@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PAK2_HUMAN: (2015-10-16 )
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSNR
Atome Classification :
(96 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280..---..-----...290.-......300........310...--....320.......330.....----------------------.-----.-----------------340.......350.......360.......370.......380-.........390..---...--..400.......410....-----.--..-----420.......430.......440.......450.......460.--...-------...470.......480.......490.......-500.--.......510.......520..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSDNGELEDKPPAPPVR
M
S
S
T
I
FSTGGKDPLSANHSLKPLPSVPEEKKPRH
K
I
I
S
I
FSGTEKGSKKKEKERPEISPPSDF
E
H
T
I
H
V
GFDAVTGEFTG
M
P
E
Q
W
A
R
L
L
QTSNI
T
K
L
E
QKK
N
P
Q
A
V
L
D
V
L
K
F
YDSN
T
V
K
Q
KYLSFTPPEKDGFPSGTPALNAKGTEA
P
A
V
VTEEEDDDEETAPPVIAPRPDHT
K
S
I
Y
TRSVIDPVPAPVGDSHV
D
G
A
A
K
S
L
D
K
Q
K
K
KTKM
T
D
E
E
I
M
E
K
L
R
T
I
V
SIGD
P
K
K
K
Y
T
R
Y
E
K
IGQGASG
T
V
F
T
A
TDVALG
Q
E
V
A
I
K
Q
INLQK---Q
P
-----
K
K
E
L
I
I
N
-
E
I
L
V
M
K
EL-KNP
N
I
V
N
F
L
D
S
Y
LV--G
D
E
L
F
V
V
M
E
Y
LAGG
S
L
T
D
V
V
T
E
----------------------
T
-----C-----------------M
D
E
A
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
A
N
Q
V
I
H
R
DIKSD
N
V
L
L
GMEG---
S
V
K
L
TDF
G
F
C
AQIT---PEQ--SKRSTMVGTPYWM
A
P
E
V
V
T-----R--KA-----YGPKV
D
I
W
S
L
G
I
M
A
I
E
MVEGEPPYLNENP
L
R
A
L
Y
L
I
ATNGTPEL--Q
N
P
-------
E
K
L
S
P
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
KRG
S
A
K
E
L
L
Q
H
P
F
-
L
-
K
L
--
A
K
P
L
S
S
L
T
P
L
I
M
A
A
K
E
A
M
KSNR
118
HHSearch
90.53
91%
-113
- C1 -
3FXZ
1
?
A:
[1-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
---
Q
P
-----
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
---
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
11
PsiBlast_PDB
90.27
90%
-113
- C1 -
3FXZ
1
?
A:
[1-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
---
Q
P
-----
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
---
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
15
PsiBlast_PDB
89.45
90%
-113
- C1 -
4O0R
1
PAK1_HUMAN
A:
[1-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
---
Q
P
-----
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
---
P
E
Q
--
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
29
PsiBlast_CBE
89.04
90%
-112
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[2-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
----
P
-----
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
---
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
16
PsiBlast_PDB
88.82
90%
-110
- C1 -
4O0T
1
PAK1_HUMAN
A:
[3-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
---
Q
P
-----
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
---
P
E
Q
--
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
14
PsiBlast_PDB
88.81
90%
-113
- C1 -
4EQC
1
PAK1_HUMAN
A:
[5-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
---
Q
P
-----
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
---
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
28
PsiBlast_CBE
88.18
90%
-114
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[8-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
----
P
-----
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
---
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
12
PsiBlast_PDB
88.00
90%
-112
- C1 -
3FY0
1
PAK1_HUMAN
A:
[1-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
---
Q
P
-----
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
---
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
2
PsiBlast_PDB
87.13
91%
-119
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[3-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
------------
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
------
1
PsiBlast_PDB
86.77
91%
-118
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[8-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-------------
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
---
P
--------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
26
PsiBlast_CBE
86.52
91%
-119
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[8-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-------------
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
---
P
--------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-----
27
PsiBlast_CBE
86.24
90%
-111
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[8-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
---
Q
P
-----
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
-------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
23
PsiBlast_CBE
84.53
91%
-119
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[5-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-------------
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
------
32
PsiBlast_CBE
82.62
90%
-117
- C1 -
4P90
1
PAK1_HUMAN
B:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-----------------
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
----------------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
21
PsiBlast_CBE
81.56
91%
-121
- C1 -
4ZJJ
1
PAK1_HUMAN
D:
[6-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
E
K
L
R
S
I
V
S
V
---
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
Q
M
N
L
------
P
-----
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
----
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
-------
P
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
25
PsiBlast_CBE
80.68
91%
-110
- C1 -
4ZJI
1
?
