@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PIM3_HUMAN: (2015-10-17 )
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
Atome Classification :
(95 SA)
.........10........20........30........40........50........60........70........80-.-..--.-....90........100.......110.......120.......130.......140.......150.......160.......170.......180---.......190.....-..200.......210.......220.......230.......240......------.250.......----260.......270.......280.......290.......300........310.......320....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
L
S
K
F
G
S
L
A
H
LCGPGGVDHL
P
V
K
ILQPAKA
D
K
E
S
F
E
K
A
Y
Q
V
G
A
V
LGSGGFGTVYAGSRIADG
L
P
V
A
V
K
H
V
V
K
E
R
V
T
E
WGS-L-GG--
A
-
T
V
P
L
E
V
V
L
L
R
KVGAAGG
A
R
G
V
I
R
L
L
D
W
F
ERPD
G
F
L
L
V
LERPE
P
A
Q
D
L
F
D
F
I
T
ERGAL
D
E
P
L
A
R
R
F
F
A
Q
V
L
A
A
V
R
H
C
H
SCGVVHRDIKDE
N
L
L
V
D
LRS---G
E
L
K
L
I
DFGSG
A
L
L
K-D
T
V
YTDFDGTRVYS
P
P
E
W
I
R
Y
H
RYHGRS
A
T
V
W
S
L
G
V
L
L
Y
D
M
VCGDIPFE
Q
D
------
E
E
I
L
R
G
R
L
L
F
R----RRV
S
P
E
C
Q
Q
L
I
R
W
C
L
SLRPSERP
S
L
D
Q
I
AAHP
W
M
LGADGGVP-ESC
D
L
R
L
C
TL
D
P
D
DVASTTSSSESL
87
PsiBlast_CBE
90.02
75%
-134
- C1 -
4WRS
3
PIM1_HUMAN
A:
[15-271]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
-
T
A
E
I
H
L
H
------------------
76
PsiBlast_CBE
90.00
70%
-123
- C1 -
4A7C
2
PIM1_HUMAN
A:
[27-300]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
82
PsiBlast_CBE
89.97
69%
-125
- C1 -
2XIY
3
PIM1_HUMAN
A:
[21-294]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
68
PsiBlast_CBE
89.87
71%
-123
- C1 -
4MTA
2
PIM1_HUMAN
A:
[6-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
86
PsiBlast_CBE
89.65
75%
-135
- C1 -
4WSY
2
PIM1_HUMAN
A:
[15-271]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
-
T
A
E
I
H
L
H
------------------
20
PsiBlast_PDB
89.56
69%
-121
- C1 -
3DCV
1
PIM1_HUMAN
A:
[47-320]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
97
PsiBlast_CBE
89.39
75%
-130
- C1 -
3WE8
1
PIM1_HUMAN
A:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
-
T
A
E
I
H
L
H
------------------
24
PsiBlast_CBE
89.00
69%
-122
- C1 -
2J2I
1
PIM1_HUMAN
B:
[33-305]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
52
PsiBlast_CBE
88.96
71%
-122
- C1 -
4XH6
1
?
