@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PAK7_HUMAN: (2015-10-16 )
MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEAYYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTAGTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH
Atome Classification :
(70 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470......---.480..-----.....490...-......500........510...------....520.......530-.-......---------540--........550........560.......570......---.580--........590...--..-..-600.......610...-----.-----..---.620.......630.......640...--....650.......----660-----..----...-------....670.......680.......690.......-700........710.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFGK
K
K
K
K
I
E
ISGPSNFEHRVHTGFDP
Q
E
Q
K
FTGL
P
Q
Q
W
H
S
L
L
A
DTANRPKPMVDPSCIT
P
I
QLA
P
M
K
T
I
VRGNKPCKE
T
S
I
N
G
L
L
E
DFDN
I
S
V
TRSNSLRKESPPTPDQGASSHGPGHAEEN
G
F
I
T
F
SQYSSESDTTADY
T
T
E
K
Y
R
E
KSLYGDDL
D
P
Y
YRGSHAAKQNG
H
V
M
K
M
KHG
E
A
Y
Y
S
E
V
K
P
L
K
S
D
F
A
R
F
S
A
D
Y
H
S
H
L
D
SLSKPSEYSD
L
K
W
E
Y
QRASSSSP
L
D
Y
S
F
QFTPSRTAGTSGCSKESLAYSESEWGPSL
D
D
YDRRP
K
S
SYLNQTSPQ
P
T
M
R
Q
RSRSGSGLQEPMMPFGA
S
A
FKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRA
Q
M
V
LSPPLSGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGY
H
K
A
T
L
Y
HHPSLQSSS
Q
Y
I
S
T
A
S
Y
L
S
S
LSLSSSTYPPPSWGSSSDQQPSRV
S
H
E
Q
F
R
A
A
L
Q
L
V
VSPG
D
P
R
E
Y
L
A
N
F
I
KIGEGS
T
G
I
V
C
I
ATEKHTG
K
Q
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N-
E
V
V
I
M
R
DY-HHD
N
V
V
D
M
Y
S
S
Y
LV------G
D
E
L
W
V
V
M
E
F
LEGGA
L
T
-
D
-
I
V
T
HTR---------M
N
---
E
E
Q
I
A
T
V
C
L
-
S
V
L
R
A
L
S
Y
L
HNQG
V
I
H
R
DIKSD
S
I
L
LTS---DG
R
---
I
K
LSDF
G
F
C
A
Q
V
S
K
--EV-PK-RKSLVGTPYWM
A
P
E
V
I
-----
S
-----RL---PYGTE
V
D
I
W
S
L
G
I
M
V
I
E
MIDGEPPYFN--EP
P
L
Q
A
M
R
R
I
R
D
SL----
P
-------
P
R
----
V
K
D
-------
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
LVREPSQ
R
A
T
A
Q
E
L
LGH
P
F
-L-KLAG
P
P
S
C
I
V
P
L
M
R
Q
YRHH
21
PsiBlast_CBE
94.56
98%
-128
- C1 -
2F57
1
B:
[20-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
D
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
T
V
C
L
-
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
---
D
G
R
---
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
K
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
L
---
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
--
E
P
P
L
Q
A
M
R
R
I
R
D
S
L
----
P
-------
P
R
----
V
K
D
-------
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
-
L
-
K
L
A
G
P
P
S
C
I
V
P
L
M
R
Q
Y
R
H
-
18
PsiBlast_PDB
89.57
84%
-128
- C1 -
4O0X
1
?
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
3
PsiBlast_PDB
89.39
83%
-129
- C1 -
2J0I
4
PAK4_HUMAN
A:
[12-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
2
PsiBlast_PDB
88.83
83%
-130
- C1 -
2CDZ
1
PAK4_HUMAN
A:
[11-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
--
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-
14
PsiBlast_PDB
88.73
84%
-127
- C1 -
2X4Z
3
A:
[4-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-
23
PsiBlast_CBE
88.50
83%
-125
- C1 -
4FIF
1
PAK4_HUMAN
B:
[52-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
22
PsiBlast_CBE
88.38
83%
-123
- C1 -
4FIG
1
?
