@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PHKG2_HUMAN: (2015-10-16 )
MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGHWVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG
Atome Classification :
(46 SA)
.........-10........20.....-...30........40........50........-60---.........70...-.....80........90........----100.......110.......120--------------------------------------.----......130.......140.......150.......-160-.---..---.--.----.----...170......-.---180-..-.--..-..190.......200........210.......220.......230.....-..----240-.........250.......260.......270.......280.......290-----......-----------...--300-----.........310.......320.......330.......340.......350.......360.......370.......380.......390.......400....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTLDVGPED-ELP
D
W
A
A
A
K
E
F
Y
Q
KYD
P
-
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
AT
G
H
E
F
A
V
K
I
M
E
V
T
A
-
E
----RL
S
P
E
Q
L
E
E
V
R
E
A
T
-
R
R
E
T
H
I
L
R
Q
VAGHP
H
I
I
T
L
I
DSYES----S
S
F
M
F
L
V
F
D
L
M
RK
G
E
L
F
D
Y
L
T
E
K
--------------------------------------V----AL
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
ANNIVHRDLKPE
N
I
-
L
---L---DD---N--
M
----
Q
----
I
R
L
SDF
G
F
S
C
HL-E---
P
G
E
-
K
L
-
R
--
E
L
-CGTPG
Y
L
A
P
E
I
L
K
-CSMDETHPGYGKE
V
D
L
W
A
C
G
V
I
L
F
T
L
LAGSPP
F
W
H
R
R
-
Q
I
----
L
---
M
L
R
M
I
MEG
Q
Y
QFSSPEWDD
R
S
S
T
V
K
D
L
I
S
R
L
LQVDPEARL
T
A
E
Q
A
L
Q
H
P
F
-------
F
E
RCEG-----------SQP--W-------NL
T
P
R
Q
R
F
R
V
A
V
W
T
V
L
AA
G
R
V
A
LSTHRVRPLTKNALLR
D
P
Y
A
L
R
S
V
R
H
L
I
D
N
C
A
F
R
L
Y
G
H
W
V
KKGEQQ
N
R
A
A
L
FQHRPPGPFPIMGPEEEGDSAAITED
E
A
V
L
V
LG
22
PsiBlast_CBE
94.79
99%
-133
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[82-365]
----------
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
-
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
-
E
----
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
-
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
--------------------------------------
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
N
--
M
----
Q
----
I
R
L
S
D
F
G
F
S
C
H
L
-
E
---
P
G
E
-
K
L
-
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
-
Q
I
----
L
---
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-------
F
E
R
-------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.04
99%
-130
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[82-365]
----------
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
-
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
--------
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
-
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
--------------------------------------
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
N
--
M
----
Q
----
I
R
L
S
D
F
G
F
S
C
H
L
-
E
---
P
G
E
-
K
L
-
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
-
Q
I
----
L
---
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-------
F
E
R
-------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
92.41
99%
-132
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[82-365]
----------
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
-
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
-
E
----
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
-
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
--------------------------------------
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
N
--
M
----
Q
----
I
R
L
S
D
F
G
F
S
C
H
L
-
E
---
P
G
E
-
K
L
-
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
-
Q
I
----
L
---
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-------
F
E
R
-------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.41
99%
-132
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[82-365]
----------
E
L
P
D
W
A
A
A
K
E
F
Y
Q
K
Y
D
P
-
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
-
E
----
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
-
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
--------------------------------------
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
N
--
M
----
Q
----
I
R
L
S
D
F
G
F
S
C
H
L
-
E
---
P
G
E
-
K
L
-
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
-
Q
I
----
L
---
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-------
F
E
R
-------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.05
69%
-134
- C1 -
2PHK
2
PHKG1_RABIT
A:
[2-276]
--------------------
F
Y
E
N
Y
E
P
-
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
-
G
G---
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
-
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
----
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
--------------------------------------
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
D
--
M
----
N
----
I
K
L
T
D
F
G
F
S
C
Q
L
-
D
---
P
G
E
-
K
L
-
R
--
E
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
-
Q
M
----
L
---
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
-------
F
Q
Q
Y
------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.17
67%
-127
- C1 -
1PHK
1
PHKG1_RABIT
A:
[15-289]
--------------------
F
Y
E
N
Y
E
P
-
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
-
G
G---
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
-
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
----
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
--------------------------------------
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
D
--
M
----
N
----
I
K
L
T
D
F
G
F
S
C
Q
L
-
D
---
P
G
E
-
K
L
-
R
--
E
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
-
Q
M
----
L
---
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
-------
F
Q
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
82.56
65%
-127
- C1 -
1PHK
1
PHKG1_RABIT
A:
[15-291]
--------------------
F