A:
[6-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
89
PsiBlast_CBE
88.84
75%
-131
- C1 -
4K0Y
1
PIM1_HUMAN
A:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
-
T
A
E
I
H
L
H
S
-----------------
91
PsiBlast_CBE
88.74
75%
-131
- C1 -
3C4E
2
PIM1_HUMAN
D:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
-
T
A
E
I
H
L
H
------------------
26
PsiBlast_CBE
88.39
69%
-124
- C1 -
4N6Z
4
PIM1_HUMAN
A:
[48-320]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
75
PsiBlast_CBE
88.29
71%
-123
- C1 -
4IAA
1
PIM1_HUMAN
A:
[9-281]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
85
PsiBlast_CBE
88.21
75%
-133
- C1 -
4WT6
2
PIM1_HUMAN
A:
[15-271]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
-
T
A
E
I
H
L
H
------------------
8
PsiBlast_PDB
88.11
69%
-121
- C1 -
3BGQ
1
PIM1_HUMAN
A:
[53-325]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
16
PsiBlast_PDB
87.98
69%
-119
- C1 -
2OI4
5
PIM1_HUMAN
X:
[32-306]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
31
PsiBlast_CBE
87.94
69%
-122
- C1 -
4BZN
1
PIM1_HUMAN
A:
[34-306]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
90
PsiBlast_CBE
87.85
75%
-130
- C1 -
4K1B
1
PIM1_HUMAN
A:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
-
T
A
E
I
H
L
H
------------------
88
PsiBlast_CBE
87.84
75%
-135
- C1 -
4TY1
2
PIM1_HUMAN
A:
[15-271]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
-
T
A
E
I
H
L
H
------------------
30
PsiBlast_CBE
87.84
69%
-121
- C1 -
4BZO
1
PIM1_HUMAN
A:
[34-306]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
79
PsiBlast_CBE
87.82
69%
-124
- C1 -
2XJ2
1
PIM1_HUMAN
A:
[21-294]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
44
PsiBlast_CBE
87.81
71%
-122
- C1 -
3VBV
1
PIM1_HUMAN
A:
[8-278]
------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
-----
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
27
PsiBlast_CBE
87.74
69%
-124
- C1 -
4N6Y
1
PIM1_HUMAN
A:
[47-320]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
93
PsiBlast_CBE
87.69
75%
-125
- C1 -
3C4E
2
PIM1_HUMAN
B:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
-
T
A
E
I
H
L
H
------------------
83
PsiBlast_CBE
87.61
75%
-129
- C1 -
4K18
1
PIM1_HUMAN
A:
[1-259]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
-
T
A
E
I
H
L
H
S
L
S
---------------
3
PsiBlast_PDB
87.61
69%
-121
- C1 -
4JX7
1
PIM1_HUMAN
A:
[33-306]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
96
PsiBlast_CBE
87.57
75%
-132
- C1 -
4AS0
1
PIM1_HUMAN
A:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
-
T
A
E
I
H
L
H
------------------
19
PsiBlast_PDB
87.47
69%
-126
- C1 -
3CY2
2
PIM1_HUMAN
A:
[34-306]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P----
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
12
PsiBlast_PDB
87.39
69%
-122
- C1 -
2BZJ
1
PIM1_HUMAN
A:
[33-305]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
60
PsiBlast_CBE
87.30
71%
-120
- C1 -
1YXX
2
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
95
PsiBlast_CBE
87.29
68%
-123
- C1 -
2XIX
1
PIM1_HUMAN
A:
[21-294]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
78
PsiBlast_CBE
87.27
71%
-116
- C1 -
3F2A
1
PIM1_HUMAN
A:
[19-295]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
S
--------------
25
PsiBlast_CBE
87.22
69%
-121
- C1 -
4N70
1
PIM1_HUMAN
A:
[47-321]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
23
PsiBlast_CBE
87.21
69%
-123
- C1 -
3JPV
1
PIM1_HUMAN
A:
[34-306]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
15
PsiBlast_PDB
87.21
69%
-121
- C1 -
2BZH
2
PIM1_HUMAN
B:
[32-306]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
47
PsiBlast_CBE
87.16
71%
-127
- C1 -
3R02
4
PIM1_HUMAN
A:
[8-278]
------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
65
PsiBlast_CBE
87.09
71%
-121
- C1 -
1YXU
2
PIM1_HUMAN
A:
[5-277]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
29
PsiBlast_CBE
87.00
69%
-121
- C1 -
3CY3
2
PIM1_HUMAN
A:
[34-306]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P----
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
59
PsiBlast_CBE
86.98
71%
-121
- C1 -
2O3P
3
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
50
PsiBlast_CBE
86.98
71%
-122
- C1 -
3A99
1
