--
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
S
L
-----
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
P
P
K
L
--
K
N
S
-------
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
-
L
-
L
Q
--
T
G
L
P
E
C
L
V
P
L
I
Q
----------
54
PsiBlast_CBE
73.45
49%
-103
- C1 -
4KS7
2
A:
[4-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
--
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
S
Q
----------------------
V
-----
R
-----------------
L
N
E
E
----
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
-----
K
D
V
--
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
S
L
-----
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
P
P
K
L
--
K
N
S
-------
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
-
L
-
L
Q
--
T
G
L
P
E
C
L
V
P
L
I
Q
----------
47
PsiBlast_CBE
73.24
53%
-102
- C1 -
4O0X
1
?
A:
[2-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
-------
43
PsiBlast_CBE
72.72
53%
-101
- C1 -
4APP
2
A:
[4-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
R
-----
48
PsiBlast_CBE
72.51
53%
-102
- C1 -
4O0V
1
A:
[2-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
-------
37
PsiBlast_CBE
72.46
52%
-101
- C1 -
4FIG
1
?
B:
[53-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
------
46
PsiBlast_CBE
72.42
53%
-102
- C1 -
4O0Y
1
A:
[2-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
-------
40
PsiBlast_CBE
72.17
52%
-96
- C1 -
4FIF
1
PAK4_HUMAN
A:
[51-340]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
-------
38
PsiBlast_CBE
71.98
52%
-103
- C1 -
4FIG
1
?
A:
[53-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
------
42
PsiBlast_CBE
70.94
53%
-101
- C1 -
4NJD
1
PAK4_HUMAN
A:
[4-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
-------
7
PsiBlast_PDB
64.80
99%
-63
- C1 -
4ZLO
2
?
A:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
--
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-------------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
----
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
---
G
--
S
V
K
L
T
D
F
G
----------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
--
84
PsiBlast_CBE
64.29
45%
-101
- C1 -
3A7I
1
STK24_HUMAN
A:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
127
HHSearch
64.09
45%
-98
* C1 *
3A7I
1
STK24_HUMAN
A:
[18-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
D-
E
I
E
D
I
Q
Q
-
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
----
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
L
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
83
PsiBlast_CBE
61.54
45%
-99
- C1 -
3A7J
1
STK24_HUMAN
A:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
59
PsiBlast_CBE
61.21
44%
-99
- C1 -
3GGF
1
STK26_HUMAN
A:
[18-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----------------------
G
-----
P
-----------------
F
D
E
F
----
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
---
G
--
D
V
K
L
A
D
F
G
V
A
----------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
86
PsiBlast_CBE
61.11
45%
-95
- C1 -
3A7H
1
STK24_HUMAN
A:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
85
PsiBlast_CBE
60.68
45%
-97
- C1 -
3A7H
1
STK24_HUMAN
B:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
91
PsiBlast_CBE
59.41
45%
-100
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
----------
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
106
PsiBlast_CBE
59.29
39%
-101
- C1 -
4USD
1
?
B:
[16-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
---
E
---
E
--
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----------------------------------------------
L
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
---
G
--
D
I
R
L
A
D
F
G
V
----------------------
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
---------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
----
87
PsiBlast_CBE
59.24
44%
-95
- C1 -
2XIK
2
STK25_HUMAN
A:
[16-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
---
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
--
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
P
----------------------
G
-----
P
-----------------
L
E
E
T
----
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
---
G
--
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
L
F
L
I
P
K
N
S
P
P
T
L
--
E
G
Q
-------
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
--
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
---
62
PsiBlast_CBE
59.12
44%
-95
- C1 -
4FZA
3
STK26_HUMAN
B:
[3-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----------------------
G
-----
P
-----------------
F
D
E
F
----
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
---
G
--
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--
61
PsiBlast_CBE
59.09
44%
-104
- C1 -
4FZD
1
STK26_HUMAN
B:
[3-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----------------------
G
-----
P
-----------------
F
D
E
F
----
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
---
G
--
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--
60
PsiBlast_CBE
58.84
44%
-94
- C1 -
4FZF
1
?
B:
[3-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----------------------
G
-----
P
-----------------
F
D
E
F
----
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
---
G
--
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--
92
PsiBlast_CBE
58.41
40%
-98
- C1 -
4USF
1
?
B:
[13-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
---
E
---
E
--
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
----------------------
L
-----
E
R
P
---------------
L
T
E
S
----
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
---
G
--
D
I
K
L
A
D
F
G
V
S
A
K
N
----------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETSK
D
--
R
P
-----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
--
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
-
T
V
DS
N
K
P
I
R
E
---
L
I
A
E
A
K
A
E
-----
58
PsiBlast_CBE
58.40
44%
-95
- C1 -
3GGF
1
STK26_HUMAN
B:
[19-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----------------------
G
-----
P
-----------------
F
D
E
F
----
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
---
G
--
D
V
K
L
A
D
F
G
V
A
-----------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--
64
PsiBlast_CBE
58.09
44%
-95
- C1 -
4O27
1
STK24_HUMAN
B:
[1-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
--
93
PsiBlast_CBE
57.89
40%
-105
- C1 -
4USF
1
?
