@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RET_HUMAN: (2015-10-18 )
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS
Atome Classification :
(76 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710..-.....720......-.730.......740.----------...-..--.-750.-.-.......760.......770.......780-.-......790....-...800.......810.......820.......830.......840-........850.......860.......870.......880.-----......890.......900...-...-.910.......920.......930.......940......-.950....-.-..960.....-------..970.......980.......990.......1000......1010........1020......1030......1040......1050......1060......1070......1080......1090......1100......1110.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKATSG
A
A
G
L
R
L
L
L
L
L
L
L
P
L
L
G
K
V
A
L
G
L
Y
FSRD
A
Y
W
E
K
L
Y
VDQAAGT
P
L
L
Y
V
H
A
L
RDA
P
E
EV
P
S
F
R
L
G
Q
H
L
Y
G
T
Y
R
T
R
LHEN
N
W
I
C
I
QEDT
G
L
L
Y
L
NRSLDHS
S
W
E
KLSVRNRG
F
P
L
L
T
V
Y
L
K
V
FLSPTSLREGECQWP
G
C
A
R
V
Y
F
S
F
FNTSFPACSSLK
P
R
ELCFPETRPS
F
R
IRENRPPGTF
H
Q
F
R
L
L
P
V
Q
F
LCP
N
I
S
V
A
Y
RLLEGEG
L
P
F
RCAPDS
L
E
V
S
T
R
WAL
D
R
E
Q
REK
Y
E
L
V
A
V
C
T
VHAGARE
E
V
V
M
VPF
P
V
T
V
YDEDDSAPTFPAGV
D
T
A
S
A
V
V
E
FKRKED
T
V
V
A
T
L
R
V
F
DADVVPA
S
G
E
L
V
R
R
Y
T
S
TLLPGD
T
W
A
Q
Q
T
F
R
V
EHWPNETSVQANG
S
F
V
R
A
T
V
H
D
Y
R
L
V
LNRNLSISEN
R
T
M
Q
L
A
V
L
V
NDSDFQGPG
A
G
V
L
L
L
H
FN
V
S
V
L
P
V
S
L
HLPS
T
Y
S
L
S
V
S
R
R
A
R
R
F
A
Q
I
G
K
V
C
V
E
N
C
Q
AFSG
I
N
V
Q
Y
K
LHSSGAN
C
S
T
L
G
V
V
TSAEDT
S
G
I
L
F
VND
T
K
A
LRRPKCA
E
L
H
Y
M
V
V
ATDQQTSRQA
Q
A
Q
L
L
V
T
VEG
S
Y
VAEEAGCP
L
S
C
A
V
S
KRRL
E
C
E
ECGGLGSPTGR
C
E
WRQGDGKGITRNFSTCSPSTKTCPDGHC
D
V
V
ETQDINI
C
P
Q
D
CLRGSIVGGHEPGEPRGIKAGYGTCNCFP
E
E
E
KCFC
E
P
E
DIQ
D
P
L
C
D
E
L
C
R
T
V
I
A
A
A
V
L
F
S
F
I
V
S
V
L
L
S
A
F
C
I
H
C
Y
H
K
F
AHKPPISSAE
M
T
FRRPAQAFPVSYSSSGARRPS
L
D
S
M
E
NQVS
V
D
A
F
K
ILED-PKWEFPRKN
L
V
L
G
K
-TLGEGEFG
K
V
V
K
A
T
A
----------
F
H
L-KG--R-A--G-
Y
-
T
T
V
A
V
K
M
L
K
ENA
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
QV-N-HP
H
V
I
K
L
Y
GACSQ-DG
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
SRKVGPGYLGSGGSRNSSSLDHP--
D
E
RA
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
AR
N
I
L
VA-----EG
R
K
M
K
I
SDFGLSRDVYEED
S
Y
-
V
KR-SQGRI
P
V
K
W
M
A
I
E
S
L
F
D
H
I
YTT
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
TLG-GNPYPGI
P
-
P
-
E
R
L
F
N
L
L
KTG-------HRMERPD
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
KQEPDKR
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
--
R
R
D
Y
L
D
LAASTPSD
S
L
I
YDDGLSEEET
P
L
V
DCNNAPLPRA
L
P
S
T
W
I
ENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPND
S
V
Y
A
N
W
MLS
P
S
A
A
K
L
M
D
TFDS
117
HHSearch
74.42
99%
-100
- C2 -
4CKJ
17
A:
[4-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
S
V
D
A
F
K
I
L
E
D
-
P
K
W
E
F
P
R
K
N
L
V
L
G
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
----------
F
H
L
-
K
G
--
R
-
A
--
G
-
Y
-
T
T
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
-----------------------
R
A
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
-
V
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
-
G
N
P
Y
P
G
I
P
-
P
-
E
R
L
F
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
--
R
R
-----------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.04
99%
-100
- C2 -
4CKJ
16
A:
[5-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
V
D
A
F
K
I
L
E
D
-
P
K
W
E
F
P
R
K
N
L
V
L
G
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
----------
F
H
L
-
K
G
--
R
-
A
--
G
-
Y
-
T
T
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
-----------------------
R
A
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
-
V
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
-
G
N
P
Y
P
G
I
P
-
P
-
E
R
L
F
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
--
R
R
-----------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
64.70
53%
-101
- C2 -
4F64
3
FGFR1_HUMAN
A:
[8-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
-----
G
Q
V
V
L
A
E
A
----------
I
G
L
--------PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