PIM1_HUMAN
A:
[40-312]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
22
PsiBlast_CBE
86.97
69%
-124
- C1 -
3QF9
1
PIM1_HUMAN
A:
[33-306]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
62
PsiBlast_CBE
86.73
71%
-123
- C1 -
1YXU
2
PIM1_HUMAN
D:
[5-277]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
18
PsiBlast_PDB
86.72
69%
-123
- C1 -
3CXW
1
PIM1_HUMAN
A:
[34-307]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P----
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
7
PsiBlast_PDB
86.72
69%
-121
- C1 -
3BGP
1
PIM1_HUMAN
A:
[53-325]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
61
PsiBlast_CBE
86.63
71%
-122
- C1 -
1YXV
2
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
92
PsiBlast_CBE
86.50
75%
-128
- C1 -
3C4E
2
PIM1_HUMAN
C:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
-
T
A
E
I
H
L
H
------------------
63
PsiBlast_CBE
86.44
71%
-122
- C1 -
1YXU
2
PIM1_HUMAN
C:
[6-277]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
74
PsiBlast_CBE
86.43
71%
-124
- C1 -
4MED
1
PIM1_HUMAN
A:
[9-281]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
81
PsiBlast_CBE
86.34
69%
-123
- C1 -
2XIZ
1
PIM1_HUMAN
A:
[21-294]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
94
PsiBlast_CBE
86.31
75%
-128
- C1 -
3C4E
2
PIM1_HUMAN
A:
[2-258]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
P
Q
E
-
T
A
E
I
H
L
H
------------------
13
PsiBlast_PDB
86.26
69%
-124
- C1 -
2BZK
1
PIM1_HUMAN
B:
[33-305]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
-----
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
80
PsiBlast_CBE
86.20
69%
-122
- C1 -
2XJ1
1
PIM1_HUMAN
A:
[21-294]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
1
PsiBlast_PDB
86.04
69%
-118
- C1 -
4RPV
1
PIM1_HUMAN
A:
[130-402]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
17
PsiBlast_PDB
86.02
69%
-120
- C1 -
3BWF
1
PIM1_HUMAN
A:
[33-305]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
6
PsiBlast_PDB
85.95
69%
-118
- C1 -
2OBJ
1
PIM1_HUMAN
A:
[53-325]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
42
PsiBlast_CBE
85.90
71%
-122
- C1 -
3VBX
1
PIM1_HUMAN
A:
[8-278]
------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
-----
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
49
PsiBlast_CBE
85.74
71%
-122
- C1 -
3R00
2
PIM1_HUMAN
A:
[6-279]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
40
PsiBlast_CBE
85.68
71%
-121
- C1 -
1XR1
1
PIM1_HUMAN
A:
[19-295]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
S
--------------
46
PsiBlast_CBE
85.54
71%
-122
- C1 -
3R04
4
PIM1_HUMAN
A:
[8-278]
------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
10
PsiBlast_PDB
85.39
69%
-121
- C1 -
4ALW
3
PIM1_HUMAN
A:
[49-321]
-----------------------------------
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
21
PsiBlast_CBE
85.38
69%
-122
- C1 -
4GW8
2
PIM1_HUMAN
A:
[34-306]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
55
PsiBlast_CBE
85.03
71%
-122
- C1 -
3JXW
1
PIM1_HUMAN
A:
[6-279]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
36
PsiBlast_CBE
85.03
69%
-120
- C1 -
2BZI
1
PIM1_HUMAN
B:
[33-305]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
58
PsiBlast_CBE
84.79
71%
-120
- C1 -
2O63
4
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
9
PsiBlast_PDB
84.79
69%
-121
- C1 -
4ALV
2
PIM1_HUMAN
A:
[48-321]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
56
PsiBlast_CBE
84.74
71%
-118
- C1 -
2O65
2
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
33
PsiBlast_CBE
84.46
70%
-123
- C1 -
4ENX
1
PIM1_HUMAN
A:
[10-278]
--------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
-----
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
28
PsiBlast_CBE
84.30
69%
-123
- C1 -
3T9I
1
PIM1_HUMAN
A:
[48-321]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
53
PsiBlast_CBE
84.26
71%
-119
- C1 -
3JYA
1
PIM1_HUMAN
A:
[6-279]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
35
PsiBlast_CBE
84.10
70%
-121
- C1 -
3UIX
2
PIM1_HUMAN
A:
[10-278]
--------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
-----
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
64
PsiBlast_CBE
83.97
71%
-118
- C1 -
1YXU
2
PIM1_HUMAN