B:
[53-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-
17
PsiBlast_PDB
88.17
84%
-128
- C1 -
4O0V
1
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
15
PsiBlast_PDB
88.17
84%
-125
- C1 -
4APP
2
A:
[4-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
R
11
PsiBlast_PDB
87.79
83%
-125
- C1 -
4JDI
1
PAK4_HUMAN
A:
[55-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
16
PsiBlast_PDB
87.69
84%
-128
- C1 -
4NJD
1
PAK4_HUMAN
A:
[4-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
6
PsiBlast_PDB
86.99
83%
-127
- C1 -
4FIG
1
?
A:
[53-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-
4
PsiBlast_PDB
86.92
83%
-126
- C1 -
2Q0N
7
PAK4_HUMAN
A:
[8-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
R
5
PsiBlast_PDB
86.55
83%
-124
- C1 -
4FIF
1
PAK4_HUMAN
A:
[51-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
19
PsiBlast_PDB
86.25
84%
-124
- C1 -
4O0Y
1
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
27
PsiBlast_CBE
84.63
75%
-125
- C1 -
4KS7
2
A:
[4-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
---
M
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
------
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
-
D
-
I
V
S
Q
V
R
---------
L
N
---
E
E
Q
I
A
T
V
C
E
-
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
--
D
V
-
P
K
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
S
---
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
--
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
----
P
-------
P
K
----
L
K
N
-------
S
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
-
L
-
L
Q
T
G
L
P
E
C
L
V
P
L
I
Q
-----
26
PsiBlast_CBE
82.22
75%
-126
- C1 -
4KS8
1
A:
[3-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
---
M
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
------
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
-
D
-
I
V
S
Q
V
R
---------
L
N
---
E
E
Q
I
A
T
V
C
E
-
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
--
D
V
-
P
K
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
S
---
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
--
D
S
P
V
Q
A
M
K
R
L
R
D
S
P
----
P
-------
P
K
----
L
K
N
-------
S
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
-
L
-
L
Q
T
G
L
P
E
C
L
V
P
L
I
------
41
PsiBlast_CBE
74.96
52%
-129
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
L
Q
Q
------
P
K
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
-
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
46
PsiBlast_CBE
73.90
52%
-129
- C1 -
4O0R
1
PAK1_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
L
Q
Q
-----
Q
P
K
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
-
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
40
PsiBlast_CBE
73.87
52%
-132
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[8-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
L
Q
Q
------
P
K
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
-
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
44
PsiBlast_CBE
72.36
51%
-132
- C1 -
3Q4Z
1
PAK1_HUMAN
A:
[4-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
I
I
V
S
V
G
D
P
K
-----
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
---
Q
M
N
L
----------
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
-
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
45
PsiBlast_CBE
71.18
52%
-124
- C1 -
4O0T
1
PAK1_HUMAN
A:
[3-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
L
Q
Q
-----
Q
P
K
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
-
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
38
PsiBlast_CBE
71.06
52%
-130
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[8-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
L
Q
Q
-----
Q
P
K
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
-----------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
31
PsiBlast_CBE
70.47
52%
-134
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[3-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
L
Q
---------
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
-
42
PsiBlast_CBE
70.24
52%
-128
- C1 -
4ZY4
1
PAK1_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
-----
Q
P
K
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
-
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
35
PsiBlast_CBE
69.41
52%
-133
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
L
----------
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
----------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
34
PsiBlast_CBE
68.93
52%
-133
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
L
Q
----------
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
----------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
30
PsiBlast_CBE
68.46
52%
-134
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[5-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
L
----------
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
-
39
PsiBlast_CBE
67.62
52%
-128
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[4-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------------
Q
P
K
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
--
E
Q
-
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
33
PsiBlast_CBE
65.10
52%
-130
- C1 -
4ZJI
1
?