----------------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
-----------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
63.43
53%
-100
- C2 -
4RWJ
1
B:
[12-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
D
K
D
--
K
-
P
--
N
R
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
-----------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
---------
Y
-
K
K
T
-
T
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
----------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
63.26
53%
-97
- C2 -
4NKS
1
FGFR1_HUMAN
A:
[9-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
-----
G
Q
V
V
L
A
E
A
----------
I
----------N-
R
-
V
-
T
K
V
A
V
K
M
L
K
-
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
-----------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
63.25
53%
-97
- C2 -
4NKA
3
FGFR1_HUMAN
A:
[8-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
----
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
--
D
-
K
PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
----------------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
62.94
51%
-102
- C2 -
4J95
2
?
D:
[23-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
--------------------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
-------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
62.89
53%
-95
- C2 -
4RWK
1
B:
[12-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
D
K
D
--
K
-
P
--
N
R
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
-
K
K
T
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
----------------------------------------------------------------------------------------------------
126
HHSearch
62.77
47%
-89
- C2 -
3VHE
1
A:
[9-357]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
----------
F
G
I
-
D
K
--
T
-
A
--
T
-
C
-
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
-
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
--------------DL
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
-----
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
-
V
R
K
---
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
-
A
S
P
Y
P
G
V
K
-
I
D
E
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
--
N
A
Q
----------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
62.74
53%
-94
- C2 -
4RWL
1
B:
[12-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
D------
P
--
N
R
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-----------------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
---------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
62.69
51%
-96
- C2 -
4J95
1
FGFR2_HUMAN
A:
[23-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-------------------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
----
Y
Y
-
K
N
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
62.52
53%
-99
- C2 -
4F63
3
B:
[5-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
----------
I
G
L
--------PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
-
K
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
62.47
53%
-99
- C2 -
4NK9
5
FGFR1_HUMAN
A:
[8-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
---
D
-
K
PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-----------------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
62.28
51%
-95
- C2 -
4J99
1
FGFR2_HUMAN
A:
[22-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-------------------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
--
D
Y
Y
-
K
T
---
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
62.28
53%
-97
- C2 -
4V01
7
FGFR1_HUMAN
A:
[9-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
----
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
-----PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
62.14
53%
-95
- C2 -
4V05
4
FGFR1_HUMAN
A:
[8-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
--
D
-
K
PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
---------------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
62.04
51%
-96
- C2 -
4J99
1
?
