@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PLK4_HUMAN: (2015-10-17 )
MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRVIQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERYSPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWFGNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQNTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMHSAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILLMFSNPTPNFH
Atome Classification :
(80 SA)
.........10-........20........30........40........50--.-.......60.....-...70........80........90........100.......110.......120.......130.......140......----.150.......160.......170.......180....-...190.......200.......210.......220..----------------....------------.230----.......240.......250.....-..260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
T
C
I
G
E
K
I
E
D-FKVG
N
L
LGKGS
F
A
G
V
Y
R
A
E
S
IH
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
--
G
-
M
V
Q
R
V
QN
E
V
K
I
H
C
Q
-LKH
P
S
I
L
E
L
Y
N
Y
FEDS
N
Y
V
Y
L
V
L
E
M
CHNG
E
M
N
R
Y
L
K
N
RVKPFSE
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
HSHGILHRD
L
T
L
S
N
L
L
L
TRNM----
N
I
K
I
ADFGL
A
T
QLKMPHEK
H
Y
T
LCGTPNYISP
E
I
ATRS-AHGL
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
IGRPPF
D
T
D
T
V
K
N
T
L
N
K
V
V
----------------
L
ADY------------EMP
S
----
F
LSI
E
A
K
D
L
I
H
Q
L
L
RRNPADR
L
S
L
S
-
S
V
LDHPFMSRNSSTKSKDLGTVEDSIDSGH
A
T
I
S
T
A
I
TASSSTSISG
S
L
F
DKRRLLIGQPLPNK
M
T
V
FPKNKSSTDFSSSGDGN
S
F
Y
T
QWGNQETSNSGRG
R
V
I
Q
D
A
E
ER
P
H
S
R
Y
L
R
R
A
YSSDRSGTSNSQSQ
A
K
T
Y
T
M
E
R
CHS
A
E
M
L
S
V
SKRSGGGENEERYSPTDNN
A
N
I
F
N
F
F
K
E
KTSSSSGSFERPDN
N
Q
A
L
SNHLCPGKTPFPFADPTP
Q
T
E
T
V
Q
Q
W
FGN
L
Q
I
N
A
H
L
RKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDN
A
H
S
V
K
Q
Q
N
T
M
K
Y
M
T
A
LHSK
P
E
I
I
Q
Q
ECVFGSDPL
S
E
Q
S
KTRGMEPPWGYQN
R
T
L
R
S
I
T
S
P
L
V
A
H
R
L
K
P
I
R
Q
K
T
K
K
A
V
V
S
ILD
S
E
E
V
C
V
E
L
V
K
E
Y
A
S
Q
E
Y
V
K
E
V
L
Q
ISSDG
N
T
I
T
I
Y
YPNGGRGFPLADRPPSPTDNISRYSFDNL
P
E
K
Y
W
R
K
Y
Q
Y
A
S
R
F
V
Q
L
V
RSKSP
K
I
T
Y
F
T
R
Y
A
K
C
I
L
M
ENSPGA
D
F
E
V
W
F
YD
G
V
K
I
H
K
T
E
D
F
I
Q
V
I
E
KTGK
S
Y
TLKSE
S
E
V
N
S
L
K
E
E
I
K
M
Y
M
D
HANEGH
R
I
C
L
A
L
E
S
I
I
S
E
E
E
RKTRSAP
F
F
P
I
I
I
GRKPGSTSSPKALSPPPSVDSNYPT
R
E
RASF
N
R
M
V
M
HSAASPTQAPILNPSMVTNEGL
G
L
T
TTASGTDIS
S
N
S
L
K
D
CL
P
K
S
A
Q
L
L
K
S
V
F
V
KNVGWATQLTS
G
A
V
W
V
Q
FNDG
S
Q
L
V
V
QAGVS
S
I
S
YTSPNGQTTRYGENEK
L
P
D
Y
I
K
Q
K
L
Q
C
L
S
S
I
L
L
M
FSNPTPNFH
3
PsiBlast_PDB
86.20
100%
-137
- C2 -
4JXF
2
PLK4_HUMAN
A:
[1-264]
---
C
I
G
E
K
I
E
D
-
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
--
G
-
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
-
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
----
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
M
P
H
E
--------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
V
K
N
T
L
N
K
V
V
----------------
L
A
D
Y
------------
E
M
P
S
----
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
-
S
V
L
D
H
P
F
M
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
84.64
99%
-136
- C2 -
3COK
1
PLK4_HUMAN
A:
[2-267]
L
A
T
C
I
G
E
K
I
E
D
-
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
--
G
-
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
-
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
----
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
-----------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
D
T
V
K
-----
V
V
----------------
L
A
D
Y
------------
E
M
P
S
----
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
-
S
V
L
D
H
P
F
M
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.64
99%
-136
- C2 -
3COK
1
PLK4_HUMAN
A:
[2-267]
L
A
T
C
I
G
E
K
I
E
D
-
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
--
G
-