C:
[4-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
---
Q
M
N
----------
K
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
C
A
Q
--------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
32
PsiBlast_CBE
63.86
52%
-129
- C1 -
4ZJI
1
?
D:
[7-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
----------
K
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
-
A
Q
I
T
------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
47
PsiBlast_CBE
63.85
52%
-134
- C1 -
4P90
1
PAK1_HUMAN
B:
[9-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
L
----------------
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
--------------
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
20
PsiBlast_PDB
63.73
84%
-89
- C1 -
5BMS
1
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
L
R
K
-----
Q
Q
R
R
E
L
--
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
-
D
-
I
V
T
H
T
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
-
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
R
---
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
-
P
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
--
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----
P
-------
P
R
----
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
-
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
28
PsiBlast_CBE
61.95
52%
-139
- C1 -
4ZJJ
1
PAK1_HUMAN
D:
[6-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
E
K
L
R
S
I
V
S
V
---
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
---
Q
M
N
L
--------
P
K
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
--------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
F
C
----
P
--
E
Q
-
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
29
PsiBlast_CBE
58.67
52%
-131
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[5-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
---
Q
M
N
L
Q
--------
K
K
E
L
--
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
-
D
-
V
V
T
E
T
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
-
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
S
---
V
K
L
T
D
F
G
---------
E
Q
-
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
----------
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
--
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
----
T
-------
P
E
----
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
-
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
52
PsiBlast_CBE
57.55
38%
-103
* C1 *
4O27
1
STK24_HUMAN
B:
[2-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
L
E
E
-----
A
E
D
E
I
E
--
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
-
D
-
L
L
E
P
G
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
-
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
E
---
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
--
T
Q
-
I
K
-
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
--
L
H
P
M
K
V
L
F
L
I
P
K
N
N
----
P
-------
P
T
----
L
E
G
-------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
-
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
64
PsiBlast_CBE
56.54
35%
-123
- C1 -
4USF
1
?
A:
[13-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
---
V
I
D
T
K
S
-----
E
E
E
L
E
D
--
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
-
A
-
V
M
L
E
L
E
RP-------
L
T
---
E
S
Q
I
Q
V
V
C
K
-
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
---
D
G
D
---
I
K
L
A
D
F
G
V
S
A
K
-----------------
T
P
Y
W
M
A
P
E
V
V
M
C
E---------
R
---
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
E
----
P
-------
P
T
----
L
A
Q
-------
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
-
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
-
63
PsiBlast_CBE
55.01
35%
-121
- C1 -
4USF
1
?
B:
[13-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
---
V
I
D
T
K
S
-----
E
E
E
L
E
D
--
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
-
A
-
V
M
L
E
L
E
R
P
-------
L
T
---
E
S
Q
I
Q
V
V
C
K
-
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
---
D
G
D
---
I
K
L
A
D
F
G
V
S
A
K
N
-------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCETS
K
-----
D
R
---
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
E
----
P
-------
P
T
----
L
A
Q
-------
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
-
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
A
E
-
81
PsiBlast_CBE
54.61
35%
-117
- C1 -
4NZW
1
STK25_HUMAN
B:
[17-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
---
I
I
D
L
E
E
-----
A
E
D
E
I
E
--
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
------
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
-
D
-
L
L
K
P
G
P
---------
L
E
---
E
T
Y
I
A
T
I
L
R
-
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
---
V
K
L
A
A
F
G
V
A
G
------------------
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-----
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
--
L
H
P
M
R
V
L
F
L
I
P
K
N
S
----
P
-------
P
T
----
L
E
G
-------
Q
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
70
PsiBlast_CBE
51.84
37%
-126
- C1 -
4USD
1
?
