@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PASK_HUMAN: (2015-10-16 )
MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS
Atome Classification :
(81 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050........1060-.........1070......1080......1090......1100......1110......1120......1130...-...1140.......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEDGGLT
A
F
E
E
D
Q
R
C
L
S
QSLPLPVSAEGPAAQTTAEPSR
S
F
S
S
A
H
R
H
L
S
R
R
N
G
L
S
R
L
C
Q
S
R
TALS
E
D
R
W
S
S
Y
C
L
S
S
L
A
A
Q
N
I
C
TSKLHCPAAPEHTDPSEPRG
S
V
S
C
C
S
L
L
R
G
L
S
SGWSSPLLPAPVCNPN
K
A
I
F
T
VDA
K
T
T
E
I
L
V
ANDKACGLLGYS
S
Q
D
L
I
G
Q
K
L
T
Q
F
F
LRS
D
S
D
V
V
E
A
L
S
E
E
H
MEADG
H
A
A
V
V
F
G
T
V
V
D
I
I
SRSGEKI
P
V
S
V
W
M
K
R
M
R
Q
ERR
L
C
C
V
V
V
L
E
P
V
E
R
V
S
T
W
V
A
FQSDGTVT
S
C
D
S
L
F
A
H
L
H
G
YVSGEDV
A
G
Q
H
I
T
D
LIPSVQLPPSGQHIPKN
L
K
I
Q
R
SVGRARDG
T
T
F
P
L
S
L
K
LKSQPSSEEATTGEAAPVSG
Y
R
A
S
V
W
V
F
C
TI
S
G
L
I
T
LLPDGTIHGIN
H
S
F
A
L
T
L
F
GY
G
K
T
E
LLGKN
I
T
F
L
I
P
G
F
Y
S
Y
M
D
L
AYNSSLQL
P
D
L
A
S
C
L
DVGNESGCGERTLDPWQGQDPAEGGQD
P
R
I
N
V
V
L
AGGHVV
P
R
D
E
I
R
K
L
M
E
SQDIFTGTQ
T
E
L
IAGGQ
L
L
S
CLSPQPAPGVDNVPEGSLPVHGEQALPKDQ
Q
I
T
ALGREE
P
V
AIESP
G
Q
D
L
LGESRSEPVDVKPFASCEDSEAPVPAEDGGSDA
G
M
C
G
L
C
Q
K
A
Q
L
E
R
MGVSGPSGSDLWAGAAVAKPQAKGQLAGG
S
L
L
M
HCPCYGSEWG
L
W
W
RSQDLAPSPSGMAGLSFGTPTLDEPWLGVEN
D
R
E
E
L
Q
T
C
L
I
K
E
Q
L
S
Q
LSLAGALDVPHAELVPTEC
Q
A
VTAP
V
S
SCDLGGRDLCGGCTGSSS
A
C
Y
A
L
ATDLPGGLEA
V
E
A
QEVDVNSFS
W
N
L
K
E
L
FFSDQTDQTSSNCSC
A
T
S
E
L
RETPSSLAVGSDPDVG
S
L
Q
EQG
S
C
V
LDDR
E
L
L
L
L
T
GTCVDLGQG
R
R
F
R
E
S
CVGHDPTE
P
L
E
V
C
L
VSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEE
P
R
L
N
V
Q
V
TST
P
V
I
V
M
RGAA
G
L
Q
R
E
I
Q
EGAYSG
S
C
Y
H
RD
G
L
R
L
S
I
Q
F
E
V
R
R
V
E
LQGP
T
P
L
F
C
C
W
L
V
K
D
L
L
H
SQRDS
A
A
R
T
R
L
F
L
ASLPGSTHS
T
A
A
ELT
G
P
S
L
V
E
V
L
R
ARPWFEEPPK
A
V
E
LE
G
L
AACEG
E
Y
SQKYSTMSPLGSGA
F
G
F
V
W
T
AVDKEK
N
K
E
V
V
V
K
F
I
K
K
E
K
V
L
E
D
CWIEDPKL
G
K
V
T
--
L
E
I
A
I
L
S
RVE----HA
N
I
I
K
V
L
D
I
FENQ
G
F
F
Q
L
V
M
E
KHGSGL
D
L
F
A
F
I
DRHPRLD
E
P
L
A
S
Y
I
F
R
Q
L
V
S
A
V
G
Y
L
R
L
K
D
I
I
H
RDIKDE
N
I
V
I
-AED
F
-
T
I
K
L
I
DFG
S
A
A
Y
L
ERG
K
L
F
Y
T
F
CG
T
I
E
YCA
P
E
VLMGNPYRGPE
L
E
M
W
S
L
G
V
T
L
Y
T
L
V
FEENPFC
E
L
E
E
T
V
E
A
AIHP
P
Y
L
V
S
K
E
L
M
S
L
V
S
G
L
LQPVP
E
R
R
T
T
L
E
K
LVTDPWVTQPVN
L
A
D
Y
T
W
E
E
V
F
RVNKPESGV
L
S
A
A
S
LEMGN
R
S
L
S
D
V
A
Q
A
Q
E
LCGGPVPGEAPNGQGCLHPGDPRLLTS
52
PsiBlast_CBE
65.84
34%
-98
- C1 -
3R02
4
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
102
PsiBlast_CBE
65.60
34%
-94
- C1 -
3F2A
1
PIM1_HUMAN
A:
[24-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
S
------------------------------------------------------
105
PsiBlast_CBE
65.15
34%
-96
- C1 -
4N6Z
4
PIM1_HUMAN
A:
[52-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
69
PsiBlast_CBE
64.67
34%
-97
- C1 -
4MTA
2
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
108
PsiBlast_CBE
64.22
34%
-94
- C1 -
3DCV
1
PIM1_HUMAN
A:
[52-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
96
PsiBlast_CBE
63.91
34%
-99
- C1 -
2XIY
3
PIM1_HUMAN
A:
[25-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
56
PsiBlast_CBE
63.90
34%
-99
- C1 -
3CXW
1
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
--
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
95
PsiBlast_CBE
63.72
34%
-99
- C1 -
2XIZ
1
PIM1_HUMAN
A:
[25-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
93
PsiBlast_CBE
63.50
34%
-96
- C1 -
2XJ2
1
PIM1_HUMAN
A:
[25-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
78
PsiBlast_CBE
63.34
34%
-93
- C1 -
2J2I
1
PIM1_HUMAN
B:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
