@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PKN3_HUMAN: (2015-10-17 )
MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP
Atome Classification :
(68 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550....--...560.......570.....---.---.---580.......590....-...600.......610.......620.......630.......640.......650.-.-..-....660.......670....-...680.......690.......700.......710.-......720.......730...----....740.......750.......-----760.......770...----..-..780.......790.......800.......-810........820.......830.......840.......850.......860.......870.......880.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEEGAPRQPGPSQWPPE
D
E
K
E
V
I
R
R
A
I
Q
K
E
L
K
I
K
E
G
V
E
N
L
R
R
V
A
TD
R
R
H
L
G
H
V
Q
Q
L
L
R
SSN
R
R
L
E
Q
L
H
G
E
L
R
E
L
H
A
R
I
LLPGPGPGPAEPVASGPR
P
W
A
E
Q
L
R
A
R
H
L
E
A
L
R
R
Q
L
H
V
E
L
K
V
KQGAENMTHTCASG
T
P
K
E
R
K
L
L
A
A
A
Q
Q
M
L
R
D
S
Q
L
K
V
A
L
L
R
M
K
I
S
SLEASGSPEP
G
P
E
L
L
A
E
E
L
Q
H
R
L
H
V
E
A
A
V
A
E
G
A
K
N
V
V
K
L
L
S
SRRT
Q
D
R
K
A
L
A
E
A
Q
A
Q
L
Q
E
S
S
Q
K
L
D
L
L
R
L
A
L
E
Q
L
L
E
QLPPAH
P
L
R
S
R
V
T
R
E
L
R
A
AVPGYPQPSGTPVKP
T
A
L
T
G
T
L
Q
V
R
L
L
G
C
E
Q
L
L
T
AVPGRS
P
A
A
A
LASSPSE
G
W
L
R
T
K
A
K
HQRG
R
G
E
L
A
S
E
V
L
A
V
L
KVDN
R
V
VGQTG
W
G
Q
V
A
E
QSWD
Q
T
F
V
I
P
L
ERARELEIGV
H
W
R
D
W
R
Q
L
C
G
V
A
F
L
R
L
E
D
F
L
D
N
A
C
H
Q
L
S
L
S
L
VPQG
L
L
F
A
Q
V
T
FC
D
P
V
I
E
R
R
P
R
L
Q
R
Q
E
R
I
F
S
K
RR
G
Q
D
F
L
R
A
S
Q
MN
L
G
M
A
A
W
G
R
L
V
M
N
LLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKP
P
R
L
YLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPR
L
--
Q
D
F
R
C
L
A
V
LGRGHF
G
K
V
L
L
V
Q
---
F
---K---GTG
K
Y
Y
A
I
K
A
L
K
K
Q
E
V
L
-
S
R
D
E
I
E
S
L
Y
C
E
K
R
I
L
E
A
VGCTG
H
P
F
L
L
S
L
L
A
C
FQTSSH
A
C
F
V
T
E
FVPG
G
D
L
M
M
Q
I
-
H
-
E
-DV-FPEP
Q
A
R
F
Y
V
A
C
V
V
L
G
L
Q
F
L
H
-EK
K
I
I
Y
RDLKLD
N
L
L
LDAQ
G
F
L
K
I
A
D
F
G
L
C
K
EGIGFG-DRTSTFCG
T
P
E
FL
A
P
E
V
L
T
Q
E
A
----
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
VGECPF-----PGD
T
E
E
E
V
F
D
C
I
VNMD----AP-YP
G
F
L
SV
Q
G
L
E
F
I
Q
K
L
L
Q
KC
P
E
K
RLGAGEQ
D
A
-
E
E
-
I
K
V
Q
P
F
F
RTT
N
W
Q
A
L
L
A
RTIQPPFVPTLCGPAD
L
R
Y
FEGEFTGLPPALTPPA
P
H
S
L
L
T
A
R
Q
Q
A
AFR
D
F
D
F
V
S
E
R
FLEP
3
PsiBlast_PDB
94.75
66%
-121
- C2 -
4OTI
1
A:
[6-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
P
L
T
L
--
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
---
F
---
R
---
P
S
G
E
L
F
A
I
K
A
L
K
K
G
D
I
V
-
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
A
A
V
T
S
A
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
-
H
-
S
-
D
V
-
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
-
E
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
F
-----
P
G
D
D
E
E
E
V
F
D
S
I
V
N
D
E
----
V
R
-
Y
P
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
S
S
E
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
E
E
F
T
G
E
A
P
T
L
S
P
P
R
D
A
R
P
L
T
A
A
E
Q
A
A
F
L
D
F
D
F
V
A
G
-----
2
PsiBlast_PDB
94.73
66%
-115
- C2 -
4OTG
1
A:
[6-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
P
L
T
L
--
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
---
F
---
R
---
P
S
G
E
L
F
A
I
K
A
L
K
K
G
D
I
V
-
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
A
A
V
T
S
A
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
-
H
-
S
-
D
V
-
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
-
E
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
E
G
M
G
Y
G
-
D
R
T
S
T
F
C
G
T
P
E
F
L
A
P
E
V
L
T
D
T
S
----
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
F
-----
P
G
D
D
E
E
E
V
F
D
S
I
V
N
D
E
----
V
R
-
Y
P
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
S
S
E
R
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
------------
F
T
G
E
A
P
T
L
S
P
P
R
D
A
R
P
L
T
A
A
E
Q
A
A
F
L
D
F
D
F
V
A
G
-----
5
PsiBlast_PDB
88.88
44%
-112
- C2 -
2JDR
1
AKT2_HUMAN
A:
[9-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
---
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
----
I
R
-
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
--------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
----
7
PsiBlast_PDB
87.88
44%
-113
- C2 -
2X39
1
AKT2_HUMAN
A:
[9-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
---
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
----
I
R
-
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
--------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
----
6
PsiBlast_PDB
87.62
44%
-114
- C2 -
2UW9
1
AKT2_HUMAN
A:
[9-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
---
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
----
I
R
-
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
--------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
----
9
PsiBlast_PDB
87.26
44%
-115
- C2 -
1O6L
1
AKT2_HUMAN
A:
[4-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