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
-
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
----
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
-----------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
D
T
V
K
-----
V
V
----------------
L
A
D
Y
------------
E
M
P
S
----
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
-
S
V
L
D
H
P
F
M
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.85
100%
-142
- C2 -
4YUR
1
PLK4_HUMAN
A:
[8-269]
----
I
G
E
K
I
E
D
-
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
--
G
-
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
-
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
----
N
I
K
I
A
D
F
----------------------------------
G
L
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---
T
V
K
N
T
L
N
K
V
V
----------------
L
A
D
Y
------------
E
M
P
S
----
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
-
S
V
L
D
H
P
F
M
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
66.61
38%
-111
- C2 -
3D14
1
AURKA_MOUSE
A:
[11-269]
--------
L
E
D
-
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
66.01
38%
-117
- C2 -
3D2I
1
AURKA_MOUSE
A:
[11-269]
--------
L
E
D
-
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
-------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
65.69
37%
-107
- C2 -
2J4Z
2
AURKA_HUMAN
B:
[33-294]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
C
Q
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
65.64
38%
-113
- C2 -
3DJ7
1
AURKA_MOUSE
A:
[11-269]
--------
L
E
D
-
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
65.52
37%
-118
- C2 -
2X81
1
AURKA_HUMAN
A:
[11-269]
--------
L
E
D
-
F
E
I
G
R
P
L
G
---
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
-------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
65.36
37%
-112
- C2 -
4UZD
1
AURKA_HUMAN
A:
[7-265]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
----------
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
65.31
38%
-111
- C2 -
3D15
1
AURKA_MOUSE
A:
[11-269]
--------
L
E
D
-
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
-------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
65.30
37%
-111
- C2 -
3UOD
3
AURKA_HUMAN
A:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
65.08
37%
-106
- C2 -
4UZD
1
AURKA_HUMAN
B:
[7-266]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
---------
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
65.04
37%
-111
- C2 -
4JAJ
1
AURKA_HUMAN
A:
[18-277]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
64.57
37%
-108
- C2 -
3UO5
1
AURKA_HUMAN
A:
[8-268]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
64.57
37%
-111
- C2 -
3UP2
3
AURKA_HUMAN
A:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
64.43
37%
-114
- C2 -
3MYG
2
AURKA_HUMAN
A:
[11-269]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
-------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
64.29
37%
-115
- C2 -
4BYI
1
AURKA_HUMAN
A:
[12-270]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
---------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
64.13
37%
-114
- C2 -
3UO4
4
AURKA_HUMAN
A:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
63.99
37%
-118
- C2 -
3EFW
1
AURKA_HUMAN
B:
[130-389]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
-------------------
L
D
Y
L
P
P
E
M
I
E
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
63.81
37%
-107
- C2 -
4DEE
1
AURKA_HUMAN
A:
[8-269]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
63.79
37%
-116
- C2 -
4BYJ
1
AURKA_HUMAN
A:
[12-270]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
-------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
63.68
37%
-107
- C2 -
4DEA
4
AURKA_HUMAN
A:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
63.67
39%
-110
- C2 -
3DB6
1
?
