@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PAK4_HUMAN: (2015-10-16 )
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
Atome Classification :
(83 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350....-...360...-....370.-......380.....------..390.......400.......----410--------..---......420.......430.......440......-.450.......460.....--..470........480.....-----.-----.490--........500.......510.....--..520.......530.....-------..540.......550.......560.......570.......580.......590
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFGKR
K
K
R
V
E
ISAPSNFEHRVHTG
F
D
Q
H
E
Q
K
FTGL
P
R
Q
W
Q
S
L
I
E
E
SARRPKPLV
D
P
A
C
ITSIQPGAP
K
T
I
VRGSKGAKDG
A
L
T
L
L
L
D
EFEN
M
S
VTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQR
E
P
Q
RV
S
H
E
Q
F
R
A
A
L
Q
L
V
VDPGD
P
R
S
Y
L
D
N
F
I
KIGEGST
G
I
V
C
I
A
T
VRSS
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N-
E
V
V
I
M
RDY-QH
E
N
V
V
E
M
Y
N
S
YLV------G
D
E
L
W
V
V
M
E
F
LEGGA
L
T
D
I
V
T
H----TR---------M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
AQG
V
I
H
RDIKSD
S
I
L
L
-THDG
R
V
K
LS
D
F
G
F
C
A
Q
V
S
K
--EVPR-RKSLVGTPYWM
A
P
E
L
I
-----
S
-----RL-P--YGPEV
D
I
W
S
L
G
I
M
V
I
E
MVDGEPPYFN--EP
P
L
K
A
M
K
M
I
R
DNL
P
P
R
L
K
N
-------
L
H
KV
S
P
S
L
K
G
F
L
D
R
L
L
VRDP
A
Q
R
A
T
A
A
E
L
L
KHPFLAKAGP
P
A
S
I
V
P
L
M
RQNRTR
21
PsiBlast_CBE
97.14
99%
-125
- C3 -
4FIG
1
?
B:
[53-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-
12
PsiBlast_PDB
96.91
99%
-132
- C3 -
2J0I
4
PAK4_HUMAN
A:
[12-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
22
PsiBlast_CBE
96.61
99%
-126
- C3 -
4FIF
1
PAK4_HUMAN
B:
[52-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
10
PsiBlast_PDB
96.52
99%
-128
- C3 -
2Q0N
7
PAK4_HUMAN
A:
[8-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
R
25
PsiBlast_CBE
95.96
84%
-135
- C3 -
2F57
1
PAK7_HUMAN
A:
[24-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
D
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
S
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
K
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
L
-
P
--
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
--
E
P
P
L
Q
A
M
R
R
I
R
D
S
L
P
P
R
V
K
D
-------
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
K
L
A
G
P
P
S
C
I
V
P
L
M
R
Q
----
11
PsiBlast_PDB
95.93
99%
-131
- C3 -
2CDZ
1
PAK4_HUMAN
A:
[11-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
--
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-
19
PsiBlast_PDB
95.92
99%
-128
- C3 -
4O0X
1
?
A:
[2-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
7
PsiBlast_PDB
95.53
99%
-127
- C3 -
4JDI
1
PAK4_HUMAN
A:
[55-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
2
PsiBlast_PDB
95.47
99%
-128
- C3 -
4FIG
1
?
