@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PDPK1_HUMAN: (2015-10-16 )
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ
Atome Classification :
(50 SA)
.........10........20........30........40........50........60........70........80........90........100---.---......110.......120-.-......130.-...-...140.......150.......160.......170.......180.......190......-.200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.--.-.....360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAR
T
T
S
Q
L
YDAVPIQS
S
V
V
L
C
SCPSPS
M
V
R
TQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKF
G
K
I
LGEGS
F
S
T
V
V
L
A
R
E
L
---A---T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
KEN-K-V
P
Y
V
T
R
E
R
D
V
-
M
S
R-LDH
P
F
F
V
K
L
Y
F
T
FQDD
E
K
L
Y
F
G
L
SYAKN
G
E
L
L
K
Y
I
R
K
IGS
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
HG-KG
I
I
HRDLKPE
N
I
L
LNED
M
H
I
Q
I
TDFGTAKVLSPE
S
K
Q
ARANSFVGTAQYV
S
P
E
L
L
T
E
K
SACKSSD
L
W
A
L
G
C
I
I
Y
Q
L
V
AGLPPFRAGN
E
Y
L
I
F
Q
K
I
I
K
L
EYDF
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
RLG
C
E
E
M
EGYGPLKAHP
F
F
E
SV
T
W
E
N
L
HQQ--T-PP
K
L
T
A
YLPAMSED
D
E
D
CYG
N
Y
D
N
L
L
S
QFG
C
M
Q
VSSSSSSHSLSASDTGLPQRSGS
N
I
E
Q
Y
I
H
DLDSN
S
F
E
L
D
L
Q
FSED
E
K
R
L
L
L
EKQAGG
N
P
W
H
Q
F
V
EN
N
L
I
L
KMGP
V
D
K
R
K
G
L
F
A
R
R
R
Q
L
L
LTEGP
H
L
Y
Y
VD
P
V
N
K
VLKGEIPWSQELRPEAKN
F
K
T
F
F
V
HTP
N
R
T
Y
Y
L
MDPSG
N
A
H
K
W
C
R
K
I
Q
E
V
W
R
Q
R
Y
QSHPDAAVQ
6
PsiBlast_PDB
91.57
99%
-115
- C2 -
3QCX
6
PDPK1_HUMAN
A:
[26-311]
------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.37
100%
-120
- C2 -
3ION
1
PDPK1_HUMAN
A:
[28-312]
--------------------------------------------------------------------------
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-----------
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
91.10
99%
-113
- C2 -
3QD3
3
PDPK1_HUMAN
A:
[24-311]
----------------------------------------------------------------------
P
P
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.07
100%
-116
- C2 -
2R7B
2
PDPK1_HUMAN
A:
[28-312]
--------------------------------------------------------------------------
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
-----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
91.00
99%
-118
- C2 -
3IOP
1
PDPK1_HUMAN
A:
[28-312]
--------------------------------------------------------------------------
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
90.92
99%
-115
- C2 -
3QCS
5
PDPK1_HUMAN
A:
[26-311]
------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
90.74
99%
-112
- C2 -
1H1W
9
PDPK1_HUMAN
A:
[1-289]
----------------------------------------------------------------------
P
P
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
----
A
R
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.74
99%
-112
- C2 -
3QCY
5
PDPK1_HUMAN
A:
[26-311]
------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-----------
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
90.66
99%
-113
- C2 -
3RWP
5
PDPK1_HUMAN
A:
[25-311]
------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
90.57
99%
-112
- C2 -
3PWY
1
PDPK1_HUMAN
A:
[23-311]
----------------------------------------------------------------------
P
P
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
C
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
--------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
S
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
90.44
99%
-108
- C2 -
3HRF
4
PDPK1_HUMAN
A:
[27-311]
--------------------------------------------------------------------------
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
K
Q
A
R
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
I
F
A
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
90.42
99%
-113
- C2 -
3QD4
1
PDPK1_HUMAN
A:
[24-311]
----------------------------------------------------------------------
P
P
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
90.20
99%
-114
- C2 -
3SC1
3
PDPK1_HUMAN
A:
[25-311]
------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
--------
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
89.99
99%
-111
- C2 -
2XCH
7
PDPK1_HUMAN
A:
[23-309]
------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
--------
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
89.96
99%
-115
- C2 -
2PE2
9
PDPK1_HUMAN
A:
[1-286]
-------------------------------------------------------------------------
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
89.93
99%
-112
- C2 -
2PE0
4
PDPK1_HUMAN
A:
[1-286]
-------------------------------------------------------------------------
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
89.90
99%
-113
- C2 -
1Z5M
4
PDPK1_HUMAN
A:
[1-286]
-------------------------------------------------------------------------
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.75
99%
-116
- C2 -
3QCQ
5
PDPK1_HUMAN
A:
[26-311]
------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
89.73
99%
-112
- C2 -
3HRC
1
PDPK1_HUMAN
A:
[28-311]
---------------------------------------------------------------------------