B:
[16-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
---
V
I
E
T
K
S
-----
E
E
E
L
E
D
--
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
-
A
-
I
M
L
E
L
D
R
G
-------
L
T
---
E
P
Q
I
Q
V
V
C
R
-
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
---
E
G
D
---
I
R
L
A
D
F
G
V
-------------------
G
T
P
Y
W
M
A
P
E
V
V
MC---------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
----
P
-------
P
T
----
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
80
PsiBlast_CBE
51.81
38%
-125
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[18-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
---
R
I
N
L
E
K
C----
Q
T
S
M
D
E
--
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
-
D
-
I
I
K
H
I
V
A
K
GEHKSGV
L
D
---
E
S
T
I
A
T
I
L
R
-
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
---
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG----------
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
--
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
----
P
-------
P
S
LETG
V
Q
D
KEM----
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
A
K
---------------
60
PsiBlast_CBE
50.74
37%
-114
- C1 -
4FZA
3
STK26_HUMAN
B:
[4-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
---
I
I
D
L
E
E
-----
A
E
D
E
I
E
--
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
-
D
-
L
L
R
A
G
P
---------
F
D
---
E
F
Q
I
A
T
M
L
K
-
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
---
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
--
T
Q
-
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
---
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
--
M
H
P
M
R
V
L
F
L
I
P
K
N
N
----
P
-------
P
T
----
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
-
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
78
PsiBlast_CBE
50.55
38%
-125
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[18-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
---
R
I
N
L
E
K
C----
Q
T
S
M
D
E
--
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
-
D
-
I
I
K
H
I
V
A
K
GEHKSGV
L
D
---
E
S
T
I
A
T
I
L
R
-
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
---
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
-------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
--
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
----
P
-------
P
S
LETG
V
Q
D
KEM----
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
A
K
---------------
56
PsiBlast_CBE
50.55
38%
-118
- C1 -
3GGF
1
STK26_HUMAN
B:
[19-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
---
I
I
D
L
E
E
-----
A
E
D
E
I
E
--
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
-
D
-
L
L
R
A
G
P
---------
F
D
---
E
F
Q
I
A
T
M
L
K
-
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
---
V
K
L
A
D
F
G
V
A
--------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
---
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
--
M
H
P
M
R
V
L
F
L
I
P
K
N
N
----
P
-------
P
T
----
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
-
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
77
PsiBlast_CBE
49.76
38%
-126
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[18-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
---
R
I
N
L
E
K
C----
Q
T
S
M
D
E
--
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
-
D
-
I
I
K
H
I
V
A
K
GEHKSGV
L
D
---
E
S
T
I
A
T
I
L
R
-
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
---
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
I
-
T
R
N---
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
--
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
----
P
-------
P
S
LETG
V
Q
D
KEM----
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
A
K
---------------
88
PsiBlast_CBE
49.42
37%
-117
- C1 -
4U43
1
M4K4_HUMAN
A:
[32-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
V
T
E
-----
D
E
E
E
E
I
--
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
-
D
-
L
V
K
N
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
-
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
E
---
V
K
L
V
D
F
G
V
---------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
----
P
-------
P
R
----
L
K
S
-------
K
K
W
S
K
K
F
F
S
-
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
-
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
79
PsiBlast_CBE
49.33
38%
-123
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[18-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
---
R
I
N
L
E
K
C----
Q
T
S
M
D
E
--
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
-
D
-
I
I
K
H
I
V
A
K
GEHKSGV
L
D
---
E
S
T
I
A
T
I
L
R
-
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
---
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
-----------
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
--
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
----
P
-------
P
S
LETG
V
Q
D
KEM----
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
A
K
---------------
96
PsiBlast_CBE
49.29
31%
-118
- C1 -
3MFR
1
CSKP_HUMAN
A:
[32-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
---
I
V
D
V
A
K
F
T
S
SP
G
L
S
T
E
D
--
L
K
R
-
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
-
I
V
K
R
A
D
A
G
F
------
V
Y
---
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
---
K
E
N
S
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
--
S
G
-
L
V
-
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-----
K
-----
R
E
---
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
----
N
-------
P
R
------
Q
-------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-
L
-
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
57
PsiBlast_CBE
49.21
38%
-118
- C1 -
3GGF
1
STK26_HUMAN
A:
[19-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
---
I
I
D
L
E
E
-----
A
E
D
E
I
E
--
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
-
D
-
L
L
R
A
G
P
---------
F
D
---
E
F
Q
I
A
T
M
L
K
-
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
---
V
K
L
A
D
F
G
V
A
-------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
---
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
--
M
H
P
M
R
V
L
F
L
I
P
K
N
N
----
P
-------
P
T
----
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
-
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
85
PsiBlast_CBE
49.18
37%
-121
- C1 -
4ZK5
2
?