---
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
----
I
R
-
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
--------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
----
4
PsiBlast_PDB
86.75
44%
-115
- C2 -
2JDO
2
AKT2_HUMAN
A:
[9-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
---
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
----
I
R
-
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
----------------
M
F
E
D
F
D
Y
I
A
D
W
----
13
PsiBlast_PDB
86.15
44%
-113
- C2 -
3E87
1
AKT2_HUMAN
A:
[4-330]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
---
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
----
I
R
-
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
P
P
---------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
---
8
PsiBlast_PDB
85.70
44%
-116
- C2 -
2XH5
1
AKT2_HUMAN
A:
[9-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
---
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
----
I
R
-
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
--------------
Q
E
M
F
E
D
F
D
Y
I
A
D
W
----
12
PsiBlast_PDB
85.17
44%
-113
- C2 -
1O6K
1
AKT2_HUMAN
A:
[4-330]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
---
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
----
I
R
-
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
----
14
PsiBlast_PDB
85.01
44%
-112
- C2 -
3E88
1
AKT2_HUMAN
A:
[4-330]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
---
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
----
I
R
-
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
-----------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
---
15
PsiBlast_PDB
84.95
44%
-111
- C2 -
3D0E
1
AKT2_HUMAN
A:
[4-330]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
---
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
-
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
E
----
I
R
-
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
P
P
D
--------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
---
24
PsiBlast_CBE
84.44
41%
-116
- C2 -
4DC2
1
KPCI_MOUSE
A:
[51-386]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
-
Q
R
Q
-
R
K
-
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
-
D
T
T
S
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
DIVGS--
N
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
----
I
R
-
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
D
I
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
-----
20
PsiBlast_PDB
83.72
45%
-110
- C2 -
3TXO
1
KPCL_HUMAN
A:
[23-348]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
---
V
---
K
---
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
-
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
--
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
-
Q
-
K
-
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
-
D
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
-----
E
A
E
N
E
D
D
L
F
E
A
I
L
N
D
E
----
V
V
-
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
Q
G
G
-
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
-
P
I
D
E
G
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
-----
22
PsiBlast_CBE
83.49
46%
-118
- C2 -
4EJN
3
AKT1_HUMAN
A:
[147-438]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--------------
V
L
Q
N
---
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
------
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
-
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
-----------------------------------------
30
PsiBlast_CBE
82.86
40%
-111
- C2 -
4L43
1
KS6B1_HUMAN
A:
[10-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
RP
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
-
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
V
------------
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
----
18
PsiBlast_PDB
82.61
45%
-116
- C2 -
1XJD
1
A:
[16-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
--
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
-
Q
-
S
C
H
K
-
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
-
A
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
-----
H
G
Q
D
E
E
E
L
F
H
S
I
-
R
M
D
----
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
----
R
-
G
D
-
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
---------------------------------------
Q
N
M
F
R
N
F
S
F
--------
28
PsiBlast_CBE
81.40
40%
-112
- C2 -
4L42
1
KS6B1_HUMAN
A:
[13-345]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
RP
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
-
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
-
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
-------------------------------------
E
M
F
R
D
F
E
Y
I
A
D
W
----
17
PsiBlast_PDB
81.18
45%
-109
- C2 -
4RA4
1