A:
[31-281]
---------------
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
--
H
-
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
-
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
----
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
E
R
K
K
D
L
C
G
T
P
N
Y
I
A
P
E
V
L
C
K
K
-
G
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
----------------
K
N
E
Y
------------
S
V
P
R
----
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
-
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
63.59
38%
-116
- C2 -
3DJ6
1
AURKA_MOUSE
A:
[11-269]
--------
L
E
D
-
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
----
E
L
K
I
A
D
F
G
W
-----------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
63.56
38%
-118
- C2 -
3DJ5
1
AURKA_MOUSE
A:
[11-269]
--------
L
E
D
-
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
N
G
----
E
L
K
I
A
D
F
G
W
-----------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
63.32
37%
-113
- C2 -
4B0G
1
AURKA_HUMAN
A:
[10-271]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
-------
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
--------------
T
L
D
Y
L
P
P
E
M
I
E
----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
63.24
39%
-110
- C2 -
3D5W
1
?
A:
[47-297]
---------------
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
--
P
--
H
-
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
-
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
----
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
C
K
K
-
G
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
----------------
K
N
E
Y
------------
S
V
P
R
----
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
-
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
63.11
37%
-110
- C2 -
4DEB
3
AURKA_HUMAN
A:
[8-266]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
63.03
37%
-103
- C2 -
4UTD
1
?
A:
[9-270]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
63.00
37%
-116
- C2 -
3O50
1
AURKA_HUMAN
A:
[6-264]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
----------------
T
L
D
Y
L
P
P
E
M
I
E
----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
62.73
37%
-117
- C2 -
3EFW
1
AURKA_HUMAN
A:
[130-388]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
-------------------
L
D
Y
L
P
P
E
M
I
E
-------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
62.58
37%
-116
- C2 -
4PRJ
1
AURKA_HUMAN
A:
[8-266]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
---
N
V
Y
L
A
R
E
K
N
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
D
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
62.29
37%
-108
- C2 -
4DED
4
AURKA_HUMAN
A:
[8-266]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
62.22
37%
-102
- C2 -
3UOH
4
AURKA_HUMAN
A:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
62.17
37%
-112
- C2 -
4JAI
1
AURKA_HUMAN
A:
[18-278]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
62.05
37%
-113
- C2 -
4C2V
1
AUKBA_XENLA
A:
[14-272]
-------
T
I
D
D
-
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
--
G
-
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
-
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
----
E
L
K
I
A
D
F
G
W
S
V
H
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
-
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
----------------
N
V
D
L
------------
K
F
P
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
P
L
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
V
Y
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
61.86
37%
-109
- C2 -
3UP7
1
AURKA_HUMAN
A:
[8-265]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
61.85
37%
-107
- C2 -
1MQ4
1
AURKA_HUMAN
A:
[11-269]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
--
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
61.82
37%
-110
- C2 -
4C3P
1
AURKA_HUMAN
A:
[9-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
61.81
37%
-109
- C2 -
2WTW
1
AURKA_HUMAN
A:
[12-271]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
61.73
37%
-112
- C2 -
3COH
1
AURKA_HUMAN
B:
[7-265]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
N
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
----------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
D
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
61.68
37%
-117
- C2 -
3W16
1
AURKA_HUMAN
A:
[5-263]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
-------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
61.64
37%
-101
- C2 -
3UOL
8
AURKA_HUMAN
B:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
61.41
37%
-101
- C2 -
3UOL
6
AURKA_HUMAN
A:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
61.33
37%
-107
- C2 -
4O0S
1
AURKA_HUMAN
A:
[9-270]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
61.25
37%
-112
- C2 -
3COH
1
AURKA_HUMAN
A:
[7-265]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
N
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
----------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
D
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
61.24
37%
-115
- C2 -
3O50
1
AURKA_HUMAN
B:
[6-265]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