C:
[4-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
-------------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
C
A
Q
----------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
117
HHSearch
78.63
46%
-101
- C1 -
4FIE
1
PAK4_HUMAN
A:
[46-421]
----------------------------------------------------------------------------------------------------------------------
R
P
K
P
L
V
D
---------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
------
24
PsiBlast_CBE
78.24
91%
-110
- C1 -
4ZJI
1
?
D:
[7-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-------------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
--------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
18
PsiBlast_PDB
78.10
41%
-100
- C1 -
4FIE
1
PAK4_HUMAN
A:
[46-421]
----------------------------------------------------------------------------------------------------------------------
R
P
K
P
L
V
D
---------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
33
PsiBlast_CBE
78.07
41%
-100
- C1 -
4FIE
1
PAK4_HUMAN
B:
[46-421]
----------------------------------------------------------------------------------------------------------------------
R
P
K
P
L
V
D
---------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
20
PsiBlast_PDB
77.75
51%
-107
- C1 -
2CDZ
1
PAK4_HUMAN
A:
[11-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
--
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
22
PsiBlast_CBE
77.57
91%
-112
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[5-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
Q
-----------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
----
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
----------
E
Q
--
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
---------
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
51
PsiBlast_CBE
77.14
50%
-110
- C1 -
2F57
1
PAK7_HUMAN
A:
[23-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
D
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
D
G
---
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
L
P
-----
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
P
P
L
Q
A
M
R
R
I
R
D
S
L
P
P
R
V
--
K
D
L
-------
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
-
L
-
K
L
--
A
G
P
P
S
C
I
V
P
L
M
R
Q
---------
44
PsiBlast_CBE
76.37
52%
-103
- C1 -
2X4Z
3
A:
[4-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
35
PsiBlast_CBE
76.24
51%
-102
- C1 -
4JDI
1
PAK4_HUMAN
A:
[55-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
119
HHSearch
75.58
52%
-103
- C1 -
4JDI
1
PAK4_HUMAN
A:
[55-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
-------
34
PsiBlast_CBE
75.50
51%
-104
- C1 -
2J0I
4
PAK4_HUMAN
A:
[12-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
40
PsiBlast_CBE
75.48
51%
-102
- C1 -
4FIF
1
PAK4_HUMAN
B:
[52-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
19
PsiBlast_PDB
75.28
51%
-102
- C1 -
2Q0N
7
PAK4_HUMAN
A:
[8-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
50
PsiBlast_CBE
74.77
50%
-102
- C1 -
2F57
1
B:
[23-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
D
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
D
G
---
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
L
P
-----
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
P
P
L
Q
A
M
R
R
I
R
D
S
L
P
P
R
V
--
K
D
L
-------
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
-
L
-
K
L
--
A
G
P
P
S
C
I
V
P
L
M
R
Q
Y
R
H
------
53
PsiBlast_CBE
74.76
50%
-108
- C1 -
4KS8
1
A:
[3-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
--
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
S
Q
----------------------
V
-----
R
-----------------
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
---
K
D
V
--
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
S
L
-----
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
P
P
K
L
--
K
N
S
-------
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
-
L
-
L
Q
--
T
G
L
P
E
C
L
V
P
L
I
-----------
48
PsiBlast_CBE
74.44
52%
-101
- C1 -
4O0X
1
?
A:
[2-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
49
PsiBlast_CBE
74.25
52%
-101
- C1 -
4O0V
1
A:
[2-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
38
PsiBlast_CBE
73.65
51%
-101
- C1 -
4FIG
1
?
B:
[53-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
43
PsiBlast_CBE
73.63
52%
-100
- C1 -
4APP
2
A:
[4-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
47
PsiBlast_CBE
73.34
52%
-101
- C1 -
4O0Y
1
A:
[2-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
39
PsiBlast_CBE
73.32
51%
-104
- C1 -
4FIG
1
?
