@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PRP4B_HUMAN: (2015-10-17 )
MAAAETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKLLAPDMFTESDDMFAAYFDSARLRAAGIGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI
Atome Classification :
(39 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......---630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760...--....770.......780-----........790------........800.......810.......820.---------...------------------.---------..830.......840.......850-.......860-.......870.......880.......890.......900.......910.......920.......930........940.......950.......960.......970.....--------..980.......990.......1000....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAA
A
E
T
Q
S
L
REQPEMEDANSEKSINEENGEVSEDQSQ
N
K
H
S
R
H
K
K
K
K
H
K
H
R
S
K
H
K
KHKHSSEE
D
K
D
K
K
H
K
H
K
H
K
H
K
K
H
K
R
K
E
IIDASDKEGMSPAKRTKL
D
D
L
A
L
L
E
D
L
E
K
Q
R
A
L
I
K
A
E
LD
N
E
L
M
E
G
K
V
Q
SG
M
G
L
I
L
QGYESGSEEE
G
E
I
H
E
K
ARNGNRSSTRSSSTKG
K
L
E
L
VDNKIT
T
K
K
RSKSR
S
K
E
R
T
RHRSDKKKSKGG
I
E
I
V
K
E
KTTR
S
K
S
K
E
R
KKSKSPSKRSK
S
Q
D
Q
A
RKSKS
P
T
L
R
R
R
S
Q
E
K
IGKARSPTD
D
K
V
K
IEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGK
S
K
D
R
R
S
R
S
K
E
R
K
SKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLL
N
D
R
RSKQSKSPSRTLSPG
R
R
A
K
S
R
S
L
E
R
K
RR
E
P
E
R
R
RLSSPRTR
P
R
D
D
I
L
S
R
R
ERSKDASPINRWSPTRRRSRS
P
I
R
R
RSRSPLRRSRSPRRRSRSP
R
R
R
D
R
G
R
R
S
R
S
R
L
R
R
R
S
RSRGGRRRRSRSKV
K
E
D
K
FKG
S
L
SEG
M
K
VEQESSSDDNLEDFDVEE
E
D
E
E
A
L
I
E
Q
R
R
I
Q
R
Q
A
I
V
Q
K
Y
K
Y
L
AEDSNMSVPSEPSSPQSSTRTRSP
S
P
D
D
I
L
E
R
V
A
A
D
V
K
E
Y
E
R
ENV
D
T
F
E
A
S
VKAKH
N
L
M
T
V
EQNNGSSQ
K
K
LLA---PDMFTESD
D
M
F
A
A
Y
F
DSA
R
L
R
AAGIGKDFKENPNLRDNWTDAE
G
Y
Y
R
V
N
I
G
E
V
L
D
KRYNVYGYTG
Q
G
V
F
S
N
V
V
R
ARDNARAN
Q
E
V
A
V
K
I
I
RN
N
E
L
M
Q
K
TG
L
K
E
L
E
F
L
K
K
LNDADPDD
K
F
H
C
L
R
L
F
R
H
F
Y
H
KQ
H
L
C
L
--
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y------GKDVG
L
H
I
K
A
-------
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
RCN
I
L
HADIKPD
N
I
L
V---------NES------------------
K
---------
T
I
L
K
LCDFGSASHVADNDI
T
P
Y
L
V
S
-
R
F
YRAP
E
I
I
I
-GKSYDYGID
M
W
S
VG
C
T
L
Y
E
LYT
G
K
I
LFPGKTNN
H
M
L
K
L
A
M
D
LKGKM
P
N
K
M
I
R
KGVFKDQHFDQNL
N
F
M
-
Y
I
EVDKVTER
E
K
V
T
V
M
STIN
P
T
K
D
L
L
A
D
L
I
G
C
QRL
P
E
D
Q
R
K
K
V
H
Q
L
K
--------
D
L
L
D
Q
I
L
MLDP
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
QEKI
23
PsiBlast_CBE
98.17
99%
-109
- C3 -
4IFC
1
B:
[15-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
-
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
--
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
------
G
K
D
V
G
L
H
I
K
A
-------
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
---------
N
E
S
------------------
K
---------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
-
R
F
Y
R
A
P
E
I
I
I
-
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
Q
H
F
D
Q
N
L
N
F
M
-
Y
I
E
V
D
---
E
R
E
K
V
T
V
M
S
T
I
N
P
T
K
D
L
L
A
D
L
I
--
Q
R
L
P
E
D
Q
R
K
K
V
H
Q
L
K
--------
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
--
22
PsiBlast_CBE
96.94
99%
-110
- C3 -
4IIR
1
B:
[15-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
---
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
--
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
------
G
K
D
V
G
L
H
I
K
A
-------
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
---------
N
E
S
------------------
K
---------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
-
R
F
Y
R
A
P
E
I
I
I
-
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
Q
H
F
D
Q
N
L
N
F
M
-
Y
I
E
V
D
---
E
R
E
K
V
T
V
M
S
T
I
N
P
T
K
D
L
L
A
D
L
I
--
Q
R
L
P
E
D
Q
R
K
K
V
H
Q
L
K
--------
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
--
2
PsiBlast_PDB
96.67
99%
-110
- C3 -
4IFC
1
PRP4B_HUMAN
A:
[13-350]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
--
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
------
G
K
D
V
G
L
H
I
K
A
-------
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
---------
N
E
S
------------------
K
---------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
-
R
F
Y
R
A
P
E
I
I
I
-
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
Q
H
F
D
Q
N
L
N
F
M
-
Y
I
E
------
R
E
K
V
T
V
M
S
T
I
N
P
T
K
D
L
L
A
D
L
I
----
L
P
E
D
Q
R
K
K
V
H
Q
L
K
--------
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
--
21
PsiBlast_CBE
96.50
99%
-107
- C3 -
4IJP
1
B:
[13-350]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
--
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
------
G
K
D
V
G
L
H
I
K
A