Y
E
N
Y
E
P
-
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
G
----
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
-
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
----
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
--------------------------------------
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
D
--
M
----
N
----
I
K
L
T
D
F
G
F
S
C
Q
L
-
D
---
P
G
E
-
K
L
-
R
--
E
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
-
Q
M
----
L
---
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
-------
F
Q
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.45
67%
-124
- C1 -
1QL6
1
PHKG1_RABIT
A:
[11-289]
----------------
S
T
H
G
F
Y
E
N
Y
E
P
-
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
-
G
G---
S
F
S
A
E
E
V
Q
E
L
R
E
A
T
-
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
----
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
--------------------------------------
V
----
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
D
D
---
D
--
M
----
N
----
I
K
L
T
D
F
G
F
S
C
Q
L
-
D
---
P
G
E
-
K
L
-
R
--
S
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
-
Q
M
----
L
---
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
-------
F
Q
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.06
40%
-134
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[10-276]
--------------
W
K
Q
A
E
D
I
R
D
I
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
------------
I
A
K
E
-----------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--------------------------------------
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
-
L
YYS
L
---
D
E
---
D
--
S
----
K
----
I
M
I
S
D
F
--------------------------
T
P
G
Y
V
A
P
E
V
L
-------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
A
----
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-------
I
A
G
D
T
A
-----------
L
D
K
--
N
-------
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
--------------------------------------------------------------------------------------------
106
PsiBlast_CBE
58.75
37%
-119
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[14-283]
------------------------
Y
D
I
-
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
-
S
----
R
A
S
R
R
G
V
S
--
R
E
E
I
-
E
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--------------------------------------
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
K
---
N
--
I
P
I
P
-
H
----
I
K
L
I
D
F
G
L
A
H
E
I
-
E
---
D
G
V
-
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
----
E
---
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-------
I
T
P
V
D
N
-----------
Q
Q
A
--
M
-------
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-----------------------------------------------------------------------------------------
14
PsiBlast_PDB
58.73
38%
-110
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[15-304]
------
T
E
N
L
Y
F
Q
S
M
A
T
C
T
R
F
T
D
D
Y
Q
L
-
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
--
I
N
T
-
K
----
K
L
S
A
R
D
H
Q
K
L
E
-----
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--------------------------------------
E
----
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
A
S
---
K
--
C
----
K
GAA-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
----
G
E
-
Q
Q
-
A
WF
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
----
K
---
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
-------
V
--
C
Q
R
-----------
S
T
V
--
A
-------
S
M
M
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
-----------------------------------------------------------------------------------
131
HHSearch
57.98
37%
-105
- C1 -
3C0I
1
CSKP_HUMAN
A:
[21-317]
-------------------
L
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
-
F
T
S
SP
G
L
S
T
E
-------
D
L
-
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--------------------------------------
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
---
A
S
---
K
--
E
----
N
S
A
P
-
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
---
E
S
G
L
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-
R
------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
-----
R
---
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-------
L
K
E
R
D
R
YAYKIHL
P
E
T
V
E
Q
L
--
R
-------
K
F
N
A
R
R
K
---------------------------------------------------------------------------------------------------
146
HHSearch
57.94
32%
-116
- C1 -
3LM5
1
ST17B_HUMAN
A:
[22-299]
----------------
S
M
E
N
F
N
N
F
Y
I
L
T
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
R
-
R
----
G
--
Q
----
D
C
R
A
E
I
-
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
----
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
L-------------------------------------
E
----
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
---
L
---
S
S
IYP
L
--
G
----
D
----
I
K
I
V
D
F
G
M
S
R
K
I
------------------
M
G
T
P
E
Y
L
A
P
E
I
L
N
-
Y
------
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
-
N
Q
----
E
---
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
-------
L
Q
Q
W
D
F
-----------
E
N
L
--------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
57.93
37%
-121
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[14-283]
------------------------
Y
D
I
-
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
-
S
----
R
A
S
R
R
G
V
S
--
R
E
E
I
-
E
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--------------------------------------
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
K
---
N
--
I
P
I
P
-
H
----
I
K
L
I
D
F
G
L
A
H
E
I
-
E
---
D
G
V
-
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
----
E
---
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-------
I
T
P
V
D
N
-----------
Q
Q
A
--
M
-------