A:
[53-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-
18
PsiBlast_PDB
95.43
99%
-128
- C3 -
4O0V
1
A:
[2-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
15
PsiBlast_PDB
95.33
99%
-128
- C3 -
4NJD
1
PAK4_HUMAN
A:
[4-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
1
PsiBlast_PDB
95.19
99%
-125
- C3 -
4FIF
1
PAK4_HUMAN
A:
[51-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
20
PsiBlast_PDB
94.35
99%
-125
- C3 -
4O0Y
1
A:
[2-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
24
PsiBlast_CBE
94.04
84%
-125
- C3 -
2F57
1
B:
[24-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
D
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
S
D
G
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
K
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
L
-
P
--
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
--
E
P
P
L
Q
A
M
R
R
I
R
D
S
L
P
P
R
V
K
D
-------
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
K
L
A
G
P
P
S
C
I
V
P
L
M
R
Q
Y
R
H
-
28
PsiBlast_CBE
90.68
75%
-128
- C3 -
4KS7
2
A:
[4-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
------
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
S
Q
----
V
R
---------
L
N
---
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
L
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
--
D
V
P
K
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
S
-
L
--
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
--
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
P
P
K
L
K
N
-------
S
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
T
G
L
P
E
C
L
V
P
L
I
Q
-----
27
PsiBlast_CBE
88.15
75%
-128
- C3 -
4KS8
1
A:
[3-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
------
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
S
Q
----
V
R
---------
L
N
---
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
L
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
--
D
V
P
K
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
S
-
L
--
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
--
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
P
P
K
L
K
N
-------
S
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
T
G
L
P
E
C
L
V
P
L
I
------
40
PsiBlast_CBE
84.29
53%
-132
- C3 -
4ZY4
2
PAK1_HUMAN
B:
[2-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
45
PsiBlast_CBE
83.40
53%
-130
- C3 -
4O0R
1
PAK1_HUMAN
A:
[1-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
39
PsiBlast_CBE
81.69
53%
-134
- C3 -
4ZY5
2
PAK1_HUMAN
B:
[8-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
44
PsiBlast_CBE
81.16
53%
-124
- C3 -
4O0T
1
PAK1_HUMAN
A:
[3-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
41
PsiBlast_CBE
80.39
53%
-131
- C3 -
4ZY4
1
PAK1_HUMAN
A:
[2-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-----
Q
-
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
47
PsiBlast_CBE
80.24
52%
-132
- C3 -
3Q4Z
1
PAK1_HUMAN
A:
[4-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
I
I
V
S
V
G
D
P
K
-----
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
Q
M
N
L
------
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
38
PsiBlast_CBE
80.23
53%
-131
- C3 -
4ZY6
1
PAK1_HUMAN
A:
[4-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-------
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
37
PsiBlast_CBE
79.32
53%
-133
- C3 -
4ZY6
1
PAK1_HUMAN
B:
[8-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
----------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
23
PsiBlast_CBE
79.05
99%
-85
- C3 -
5BMS
1
A:
[2-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-
Q
Q
R
R
E
L
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
32
PsiBlast_CBE
78.92
53%
-136
- C3 -
4ZJJ
1
PAK1_HUMAN
A:
[3-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-----
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
-
31
PsiBlast_CBE
78.82
53%
-136
- C3 -
4ZJJ
1
PAK1_HUMAN
B:
[5-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
----------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
-
36
PsiBlast_CBE
78.58
53%
-134
- C3 -
4ZJI
1
PAK1_HUMAN
A:
[8-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
35
PsiBlast_CBE
78.27
53%
-136
- C3 -
4ZJI
1
PAK1_HUMAN
B:
[8-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
------
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
---------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
34
PsiBlast_CBE
78.24
53%
-131
- C3 -
4ZJI
1
?
C:
[4-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
-------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
33
PsiBlast_CBE
77.93
53%
-130
- C3 -
4ZJI
1
?
D:
[7-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
-----
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
48
PsiBlast_CBE
76.74
53%
-136
- C3 -
4P90
1
PAK1_HUMAN
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
----------
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
-------------
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
29
PsiBlast_CBE
74.94
53%
-141
- C3 -
4ZJJ
1
PAK1_HUMAN
D:
[6-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
E
K
L
R
S
I
V
S
V
---
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
Q
M
N
L
----
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
--------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
----
P
--
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
30
PsiBlast_CBE
72.44
53%
-132
- C3 -
4ZJJ
1
PAK1_HUMAN
C:
[5-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
Q
----
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
----
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
---------
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
--------
A
--
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
72
PsiBlast_CBE
71.82
34%
-130
- C3 -
4USF
1
?