D:
[21-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
--------------------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
T
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
62.02
52%
-99
- C2 -
4K33
1
A:
[25-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
D
-
P
K
W
E
L
S
R
A
R
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
I
G
I
D
K
D
--
R
-
A
--
A
-
K
P
V
T
V
A
V
K
M
L
K
D
D
A
T
D
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
G
G
P
L
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
L
D
Y
--------
S
F
D
T
S
------
E
Q
L
T
F
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
V
H
N
L
D
Y
Y
-
K
E
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
V
L
T
V
--
T
------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
61.94
51%
-93
- C2 -
4J97
1
FGFR2_HUMAN
A:
[24-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
---
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
-----PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
--------------------
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
E
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
61.93
52%
-94
- C2 -
3RI1
1
?
A:
[13-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-----------------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
T
-----------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
61.82
53%
-91
- C2 -
3JS2
1
FGFR1_HUMAN
A:
[16-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
D
K
D
--
K
-
P
--
N
R
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
---------------
H
N
--
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
61.80
53%
-94
- C2 -
5A4C
7
?
B:
[5-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
------PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-----------------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
61.69
53%
-95
- C2 -
3RHX
5
FGFR1_HUMAN
A:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
--
D
-
K
PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
----------------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
---------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
61.69
51%
-97
- C2 -
4J97
1
?
C:
[23-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
---
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
--------
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
---------------
I
N
R
V
--
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
E
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
61.61
53%
-99
- C2 -
4F65
6
FGFR1_HUMAN
A:
[8-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
-----PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
---------------------
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
----------
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
61.47
53%
-96
- C2 -
4F65
4
B:
[4-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
------PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
-------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
-------
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
----------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
61.36
51%
-95
- C2 -
2PY3
1
FGFR2_HUMAN
A:
[24-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
----
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-----------------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
T
N
----------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
61.31
53%
-98
- C2 -
3RHX
2
B:
[4-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
--------PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
61.27
53%
-97
- C2 -
4F64
3
B:
[5-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
--------PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
-
K
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
61.25
53%
-100
- C2 -
4F63
3
FGFR1_HUMAN
A:
[8-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
-----
G
Q
V
V
L
A
E
A
----------
I
G
L
--------PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
----------------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
-----------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
61.24
51%
-98
- C2 -
2PVY
1
?
D:
[23-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
------
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
-----------------
V
--
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
N
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
61.11
53%
-99
- C2 -
5AM7
1
B:
[5-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
---
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
--
D
-
K
PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
--------------------
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
-----------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
61.11
53%
-99
- C2 -
4NK9
2
B:
[4-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
-----PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
--------
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
60.99
53%
-95
- C2 -
4NKA
2
B:
[4-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
-----PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-----------------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
------
H
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
119
HHSearch
60.94
53%
-92
- C2 -
2PVF
1
A:
[23-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
DK
P
--------
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
S
Y
------------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
TT-------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
60.91
52%
-93
- C2 -
3RI1
1
FGFR2_HUMAN
B:
[13-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
------PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-----------------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
T
N
----------------------------------------------------------------------------------------------------
122
HHSearch
60.78
54%
-88
- C2 -
3TT0
1
FGFR1_HUMAN
A:
[54-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
D-
K
P
N
--
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
S
Y
N
P
S
--------
H
N
--
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
60.38
53%
-94
- C2 -
5AM7
1
FGFR1_HUMAN
A:
[5-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
---
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
--
D
-
K
PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
--------------------
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
---------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
60.34
53%
-95
- C2 -
4RWJ
1
FGFR1_HUMAN
A:
[12-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
D
K
D
--
K
-
P
--
N
R
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
-----
S
Y
N
P
S
---
H
N
--
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
-
K
K
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
---------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
60.29
51%
-94
- C2 -
3B2T
1
FGFR2_HUMAN
A:
[7-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
------PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
------------------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
T
N
Q
E
--------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
60.23
51%
-94
- C2 -
4J95
1
?