A:
[53-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
41
PsiBlast_CBE
73.27
51%
-97
- C1 -
4FIF
1
PAK4_HUMAN
A:
[51-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
120
HHSearch
73.19
50%
-109
- C1 -
4KS7
2
A:
[4-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
--
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
S
Q
----------------------
V
-----
R
-----------------
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
---
K
D
V
--
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
S
L
-----
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
P
P
K
L
--
K
N
S
-------
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
-
L
-
L
Q
--
T
G
L
P
E
C
L
V
P
L
I
Q
----------
54
PsiBlast_CBE
73.19
50%
-109
- C1 -
4KS7
2
A:
[4-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
--
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
S
Q
----------------------
V
-----
R
-----------------
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
---
K
D
V
--
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
S
-----
R
--
S
L
-----
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
P
P
K
L
--
K
N
S
-------
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
-
L
-
L
Q
--
T
G
L
P
E
C
L
V
P
L
I
Q
----------
42
PsiBlast_CBE
71.93
52%
-101
- C1 -
4NJD
1
PAK4_HUMAN
A:
[4-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
133
HHSearch
66.61
45%
-99
* C1 *
3A7I
1
STK24_HUMAN
A:
[18-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
D----
E
I
E
D
I
Q
Q
-
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
----
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
L
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
67
PsiBlast_CBE
66.18
44%
-102
- C1 -
3A7I
1
STK24_HUMAN
A:
[18-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
91
PsiBlast_CBE
63.61
43%
-98
- C1 -
2XIK
2
STK25_HUMAN
A:
[16-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
---
A
E
------
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
--
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
P
----------------------
G
-----
P
-----------------
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
---
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
L
F
L
I
P
K
N
S
P
P
T
L
--
E
G
Q
-------
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
--
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
---
104
PsiBlast_CBE
63.23
39%
-106
- C1 -
5AJQ
2
STK10_HUMAN
A:
[13-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
E
-----
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----------------------
L
D
R
---
G
-----------------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
---
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---
K
T
--------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
T
MKDTP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
------
66
PsiBlast_CBE
62.69
44%
-101
- C1 -
3A7J
1
STK24_HUMAN
A:
[18-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
69
PsiBlast_CBE
62.16
44%
-98
- C1 -
3A7H
1
STK24_HUMAN
A:
[18-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
68
PsiBlast_CBE
62.05
44%
-100
- C1 -
3A7H
1
STK24_HUMAN
B:
[18-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
61
PsiBlast_CBE
60.65
44%
-107
- C1 -
4FZD
1
STK26_HUMAN
B:
[3-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----------------------
G
-----
P
-----------------
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
---
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
-----------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--
87
PsiBlast_CBE
60.35
44%
-101
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
----------
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
64
PsiBlast_CBE
60.22
44%
-98
- C1 -
4O27
1
STK24_HUMAN
B:
[1-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
--
59
PsiBlast_CBE
59.59
45%
-104
- C1 -
3GGF
1
STK26_HUMAN
A:
[18-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----------------------
G
-----
P
-----------------
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
---
D
V
K
L
A
D
F
G
V
A
--------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
8
PsiBlast_PDB
59.49
90%
-65
- C1 -
4ZLO
2
?
A:
[2-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
--
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-------------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----------------------
T
-----
C
-----------------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
---
S
V
K
L
T
D
F
G
--------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
-----
R
--
K
A
-----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
--
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
--
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
--
101
PsiBlast_CBE
58.34
39%
-102
- C1 -
4AOT
1
STK10_HUMAN
B:
[16-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
---
E
E
-----
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----------------------
L
D
R
---
G
-----------------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
---
D
I
R
L
A
D
F
G
V
S
A
K
----------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
----------P----
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
----
98
PsiBlast_CBE
58.34
39%
-108
- C1 -
4USD
1
?
B:
[16-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
---
E
E
-----
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----------------------
L
D
R
---
G
-----------------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
---
D
I
R
L
A
D
F
G
V
--------------------
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
---------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
----
60
PsiBlast_CBE
58.13
44%
-96
- C1 -
4FZF
1
?
B:
[3-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----------------------
G
-----
P
-----------------
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
---
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--
93
PsiBlast_CBE
57.95
37%
-108
- C1 -
4USF
1
?
A:
[2-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
E
H
V
T
R
D
L
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
---
E
E
-----
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
----------------------
L
-----
E
RP---------------
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
---
D
I
K
L
A
D
F
G
V
S
A
K
------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E------
R
P
-----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
--
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
-
T
V
DS
N
K
P
I
R
E
L
I
A
E
A
K
A
E
--------
58
PsiBlast_CBE
57.73
45%
-100
- C1 -
3GGF
1
STK26_HUMAN
B:
[19-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----------------------
G
-----
P
-----------------
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
---
D
V
K
L
A
D
F
G
V
A
---------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--
62
PsiBlast_CBE
57.72
44%
-96
- C1 -
4FZA
3
STK26_HUMAN
B:
[3-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----------------------
G
-----
P
-----------------
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
---
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
--
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
--
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--
92
PsiBlast_CBE
57.57
37%
-101
- C1 -
4USF
1
?