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
----
A
R
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
I
F
A
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
89.57
100%
-118
- C2 -
3NAX
1
PDPK1_HUMAN
A:
[25-309]
---------------------------------------------------------------------------
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
K
Q
A
R
A
-------
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
89.56
99%
-114
- C2 -
2PE1
5
PDPK1_HUMAN
A:
[1-286]
-------------------------------------------------------------------------
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
89.40
99%
-113
- C2 -
2XCK
5
PDPK1_HUMAN
A:
[26-309]
---------------------------------------------------------------------------
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
T
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
--------
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
89.40
99%
-107
- C2 -
3RWQ
4
PDPK1_HUMAN
A:
[24-311]
-----------------------------------------------------------------------
P
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
----
A
R
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
89.38
99%
-109
- C2 -
1UVR
8
PDPK1_HUMAN
A:
[1-289]
----------------------------------------------------------------------
P
P
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
----
A
R
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
89.03
99%
-111
- C2 -
3RCJ
1
PDPK1_HUMAN
A:
[29-310]
----------------------------------------------------------------------------
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
K
Q
A
R
A
N
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
G
L
I
F
A
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.50
99%
-110
- C2 -
3QD0
6
PDPK1_HUMAN
A:
[26-311]
------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
---
A
---
T
S
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
N
-
K
-
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
-
L
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
-
P
P
K
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
67.92
37%
-104
- C2 -
4EJN
3
AKT1_HUMAN
A:
[145-430]
----------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
---------------
V
-
L
Q
N
-
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-------
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K-
L
-
S
P
---
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
HHSearch
66.96
37%
-99
- C2 -
1RDQ
3
KAPCA_MOUSE
E:
[36-319]
--------------------------------------------------------------------------
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
---
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
-
Q
-
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
-----
R
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
--
K
-
V
E
--
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
66.03
37%
-98
- C2 -
2F7E
1
KAPCA_BOVIN
E:
[34-309]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
-
Q
-
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
--
K
-
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
65.91
37%
-102
- C2 -
2OH0
1
KAPCA_BOVIN
E:
[34-309]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
-
Q
-
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
--
K
-
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
65.50
37%
-104
- C2 -
2UZT
1
KAPCA_BOVIN
A:
[19-294]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
-
Q
-
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
--
K
-
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
65.27
37%
-100
- C2 -
2OJF
1
KAPCA_BOVIN
E:
[34-309]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
-
Q
-
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
--
K
-
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
65.18
37%
-100
- C2 -
2UZU
1
KAPCA_BOVIN
E:
[19-294]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
-
Q
-
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
--
K
-
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
64.96
37%
-98
- C2 -
2F7X
1
KAPCA_BOVIN
E:
[34-309]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
-
Q
-
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
--
K
-
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
64.69
37%
-104
- C2 -
2F7Z
1
KAPCA_BOVIN
E:
[34-309]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
-
Q
-
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
--
K
-
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
63.92
37%
-97
- C2 -
2UZW
1
KAPCA_BOVIN
E:
[19-294]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
-
Q
-
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-----
K
G
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
--
K
-
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
83
HHSearch
63.91
37%
-101
* C2 *
4GV1
5
AKT1_HUMAN
A:
[5-290]
----------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
-
E
-
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
--
K
L
S
P
---
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