A:
[13-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
---
E
---
E
--
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
----------------------
L
-----
E
RP---------------
L
T
E
S
----
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
---
G
--
D
I
K
L
A
D
F
G
V
S
A
K
--------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E------
R
P
-----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
--
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
-
T
V
DS
N
K
P
I
R
E
---
L
I
A
E
A
K
A
E
-----
123
HHSearch
56.15
40%
-96
- C1 -
2J7T
1
STK10_HUMAN
A:
[15-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----------
E
--
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D--------------------
R
-----
G
-----------------
L
T
E
P
----
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
---
G
--
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----
K
T
L
--
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
--
T
P
-----
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-
125
HHSearch
55.98
42%
-106
- C1 -
4OBO
2
M4K4_HUMAN
A:
[17-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
--------------
E
I
K
L
-
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
----------------------
T
KGN--
T
-----------------
L
K
E
D
----
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
---
A
--
E
V
K
L
V
D
F
G
------------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
CDENP
D
--
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
--
K
-
S
-------
K
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
-
R
D
--
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
---
94
PsiBlast_CBE
55.45
40%
-95
- C1 -
2UV2
6
SLK_HUMAN
A:
[34-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
---
E
---
E
--
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
----------------------
L
-----
E
R
P
---------------
L
T
E
S
----
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
---
G
--
D
I
K
L
A
D
F
G
V
S
A
K
N
T
-----
R
T
I
--
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETSK
D
--
R
P
-----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
--
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
-
T
V
DS
N
K
P
I
R
E
---
L
I
A
E
A
K
-------
65
PsiBlast_CBE
55.42
44%
-100
- C1 -
4NZW
1
STK25_HUMAN
B:
[17-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
--
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
P
----------------------
G
-----
P
-----------------
L
E
E
T
----
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
---
G
--
D
V
K
L
A
A
F
G
V
A
G
---------------------
T
P
F
W
M
A
P
E
V
I
K
-----
Q
---------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
L
F
L
I
P
K
N
S
P
P
T
L
--
E
G
Q
-------
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
--
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
---
103
PsiBlast_CBE
54.89
41%
-103
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[12-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C--
Q
---
T
--
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
----------------------
I
-----
V
A
K
GEHKSGV--------
L
D
E
S
----
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
---
G
--
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG-------------
V
G
T
P
C
W
M
A
P
E
V
M
E
-----
Q
V
-
R
G
-----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
--
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
--
A
K
--------------------
100
PsiBlast_CBE
54.61
41%
-102
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[12-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C--
Q
---
T
--
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
----------------------
I
-----
V
A
K
GEHKSGV--------
L
D
E
S
----
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
---
G
--
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGDI
T
R
N
-------
F
V
G
T
P
C
W
M
A
P
E
V
M
E
-----
Q
V
-
R
G
-----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
--
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
--
A
K
--------------------
95
PsiBlast_CBE
53.94
40%
-95
- C1 -
2J51
5
SLK_HUMAN
A:
[34-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
---
E
---
E
--
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
----------------------
L
-----
E
RP---------------
L
T
E
S
----
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
---
G
--
D
I
K
L
A
D
F
G
V
S
A
K
N
T
-----
R
T
I
--
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETSK
D
--
R
P
-----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
--
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
-
T
V
DS
N
K
P
I
R
E
---
L
I
A
E
A
K
-------
101
PsiBlast_CBE
53.56
41%
-103
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[12-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C--
Q
---
T
--
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
----------------------
I
-----
V
A
K
GEHKSGV--------
L
D
E
S
----
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
---
G
--
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGD----------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
E
-----
Q
V
-
R
G
-----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
--
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
--
A
K
--------------------
96
PsiBlast_CBE
53.08
41%
-105
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[17-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C--
Q
---
T
--
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
----------------------
I
-----
V
A
K
GEHKSGV--------
L
D
E
S
----
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
---
G
--
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG-----------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
E
-----
Q
V-
R
G
-----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
--
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
--
A
K
N
K
E
-----------------
102
PsiBlast_CBE
52.80
41%
-103
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[12-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C--
Q
---
T
--
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
----------------------
I
-----
V
A
K
GEHKSGV--------
L
D
E
S
----
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
---
G
--
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGD--------------
T
P
C
W
M
A
P
E
V
M
E
-----
Q
V
-
R
G
-----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
--
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
--
A
K
--------------------
105
PsiBlast_CBE
52.63
39%
-91
- C1 -
4USE
1
?