A:
[13-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
-
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
----
L
E
RP-------
L
T
---
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
----------------
T
P
Y
W
M
A
P
E
V
V
M
C
E---------
R
-
P
--
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
-------
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
-
87
PsiBlast_CBE
71.55
37%
-123
- C3 -
4ZK5
2
?
A:
[21-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
E
I
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
----
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
-------
K
-
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
90
PsiBlast_CBE
71.29
37%
-124
- C3 -
4U44
2
M4K4_HUMAN
A:
[21-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
E
I
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SH---
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
----
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
-------------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
-------
K
-
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
85
PsiBlast_CBE
71.29
35%
-126
- C3 -
5AJQ
2
STK10_HUMAN
A:
[13-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
R
G
-------
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
--
T
-------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCETM
K
-----
D
T
-
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
-
89
PsiBlast_CBE
70.37
37%
-118
* C3 *
4U45
1
M4K4_HUMAN
A:
[21-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
E
I
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPP--
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
----
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
-------
K
-
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
91
PsiBlast_CBE
70.24
37%
-122
- C3 -
4U43
1
M4K4_HUMAN
A:
[21-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
E
I
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
----
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
-------
K
-
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
93
PsiBlast_CBE
70.01
37%
-127
- C3 -
4OBP
2
M4K4_HUMAN
A:
[21-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
-
D
E
E
E
E
I
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KS----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
----
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
-------
K
-
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
71
PsiBlast_CBE
69.94
34%
-127
- C3 -
4USF
1
?
B:
[13-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
-
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
----
L
E
R
P
-------
L
T
---
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCETS
K
-----
D
R
-
P
--
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
-------
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
-
60
PsiBlast_CBE
69.89
37%
-110
- C3 -
4FZA
3
STK26_HUMAN
B:
[4-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----
G
P
---------
F
D
---
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
--
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
-
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
--
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
59
PsiBlast_CBE
69.82
37%
-121
- C3 -
4FZD
1
STK26_HUMAN
B:
[4-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----
G
P
---------
F
D
---
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
---------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
-
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
--
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
68
PsiBlast_CBE
69.76
37%
-110
- C3 -
4O27
1
STK24_HUMAN
B:
[2-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
----
G
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
--
T
Q
I
K
-
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
--
L
H
P
M
K
V
L
F
L
I
P
K
N
N
P
P
T
L
E
G
---------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
66
PsiBlast_CBE
69.69
38%
-124
- C3 -
3DAK
1
OXSR1_HUMAN
A:
[18-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
----
I
V
A
K
GEHKSGV
L
D
---
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG---------
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
GVQDKEM
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
---------------
95
PsiBlast_CBE
69.66
37%
-129
- C3 -
4OBO
2
M4K4_HUMAN
A:
[21-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
------
E
I
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
----
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
--------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
-------
K
-
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
92
PsiBlast_CBE
69.63
37%
-123
- C3 -
4OBQ
2
M4K4_HUMAN
A:
[21-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
-------------
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
----
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
-------
K
-
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
64
PsiBlast_CBE
69.57
38%
-124
- C3 -
3DAK
1
OXSR1_HUMAN
C:
[18-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
----
I
V
A
K
GEHKSGV
L
D
---
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
GVQDKEM
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
---------------
82
PsiBlast_CBE
69.41
35%
-125
- C3 -
4AOT
1
STK10_HUMAN
B:
[16-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
-
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
R
G
-------