B:
[24-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-------------------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
N
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
60.21
51%
-92
- C2 -
4J98
1
FGFR2_HUMAN
B:
[19-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
--------
S
Y
D
I
N
R
V
--
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
Q
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
60.18
51%
-94
- C2 -
4J97
1
B:
[24-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
---
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
--------
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
--------------
I
N
R
V
--
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
E
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
60.12
53%
-90
- C2 -
3JS2
1
B:
[12-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
D
K
D
--
K
-
P
--
N
R
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-----------------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
-----------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
60.07
53%
-88
- C2 -
3TT0
1
FGFR1_HUMAN
A:
[54-351]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
D
K
D
--
K
-
P
--
N
R
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
-----
S
Y
N
P
S
---
H
N
--
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
60.05
51%
-97
- C2 -
4J97
1
?
D:
[22-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
-----
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-----------------
R
V
--
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
E
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
60.05
53%
-102
- C2 -
3TT0
4
B:
[53-351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
D
K
D
--
K
-
P
--
N
R
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
----------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
59.91
53%
-95
- C2 -
4NKS
1
B:
[5-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
----------
I
G
L
--------PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
-
K
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
59.86
51%
-93
- C2 -
3B2T
1
B:
[6-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
----
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
-----PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
------------------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
59.81
51%
-97
- C2 -
2PZR
1
B:
[23-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
------
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
----------------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
T
N
----------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
59.75
51%
-91
- C2 -
4J99
1
?
C:
[23-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
--------
S
Y
D
---------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
T
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
59.43
51%
-88
- C2 -
4J99
1
B:
[23-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
--------
S
Y
D
---------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
T
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
59.40
53%
-85
- C2 -
4RWK
1
FGFR1_HUMAN
A:
[12-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
D
K
D
--
K
-
P
--
N
R
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
-----
S
Y
N
P
S
---
H
N
--
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
---------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
59.31
53%
-92
- C2 -
5A4C
6
?
A:
[6-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
--
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
--
D
-
K
PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
-----
S
Y
N
P
S
---
H
N
--
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
59.18
52%
-91
- C2 -
2PWL
1
FGFR2_HUMAN
B:
[24-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
H
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
----------------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
T
-----------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
59.15
51%
-96
- C2 -
4J95
1
?
C:
[24-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
--------------------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
N
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
58.96
53%
-89
- C2 -
4UWB
4
?
A:
[8-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
--
D
-
K
PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
-----
S
--
P
S
---
H
N
--
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
58.89
52%
-91
- C2 -
1OEC
1
A:
[15-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-------
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
-------------------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
T
-----------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
58.53
51%
-95
- C2 -
2PZR
1
FGFR2_HUMAN
A:
[24-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
------
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
----------------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
T
-----------------------------------------------------------------------------------------------------
127
HHSearch
58.50
38%
-85
- C2 -
3CBL
3
A:
[106-376]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
K
W
V
L
N
H
E
D
L
V
L
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--------------
R
A
-------
D
-
N
-
T
L
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
P
N
I
V
R
L
I
G
V
C
T
Q
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
-------------------------
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-----
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
-
D
G
V
Y
-
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
-
A
S
P
Y
P
N
L
S
-
N
-
Q
Q
T
R
E
F
V
E
K
G
-------
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
--
H
------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
58.49
53%
-90
- C2 -
4UWC
9
?
B:
[4-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
-----PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
-----
S
Y
------
H
N
--
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
---------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
58.29
51%
-91
- C2 -
4J96
1
FGFR2_HUMAN
B:
[19-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
--------
S
Y
D
I
N
R
V
--
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
M
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
T
N
----------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
58.23
51%
-93
- C2 -
2PY3
1
B:
[24-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
----
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
---------------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
T
N
----------------------------------------------------------------------------------------------------
132
HHSearch
58.14
38%
-94
- C2 -
4AOJ
1
NTRK1_HUMAN
A:
[33-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
C
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
H
N
L
-
L
P
---------
K
-
M
L
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
----------------------
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
-
K
Q
P
W
Y
Q
L
S
-
N
-
T
E
A
I
D
C
I
T
Q
G
-------
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
--
P
P
-----------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
58.11
53%
-89
- C2 -
4UWB
3
?
