@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PLK2_HUMAN: (2015-10-17 )
MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTLLMSGCSSELKNRMEYALNMLLQRCN
Atome Classification :
(57 SA)
.........10........20........30........40........50........60......-..70........80........90........100.......110.......120.......130.......140.......150--.......160.......170.----.-.....180.......190.......200.......210.......220......-----.230.......240.......250.....-..260.......270.......280.......290.....-..300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
L
L
R
T
ITYQPAA
S
T
K
M
C
E
Q
A
L
GKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHHHHSHSGP-
E
I
S
R
I
I
VDPTTGK
R
Y
CRGKVLGKGGF
A
K
C
Y
E
M
TDLTNN
K
V
Y
A
A
K
IIPHSRVAK
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
FEDK--E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
----
R
-
K
VLT
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
LK
L
G
N
F
F
I
NE
A
M
E
LKVGDF
G
L
A
A
-----R
L
E
P
L
E
H
R
R
R
TICGTPNYL
S
P
E
V
L
NKQGH-GC
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
LGRPPFETT
N
L
K
E
T
Y
R
C
I
R
E
A
RY-TM
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
SKNPEDRP
S
L
D
D
I
I
R
H
D
F
F
LQGF
T
P
D
R
LSSSCCHTVPDFHLS
S
P
A
K
N
F
F
K
K
A
A
A
A
L
FGGKKDK
A
R
Y
IDTHNRVSKE
D
E
D
I
Y
K
L
R
H
D
L
K
K
TSITQQPSKHRTDEELQPPTTTVARSGTPAVE
N
K
Q
Q
I
G
D
A
I
R
M
I
V
R
GTLGSCS
S
S
S
E
CLEDSTM
G
S
V
A
D
T
V
A
R
V
L
R
G
C
L
ENMPEADCI
P
K
E
Q
L
S
T
S
F
Q
W
V
T
K
W
VDYSNKYG
F
G
Y
QLSD
H
T
V
G
V
L
FNNGA
H
M
SLLPDK
K
T
V
H
Y
Y
A
ELGQCSVFPATD
A
P
E
Q
F
I
S
Q
V
T
V
L
K
Y
F
S
H
Y
M
E
E
NLMDGGDLPS
V
T
DIR
R
P
R
L
Y
L
L
Q
W
L
KSD
K
A
L
M
M
L
FND
G
T
F
Q
V
N
F
Y
HD
H
T
K
I
I
I
CSQNE
E
Y
L
L
T
Y
INEDRIS
T
T
F
R
L
T
T
L
L
M
S
G
C
S
S
E
L
K
N
R
M
E
Y
A
L
N
M
L
L
Q
RCN
2
PsiBlast_PDB
88.45
97%
-115
- C1 -
4I6B
1
PLK2_HUMAN
A:
[19-303]
-----------------------------------------------------------------------
R
I
I
V
D
P
T
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
--
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
----
R
-
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
A
-----
R
L
E
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
N
K
Q
G
H
-
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
E
A
R
Y
-
T
M
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
87.68
98%
-115
- C1 -
4I5P
1
PLK2_HUMAN
A:
[19-302]
-----------------------------------------------------------------------
R
I
I
V
D
P
T
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
--
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
----
R
-
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
A
-----
R
L
E
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
N
K
Q
G
H
-
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
E
A
R
Y
-
T
M
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.49
97%
-114
- C1 -
4I6F
1
PLK2_HUMAN
A:
[19-303]
-----------------------------------------------------------------------
R
I
I
V
D
P
T
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
--
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
----
R
-
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
A
-----
R
L
E
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
N
K
Q
G
H
-
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
E
A
R
Y
-
T
M
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.43
97%
-115
- C1 -
4I5P
1
PLK2_HUMAN
A:
[19-302]
-----------------------------------------------------------------------
R
I
I
V
D
P
T
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
--
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
----
R
-
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
A
-----
R
L
E
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
N
K
Q
G
H
-
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
E
A
R
Y
-
T
M
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.45
97%
-115
- C1 -
4I6H
1
PLK2_HUMAN
A:
[19-303]
-----------------------------------------------------------------------
R
I
I
V
D
P
T
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
--
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
----
R
-
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
A
-----
R
L
E
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
N
K
Q
G
H
-
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
E
A
R
Y
-
T
M
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.09
97%
-117
- C1 -
4I5M
1
PLK2_HUMAN
A:
[19-302]