S
M
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
----------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
63.08
37%
-90
- C2 -
4L3L
1
KS6B1_HUMAN
A:
[14-289]
---------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
---
T
GAN
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
D
T
A
H
T
K
A
E
R
N
I
-
L
E
E
-
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
D
G
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
--
K
-
V
E
P
P
F
K
P
L
L
Q
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
62.61
38%
-91
- C2 -
3A60
1
KS6B1_HUMAN
B:
[13-288]
---------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
---
T
GAN
T
G
K
I
F
A
M
K
V
L
K
K
--------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
----------
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
--
K
-
V
E
P
P
F
K
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
62.41
37%
-93
- C2 -
4L3J
1
KS6B1_HUMAN
A:
[14-289]
---------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
---
T
GAN
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
D
T
A
H
T
K
A
E
R
N
I
-
L
E
E
-
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
D
G
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
--
K
-
V
E
P
P
F
K
P
L
L
Q
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
HHSearch
62.33
40%
-104
- C2 -
2R5T
1
SGK1_HUMAN
A:
[34-320]
---------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
-
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
--
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K-
I
-
T
P
---
P
F
N
P
N
V
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
62.32
40%
-101
- C2 -
2R5T
1
SGK1_HUMAN
A:
[29-313]
---------------------------------------------------------------------
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
-
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
KI
T
-
P
P
F
N
P
N
V
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
61.05
37%
-92
- C2 -
4L42
1
KS6B1_HUMAN
A:
[13-289]
--------------------------------------------------------------------------
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
---
T
GAN
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
-
K
D
T
A
H
T
K
A
E
R
N
I
-
L
E
E
-
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
S
I
H
D
G
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
--
K
-
V
E
P
P
F
K
E
M
F
R
D
F
E
Y
I
A
D
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
HHSearch
60.89
38%
-87
- C2 -
3WF7
2
KS6B1_HUMAN
A:
[13-293]
-------------------------------------------------------------------------
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
-
T
A
H
T
K
A
E
R
N
I
-
L
E
E
-
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
-----
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
--
K
-
V
E
P
P
F
K
P
L
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
60.63
40%
-100
- C2 -
3HDN
1
SGK1_HUMAN
A:
[29-313]
---------------------------------------------------------------------
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
-
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
KI
T
-
P
P
F
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
60.42
38%
-99
- C2 -
3A61
1
KS6B1_HUMAN
A:
[15-288]
-----------------------------------------------------------------------------
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
---
T
GAN
T
G
K
I
F
A
M
K
V
L
K
----------------
A
E
R
N
I
-
L
E
E
-
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
--
K
-
V
E
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
60.26
40%
-97
- C2 -
3HDM
1
SGK1_HUMAN
A:
[29-313]
---------------------------------------------------------------------
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
---
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
-
L
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
KI
T
-
P
P
F
N
P
N
V
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
60.12
38%
-94
- C2 -
3A60
1
KS6B1_HUMAN
A:
[13-288]
---------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
---
T
GAN
T
G
K
I
F
A
M
K
V
L
K
K
A
M
------------
K
A
E
R
N
I
-
L
E
E
-
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
-------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
--
K
-
V
E
P
P
F
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
HHSearch
58.82
38%
-93
- C2 -
1XJD
1
A:
[16-284]
------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
---
K
---
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
D
-
D
-
V
E
C
T
M
V
E
K
R
V
-
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
--
D
A
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
G
-----
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
--
E
-
I
D
P
Q
N
M
F
R
N
F
S
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
27.97
37%
21
- C2 -
2UZV
1
KAPCA_BOVIN
A:
[19-294]
-----------------------------------------------------------------------
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
-
Q
-
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
N
F
P
F
L
V
K
L
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