-------
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
---------
N
E
S
------------------
K
---------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
-
R
F
Y
R
A
P
E
I
I
I
-
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
Q
H
F
D
Q
N
L
N
F
M
-
Y
I
E
V
D
----
R
E
K
V
T
V
M
S
T
I
N
P
T
K
D
L
L
A
D
L
I
G
C
Q
R
L
P
E
D
Q
R
K
K
V
H
Q
L
K
--------
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
--
4
PsiBlast_PDB
95.83
99%
-112
- C3 -
4IJP
1
PRP4B_HUMAN
A:
[15-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
--
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
------
G
K
D
V
G
L
H
I
K
A
-------
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
---------
N
E
S
------------------
K
---------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
-
R
F
Y
R
A
P
E
I
I
I
-
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
Q
H
F
D
Q
N
L
N
F
M
-
Y
I
E
V
D
---
E
R
E
K
V
T
V
M
S
T
I
N
P
T
K
D
L
L
A
D
L
I
--
Q
R
L
P
E
D
Q
R
K
K
V
H
Q
L
K
--------
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
--
3
PsiBlast_PDB
95.73
99%
-111
- C3 -
4IIR
1
PRP4B_HUMAN
A:
[13-350]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
--
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
--
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
------
G
K
D
V
G
L
H
I
K
A
-------
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
---------
N
E
S
------------------
K
---------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
-
R
F
Y
R
A
P
E
I
I
I
-
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
Q
H
F
D
Q
N
L
N
F
M
-
Y
I
E
------
R
E
K
V
T
V
M
S
T
I
N
P
T
K
D
L
L
A
D
L
I
----
L
P
E
D
Q
R
K
K
V
H
Q
L
K
--------
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
--
57
PsiBlast_CBE
69.82
31%
-92
- C3 -
2WU6
7
CLK3_HUMAN
A:
[36-369]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
--
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-------
N
N
F
Q
P
Y
P
L
P
H
-------
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
E
F
E
T
L
Y
N
E
H
------------------
K
S
C
E
E
K
S
V
KN
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
-
T
T
I
V
A
T
-
R
H
Y
R
P
P
E
V
I
L
-
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
--
R
K
Q
K
Y
F
Y
K
G
G
L
V
-
W
D
E
----
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
---------
Q
D
S
L
E
H
V
-
Q
L
F
--------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
5
PsiBlast_PDB
69.34
31%
-87
- C3 -
3NR9
1
CLK2_HUMAN
A:
[18-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
--
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-------
N
N
Y
L
P
Y
P
I
H
Q
-------
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
---------
V
N
S
D
Y
E
L
TD
E
R
S
V
K-------
S
---------
T
A
V
R
V
V
D
F
G
S
A
T
--
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
-
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
-
K
Q
K
Y
F
Y
R
G
R
-----
L
D
W
D
E
N
T
S
A
G
R
Y
-
V
R
E
N
C
K
P
L
R
----------
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
--------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
25
PsiBlast_CBE
68.46
31%
-87
- C3 -
3NR9
1
CLK2_HUMAN
B:
[18-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
--
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-------
N
N
Y
L
P
Y
P
I
H
Q
-------
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
---------
V
N
S
D
Y
E
L
T
Y
NLEKK
R
D
E
R
S
V
K
S
---------
T
A
V
R
V
V
D
F
G
S
A
T
--
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
-
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
-
K
Q
K
Y
F
Y
R
G
R
-----
L
D
W
D
E
N
T
S
A
G
R
Y
-
V
R
E
N
C
K
P
L
R
----------
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
--------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
-
24
PsiBlast_CBE
68.29
31%
-84
- C3 -
3NR9
1
CLK2_HUMAN
C:
[18-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
--
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-------
N
N
Y
L
P
Y
P
I
H
Q
-------
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
---------
V
N
S
DYELTYNLEKKRDERSVK
S
---------
T
A
V
R
V
V
D
F
G
S
A
T
--
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
-
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
-
K
Q
K
Y
F
Y
R
G
R
-----
L
D
W
D
E
N
T
S
A
G
R
Y
-
V
R
E
N
C
K
P
L
R
----------
R
Y
L
T
S
E
A
E
E
H
H
Q
L
F
--------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
56
PsiBlast_CBE
67.08
31%
-91
- C3 -
2WU7
1
CLK3_HUMAN
A:
[36-369]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
--
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-------
N
N
F
Q
P
Y
P
L
P
H
-------
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