-----------------------------------------------------------------------
R
I
I
V
D
P
T
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
--
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
----
R
-
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
A
-----
R
L
E
-----------
T
P
N
Y
L
S
P
E
V
L
N
K
Q
G
H
-
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
E
A
R
Y
-
T
M
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
78.41
68%
-109
- C1 -
4B6L
1
PLK3_HUMAN
A:
[1-281]
------------------------------------------------------------------------
L
I
T
D
P
R
S
G
R
T
Y
L
K
G
R
L
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
P
Q
S
R
V
A
K
P
H
Q
R
E
K
I
L
N
E
I
E
L
H
R
D
L
Q
H
R
H
I
V
R
F
S
H
H
F
E
D
A
--
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
I
W
K
A
----
R
-
H
T
L
L
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
R
G
I
L
H
R
D
L
K
L
G
N
F
F
I
T
E
N
M
E
L
K
V
G
D
F
G
L
A
A
-----
R
L
E
P
P
E
Q
R
K
K
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
L
R
Q
G
H
-
G
P
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
P
F
E
T
A
D
L
K
E
T
Y
R
C
I
K
Q
V
H
Y
-
T
L
P
A
S
L
S
L
P
A
R
Q
L
L
A
A
I
L
R
A
S
P
R
D
R
P
S
I
D
Q
I
L
R
H
D
F
F
T
K
G
Y
T
P
D
R
L
P
I
S
S
C
V
T
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
78.39
50%
-116
- C1 -
2RKU
6
PLK1_HUMAN
A:
[3-292]
--------------------------------------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
--
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
-----
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
-
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
-
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
78.35
50%
-119
- C1 -
2OU7
1
PLK1_HUMAN
A:
[29-318]
--------------------------------------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
--
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
-----
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
-
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
-
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
78.17
67%
-109
- C1 -
4B6L
1
PLK3_HUMAN
A:
[1-281]
------------------------------------------------------------------------
L
I
T
D
P
R
S
G
R
T
Y
L
K
G
R
L
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
P
Q
S
R
V
A
K
P
H
Q
R
E
K
I
L
N
E
I
E
L
H
R
D
L
Q
H
R
H
I
V
R
F
S
H
H
F
E
D
A
--
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
I
W
K
A
----
R
-
H
T
L
L
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
R
G
I
L
H
R
D
L
K
L
G
N
F
F
I
T
E
N
M
E
L
K
V
G
D
F
G
L
A
A
-----
R
L
E
P
P
E
Q
R
K
K
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
L
R
Q
G
H
-
G
P
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
P
F
E
T
A
D
L
K
E
T
Y
R
C
I
K
Q
V
H
Y
-
T
L
P
A
S
L
S
L
P
A
R
Q
L
L
A
A
I
L
R
A
S
P
R
D
R
P
S
I
D
Q
I
L
R
H
D
F
F
T
K
G
Y
T
P
D
R
L
P
I
S
S
C
V
T
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
77.84
50%
-119
- C1 -
2OWB
1
PLK1_HUMAN
A:
[29-318]
--------------------------------------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
--
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
-----
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
-
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
-
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
77.75
50%
-116
- C1 -
2RKU
6
PLK1_HUMAN
A:
[4-291]
---------------------------------------------------------------------
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
--
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
-----
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
-
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
-
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
77.60
50%
-117
- C1 -
4J53
1
PLK1_HUMAN
A:
[2-291]
--------------------------------------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
--
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
-----
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
-
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
-
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
77.43
50%
-118
- C1 -
3FC2
7
PLK1_HUMAN
A:
[29-318]
--------------------------------------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
--
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
-----
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
-
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
-
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.29
48%
-114
- C1 -
3D5W
1
?