B:
[5-277]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
120
HHSearch
83.90
68%
-121
* C1 *
3A99
1
PIM1_HUMAN
A:
[40-312]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
-
P
Q
-
E
T
A
E
I
H
L
H
-----------------
57
PsiBlast_CBE
83.79
71%
-121
- C1 -
2O64
3
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
34
PsiBlast_CBE
83.77
70%
-126
- C1 -
3UMW
2
PIM1_HUMAN
A:
[10-277]
--------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
-------
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
------------------
43
PsiBlast_CBE
83.74
71%
-122
- C1 -
3VBW
1
PIM1_HUMAN
A:
[8-278]
------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
----
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
-----
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
54
PsiBlast_CBE
83.64
71%
-121
- C1 -
3JY0
1
PIM1_HUMAN
A:
[6-280]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
L
---------------
41
PsiBlast_CBE
83.61
71%
-119
- C1 -
3VC4
2
PIM1_HUMAN
A:
[6-279]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
66
PsiBlast_CBE
83.45
71%
-115
- C1 -
1YXT
1
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
32
PsiBlast_CBE
83.19
70%
-124
- C1 -
4ENY
3
PIM1_HUMAN
A:
[10-278]
--------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
-
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
----------
R
V
P
M
E
V
V
L
L
K
K
V
S
S
---
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
51
PsiBlast_CBE
82.64
71%
-118
- C1 -
4MBI
1
PIM1_HUMAN
A:
[5-278]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
14
PsiBlast_PDB
82.57
69%
-119
- C1 -
2C3I
1
PIM1_HUMAN
B:
[37-305]
--------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
----
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
48
PsiBlast_CBE
82.51
71%
-121
- C1 -
3R01
3
PIM1_HUMAN
A:
[6-279]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
38
PsiBlast_CBE
81.46
69%
-123
- C1 -
3MA3
1
PIM1_HUMAN
A:
[38-306]
--------------------------------------
Q
Y
Q
V
G
P
L
L
G
--
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
G
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
98
PsiBlast_CBE
80.77
69%
-116
- C1 -
4ALU
2
PIM1_HUMAN
A:
[48-321]
----------------------------------
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
S
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
P
N
G
--
T
-
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------
101
PsiBlast_CBE
76.89
64%
-128
- C1 -
2IWI
1
PIM2_HUMAN
B:
[25-288]
-------------------------------
D
R
E
A
F
E
A
E
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
-----------------
T
C
P
L
E
V
A
L
L
W
K
V
G
A
G
G
G
H
P
G
V
I
R
L
L
D
W
F
E
----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
---
G
C
A
K
L
I
D
F
G
S
G
A
L
L
H
-
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
------
Q
E
I
L
E
A
E
L
H
F
P
----
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
---------------------------------
99
PsiBlast_CBE
75.11
64%
-127
- C1 -
4X7Q
1
PIM2_HUMAN
B:
[28-288]
----------------------------------
A
F
E
A
E
Y
R
L
G
P
L
L
G
K
G
-
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
------------------
C
P
L
E
V
A
L
L
W
K
V
G
A
G
G
G
H
P
G
V
I
R
L
L
D
W
F
E
T
---
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
---
G
C
A
K
L
I
D
F
G
S
G
A
L
L
H
-
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
------
Q
E
I
L
E
A
E
L
H
F
P
----
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
---------------------------------
5
PsiBlast_PDB
75.00
69%
-102
- C1 -
4XHK
1
PIM1_HUMAN
B:
[34-307]
---------------------------------
E
P
L
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
W
G
E
-
L
-------
R
V
P
M
E
V
V
L
L
K
K
V
S
S
--
G
F
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
T
E
R
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
D
L
N
R
---
G
E
L
K
L
I
D
F
G
S
G
A
L
L
K
-
D
T
V
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
R
Y
H
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
H
D
------
E
E
I
I
R
G
Q
V
F
F
R
----
Q
R
V
S
S
E
C
Q
H
L
I
R
W
C
L
A
L
R
P
S
D
R
P
T
F
E
E
I
Q
N
H
P
W
M
--
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------
121
HHSearch
72.40
65%
-129
- C1 -
2IWI
1
PIM2_HUMAN