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-----------------------------------------------------------------------------------------
28
PsiBlast_CBE
57.43
40%
-122
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[6-277]
---------------------
Y
Q
L
Y
E
D
----
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
-
K
----
K
L
S
A
R
D
H
Q
K
L
-----
E
R
E
A
R
I
C
R
-
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--------------------------------------
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
A
S
---
K
--
C
----
K
GAA-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
---
G
D
Q
-
Q
A
W
F
--
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
----
K
---
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
-------
V
--
C
Q
R
-----------
S
T
V
--
A
-------
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
------------------------------------------------------------------------------------
103
PsiBlast_CBE
56.91
37%
-119
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[14-283]
------------------------
Y
D
I
-
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
-
S
----
R
A
S
R
R
G
V
S
--
R
E
E
I
-
E
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--------------------------------------
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
K
---
N
--
I
PIP-
H
----
I
K
L
I
D
F
G
L
A
H
E
I
-
E
---
D
G
V
-
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
----
E
---
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-------
I
T
P
V
D
N
-----------
Q
Q
A
--
M
-------
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-----------------------------------------------------------------------------------------
104
PsiBlast_CBE
56.59
37%
-118
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[14-283]
------------------------
Y
D
I
-
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
-
S
----
R
A
S
R
R
G
V
S
--
R
E
E
I
-
E
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--------------------------------------
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
K
---
N
--
I
PIP-
H
----
I
K
L
I
D
F
G
L
A
H
E
I
-
E
---
D
G
V
-
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
----
E
---
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-------
I
T
P
V
D
N
-----------
Q
Q
A
--
M
-------
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-----------------------------------------------------------------------------------------
141
HHSearch
56.41
34%
-108
- C1 -
3HKO
2
?
A:
[21-338]
-----------------
L
L
E
L
Q
K
K
Y
H
L
-
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
-
I
R
---
Q
---
K
D
V
----
E
R
I
-
K
T
E
V
R
L
M
K
K
L
-
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
----
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
----
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
-
L
---
F
---
S
T
---
N
KS
F
----
E
----
I
K
L
V
D
F
G
L
S
K
E
F
-
Y
KLN
N
G
-----------
A
G
T
P
Y
F
V
A
P
E
V
L
N
-
T
----
T
N
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
-
D
A
----
D
---
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
-------
I
S
Q
F
S
D
-----------
K
I
Y
--
K
-------
M
S
--------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
56.02
40%
-128
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[12-277]
-------------------------------
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
-
K
----
K
L
S
A
R
D
H
Q
K
L
E
-----
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--------------------------------------
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
A
S
---
K
--
S
----
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
---
G
D
Q
-
Q
A
W
F
--
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
----
R
---
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
-------
I
--
C
Q
R
------------------------
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
A
---------------------------------------------------------------------
86
PsiBlast_CBE
55.93
37%
-114
- C1 -
3C0H
1
CSKP_HUMAN
A:
[22-291]
--------------------
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
-
F
----
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--------------------------------------
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
ASK
E
N
---
S
--
A
----
P
----
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
---
S
G
L
-
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
----
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-------
L
K
E
R
D
R
-----------
Y
A
Y
--
K
-------
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
---------------------------------------------------------------------------------------
16
PsiBlast_PDB
55.77
40%
-122
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[6-277]
---------------------
Y
Q
L
Y
E
D
----
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
-
K
----
K
L
S
A
R
D
H
Q
K
L
-----
E
R
E
A
R
I
C
R
-
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--------------------------------------
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
A
S
---
K
--
C
----
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
---
G
D
Q
-
Q
A
W
F
--
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
----
K
---
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
-------
V
--
C
Q
R
-----------
S
T
V
--
A
-------
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
------------------------------------------------------------------------------------
33
PsiBlast_CBE
55.64
38%
-115
- C1 -
3MFR
1
CSKP_HUMAN
A:
[22-291]
--------------------
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
-
F
----
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--------------------------------------
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
-
L
---
L
ASK
E
N
---
S
--
A
----
P
----
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
---
S
G
L
-