A:
[32-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
V
T
E
-----
D
E
E
E
E
I
--
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
-
D
-
L
V
K
N
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
-
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
E
---
V
K
L
V
D
F
G
V
S
A
-------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
----
P
-------
P
R
----
L
K
S
-------
K
K
W
S
K
K
F
F
S
-
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
-
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
65
PsiBlast_CBE
48.83
38%
-127
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[23-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
---
R
I
N
L
E
K
C----
Q
T
S
M
D
E
--
L
L
K
-
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
-
D
-
I
I
K
H
I
V
A
K
GEHKSGV
L
D
---
E
S
T
I
A
T
I
L
R
-
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
S
---
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG--------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R--
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
----
P
-------
P
S
LETG
V
Q
D
KEM----
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
-
Q
K
A
K
N
K
E
------------
94
PsiBlast_CBE
48.66
31%
-114
- C1 -
3MFU
1
CSKP_HUMAN
A:
[32-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
---
I
V
D
V
A
K
F
T
SSP
G
L
S
T
E
D
--
L
K
R
-
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
-
I
V
K
R
A
D
A
G
F
------
V
Y
---
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
---
K
E
N
S
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
--
S
G
-
L
V
-
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-----
K
-----
R
E
---
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
----
N
-------
P
R
------
Q
-------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-
L
-
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
87
PsiBlast_CBE
48.66
37%
-117
- C1 -
4U44
2
M4K4_HUMAN
A:
[32-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
V
T
E
-----
D
E
E
E
E
I
--
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SH---
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
-
D
-
L
V
K
N
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
-
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
E
---
V
K
L
V
D
F
G
V
S
A
--------------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
----
P
-------
P
R
----
L
K
S
-------
K
K
W
S
K
K
F
F
S
-
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
-
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
58
PsiBlast_CBE
48.13
37%
-115
- C1 -
4FZF
1
?
B:
[4-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
---
I
I
D
L
E
E
-----
A
E
D
E
I
E
--
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
-
D
-
L
L
R
A
G
P
---------
F
D
---
E
F
Q
I
A
T
M
L
K
-
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
D
---
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
--
T
Q
-
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
---
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
--
M
H
P
M
R
V
L
F
L
I
P
K
N
N
----
P
-------
P
T
----
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
-
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
90
PsiBlast_CBE
47.57
37%
-124
- C1 -
4OBP
2
M4K4_HUMAN
A:
[32-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
V
T
E
-----
D
E
E
E
E
I
--
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KS----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
-
D
-
L
V
K
N
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
-
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
E
---
V
K
L
V
D
F
G
V
S
A
-------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
----
P
-------
P
R
----
L
K
S
-------
K
K
W
S
K
K
F
F
S
-
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
-
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
61
PsiBlast_CBE
47.22
35%
-115
- C1 -
2UV2
6
SLK_HUMAN
A:
[34-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
---
V
I
D
T
K
S
-----
E
E
E
L
E
D
--
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
-
A
-
V
M
L
E
L
E
R
P
-------
L
T
---
E
S
Q
I
Q
V
V
C
K
-
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
---
D
G
D
---
I
K
L
A
D
F
G
V
S
A
K
N
T
R
--
T
I
-
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
-----
D
R
---
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
E
----
P
-------
P
T
----
L
A
Q
-------
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
-
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
---
62
PsiBlast_CBE
46.97
35%
-111
- C1 -
2J51
5
SLK_HUMAN
A:
[34-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
---
V
I
D
T
K
S
-----
E
E
E
L
E
D
--
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
-
A
-
V
M
L
E
L
E
RP-------
L
T
---
E
S
Q
I
Q
V
V
C
K
-
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
---
D
G
D
---
I
K
L
A
D
F
G
V
S
A
K
N
T
R
--
T
I
-