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
--------------
I
G
T
P
Y
W
M
A
P
E
V
V
M-------------
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
65
PsiBlast_CBE
69.07
38%
-122
- C3 -
3DAK
1
OXSR1_HUMAN
B:
[18-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
----
I
V
A
K
GEHKSGV
L
D
---
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
----------
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
GVQDKEM
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
---------------
63
PsiBlast_CBE
68.79
38%
-127
- C3 -
3DAK
1
OXSR1_HUMAN
D:
[18-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
----
I
V
A
K
GEHKSGV
L
D
---
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
I
T
R
N---
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
GVQDKEM
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
---------------
57
PsiBlast_CBE
68.54
37%
-114
- C3 -
3GGF
1
STK26_HUMAN
A:
[19-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----
G
P
---------
F
D
---
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
-
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
--
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
84
PsiBlast_CBE
68.52
35%
-128
- C3 -
2J7T
1
STK10_HUMAN
A:
[16-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
R
G
-------
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
--
T
L
Q
K
-----
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
-
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
83
PsiBlast_CBE
68.50
35%
-124
- C3 -
4AOT
1
STK10_HUMAN
A:
[16-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
-
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
R
G
-------
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
----------------
G
T
P
Y
W
M
A
P
E
V
V
M----------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
96
PsiBlast_CBE
68.14
37%
-126
- C3 -
4RVT
2
M4K4_HUMAN
A:
[23-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-----
E
E
I
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
----
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
--
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
P
P
R
L
K
S
-------
K
-
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
100
PsiBlast_CBE
68.01
31%
-123
- C3 -
4BIE
2
M3K5_HUMAN
A:
[25-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
---------
L
H
E
-
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
KWGP
L
K
---------
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
---------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
-----
K
G
-
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
LG
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------
108
PsiBlast_CBE
67.66
31%
-122
- C3 -
4BF2
1
B:
[41-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
----------
E
-
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
KWGP
L
K
---------
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------------
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
-----
K
G
-
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
LG
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------
79
PsiBlast_CBE
67.65
35%
-132
- C3 -
4USD
1
?
B:
[16-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
-
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
R
G
-------
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
------------------
G
T
P
Y
W
M
A
P
E
V
V
MC---------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
107
PsiBlast_CBE
67.52
31%
-119
- C3 -
4BHN
2
B:
[41-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
Q
P
L
H
E
-
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
KWGP
L
K
---------
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
-----
K
G
-
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
LG
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-------------------
61
PsiBlast_CBE
67.48
38%
-126
- C3 -
2VWI
1
OXSR1_HUMAN
D:
[23-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
----
I
V
A
K
GEHKSGV
L
D
---
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG-------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
GVQDKEM
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
N
K
E
------------
56
PsiBlast_CBE
67.25
37%
-114
- C3 -
3GGF
1
STK26_HUMAN
B:
[19-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----
G
P
---------
F
D
---
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
-------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
-
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
--
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
105
PsiBlast_CBE
66.73
31%
-124
- C3 -
4BIB
1
B:
[25-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
Q
P
L
H
E
-
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
KWGP
L
K
---------
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
-----
K
G
-
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
LG
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------
103
PsiBlast_CBE
66.72
31%
-124
- C3 -
4BIC
2
B:
[25-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
Q
P
L
H
E
-
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
KWGP
L
K
---------
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
------------
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
-----
K
G
-
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
LG
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
----------------
78
PsiBlast_CBE
66.59
35%
-122
- C3 -
4USE
1
?