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
----
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-------
L
K
E
R
D
R
-----------
Y
A
Y
--
K
-------
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
-------------------------------------------------------------------------------------
27
PsiBlast_CBE
55.52
40%
-118
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[12-277]
-------------------------------
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
-
K
----
K
L
S
A
R
D
H
Q
K
L
E
-----
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--------------------------------------
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
A
S
---
K
--
S
----
K
GAA-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
---
G
D
Q
-
Q
A
W
F
--
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
----
R
---
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
-------
I
--
C
Q
R
-----------
S
T
V
--
A
-------
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------------------------
38
PsiBlast_CBE
55.35
36%
-108
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[14-302]
------------------------
Y
D
I
-
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
-
S
----
R
A
S
R
R
G
V
--
C
R
E
E
I
-
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--------------------------------------
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
K
---
N
--
I
P
I
P
-
H
----
I
K
L
I
D
F
G
L
A
H
E
I
-
E
---
D
G
V
-
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
----
E
---
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-------
I
T
P
V
D
T
-----------
Q
Q
A
--
M
V
R
R
E
SVV
N
L
E
N
F
K
K
Q
Y
V
------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
55.10
38%
-114
- C1 -
3MFU
1
CSKP_HUMAN
A:
[22-291]
--------------------
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
-
F
----
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--------------------------------------
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
-
L
---
L
ASK
E
N
---
S
--
A
----
P
----
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
---
S
G
L
-
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
----
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-------
L
K
E
R
D
R
-----------
Y
A
Y
--
K
-------
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
-------------------------------------------------------------------------------------
37
PsiBlast_CBE
55.00
36%
-109
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[14-302]
------------------------
Y
D
I
-
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
-
S
----
R
A
S
R
R
G
V
--
C
R
E
E
I
-
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--------------------------------------
E
----
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
K
---
N
--
I
P
I
P
-
H
----
I
K
L
I
D
F
G
L
A
H
E
I
-
E
---
D
G
V
-
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
----
E
---
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
-------
I
T
P
V
D
T
-----------
Q
Q
A
--
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
------------------------------------------------------------------------------------------------
112
PsiBlast_CBE
54.95
35%
-120
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[13-282]
------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
-
R
----
R
T
K
S
S
R
R
G
V
S
R
E
D
I
-
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--------------------------------------
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
R
---
N
--
V
P
K
P
-
R
----
I
K
I
I
D
F
G
L
A
H
K
I
-
D
---
F
G
N
-
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
----
E
---
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-------
I
K
P
K
D
T
-----------
Q
Q
A
--
L
-------
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------------------------------------
70
PsiBlast_CBE
54.92
35%
-117
- C1 -
3MA6
1
?
B:
[30-292]
--------------------
F
S
D
R
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
-
K
----
R
Q
V
K
Q
-
T
D
--
K
E
S
L
-
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--------------------------------------
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
E
S
KSK
D
--
A
----
N
----
I
R
I
I
D
F
G
L
S
T
H
F
-
E
---
A
S
K
-
K
M
-
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
----
D
---
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
-------
I
Q
T
Y
T
-----------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
54.64
40%
-122
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-276]
-------------
R
W
K
Q
A
E
D
I
R
D
I
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
------------
I
A
---------
S
M
-
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--------------------------------------
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
-
L
YYS
L
---
D
E
---
D
--
S
----
K
----
I
M
I
S
D
F
G
L
S
K
M
E
-
D
---
P
G
-------------
T
P
G
Y
V
A
P
E
V
L
-------
A
Q
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
A
----
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-------
I
A
--------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
54.27
38%
-115
- C1 -
3MFS
1
CSKP_HUMAN
A:
[22-291]
--------------------
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
-
F
----
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--------------------------------------
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
-
L
---
L
ASK
E
N
---
S
--
A
----
P
----
V
K
L
G
D
F
G
V
A
I
Q
L
G
E
---
S
G
L
-
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
----
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-------
L
K
E
R
D
R
-----------
Y
A
Y
--
K
-------
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
-------------------------------------------------------------------------------------
71
PsiBlast_CBE
54.10
35%
-117
- C1 -
3MA6
1
?