64
PsiBlast_CBE
63.30
34%
-97
- C1 -
1YXU
2
PIM1_HUMAN
C:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
99
PsiBlast_CBE
63.20
34%
-94
- C1 -
3BGQ
1
PIM1_HUMAN
A:
[57-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
86
PsiBlast_CBE
63.20
34%
-98
- C1 -
3C4E
2
PIM1_HUMAN
D:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
31
PsiBlast_CBE
63.04
34%
-93
- C1 -
4ALW
3
PIM1_HUMAN
A:
[52-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
67
PsiBlast_CBE
62.94
34%
-95
- C1 -
1YXT
1
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
27
PsiBlast_CBE
62.79
35%
-102
- C1 -
4X7Q
1
PIM2_HUMAN
A:
[33-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
----
R
L
Q
V
A
I
K
V
I
P
R
--------------------
L
E
V
A
L
L
W
K
V
G
----
H
P
G
V
I
R
L
L
D
W
F
-----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
G
-
C
A
K
L
I
D
F
G
S
G
A
-----------
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
Q
E
I
L
E
A
E
L
H
F
P
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
-----------------------------------------------------------------------
84
PsiBlast_CBE
62.65
34%
-94
- C1 -
4K0Y
1
PIM1_HUMAN
A:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
76
PsiBlast_CBE
62.65
34%
-96
- C1 -
2BZH
2
PIM1_HUMAN
B:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
54
PsiBlast_CBE
62.65
34%
-95
- C1 -
3R00
2
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
46
PsiBlast_CBE
62.56
34%
-95
- C1 -
3VC4
2
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
66
PsiBlast_CBE
62.45
34%
-95
- C1 -
1YXU
2
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
101
PsiBlast_CBE
62.38
34%
-92
- C1 -
2OBJ
1
PIM1_HUMAN
A:
[57-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
63
PsiBlast_CBE
62.36
34%
-93
- C1 -
1YXU
2
PIM1_HUMAN
D:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
91
PsiBlast_CBE
62.34
34%
-95
- C1 -
4AS0
1
PIM1_HUMAN
A:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
80
PsiBlast_CBE
62.34
34%
-92
- C1 -
3JYA
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
51
PsiBlast_CBE
62.30
34%
-94
- C1 -
3R04
4
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
44
PsiBlast_CBE
62.19
34%
-100
- C1 -
3UMW
2
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
----
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
----------------------------------------------------------
42
PsiBlast_CBE
62.14
34%
-100
- C1 -
4ENY
3
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
-
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
------
R
V
P
--
M
E
V
V
L
L
K
K
V
S
S---
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
29
PsiBlast_CBE
62.10
34%
-90
- C1 -
1XR1
1
PIM1_HUMAN
A:
[24-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
S
------------------------------------------------------
33
PsiBlast_CBE
62.07
34%
-96
- C1 -
4WT6
2
PIM1_HUMAN
A:
[14-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
94
PsiBlast_CBE
62.06
34%
-95
- C1 -
2XJ1
1
PIM1_HUMAN
A:
[25-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
30
PsiBlast_CBE
62.05
34%
-93
- C1 -
4JX7
1
PIM1_HUMAN
A:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
98
PsiBlast_CBE
61.85
34%
-94
- C1 -
4BZN
1
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
61
PsiBlast_CBE
61.82
34%
-97
- C1 -
1YXX
2
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
34
PsiBlast_CBE
61.77
34%
-95
- C1 -
4WSY
2
PIM1_HUMAN
A:
[14-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
79
PsiBlast_CBE
61.68
34%
-93
- C1 -
4XH6
1
?
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
55
PsiBlast_CBE
61.68
34%
-98
- C1 -
3CY2
2
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