E
F
E
T
L
Y
N
E
H
------------------
K
S
C
E
E
K
S
V
KN
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
-
T
T
I
V
A
T
-
R
H
Y
R
P
P
E
V
I
L
-
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
--
R
K
Q
K
Y
F
Y
K
G
G
L
V
-
W
D
E
----
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
---------
Q
D
S
L
E
H
V
-
Q
L
F
--------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
54
PsiBlast_CBE
65.96
31%
-89
- C3 -
3RAW
1
CLK3_HUMAN
B:
[36-369]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
--
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-------
N
N
F
Q
P
Y
P
L
P
H
-------
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
E
F
E
T
L
Y
N
E
H
------------------
K
S
C
E
E
K
S
V
KN
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
-
T
T
I
V
A
T
-
R
H
Y
R
P
P
E
V
I
L
-
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
--
R
K
Q
K
Y
F
Y
K
G
G
L
V
-
W
D
E
----
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
---------
Q
D
S
L
E
H
V
-
Q
L
F
--------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
55
PsiBlast_CBE
65.83
31%
-91
- C3 -
3RAW
1
CLK3_HUMAN
A:
[36-369]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
--
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-------
N
N
F
Q
P
Y
P
L
P
H
-------
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
VNS
E
F
E
T
L
Y
N
E
H
------------------
K
S
C
E
E
K
S
V
KN
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
-
T
T
I
V
A
T
-
R
H
Y
R
P
P
E
V
I
L
-
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
--
R
K
Q
K
Y
F
Y
K
G
G
L
V
-
W
D
E
----
N
S
S
D
G
R
Y
V
K
E
N
C
K
P
L
K
S
Y
M
L
---------
Q
D
S
L
E
H
V
-
Q
L
F
--------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
7
PsiBlast_PDB
58.79
30%
-68
- C3 -
4AZF
2
DYRK2_HUMAN
A:
[20-413]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
--
N
A
K
K
R
Q
G
M
T
G
-----
G
P
N
-
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
--
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-------
N
K
F
Q
G
F
S
L
P
L
-------
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K--------
Q
Q
G
------------------
R
---------
S
G
I
K
V
I
D
F
G
S
S
C
Y
-
E
H
Q
R
V
Y
T
Y
I
Q
S
-
R
F
Y
R
A
P
E
V
I
L
-
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
-
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
D
--
V
V
-----
L
N
G
G
R
S
R
R
G
K
L
R
G
----
P
P
E
S
R
E
W
G
N
A
L
K
GC
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
---
6
PsiBlast_PDB
58.70
30%
-68
- C3 -
3KVW
1
DYRK2_HUMAN
A:
[20-413]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
--
N
A
K
K
R
Q
G
M
T
G
-----
G
P
N
-
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
--
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-------
N
K
F
Q
G
F
S
L
P
L
-------
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K--------
Q
Q
G
------------------
R
---------
S
G
I
K
V
I
D
F
G
S
S
C
Y
-
E
H
Q
R
V
Y
T
Y
I
Q
S
-
R
F
Y
R
A
P
E
V
I
L
-
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
-
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
D
--
V
V
-----
L
N
G
G
R
S
R
R
G
K
L
R
G
----
P
P
E
S
R
E
W
G
N
A
L
K
GC
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
---
76
PsiBlast_CBE
48.17
31%
-81
- C3 -
3FLW
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
LM
G
A
D
L
N
N
I
V
K
C
QKLT
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
---
H
-
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
77
PsiBlast_CBE
47.59
31%
-76
- C3 -
3FLS
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
LM
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
L
--
H
-
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
97
PsiBlast_CBE
47.46
31%
-78
- C3 -
4LOO
1
MK14_MOUSE
A:
[73-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
HLM
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
L
A
R
H
-
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
71
PsiBlast_CBE
47.42
31%
-75
- C3 -
3FML
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
LM
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
-
L
A
R
H
-
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
101
PsiBlast_CBE
47.18
31%
-77
- C3 -
3K3J
2
MK14_HUMAN
A:
[74-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
HLM
G
A
D
L
N
N
I
---KLT
D
D
H
-
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
--------------
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
62
PsiBlast_CBE
47.12
31%
-78
* C3 *
3GC7
1
MK14_HUMAN
A:
[78-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
S
---------
E
-
L
K
I
L
D
F
G
L
A
R
H
-
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
78
PsiBlast_CBE
47.04
31%
-79