A:
[16-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
-
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
R
G
-------
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
--
T
L
Q
--------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
-
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
80
PsiBlast_CBE
66.47
35%
-124
- C3 -
4EQU
2
STK10_HUMAN
B:
[16-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
R
G
-------
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
-----------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
-
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
102
PsiBlast_CBE
66.03
31%
-124
- C3 -
4BID
1
M3K5_HUMAN
A:
[25-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
---------
L
H
E
-
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
KWGP
L
K
---------
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
-----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
-----
K
G
-
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
LG
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
------------------
81
PsiBlast_CBE
65.96
35%
-126
- C3 -
4EQU
2
STK10_HUMAN
A:
[16-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
R
G
-------
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
-
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
86
PsiBlast_CBE
65.90
35%
-127
- C3 -
4BC6
2
STK10_HUMAN
A:
[8-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
-
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
RG-------
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
--
T
L
Q
---------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
-
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
76
PsiBlast_CBE
65.78
36%
-110
- C3 -
4NZW
1
STK25_HUMAN
B:
[16-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
E
E
L
F
T
K
L
D
---
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
------
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
P
----
G
P
---------
L
E
---
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
-----------------
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-----
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
--
L
H
P
M
R
V
L
F
L
I
P
K
N
S
P
P
T
L
E
G
-------
Q
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
69
PsiBlast_CBE
65.72
34%
-122
- C3 -
2UV2
6
SLK_HUMAN
A:
[34-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
-
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
----
L
E
R
P
-------
L
T
---
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
--
T
I
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
-----
D
R
-
P
--
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
-------
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
---
70
PsiBlast_CBE
65.64
34%
-119
- C3 -
2J51
5
SLK_HUMAN
A:
[34-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
-
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
----
L
E
RP-------
L
T
---
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
--
T
I
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
-----
D
R
-
P
--
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
-------
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
---
73
PsiBlast_CBE
65.60
38%
-118
- C3 -
5D9H
1
?
B:
[26-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
----
I
V
NRGEHKNGV
L
E
---
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
V
T
R
N-----
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
--
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
T
L
E
T
GVEDKEM
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
K
N
R
E
Y
L
I
E
K
L
L
T
----
97
PsiBlast_CBE
65.57
31%
-122
- C3 -
2CLQ
1
B:
[28-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
Q
P
L
H
E
-
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
KWGP
L
K
---------
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
-----
K
G
-
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
LG
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------
101
PsiBlast_CBE
64.87
31%
-122
- C3 -
4BID
1
B:
[25-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
-----
S
Q
P
L
H
E
-
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
KWGP
L
K
---------
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
-----
K
G
-
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
LG
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------
99
PsiBlast_CBE
64.84
31%
-124
- C3 -
4BIE
2
B:
[25-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
--------
L
H
E
-
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
KWGP
L
K
---------
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
-----
K
G
-
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
LG
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
----------------
77
PsiBlast_CBE
64.83
35%
-126
- C3 -
4USE
1
?
B:
[16-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-----------
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
----
L
D
R
G
-------
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
--
T
L
Q
K
-------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
-
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
P
P
T
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
106
PsiBlast_CBE
64.82
31%
-119
- C3 -
4BIB
3
M3K5_HUMAN
A:
[25-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
---------
L
H
E
-
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
KWGP
L
K
---------
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
-----------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
-----
K
G
-
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
LG
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
------------------
74
PsiBlast_CBE
64.79
38%
-115
- C3 -
5D9H
1
?
A:
[26-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
----
I
V
N
R
GEHKNGV
L
E
---
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
V
T
R
-----
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
--
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
P
T
L
E
T
GVKEM--
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
K
N
R
E
Y
L
I
E
K
L
L
-----
104
PsiBlast_CBE
64.71
31%
-120
- C3 -
4BIC
2
M3K5_HUMAN
A:
[25-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
------
S
Q
P
L
H
E
-
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
KWGP
L
K
---------
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
---------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
-----
K
G
-
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
LG
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------
98
PsiBlast_CBE
64.41
31%
-119
- C3 -
2CLQ
1
M3K5_HUMAN
A:
[28-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
R
D
----
S
Q
P
L
H
E
-
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
KWGP
L
K
---------
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
G
--------
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
-----
K
G
-
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
LG
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------
109
PsiBlast_CBE
64.22
31%
-123
- C3 -
4BF2
2
M3K5_HUMAN
A:
[41-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
E
-----------
E
-
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
KWGP
L
K
---------
D
N
---
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
---------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
-----
K
G
-
P
RG
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
LG
E
P
Q
A
A
M
F
K
V
G
M
F
K
V
H
P
E
I
P
---------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
------------------
58
PsiBlast_CBE
64.10
37%
-112
- C3 -
4FZF
1
?
B:
[4-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
-
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
A
----
G
P
---------
F
D
---
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
--
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
-
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
--
M
H
P
M
R
V
L
F
L
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R