--
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
43
PsiBlast_CBE
61.62
34%
-97
- C1 -
4ENX
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
---
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
62
PsiBlast_CBE
61.56
34%
-96
- C1 -
1YXV
2
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
49
PsiBlast_CBE
61.54
34%
-97
- C1 -
3VBV
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
---
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
106
PsiBlast_CBE
61.53
34%
-95
- C1 -
4N6Y
1
PIM1_HUMAN
A:
[52-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
83
PsiBlast_CBE
61.49
34%
-90
- C1 -
4K18
1
PIM1_HUMAN
A:
[6-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
S
------------------------------------------------------
36
PsiBlast_CBE
61.47
34%
-97
- C1 -
4TY1
2
PIM1_HUMAN
A:
[14-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
107
PsiBlast_CBE
61.43
34%
-93
- C1 -
3T9I
1
PIM1_HUMAN
A:
[52-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
35
PsiBlast_CBE
61.37
34%
-94
- C1 -
4WRS
3
PIM1_HUMAN
A:
[14-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
28
PsiBlast_CBE
61.31
35%
-95
- C1 -
2IWI
1
PIM2_HUMAN
B:
[29-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
A
E
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
-----------------
T
CP
L
E
V
A
L
L
W
K
V
G
AGGG
H
P
G
V
I
R
L
L
D
W
F
E
----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
G
-
C
A
K
L
I
D
F
G
S
G
A
L
L
H
-
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
Q
E
I
L
E
A
E
L
H
F
P
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
-----------------------------------------------------------------------
19
PsiBlast_PDB
61.28
34%
-93
- C1 -
2XJ0
1
PIM1_HUMAN
A:
[25-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
-------------------------------------------------------
100
PsiBlast_CBE
61.16
34%
-93
- C1 -
3BGP
1
PIM1_HUMAN
A:
[57-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
97
PsiBlast_CBE
61.05
34%
-93
- C1 -
4BZO
1
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
87
PsiBlast_CBE
60.97
34%
-93
- C1 -
3C4E
2
PIM1_HUMAN
C:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
53
PsiBlast_CBE
60.96
34%
-93
- C1 -
3R01
3
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
58
PsiBlast_CBE
60.95
34%
-96
- C1 -
2O64
3
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
72
PsiBlast_CBE
60.71
34%
-91
- C1 -
2OI4
5
PIM1_HUMAN
X:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
16
PsiBlast_PDB
60.64
35%
-95
- C1 -
4X7Q
1
PIM2_HUMAN
B:
[29-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
A
E
Y
R
L
G
P
L
L
G
K
G
-
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
------------------CP
L
E
V
A
L
L
W
K
V
G
AGGG
H
P
G
V
I
R
L
L
D
W
F
E
T
---
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
G
-
C
A
K
L
I
D
F
G
S
G
A
L
L
H
-
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
Q
E
I
L
E
A
E
L
H
F
P
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
-----------------------------------------------------------------------
60
PsiBlast_CBE
60.56
34%
-95
- C1 -
2O3P
3
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
65
PsiBlast_CBE
60.52
34%
-95
- C1 -
1YXU
2
PIM1_HUMAN
B:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
41
PsiBlast_CBE
60.52
34%
-91
- C1 -
3JPV
1
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
104
PsiBlast_CBE
60.42
34%
-97
- C1 -
4N70
1
PIM1_HUMAN
A:
[52-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
81
PsiBlast_CBE
60.38
34%
-95
- C1 -
3JY0
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
-------------------------------------------------------
13