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
-----
D
R
---
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
E
----
P
-------
P
T
----
L
A
Q
-------
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
-
T
V
D
S
N
K
P
I
R
E
L
I
A
E
A
K
---
86
PsiBlast_CBE
46.92
37%
-115
- C1 -
4U45
1
M4K4_HUMAN
A:
[32-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
V
T
E
-----
D
E
E
E
E
I
--
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPP--
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
-
D
-
L
V
K
N
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
-
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
E
---
V
K
L
V
D
F
G
V
S
A
-------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
----
P
-------
P
R
----
L
K
S
-------
K
K
W
S
K
K
F
F
S
-
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
-
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
95
PsiBlast_CBE
46.76
31%
-115
- C1 -
3MFS
1
CSKP_HUMAN
A:
[32-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
---
I
V
D
V
A
K
F
T
S
SP
G
L
S
T
E
D
--
L
K
R
-
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
------
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
-
I
V
K
R
A
D
A
G
F
------
V
Y
---
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
---
K
E
N
S
A
P
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
--
S
G
-
L
V
-
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-----
K
-----
R
E
---
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
----
N
-------
P
R
------
Q
-------
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-
L
-
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
91
PsiBlast_CBE
46.66
37%
-125
- C1 -
4OBO
2
M4K4_HUMAN
A:
[32-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
V
T
----------
E
I
--
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
-
D
-
L
V
K
N
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
-
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
E
---
V
K
L
V
D
F
G
---------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
----
P
-------
P
R
----
L
K
S
-------
K
K
W
S
K
K
F
F
S
-
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
-
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
83
PsiBlast_CBE
45.89
37%
-116
- C1 -
5D9H
1
?
B:
[26-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
---
R
I
N
L
E
K
C----
Q
T
S
M
D
E
--
L
L
K
-
E
I
Q
A
M
S
Q
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
-
D
-
I
I
K
Y
I
V
NRGEHKNGV
L
E
---
E
A
I
I
A
T
I
L
K
-
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
---
D
G
S
---
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
V
-
T
R
N-----
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R--
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
----
P
-------
P
T
----
L
E
T
GVEDKEM
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
-
F
-
Q
K
A
K
N
R
E
Y
L
I
E
K
L
L
T
----
89
PsiBlast_CBE
45.51
37%
-122
- C1 -
4OBQ
2
M4K4_HUMAN
A:
[32-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
V
-------------------
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
-
D
-
L
V
K
N
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
-
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
E
---
V
K
L
V
D
F
G
V
---------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
----
P
-------
P
R
----
L
K
S
-------
K
K
W
S
K
K
F
F
S
-
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
-
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
84
PsiBlast_CBE
45.02
37%
-114
- C1 -
5D9H
1
?
A:
[26-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
---
R
I
N
L
E
K
C----
Q
T
S
M
D
E
--
L
L
K
-
E
I
Q
A
M
S
Q
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
-
D
-
I
I
K
Y
I
V
N
R
GEHKNGV
L
E
---
E
A
I
I
A
T
I
L
K
-
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
---
D
G
S
---
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
GG
D
V
-
T
R
-----
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
--
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
--
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
----
P
-------
P
T
----
L
E
T
GVKEM--
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
-
F
-
Q
K
A
K
N
R
E
Y
L
I
E
K
L
L
-----
92
PsiBlast_CBE
44.52
37%
-121
- C1 -
4RVT
2
M4K4_HUMAN
A:
[34-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
V
T
---------
E
E
I
--
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
-
D
-
L
V
K
N
T
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
-
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
E
---
V
K
L
V
D
F
G
V
---------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
--
M
H
P
M
R
A
L
F
L
I
P
R
N
P
----
P
-------
P
R
----
L
K
S
-------
K
K
W
S
K
K
F
F
S
-
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
-
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
93
PsiBlast_CBE
44.27
32%
-121
- C1 -
3HZT
9
?