A:
[29-315]
-------------------------------------------------------------------K
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
--
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
--
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
-----
K
I
E
F
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
C
K
K
G
H
-
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
-
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
77.28
50%
-119
- C1 -
2OWB
1
PLK1_HUMAN
A:
[30-317]
---------------------------------------------------------------------
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
--
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
-----
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
-
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
-
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
77.09
50%
-117
- C1 -
3DB6
1
?
A:
[14-299]
--------------------------------------------------------------------
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
--
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
-----
K
I
E
F
D
G
E
R
K
K
D
L
C
G
T
P
N
Y
I
A
P
E
V
L
C
K
K
G
H
-
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
-
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.76
50%
-113
- C1 -
4A4O
2
PLK1_HUMAN
A:
[5-294]
--------------------------------------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
--
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
-----
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
-
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
-
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
76.68
50%
-115
- C1 -
2YAC
2
PLK1_HUMAN
A:
[5-294]
--------------------------------------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
--
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
-----
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
-
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
-
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
76.24
50%
-117
- C1 -
4J52
1
PLK1_HUMAN
A:
[2-291]
--------------------------------------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
--
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
-----
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
-
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
-
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
76.10
50%
-114
- C1 -
4A4L
2
PLK1_HUMAN
A:
[5-294]
--------------------------------------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
--
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
-----
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
-
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
-
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
75.93
50%
-118
- C1 -
3D5X
1
?
A:
[14-298]
--------------------------------------------------------------------
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
--
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
-----
K
I
E
F
D
G
E
R
K
K
D
-------
I
A
P
E
V
L
C
K
K
G
H
-
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
-
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
75.58
48%
-126
- C1 -
3DBD
1
?
A:
[29-315]
-------------------------------------------------------------------K
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
--
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
-----
K
I
--------------------------
H
-
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
-
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.26
50%
-127
- C1 -
3DBF
1
?
A:
[14-299]
--------------------------------------------------------------------
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
--
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
-----
K
I
--------------------------
H
-
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
-
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.73
48%
-125
- C1 -
3DBC
1
?
A:
[29-315]
-------------------------------------------------------------------K
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
--
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
-----
K
I
--------------------------
H
-
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
-
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.38
50%
-116
- C1 -
3DBE
1
?
A:
[14-299]
--------------------------------------------------------------------
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
--
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
-----
K
I
E
F
D
G
E
R
K
K
D
L
---
P
N
Y
I
A
P
E
V
L
C
K
K
G
H
-
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
-
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.65
48%
-125
- C1 -
3DB8
1
?
A:
[29-315]
-------------------------------------------------------------------K
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
--
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
----
R
-
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
-----
K
I
--------------------------
H
-
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
-
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
63.36
41%
-135
- C1 -
4YUR
1
PLK4_HUMAN
A:
[18-268]
-------------------------------------------------------------------------------------
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
--
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
----
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
N
I
K
I
A
D
F
---------------------------------------
G
L
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---
T
V
K
N
T
L
N
K
V
V
L
A
D
Y
-
E
M
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
62.07
30%
-111
- C1 -
2W5A
5
NEK2_HUMAN
A:
[4-272]
------------------------------------------------------------------------------
R
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
TN
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
-
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
R
-----
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
M
-
Y
-
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
R
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
60.33
41%
-131