PsiBlast_PDB
60.33
34%
-88
- C1 -
4RPV
1
PIM1_HUMAN
A:
[134-387]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
92
PsiBlast_CBE
60.23
34%
-90
- C1 -
3WE8
1
PIM1_HUMAN
A:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
18
PsiBlast_PDB
60.09
34%
-93
- C1 -
3A99
1
PIM1_HUMAN
A:
[44-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
40
PsiBlast_CBE
60.00
34%
-92
- C1 -
3QF9
1
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
89
PsiBlast_CBE
59.89
34%
-96
- C1 -
3C4E
2
PIM1_HUMAN
A:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
82
PsiBlast_CBE
59.85
34%
-93
- C1 -
3JXW
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
39
PsiBlast_CBE
59.81
34%
-92
- C1 -
4GW8
2
PIM1_HUMAN
A:
[38-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
75
PsiBlast_CBE
59.76
34%
-92
- C1 -
2BZJ
1
PIM1_HUMAN
A:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
57
PsiBlast_CBE
59.74
34%
-86
- C1 -
2O65
2
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
73
PsiBlast_CBE
59.71
34%
-96
- C1 -
2C3I
1
PIM1_HUMAN
B:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
---
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
47
PsiBlast_CBE
59.62
34%
-95
- C1 -
3VBX
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
---
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
32
PsiBlast_CBE
59.62
34%
-93
- C1 -
4ALV
2
PIM1_HUMAN
A:
[52-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
59
PsiBlast_CBE
59.47
34%
-94
- C1 -
2O63
4
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
85
PsiBlast_CBE
59.45
34%
-93
- C1 -
4K1B
1
PIM1_HUMAN
A:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
71
PsiBlast_CBE
59.43
34%
-93
- C1 -
3BWF
1
PIM1_HUMAN
A:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
45
PsiBlast_CBE
59.14
34%
-95
- C1 -
3UIX
2
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
---
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
15
PsiBlast_PDB
58.93
35%
-96
- C1 -
2IWI
1
PIM2_HUMAN
A:
[33-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
N
R
V
L
------------
V
T
CP
L
E
V
A
L
L
W
K
V
G
AGGG
H
P
G
V
I
R
L
L
D
W
F
-----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
G
-
C
A
K
L
I
D
F
G
S
G
A
L
L
H
-
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
Q
E
I
L
E
A
E
L
H
F
P
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
T
----------------------------------------------------------------------
88
PsiBlast_CBE
58.72
34%
-95
- C1 -
3C4E
2
PIM1_HUMAN
B:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
74
PsiBlast_CBE
57.54
34%
-90
- C1 -
2BZK
1
PIM1_HUMAN
B:
[37-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
-----
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
G
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
48
PsiBlast_CBE
57.53
34%
-97
- C1 -
3VBW
1
PIM1_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
----
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
---
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------
70
PsiBlast_CBE
56.58
34%
-92
- C1 -
4MBI
1
PIM1_HUMAN
A:
[9-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
P
N
G
T
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
--------------------------------------------------------
103
PsiBlast_CBE
51.20
34%
-76
* C1 *
4XHK
1
PIM1_HUMAN
B:
[39-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
--
W
G
E
L
----
R
V
P
--
M
E
V
V
L
L
K
K
V
S
SG--
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
-
D
L
N
R
G
E
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
E
E
I
I
R
G
Q
V
F
F
R
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
---------------------------------------------------------