A:
[16-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
---
E
---
E
--
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----------------------------------------------
L
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
---
G
--
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----
K
T
L
--
Q
-------
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
--
45
PsiBlast_CBE
51.98
53%
-58
- C1 -
5BMS
1
A:
[2-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
---
Q
--
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
----
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-----
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
-------
126
HHSearch
51.46
31%
-96
- C1 -
3C0I
1
CSKP_HUMAN
A:
[24-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
---
F
T
S
S
P
GL
S
T
E
D
L
K
R
-
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
----------------------
R
-----
A
D
A
G
F
V
------------
Y
S
E
A
----
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
ENS
A
--
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
-----
E
S
G
--
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
-----
R
--
E
P
-----
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
-
R
L
F
E
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
-------
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-
L
-
K
E
--
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
130
HHSearch
50.63
34%
-96
- C1 -
3HKO
2
?
A:
[26-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q----
K
--
D
V
E
R
I
K
T
-
E
V
R
L
M
K
K
L
-
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
--
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
-----
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
R
E
K
----
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
---
K
SF
E
I
K
L
V
D
F
G
L
S
K
E
F
Y
-----
K
L
N
NG------
A
G
T
P
Y
F
V
A
P
E
V
L
N
-----
T
TN
E
S
-----
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
D
T
I
S
Q
V
L
-
N
K
K
L
C
F
--
E
N
P
NY-----
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
-
I
-
S
Q
--
F
S
D
K
I
Y
K
M
S
-------------
104
PsiBlast_CBE
49.28
39%
-91
- C1 -
4USE
1
?
B:
[16-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----------
E
--
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-------
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----------------------------------------------
L
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
---
G
--
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----
K
T
L
--
Q
K
------
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
T
M
K
DT
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
--
98
PsiBlast_CBE
48.42
41%
-103
- C1 -
2VWI
1
OXSR1_HUMAN
B:
[17-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
Q
E
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C--
Q
---
T
--
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
----------------------
I
-----
V
A
K
GEHKSGV--------
L
D
E
S
----
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
---
G
--
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GGD--------------
T
P
C
W
M
A
P
E
V
M
E
-----
Q
V
-
R
G
-----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
--
E
T
G
ML-----
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
-------------------------
128
HHSearch
44.98
31%
-96
- C1 -
2W5A
5
NEK2_HUMAN
A:
[6-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
---
M
---
T
E
A
E
K
Q
M
L
V
S
-
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
----------------------
G
T
K
E
R
Q
Y
-----------------
L
D
E
E
----
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
---
Q
--
N
V
K
L
G
D
F
G
L
A
R
I
L
--------
T
--
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
-----
R
--
M
------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
----
I
P
-------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-
I
-
L
E
--
H
H
H
H
H
H
----------------
90
PsiBlast_CBE
40.45
45%
-55
- C1 -
4W8E
1
STK24_HUMAN
A:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
72
PsiBlast_CBE
40.19
45%
-53
- C1 -
4QMW
2
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
70
PsiBlast_CBE
39.75
45%
-48
- C1 -
4QMY
2
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
68
PsiBlast_CBE
39.41
45%
-49
- C1 -
4QNA
1
?
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
75
PsiBlast_CBE
39.08
45%
-52
- C1 -
4QMT
2
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
76
PsiBlast_CBE
39.04
45%
-48
- C1 -
4QMS
2
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
71
PsiBlast_CBE
38.51
45%
-50
- C1 -
4QMX
1
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
73
PsiBlast_CBE
38.50
45%
-50
- C1 -
4QMV
3
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
69
PsiBlast_CBE
38.40
45%
-52
- C1 -
4QMZ
1
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
74
PsiBlast_CBE
38.34
45%
-50
- C1 -
4QMU
2
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
66
PsiBlast_CBE
38.11
45%
-46
- C1 -
4QO9
4
?
B:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
67
PsiBlast_CBE
38.07
45%
-50
- C1 -
4QO9
4
?
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
80
PsiBlast_CBE
38.06
45%
-47
- C1 -
4QMN
1
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
89
PsiBlast_CBE
37.84
45%
-53
- C1 -
4U8Z
1
STK24_HUMAN
A:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
78
PsiBlast_CBE
37.84
45%
-49
- C1 -
4QMP
2
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
88
PsiBlast_CBE
37.67
45%
-50
- C1 -
4W8D
1
STK24_HUMAN
A:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
81
PsiBlast_CBE
37.67
45%
-48
- C1 -
4QMM
3
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
--
77
PsiBlast_CBE
37.34
45%
-50
- C1 -
4QMQ
3
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
82
PsiBlast_CBE
37.17
45%
-46
- C1 -
4QML
2
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
79
PsiBlast_CBE
36.97
45%
-49
- C1 -
4QMO
3
STK24_HUMAN
A:
[25-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
---
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
----
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
---
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
-----
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
--