- C1 -
4JXF
2
PLK4_HUMAN
A:
[12-262]
-------------------------------------------------------------------------------------
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
--
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
----
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
N
I
K
I
A
D
F
G
L
A
T
-----
Q
L
K
M
P
H
E
--------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
V
K
N
T
L
N
K
V
V
L
A
D
Y
-
E
M
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
60.05
31%
-114
- C1 -
3MYG
2
AURKA_HUMAN
A:
[17-264]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
-----------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
59.37
31%
-113
- C1 -
4UZD
1
AURKA_HUMAN
A:
[13-260]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
---------------
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
59.22
31%
-119
- C1 -
3W18
1
AURKA_HUMAN
A:
[11-258]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
--
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
-------
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
58.44
31%
-114
- C1 -
2WTW
1
AURKA_HUMAN
A:
[18-265]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
58.11
31%
-116
- C1 -
4JAI
1
AURKA_HUMAN
A:
[24-271]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
-----------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
57.91
31%
-120
- C1 -
3W18
1
AURKA_HUMAN
B:
[11-258]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-----------
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
--------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
57.66
31%
-110
- C1 -
3UOH
3
AURKA_HUMAN
B:
[14-261]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
57.60
41%
-121
- C1 -
3COK
1
PLK4_HUMAN
A:
[16-266]
-------------------------------------------------------------------------------------
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
--
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
----
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
N
I
K
I
A
D
F
G
L
A
T
-----
Q
L
K
-----------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
D
T
V
K
-----
V
V
L
A
D
Y
-
E
M
P
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
57.31
31%
-121
- C1 -
4C3P
1
AURKA_HUMAN
D:
[15-262]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
57.06
31%
-105
- C1 -
3UOD
3
AURKA_HUMAN
A:
[14-261]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
56.87
31%
-108
- C1 -
3UP2
3
AURKA_HUMAN
A:
[14-261]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
56.80
31%
-113
- C1 -
4B8L
1
AUKBA_XENLA
A:
[20-266]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
--
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
----
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
E
L
K
I
A
D
F
-----------------------
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
-
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
-
K
F
P
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
P
L
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
56.64
31%
-105
- C1 -
3UOJ
1
AURKA_HUMAN
A:
[14-261]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
56.18
31%
-107
- C1 -
4DEE
1
AURKA_HUMAN
A:
[14-261]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
56.14
31%
-106
- C1 -
4DEA
4
AURKA_HUMAN
A:
[14-261]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
56.05
31%
-109
- C1 -
3UO4
4
AURKA_HUMAN
A:
[14-261]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
56.05
31%
-112
- C1 -
4C3P
1
AURKA_HUMAN
A:
[15-262]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
55.55
32%
-110
- C1 -
4AF3
1
AURKB_HUMAN
A:
[28-274]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
K
S
H
F
I
V
A
L
K
V
L
F
K
S
Q
I
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
Q
A
H
L
H
H
P
N
I
L
R
L
Y
N
Y
F
Y
D
R
--
R
R
I
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
----
S
-
C
T
F
D
E
Q
R
T
A
T
I
M
E
E
L
A
D
A
L
M
Y
C
H
G
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
L
K
G
E
L
K
I
A
D
F
G
-----------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
N
E
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
N
P
P
F
E
S
A
S
H
N
E
T
Y
R
R
I
V
K
V
D
L
-
K
F
P
A
S
V
P
T
G
A
Q
D
L
I
S
K
L
L
R
H
N
P
S
E
R
L
P
L
A
Q
V
S
A
H
P
W
V
R
A
N
S
R
R
V
L
P
P
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
55.42
31%
-106
- C1 -
4O0S
1
AURKA_HUMAN
A:
[15-262]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
R
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
55.01
31%
-102
- C1 -
1MQ4
1
AURKA_HUMAN
A:
[17-264]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
--
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
54.85
31%
-102
- C1 -
3UP7
1
AURKA_HUMAN
A:
[14-261]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
54.76
31%
-105
- C1 -
3UOJ
1
AURKA_HUMAN
B:
[14-261]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
53.75
31%
-113
- C1 -
1MUO
1
AURKA_HUMAN
A:
[30-277]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-----------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
53.58
31%
-106
- C1 -
4DEB
3
AURKA_HUMAN
A:
[14-261]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
53.50
31%
-104
- C1 -
4CZU
3
CIPKN_ARATH
C:
[12-280]
---------------------------------------------------------------------------------
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
--
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
-
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
G
A
L
K
V
S
D
F
G
L
S
A
LPQQV
R
E
D
G
L
L
H
---
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
E
F
-
T
C
P
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
D
A
I
F
D
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
52.80
31%
-100
- C1 -
4DED
4
AURKA_HUMAN
A:
[14-261]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
-
T
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
22.34
31%
-68
- C1 -
2NP8
1
AURKA_HUMAN
A:
[17-166]
-------------------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
--
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
----
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-------
V
H
A
P
S
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------