KPCA_HUMAN
A:
[18-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
--
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
A
D
---
R
---
K
---
G
T
E
E
L
Y
A
I
K
I
L
K
K
D
V
V
I
-
Q
D
D
D
V
E
C
T
M
V
E
K
R
V
L
A
L
L
--
D
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
-
Q
-
Q
V
G
K
-
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
-
K
R
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
H
M
M
D
G
-
V
T
T
R
T
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
P
----
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
Q
P
P
F
-----
D
G
E
D
E
D
E
L
F
Q
S
I
M
E
H
N
----
V
S
-
Y
P
K
S
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
R
L
G
C
G
P
E
G
E
-
R
D
-
V
R
E
H
A
F
F
R
R
I
D
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
K
----------------
G
Q
P
V
L
T
P
P
-
D
Q
L
V
I
A
N
I
D
Q
S
D
F
E
G
F
S
Y
V
N
P
Q
F
V
H
P
23
PsiBlast_CBE
79.21
47%
-115
- C2 -
3O96
1
AKT1_HUMAN
A:
[150-432]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-
A
----------
N
R
V
L
Q
N
---
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
---------------
P
E
Y
L
A
P
E
V
L
E
D
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
-
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
--------------------------------------------------
94
PsiBlast_CBE
78.96
35%
-103
- C2 -
2ETK
1
ROCK1_HUMAN
A:
[71-403]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
--
89
PsiBlast_CBE
78.65
35%
-99
- C2 -
3D9V
1
ROCK1_HUMAN
A:
[71-403]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
--
92
PsiBlast_CBE
78.40
35%
-100
- C2 -
2ETR
1
ROCK1_HUMAN
A:
[71-403]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
--
66
PsiBlast_CBE
78.24
35%
-103
- C2 -
4YVC
1
ROCK1_HUMAN
A:
[71-403]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-----
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
-------
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
--
96
PsiBlast_CBE
78.17
35%
-100
- C2 -
2ESM
1
ROCK1_HUMAN
A:
[71-403]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NSLT
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
--
29
PsiBlast_CBE
78.11
40%
-107
- C2 -
4L44
1
KS6B1_HUMAN
A:
[10-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
RP
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
------
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
-
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
-
D
S
K
F
T
R
Q
T
------------
S
E
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
----
93
PsiBlast_CBE
77.48
35%
-101
- C2 -
2ETK
1
ROCK1_HUMAN
B:
[71-402]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-----
63
PsiBlast_CBE
77.47
35%
-101
- C2 -
4YVE
1
ROCK1_HUMAN
B:
[71-402]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
-----
E
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-----
39
PsiBlast_CBE
77.30
42%
-108
- C2 -
4L3J
1
KS6B1_HUMAN
A:
[14-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
RP
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
-
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
-
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
------------------------------------------------
88
PsiBlast_CBE
77.22
35%
-101
- C2 -
3D9V
1
ROCK1_HUMAN
B:
[71-402]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-----
91
PsiBlast_CBE
77.15
35%
-98
- C2 -
2ETR
1
ROCK1_HUMAN
B:
[71-402]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-----
44
PsiBlast_CBE
76.99
40%
-111
- C2 -
2F7E
1
KAPCA_BOVIN
E:
[33-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
A
Q
N
T
A
H
L
--
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
----
V
R
-
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------
64
PsiBlast_CBE
76.97
35%
-102
- C2 -
4YVE
1
ROCK1_HUMAN
A:
[71-403]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
--GY--
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
------
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
--
61
PsiBlast_CBE
76.52
35%
-104
* C2 *
5BML
1
ROCK1_HUMAN
B:
[71-402]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
---
E
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-----
43
PsiBlast_CBE
76.44
40%
-106
- C2 -
2F7X
1
KAPCA_BOVIN
E:
[33-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
A
Q
N
T
A
H
L
--
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
----
V
R
-
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------
46
PsiBlast_CBE
76.42
40%
-110
- C2 -
2UZW
1
KAPCA_BOVIN
E:
[18-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
A
Q
N
T
A
H
L
--
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
----
V
R
-
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------
90
PsiBlast_CBE
76.39
35%
-103
- C2 -
2V55
1
ROCK1_HUMAN
A:
[71-403]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
------
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