A:
[33-289]
---------------------------------------
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
N
R
V
L
-----------
V
-
T
C
P
L
E
V
A
L
L
W
K
V
G
A
G
G
G
H
P
G
V
I
R
L
L
D
W
F
-----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
---
G
C
A
K
L
I
D
F
G
S
G
A
L
L
H
-
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
------
Q
E
I
L
E
A
E
L
H
F
P
----
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
T
--------------------------------
102
PsiBlast_CBE
71.92
64%
-129
- C1 -
2IWI
1
PIM2_HUMAN
A:
[33-289]
---------------------------------------
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
N
R
V
L
------------V
T
C
P
L
E
V
A
L
L
W
K
V
G
A
G
G
G
H
P
G
V
I
R
L
L
D
W
F
-----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
---
G
C
A
K
L
I
D
F
G
S
G
A
L
L
H
-
D
E
P
Y
T
D
F
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
------
Q
E
I
L
E
A
E
L
H
F
P
----
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
T
--------------------------------
100
PsiBlast_CBE
69.68
64%
-131
- C1 -
4X7Q
1
PIM2_HUMAN
A:
[33-288]
---------------------------------------
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
----
R
L
Q
V
A
I
K
V
I
P
R
--------------------
L
E
V
A
L
L
W
K
V
G
----
H
P
G
V
I
R
L
L
D
W
F
-----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
T
E
K
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D
L
R
R
---
G
C
A
K
L
I
D
F
G
S
G
A
-----------
D
G
T
R
V
Y
S
P
P
E
W
I
S
R
H
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
D
M
V
C
G
D
I
P
F
E
R
D
------
Q
E
I
L
E
A
E
L
H
F
P
----
A
H
V
S
P
D
C
C
A
L
I
R
R
C
L
A
P
K
P
S
S
R
P
S
L
E
E
I
L
L
D
P
W
M
Q
---------------------------------
107
PsiBlast_CBE
53.97
32%
-122
- C1 -
4CQG
1
MELK_MOUSE
A:
[3-264]
-------------------------------
D
Y
D
E
L
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
------
I
M
D
K
N
A
-
L
-
G
S
D
L
P
-
R
V
K
T
E
I
D
A
L
K
S
L
R
H
----
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
-
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
-
E
N
---
H
K
L
K
L
I
D
F
G
L
C
A
K
----------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
E
V
P
----
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
N
L
L
N
H
P
W
V
M
Q
D
Y
S
C
P
V
-
E
W
Q
S
K
T
P
L
T
H
L
D
E
D
C
V
T
E
L
S
V
H
H
R
S
109
PsiBlast_CBE
52.63
32%
-125
- C1 -
4BKZ
1
MELK_HUMAN
A:
[4-265]
-------------------------------
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
------
I
M
D
K
N
T
-
L
---L-
P
-
R
I
K
T
E
I
E
A
L
K
N
L
R
H
----
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
-
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
-
E
Y
---
H
K
L
K
L
I
D
F
G
L
C
A
-------------
S
L
A
Y
A
A
P
E
L
I
Q
G
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
-
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
108
PsiBlast_CBE
49.07
32%
-122
- C1 -
4BL1
1
MELK_HUMAN
A:
[4-265]
-------------------------------
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
------
I
M
D
K
N
T
-
L
---L-
P
-
R
I
K
T
E
I
E
A
L
K
N
L
R
H
----
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
-
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
-
E
Y
---
H
K
L
K
L
I
D
F
G
L
C
A
K
------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
-
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
123
HHSearch
47.42
34%
-122
- C1 -
4BKY
1
MELK_HUMAN
A:
[4-267]
-------------------------------
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--
D
------
L
--
P
-
R
I
K
T
E
I
E
A
L
K
N
L
R
----
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
-
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
-
E
Y
---
H
K
L
K
L
I
D
F
G
L
C
A
-------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
-
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
129
HHSearch
43.29
30%
-111
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[5-279]
-------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
-
S
R
--
E
-
D
I
E
R
E
V
S
I
L
K
E
I
Q
----
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
-
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
DEYF
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
-
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
------