A:
[30-292]
--------------------
F
S
D
R
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
-
K
----
R
Q
V
K
Q
K
T
D
--
K
E
S
L
-
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--------------------------------------
K
----
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
E
S
KSK
D
--
A
----
N
----
I
R
I
I
D
F
G
L
S
T
H
F
-
E
----
S
K
-
K
M
-
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
-
E
Y
----
D
---
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
-------
I
Q
T
Y
T
K
----------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
53.95
36%
-120
- C1 -
1NXK
1
MAPK2_HUMAN
A:
[60-330]
---------------------
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
------------------
P
K
A
-
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
LYAG
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-------------------------------------------
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
-
L
---
Y
---
T
S
KRP
N
--
A
----
I
----
L
K
L
T
D
F
G
F
A
K
E
T
-
T
-------------------
P
Y
Y
V
A
P
E
V
L
G
-
P
------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
-
G
L
AISP
G
---
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
-------
I
M
Q
S
T
K
-----------
V
P
Q
--
T
-------
P
L
H
T
S
R
V
L
K
E
D
-----------------------------------------------------------------------------------------------
15
PsiBlast_PDB
53.74
40%
-119
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[12-277]
-------------------------------
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
-
K
----
K
L
S
A
R
D
H
Q
K
L
E
-----
R
E
A
R
I
C
R
-
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--------------------------------------
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
---
A
S
---
K
--
S
----
K
G
A
A
-
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
---
G
D
Q
-
Q
A
W
F
--
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
-
Q
H
----
R
---
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
-------
I
--
C
Q
R
-----------
S
T
V
--
A
-------
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------------------------
89
PsiBlast_CBE
53.57
33%
-109
- C1 -
2WEI
1
?
A:
[20-282]
--------------------
F
A
E
R
Y
N
I
-
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
-
A
----
K
------
N
K
D
T
S
T
I
-
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--------------------------------------
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
---
E
S
KEK
D
--
C
----
D
----
I
K
I
I
D
F
G
L
S
T
C
F
-
Q
---
Q
N
T
-
K
M
-
K
--
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
R
-
G
T
Y
D
E
-------
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
-
E
Y
----
D
---
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
-------
I
Q
K
Y
S
S
-----------
E
----------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
53.55
37%
-115
- C1 -
3C0G
1
CSKP_HUMAN
A:
[22-291]
--------------------
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
-
F
----
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--------------------------------------
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
ASK
E
N
---
S
--
A
----
P
----
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
---
S
G
L
-
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
----
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-------
L
K
E
R
D
R
-----------
Y
A
Y
--
K
-------
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
V
L
A
A
V
S
F
Y
G
-----------------------------------------------------------------------------
85
PsiBlast_CBE
53.50
37%
-116
- C1 -
3C0H
1
CSKP_HUMAN
B:
[22-291]
--------------------
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
-
F
----
T
S
S
P
G
L
S
T
E
D
L
K
R
E
-
A
S
I
C
H
M
L
K
----
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--------------------------------------
A
DAGF
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
ASK
E
N
---
S
--
A
----
P
----
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
---
S
G
L
-
V
A
-
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
----
L
----
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
-------
L
K
E
R
D
R
-----------
Y
A
Y
--
K
-------
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
---------------------------------------------------------------------------------------
26
PsiBlast_CBE
52.91
40%
-123
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-276]
------------------
E
D
I
R
D
I
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
------------
I
A
K
------------
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--------------------------------------
G
----
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
-
L
YYS
L
---
D
E
---
D
--
S
----
K
----
I
M
I
S
D
F
G
-----------
G
S
-
V
L
-
S
--
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
-------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
-
D
A
----
K
---
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-------
I
A
G
D
T
A
-----------
L
D
K
--
N
-------
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
--------------------------------------------------------------------------------------------
111
PsiBlast_CBE
52.14
35%
-111
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[13-282]
------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
-
R
----
R
T
K
S
S
R
R
G
V
S
R
E
D
I
-
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--------------------------------------
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
R
---
N
--
V
P
K
P
-
R
----
I
K
I
I
D
F
G
L
A
H
K
I
-
D
---
F
G
N
-
E
F
-
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
----
E
---
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-------
I
K
P
K
D
T
-----------
Q
Q
A
--
L
-------
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------------------------------------
102
PsiBlast_CBE
51.81
35%
-114
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
-
R
----
R
T
K
S
S
R
R
G
V
S
R
E
D
I
-
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--------------------------------------
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