B:
[2-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
Q
Y
E
H
V
T
R
D
L
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
---
E
E
-----
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
----------------------
L
-----
E
R
P
---------------
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
---
D
I
K
L
A
D
F
G
V
S
A
K
N
--------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETSK
D
--
R
P
-----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
--
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
-
T
V
DS
N
K
P
I
R
E
L
I
A
E
A
K
A
E
--------
103
PsiBlast_CBE
57.47
39%
-104
- C1 -
2J7T
1
STK10_HUMAN
A:
[16-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
-----
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----------------------
L
D
R
---
G
-----------------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
---
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---
K
T
L
--
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
T
M
K
D
TP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-
125
HHSearch
56.97
41%
-108
- C1 -
4OBO
2
M4K4_HUMAN
A:
[17-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
--------------
E
I
K
L
-
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
----------------------
T
KGN--
T
-----------------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
---
E
V
K
L
V
D
F
G
----------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
CDENP
D
--
A
T
-----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
--
K
-
S
-------
K
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
-
R
D
--
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
---
65
PsiBlast_CBE
56.05
43%
-102
- C1 -
4NZW
1
STK25_HUMAN
B:
[17-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
--
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
P
----------------------
G
-----
P
-----------------
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
---
D
V
K
L
A
A
F
G
V
A
G
-------------------
T
P
F
W
M
A
P
E
V
I
K
-----
Q
---------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
L
F
L
I
P
K
N
S
P
P
T
L
--
E
G
Q
-------
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
--
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
---
102
PsiBlast_CBE
55.45
39%
-100
- C1 -
4AOT
1
STK10_HUMAN
A:
[16-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
---
E
E
-----
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----------------------
L
D
R
---
G
-----------------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
---
D
I
R
L
A
D
F
G
V
S
A
------------------
G
T
P
Y
W
M
A
P
E
V
V
M
---------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
----
97
PsiBlast_CBE
55.26
39%
-100
- C1 -
4USE
1
?
A:
[16-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
---
E
E
-----
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----------------------
L
D
R
---
G
-----------------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
---
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---
K
T
L
--
Q
-------
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
--
105
PsiBlast_CBE
54.28
39%
-103
- C1 -
4BC6
2
STK10_HUMAN
A:
[8-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
---
E
E
-----
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----------------------
L
DR---
G
-----------------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
---
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---
K
T
L
--
Q
--------
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
T
M
K
D
TP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
--
94
PsiBlast_CBE
53.51
38%
-97
- C1 -
2UV2
6
SLK_HUMAN
A:
[34-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
---
E
E
-----
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
----------------------
L
-----
E
R
P
---------------
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
---
D
I
K
L
A
D
F
G
V
S
A
K
N
T
---
R
T
I
--
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETSK
D
--
R
P
-----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
--
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
-
T
V
DS
N
K
P
I
R
E
L
I
A
E
A
K
----------
106
PsiBlast_CBE
52.95
40%
-108
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[17-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C--
Q
T
-----
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
----------------------
I
-----
V
A
K
GEHKSGV--------
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
---
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG---------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
E
-----
Q
V-
R
G
-----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
--
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
--
A
K
N
K
E
-----------------
129
HHSearch
52.29
34%
-98
- C1 -
3HKO
2
?