-------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
-----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
61.22
37%
-100
- C2 -
3UOJ
1
AURKA_HUMAN
A:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
61.15
41%
-98
- C2 -
4B6L
1
PLK3_HUMAN
A:
[14-266]
---------------
G
R
L
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
P
Q
S
R
V
A
K
P
--
H
-
Q
R
E
K
I
L
N
E
I
E
L
H
R
D
-
L
Q
H
R
H
I
V
R
F
S
H
H
F
E
D
A
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
I
W
K
A
R
-
H
T
L
L
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
R
G
I
L
H
R
D
L
K
L
G
N
F
F
I
T
E
N
M
----
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
P
E
Q
R
K
K
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
L
R
Q
-
G
H
G
P
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
P
F
E
T
A
D
L
K
E
T
Y
R
C
I
K
----------------
Q
V
H
Y
------------
T
L
P
A
----
S
L
S
L
P
A
R
Q
L
L
A
A
I
L
R
A
S
P
R
D
R
P
S
I
D
-
Q
I
L
R
H
D
F
F
T
K
G
Y
T
P
D
R
L
P
I
S
S
C
V
T
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
61.03
37%
-101
- C2 -
3UNZ
3
AURKA_HUMAN
B:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
61.02
37%
-103
- C2 -
3UOH
3
AURKA_HUMAN
B:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
60.96
37%
-100
- C2 -
3UNZ
3
AURKA_HUMAN
A:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
60.72
37%
-108
- C2 -
2YAC
2
PLK1_HUMAN
A:
[24-272]
-----------------
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
--
H
-
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
-
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
----
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
-
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
----------------
K
N
E
Y
------------
S
I
P
K
----
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
-
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
60.64
37%
-109
- C2 -
4A4O
2
PLK1_HUMAN
A:
[24-272]
-----------------
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
--
H
-
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
-
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
----
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
-
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
----------------
K
N
E
Y
------------
S
I
P
K
----
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
-
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
60.61
39%
-110
- C2 -
3D5X
1
?
A:
[31-281]
---------------
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
--
H
-
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
-
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
----
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
E
R
K
K
D
-------
I
A
P
E
V
L
C
K
K
-
G
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
----------------
K
N
E
Y
------------
S
V
P
R
----
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
-
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
60.59
37%
-100
- C2 -
3UO6
3
AURKA_HUMAN
A:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
60.56
37%
-122
- C2 -
3O51
1
AURKA_HUMAN
A:
[6-264]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
-------------------
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
60.53
37%
-100
- C2 -
3UOJ
1
AURKA_HUMAN
B:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
60.50
36%
-99
- C2 -
2Y0A
1
DAPK1_HUMAN
A:
[6-277]
-----
Q
E
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
RR
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
-
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
----------------
A
V
N
Y
------------
E
F
E
D
EYFS
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
-
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
60.49
39%
-119
- C2 -
3DBD
1
?
A:
[47-297]
---------------
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
--
H
-
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
-
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
----
D
V
K
I
G
D
F
G
L
A
T
K
I
---------------------------
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
----------------
K
N
E
Y
------------
S
V
P
R
----
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
-
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
60.39
37%
-114
- C2 -
3W18
1
AURKA_HUMAN
B:
[5-263]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
--------------
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
---------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
60.32
39%
-107
- C2 -
3DBE
1
?
A:
[31-281]
---------------
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
--
H
-
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
-
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
----
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
E
R
K
K
D
L
---
P
N
Y
I
A
P
E
V
L
C
K
K
-
G
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
----------------
K
N
E
Y
------------
S
V
P
R
----
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
-
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
60.18
37%
-110
- C2 -
2X6D
1
AURKA_HUMAN
A:
[12-270]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-------
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
60.14
39%
-119
- C2 -
3DB8
1
?