---
95
PsiBlast_CBE
76.36
35%
-100
- C2 -
2ESM
1
ROCK1_HUMAN
B:
[71-402]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-----
62
PsiBlast_CBE
76.36
35%
-106
- C2 -
5BML
1
ROCK1_HUMAN
A:
[71-403]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
--
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
-----
E
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
--
65
PsiBlast_CBE
76.07
35%
-104
- C2 -
4YVC
1
ROCK1_HUMAN
B:
[71-402]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
--
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
---
A
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
-
S
-
N
-
Y
D
-
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
-----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
NS
L
T
F
P
-
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
--
R
N
G
V
-
E
E
-
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
------
E
E
T
F
P
I
P
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
Y
S
N
-----
27
PsiBlast_CBE
75.91
42%
-116
- C2 -
2R5T
1
SGK1_HUMAN
A:
[24-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
N
L
G
P
S
--
S
N
P
H
A
K
P
-----
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
---
H
---
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
-
Q
R
E
-
R
C
-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
-
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
-----
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
----
L
Q
-
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
D
D
F
-
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------
49
PsiBlast_CBE
75.74
40%
-115
- C2 -
2UZT
1
KAPCA_BOVIN
A:
[18-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
A
Q
N
T
A
H
L
--
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
----
V
R
-
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------
42
PsiBlast_CBE
75.46
40%
-117
- C2 -
2F7Z
1
KAPCA_BOVIN
E:
[33-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
A
Q
N
T
A
H
L
--
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
----
V
R
-
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------
36
PsiBlast_CBE
75.22
40%
-114
- C2 -
3WF6
1
KS6B1_HUMAN
A:
[15-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
RP
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
------------
T
K
A
E
R
N
I
L
E
E
V
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
-
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
-
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
-------------------------------------------------
34
PsiBlast_CBE
75.18
40%
-110
- C2 -
3WF9
2
KS6B1_HUMAN
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
RP
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VT
G
---
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
-
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
-
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------
40
PsiBlast_CBE
75.00
40%
-110
- C2 -
2OJF
1
KAPCA_BOVIN
E:
[33-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
A
Q
N
T
A
H
L
--
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
----
V
R
-
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------
38
PsiBlast_CBE
74.76
42%
-108
- C2 -
4L3L
1
KS6B1_HUMAN
A:
[14-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
RP
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
-
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
-
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
------------------------------------------------
48
PsiBlast_CBE
74.71
40%
-107
- C2 -
2UZU
1
KAPCA_BOVIN
E:
[18-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
A
Q
N
T
A
H
L
--
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
----
V
R
-
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------
41
PsiBlast_CBE
74.23
40%
-110
- C2 -
2OH0
1
KAPCA_BOVIN
E:
[33-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
A
Q
N
T
A
H
L
--
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
----
V
R
-
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------
35
PsiBlast_CBE
74.11
40%
-108
- C2 -
3WF8
2
KS6B1_HUMAN
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
RP
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
-
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
-
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------
37
PsiBlast_CBE
74.07
40%
-108
- C2 -
3WF5
1
KS6B1_HUMAN
A:
[15-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
RP
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
------------
T
K
A
E
R
N
I
L
E
E
V
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
-
T
V
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
-
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
-------------------------------------------------
53
PsiBlast_CBE
73.56
41%
-114
- C2 -
5D9K
2
?