A:
[25-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q-
K
-----
D
V
E
R
I
K
T
-
E
V
R
L
M
K
K
L
-
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
--
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
-----
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
K
SF-
E
I
K
L
V
D
F
G
L
S
K
E
F
Y
---
K
L
N
NG------
A
G
T
P
Y
F
V
A
P
E
V
L
N
-----
T
TN
E
S
-----
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
D
T
I
S
Q
V
L
N
-
K
K
L
C
F
--
E
N
P
NY-----
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
-
I
-
S
Q
--
F
S
D
K
I
Y
K
M
S
-------------
99
PsiBlast_CBE
52.28
39%
-103
- C1 -
4EQU
2
STK10_HUMAN
B:
[16-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
-----
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----------------------
L
D
R
---
G
-----------------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
---
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-
95
PsiBlast_CBE
52.18
38%
-96
- C1 -
2J51
5
SLK_HUMAN
A:
[34-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
---
E
E
-----
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
----------------------
L
-----
E
RP---------------
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
---
D
I
K
L
A
D
F
G
V
S
A
K
N
T
---
R
T
I
--
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETSK
D
--
R
P
-----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
--
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
-
T
V
DS
N
K
P
I
R
E
L
I
A
E
A
K
----------
126
HHSearch
52.11
32%
-100
- C1 -
3C0I
1
CSKP_HUMAN
A:
[24-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
---
F
T
S
SPGL
S
T
E
D
L
K
R
-
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
----------------------
R
-----
A
D
A
G
F
V
------------
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
NS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
---
E
S
G
--
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
-----
R
--
E
P
-----
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
-
R
L
F
E
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
-------
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-
L
-
K
E
--
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
100
PsiBlast_CBE
51.66
39%
-105
- C1 -
4EQU
2
STK10_HUMAN
A:
[16-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
--------------
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----------------------
L
D
R
---
G
-----------------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
---
D
I
R
L
A
D
F
G
V
S
A
K
N
L
--------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-
96
PsiBlast_CBE
50.84
39%
-100
- C1 -
4USE
1
?
B:
[16-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
-----
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-------
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----------------------
L
D
R
---
G
-----------------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
---
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---
K
T
L
--
Q
K
------
T
P
Y
W
M
A
P
E
V
V
M
-----
C
--
E
T
M
K
DT
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
--
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
--
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
--
46
PsiBlast_CBE
49.36
52%
-60
- C1 -
5BMS
1
A:
[2-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
-----
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----------------------
T
-----
R
-----------------
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
---
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
-----
R
--
L
P
-----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
--
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
--
A
G
P
P
A
S
I
V
P
L
-------
M
R
Q
N
R
128
HHSearch
45.56
31%
-98
- C1 -
2W5A
5
NEK2_HUMAN
A:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
---
M
T
E
A
---
E
K
Q
M
L
V
S
-
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
----------------------
G
T
K
E
R
Q
Y
-----------------
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
---
N
V
K
L
G
D
F
G
L
A
R
I
L
------
T
--
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
-----
R
--
M
------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
----
I
P
-------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
-
I
-
L
E
--
H
H
H
H
H
H
----------------
88
PsiBlast_CBE
39.83
44%
-57
- C1 -
4W8E
1
STK24_HUMAN
A:
[10-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
74
PsiBlast_CBE
38.61
44%
-50
- C1 -
4QMY
2
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
76
PsiBlast_CBE
38.46
44%
-56
- C1 -
4QMW
2
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
75
PsiBlast_CBE
38.28
44%
-53
- C1 -
4QMX
1
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
72
PsiBlast_CBE
38.13
44%
-51
- C1 -
4QNA
1
?
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
79
PsiBlast_CBE
37.90
44%
-54
- C1 -
4QMT
2
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
77
PsiBlast_CBE
37.77
44%
-54
- C1 -
4QMV
3
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
73
PsiBlast_CBE
37.73
44%
-54
- C1 -
4QMZ
1
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
90
PsiBlast_CBE
37.50
44%
-55
- C1 -
4U8Z
1
STK24_HUMAN
A:
[10-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
80
PsiBlast_CBE
37.35
44%
-51
- C1 -
4QMS
2
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
78
PsiBlast_CBE
37.32
44%
-53
- C1 -
4QMU
2
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
70
PsiBlast_CBE
37.10
44%
-49
- C1 -
4QO9
4
?
B:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
84
PsiBlast_CBE
37.09
44%
-50
- C1 -
4QMN
1
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
89
PsiBlast_CBE
37.04
44%
-54
- C1 -
4W8D
1
STK24_HUMAN
A:
[10-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
81
PsiBlast_CBE
36.76
44%
-53
- C1 -
4QMQ
3
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
82
PsiBlast_CBE
36.64
44%
-52
- C1 -
4QMP
2
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
85
PsiBlast_CBE
36.61
44%
-52
- C1 -
4QMM
3
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
--
71
PsiBlast_CBE
36.45
44%
-52
- C1 -
4QO9
4
?
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-
83
PsiBlast_CBE
36.36
44%
-52
- C1 -
4QMO
3
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
--
86
PsiBlast_CBE
35.84
44%
-48
- C1 -
4QML
2
STK24_HUMAN
A:
[25-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
A
E
-----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----------------------
G
-----
P
-----------------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
---
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
---
D
T
Q
--
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
-----
Q
--
S
A
-----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
--
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
--
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-