A:
[47-297]
---------------
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
--
H
-
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
-
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
----
D
V
K
I
G
D
F
G
L
A
T
K
I
---------------------------
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
----------------
K
N
E
Y
------------
S
V
P
R
----
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
-
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
60.00
37%
-110
- C2 -
4A4L
2
PLK1_HUMAN
A:
[24-272]
-----------------
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
--
H
-
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
-
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
----
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
-
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
----------------
K
N
E
Y
------------
S
I
P
K
----
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
-
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
59.97
37%
-101
- C2 -
3UO6
3
AURKA_HUMAN
B:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
59.91
37%
-98
- C2 -
3UOK
1
AURKA_HUMAN
A:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
59.89
37%
-113
- C2 -
1MUO
1
AURKA_HUMAN
A:
[24-282]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
59.63
37%
-121
- C2 -
4C3P
1
AURKA_HUMAN
D:
[9-269]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
59.29
37%
-97
- C2 -
3UOK
1
AURKA_HUMAN
B:
[8-267]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
-
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
59.17
37%
-115
- C2 -
3W18
1
AURKA_HUMAN
A:
[5-263]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
--
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
----------
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
-------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
59.17
39%
-118
- C2 -
3DBF
1
?
A:
[31-281]
---------------
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
--
H
-
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
-
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
----
D
V
K
I
G
D
F
G
L
A
T
K
I
---------------------------
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
----------------
K
N
E
Y
------------
S
V
P
R
----
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
-
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
58.61
37%
-109
- C2 -
3KB7
2
PLK1_HUMAN
A:
[24-270]
-----------------
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
--
H
-
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
-
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
----
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
-
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
----------------
K
N
E
Y
------------
S
I
P
K
----
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
-
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
N
M
M
F
S
I
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
58.32
39%
-113
- C2 -
3DBC
1
?
A:
[47-297]
---------------
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
--
H
-
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
-
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
----
D
V
K
I
G
D
F
G
L
A
T
K
I
---------------------------
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
----------------
K
N
E
Y
------------
S
V
P
R
----
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
-
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
57.91
37%
-113
- C2 -
2OU7
1
PLK1_HUMAN
A:
[48-296]
-----------------
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
--
H
-
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
-
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
----
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
-
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
----------------
K
N
E
Y
------------
S
I
P
K
----
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
-
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
57.88
37%
-107
- C2 -
2X6E
1
AURKA_HUMAN
A:
[12-270]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
-------------
T
L
D
Y
L
P
P
E
M
I
E
----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
----------------
R
V
E
F
------------
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
55.17
33%
-91
- C2 -
1XJD
1
A:
[16-275]
--------
I
E
D
-
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
--
D
-
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
----
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
L
F
H
S
I
R
----------------
M
D
N
P
------------
F
Y
P
R
----
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
Q
N
M
F
R
N
F
S
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
48.68
30%
-91
- C2 -
1UA2
1
CDK7_HUMAN
A:
[13-298]
-------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
I
-------------
N
R
T
A
L
R
E
I
K
L
L
Q
E
-
L
S
H
P
N
I
I
G
L
L
D
A
F
G
H
K
S
N
I
S
L
V
F
D
F
M
E
-
T
D
L
E
V
I
I
K
D
N
S
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
N
G
----
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
TLGTPTEEQWPDMCS
L
P
D
Y
V
T
FKSFPGI
P
L
H
H
I
F
S
----
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
-
Q
A
L
K
M
K
Y
F
S
N
R
P
G
P
T
P
G
C
Q
L
P
R
P
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
40.96
37%
-82
- C2 -
2NP8
1
AURKA_HUMAN
A:
[11-166]
--------
L
E
D
-
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
--
G
-
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
-
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
S
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------