A:
[32-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
---
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
V
E
V
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
-
S
-
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
----
L
G
-
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
---------------------------------------
25
PsiBlast_CBE
73.28
42%
-112
- C2 -
3HDN
1
SGK1_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
N
L
G
P
S
--
S
N
P
H
A
K
P
-----
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
---
H
---
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
-
Q
R
E
-
R
C
-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
-
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
-----
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
----
L
Q
-
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
D
D
F
-
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
----------------------------------------------------
58
PsiBlast_CBE
73.24
40%
-103
- C2 -
4NW6
1
KS6A3_HUMAN
A:
[32-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
---
I
S
GS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
V
E
V
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
-
S
-
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
-
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
----
L
G
-
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
---------------------------------------
59
PsiBlast_CBE
73.12
40%
-105
- C2 -
4NW5
1
KS6A3_HUMAN
A:
[32-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
---
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
V
E
V
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
-
S
-
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
-
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
----
L
G
-
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
---------------------------------------
55
PsiBlast_CBE
72.92
39%
-110
- C2 -
2Z7R
1
KS6A1_HUMAN
A:
[21-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
K
A
D
P
-----
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
---
K
---
V
TRP
D
S
G
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
------------
I
L
A
D
V
N
---
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
-
S
-
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
-----
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
----
L
G
-
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------
52
PsiBlast_CBE
72.73
41%
-113
- C2 -
5D9K
2
?
B:
[32-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
---
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
V
E
V
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
-
S
-
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
----
L
G
-
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
---------------------------------------
57
PsiBlast_CBE
72.47
40%
-108
- C2 -
5D9L
2
?
A:
[32-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
---
I
S
GS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
V
E
V
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
-
S
-
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
----
L
G
-
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
P
---------------------------------------
31
PsiBlast_CBE
72.08
41%
-119
- C2 -
3A61
1
KS6B1_HUMAN
A:
[15-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RP
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
G
---
A
---
N
T
G
K
I
F
A
M
K
V
L
K
---------------
A
E
R
N
I
L
E
E
V
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
-----------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
-
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------
26
PsiBlast_CBE
72.04
42%
-110
- C2 -
3HDM
1
SGK1_HUMAN
A:
[23-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
I
N
L
G
P
S
--
S
N
P
H
A
K
P
-----
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
---
H
---
K
---
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
--
L
K
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
-
Q
R
E
-
R
C
-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
-
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
-----
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
----
L
Q
-
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
D
D
F
-
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------
60
PsiBlast_CBE
71.79
40%
-106
- C2 -
4NUS
1
KS6A3_HUMAN
A:
[32-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
---
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
-
R
T
K
M
E
R
D
I
L
V
E
V
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
-
S
-
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
-
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
----
L
G
-
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
---------------------------------------
50
PsiBlast_CBE
71.60
43%
-117
- C2 -
4RLO
4
KS6B1_HUMAN
B:
[3-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
--
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
--------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
-
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------
54
PsiBlast_CBE
71.48
39%
-114
- C2 -
2Z7S
1
KS6A1_HUMAN
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
-----
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
---
K
---
V
TRP
D
S
G
H
L
Y
A
M
K
V
L
K
-------------------
I
L
A
D
V
N
---
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
-
S
-
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
-----
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
----
L
G
-
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------
56
PsiBlast_CBE
70.66
39%
-115
- C2 -
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
-----
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
---
K
---
V
TRP
D
S
G
H
L
Y
A
M
K
V
L
--------------------
I
L
A
D
V
N
---
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
-
S
-
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
-----
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
----
L
G
-
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------
32
PsiBlast_CBE
68.78
41%
-111
- C2 -
3A60
1
KS6B1_HUMAN
B:
[13-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
RP
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
KVT
G
---
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
-----------------------
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
-----------
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
-
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------
33
PsiBlast_CBE
68.63
41%
-110
- C2 -
3A60
1
KS6B1_HUMAN
A:
[13-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
RP
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
T
G
---
A
---
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
-----------
K
A
E
R
N
I
L
E
E
V
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
-
E
R
E
-
G
I
-
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
--------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
-
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------
51
PsiBlast_CBE
66.40
41%
-108
- C2 -
3G51
1
KS6A3_MOUSE
A:
[26-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
---
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
----------
I
L
V
E
V
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
-
S
-
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
-----
Q
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
----
L
G
-
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------
47
PsiBlast_CBE
36.43
40%
-7
- C2 -
2UZV
1
KAPCA_BOVIN
A:
[18-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
A
Q
N
T
A
H
L
--
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-----
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
----
V
R
-
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------