- C3 -
3FLQ
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
LM
G
A
D
L
N
N
I
V
K
C
QKLT
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
L
A
R
H
-
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
99
PsiBlast_CBE
46.94
31%
-81
- C3 -
4F9Y
5
MK14_HUMAN
A:
[95-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
HLM
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
L
A
-----------
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
73
PsiBlast_CBE
46.90
31%
-78
- C3 -
3FMH
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
LM
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
L
--
H
-
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
70
PsiBlast_CBE
46.75
31%
-81
- C3 -
3FMN
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
LM
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
-----
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
81
PsiBlast_CBE
46.69
31%
-79
- C3 -
3FKL
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
LM
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
L
A
------
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
80
PsiBlast_CBE
46.27
31%
-82
- C3 -
3FKN
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
LM
G
A
D
L
N
N
I
V
K
C
QKLT
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
---
H
-
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
65
PsiBlast_CBE
45.96
31%
-81
- C3 -
1OVE
2
MK14_HUMAN
A:
[78-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
S
---------
E
-
L
K
I
L
D
F
G
L
A
R
H
-
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
75
PsiBlast_CBE
45.87
31%
-78
- C3 -
3FLY
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
LM
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
L
--
H
-
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
83
PsiBlast_CBE
45.78
31%
-84
- C3 -
1OZ1
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
HLM
G
A
D
L
N
N
I
V
--LT
D
D
H
--
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
L
A
R
H
-
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
68
PsiBlast_CBE
45.13
31%
-83
- C3 -
3FSK
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
HLM
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
-------
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
79
PsiBlast_CBE
44.96
31%
-80
- C3 -
3FL4
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
--LT
D
D
H
--
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
-----
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
69
PsiBlast_CBE
44.87
31%
-81
- C3 -
3FSF
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
HLM
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
---
H
-
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
82
PsiBlast_CBE
44.40
31%
-79
- C3 -
2GFS
1
MK14_HUMAN
A:
[84-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
LM
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
----
H
-
T
D
D
E
M
T
G
Y
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
66
PsiBlast_CBE
44.06
31%
-81
- C3 -
2FST
3
MK14_HUMAN
X:
[79-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
LD
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
LVTHLM
G
A
D
L
N
-----QKLTDDH
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
----------------
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
98
PsiBlast_CBE
42.40
31%
-78
- C3 -
4FA2
3
MK14_HUMAN
A:
[95-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
HLM
G
A
D
L
N
N
I
V
K
C
QKLT
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
L
------------
V
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
85
PsiBlast_CBE
40.34
31%
-82
- C3 -
3ZSH
2
MK14_HUMAN
A:
[74-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
LM
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
----------------
A
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
87
PsiBlast_CBE
40.30
31%
-79
- C3 -
3ZS5
5
MK14_HUMAN
A:
[74-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
LM
G
A
D
L
N
N
I
V
K
C
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
L
A
-------------
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
100
PsiBlast_CBE
40.02
31%
-79
- C3 -
4F9W
4
MK14_HUMAN
A:
[95-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
HLM
G
A
D
L
N
N
I
V
K
C
QKLT
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
---------
N
E
D
------------------
C
---------
E
-
L
K
I
L
D
F
G
L
A
-------------
T
-
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
-------------------
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
-
P
K
M
N
F
A
N
V
F
I
G
A
N
P
L
A
----------
V
--------
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H