A:
[11-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
S
S
V
T
T
-----
T
S
N
S
G
A
--
L
L
D
-
E
V
A
V
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
------
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
-
D
E
I
I
L
R
Q
K
---------
F
S
---
E
V
D
A
A
V
I
M
K
-
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSR
D
A
L
---
I
K
I
V
D
F
G
L
S
A
H
F
----
E
V
G---------
T
A
Y
Y
I
A
P
E
V
L
-----------
R
K
---
K
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
--
Q
T
D
Q
E
I
L
K
R
V
E
K
G
K
FSFD
P
-------
P
-------
D
-------
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
A
L
N
H
P
W
-
I
-
V
K
F
C
S
Q
V
G
K
H
A
L
T
G
A
L
G
N
M
71
PsiBlast_CBE
44.02
37%
-119
- C1 -
4EQU
2
STK10_HUMAN
B:
[16-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
---
V
I
E
---------
E
E
L
E
D
--
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
-
A
-
I
M
L
E
L
D
R
G
-------
L
T
---
E
P
Q
I
Q
V
V
C
R
-
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
---
E
G
D
---
I
R
L
A
D
F
G
V
S
A
K
N
L
------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
---
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
----
P
-------
P
T
----
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
69
PsiBlast_CBE
42.75
37%
-117
- C1 -
4USE
1
?
A:
[16-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
---
V
I
E
T
K
S
-----
E
E
E
L
E
D
--
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
-
A
-
I
M
L
E
L
D
R
G
-------
L
T
---
E
P
Q
I
Q
V
V
C
R
-
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
---
E
G
D
---
I
R
L
A
D
F
G
V
S
A
K
N
L
K
--
T
L
-
Q
--------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
---
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
----
P
-------
P
T
----
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E
98
PsiBlast_CBE
41.19
31%
-122
- C1 -
2CN5
1
CHK2_HUMAN
A:
[24-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
---
I
I
S
K
R
------------N-
V
E
T
-
E
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
F
F
D
------
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
V
V
G
N
K
R
---------
L
K
---
E
A
T
C
K
L
Y
F
Y
-
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
---
I
K
I
T
D
F
G
H
-
S
K
I
L
G
--
E
T
-
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
-----
S
V
GTA
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
S
--
E
H
R
T
Q
V
--
S
L
K
D
Q
I
----
T
S
GKYNFI
P
E
----
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
-
100
PsiBlast_CBE
40.68
31%
-127
- C1 -
2YIR
1
CHK2_HUMAN
A:
[18-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
---
I
I
S
K
-------------LN
V
E
T
-
E
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
F
F
D
------
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
-
D
K
V
V
G
N
K
R
---------
L
K
---
E
A
T
C
K
L
Y
F
Y
-
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
L
---
I
K
I
T
D
F
G
H
-
S
K
I
L
G
--
E
T
-
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
-----
S
V
GTA
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
S
--
E
H
R
T
Q
V
--
S
L
K
D
Q
I
----
T
S
GKYNFI
P
E
----
V
---------
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
-
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
72
PsiBlast_CBE
40.17
37%
-122
- C1 -
4EQU
2
STK10_HUMAN
A:
[16-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
---
V
I
E
-----------
L
E
D
--
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
-
A
-
I
M
L
E
L
D
R
G
-------
L
T
---
E
P
Q
I
Q
V
V
C
R
-
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
---
E
G
D
---
I
R
L
A
D
F
G
V
S
A
K
N
L
-------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
---
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
--
L
N
P
M
R
V
L
L
K
I
A
K
S
D
----
P
-------
P
T
----
L
L
T
-------
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-
S
S
I
T
S
N
K
A
L
R
E
L
V
A
E
A
K
A
E