R
---
N
--
V
P
K
P
-
R
----
I
K
I
I
D
F
G
L
A
H
K
I
-
D
---
F
G
N
-
E
F
-
K
--
N
I
-
F
G
T
P
A
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
----
E
---
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-------
I
K
P
K
D
T
-----------
Q
Q
A
--
L
-------
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------------------------------------
115
PsiBlast_CBE
50.80
35%
-124
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[13-276]
------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
----------------
V
S
R
E
D
I
-
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
R
---
N
--
V
PK
P
-
R
----
I
K
I
I
D
F
G
L
A
H
K
I
-
D
------------------
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-
K
Q
----
E
---
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
-------
I
K
--------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
47.44
37%
-117
- C1 -
4D9U
1
A:
[19-281]
-------------------
Q
F
T
D
G
Y
E
V
-
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
-
K
S
-
K
----
R
D
P
T
E
E
I
E
------------
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
----
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
--------------------------------------
K
----
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
---
Y
---
V
D
---
E
--
S
GNPE
S
----
I
R
I
C
D
F
G
F
A
K
Q
L
-
R
---
A
E
N
-
G
L
-
L
--
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
-------
R
Q
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
G
P
-
D
D
----
T
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
-------
I
V
H
W
D
Q
-----------
L
P
Q
--
Y
-------
Q
L
N
R
Q
D
A
P
H
L
V
K
G
A
M
A
A
T
Y
S
A
L
N
R
N
Q
--------------------------------------------------------------------------------
34
PsiBlast_CBE
46.35
40%
-118
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[15-266]
-----------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
----------
K
K
S
----------
S
L
E
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
----
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
--------------------------------------
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
Y
LTP
E
E
---
N
--
S
----
K
----
I
M
I
T
D
F
G
L
S
-
K
M
-
E
---
Q
N
G
-
I
M
-
S
--
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
-------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
-
E
S
----
K
---
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
-------
I
D
G
N
T
A
-----------
L
H
R
--
D
-------
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
-------------------------------------------------------------------------------------------
35
PsiBlast_CBE
45.31
40%
-118
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[15-266]
-----------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
----------
K
K
S
----------
S
L
E
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
----
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
--------------------------------------
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
Y
LTP
E
E
---
N
--
S
----
K
----
I
M
I
T
D
F
G
L
S
-
K
M
-
E
---
Q
N
G
-
I
M
-
S
--
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
-------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
-
E
S
----
K
---
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
-------
I
D
G
N
T
A
-----------
L
H
R
--
D
-------
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
------------------------------------------------------------------------------------------
91
PsiBlast_CBE
44.96
37%
-114
- C1 -
4D9T
1
A:
[19-281]
-------------------
Q
F
T
D
G
Y
E
V
-
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
-
K
S
-
K
----
R
D
P
T
E
E
I
E
------------
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
----
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
--------------------------------------
K
----
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
---
Y
---
V
D
---
E
--
S
GNPE
S
----
I
R
I
C
D
F
G
F
A
K
Q
L
-
R
---
A
E
N
-
G
L
-
L
--
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
-------
R
Q
G
Y
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
G
P
-
D
D
----
T
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
-------
I
V
H
W
D
Q
-----------
L
P
Q
--
Y
-------
Q
L
N
R
Q
D
A
P
H
L
V
K
G
A
M
A
A
T
Y
S
A
L
N
R
N
---------------------------------------------------------------------------------
77
PsiBlast_CBE
44.83
34%
-100
- C1 -
2WNT
2
B:
[26-320]
---------------------
S
D
G
Y
V
V
-
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
I
D
-
K
S
-
K
----
R
D
P
S
E
E
I
E
------------
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
----
G
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
Q
--------------------------------------
K
----
F
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
---
Y
---
V
D
---
E
--
S
----
G
NPEC
L
R
I
C
D
F
G
F
A
K
Q
L
-
R
---
A
E
N
-
G
L
-
L
--
M
T
P
C
Y
----------
K
-------
R
Q
G
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
A
N
G
P
-
S
D
----
T
P
E
E
I
L
T
R
I
G
S
G
K
F
T
L
S
G
G
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
K
Q
V
L
Q
H
P
W
-------
V
T
Q
-
K
D
-----------
K
L
P
--
Q
-------
S
Q
L
S
H
Q
D
L
Q
L
-
V
K
G
A
M
A
A
T
Y
S
A
L
N
S
S
K
-------------------------------------------------------------------------------
18
PsiBlast_PDB
44.46
37%
-112
- C1 -
2W4O
1
KCC4_HUMAN
A:
[61-346]
-------------------------------
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
--------------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
----
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
--------------------------------------
G
----
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
Y
---
A
T
PAP
D
--
A
----
P
----
L
K
I
A
D
F
-------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
-------
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
----
F
---
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
VTGKAAN
F
V
H
M
D
T
-----------
A
Q
K
K
L
Q
-------
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
---------------------------------------------------------------------------------------