B:
[4-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
R
W
E
L
P
R
D
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
----------
I
G
L
-
D
K
-----PN
R
-
V
-
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
-----
S
Y
------
H
N
--
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
H
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
V
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
--
T
S
N
Q
E
--------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
57.96
51%
-95
- C2 -
2Q0B
1
B:
[24-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
-----
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
----------------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
T
N
----------------------------------------------------------------------------------------------------
131
HHSearch
57.91
45%
-96
* C2 *
3ZBF
1
A:
[28-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
F
P
R
E
K
L
T
L
R
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
----------
V
D
I
-
L
G
--
V
G
S
--
G
-
E
-
I
K
V
A
V
K
T
L
K
K
G
S
T
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
L
-
N
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
A
T
--
F
-----------------
Y
G
P
L
L
T
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
VKDYT
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
--------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
-
H
Q
P
Y
P
A
H
S
-
N
-
L
D
V
L
N
Y
V
Q
T
G
-------
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
--
F
L
N
S
I
Y
K
S
R
----------------------------------------------------------------------------------------------
135
HHSearch
57.52
39%
-85
- C2 -
4CLJ
1
A:
[24-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
--------------
P
-
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-----------------
S
--
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-------
G
-
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
-
Y
M
P
Y
P
S
K
S
-
N
-
Q
E
V
L
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
---
P
D
V
I
N
T
A
L
P
I
E
Y
G
-----------------------------------------------------------------------------------------
61
PsiBlast_CBE
57.50
52%
-88
- C2 -
2PWL
1
FGFR2_HUMAN
A:
[23-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
H
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------------------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
------------------------------------------------------------------------------------------------------
133
HHSearch
57.41
35%
-96
- C2 -
1U59
1
A:
[2-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
-----------
R
-----------
K
-
Q
-
I
D
V
A
I
K
V
L
K
Q
G
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
-
N
P
Y
I
V
R
L
I
G
V
C
Q
--
A
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
-------------------------
E
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
D
D
S
Y
Y
T
A
R
-
S
A
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
-
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
-------
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
--
L
A
S
K
V
E
G
H
H
H
H
H
H
------------------------------------------------------------------------------------------
120
HHSearch
57.41
47%
-85
- C2 -
1T46
1
?
A:
[2-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
-
H
K
W
E
F
P
R
N
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
----------
Y
G
L
-
I
K
--
S
-
D
--
A
-
A
-
M
T
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
----------------------
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
-----
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
-
V
V
K
-
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
-
S
S
P
Y
P
G
M
P
V
D
-
S
K
F
Y
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
--
S
T
N
----------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
56.72
51%
-96
- C2 -
2Q0B
1
FGFR2_HUMAN
A:
[24-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
K
W
E
F
P
R
D
K
L
T
L
G
K
-
P
L
-----
G
Q
V
V
M
A
E
A
----------
V
G
I
-
D
K
--
D
-
K
PK
E
-
A
-
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-----------------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
-
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
-
G
S
P
Y
P
G
I
P
-
V
-
E
E
L
F
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
--
T
T
-----------------------------------------------------------------------------------------------------
124
HHSearch
55.73
48%
-88
- C2 -
2XIR
1
A:
[13-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
P
Y
D
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
----------
F
G
I
-
D
K
--
T
-
A
--
T
-
C
-
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
-
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
-----------------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
-----
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
-
V
R
K
-
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
-
A
S
P
Y
P
G
V
K
I
D
-
E
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
--
N
A
-----------------------------------------------------------------------------------------------------
137
HHSearch
55.32
37%
-87
- C2 -
4BKJ
10
DDR1_HUMAN
A:
[3-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
V
D
F
P
R
S
R
L
R
F
K
E
-
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
SPQDLVSLD
F
P
L
-
N
V
--
R
-
K
--
G
H
P
-
L
L
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
----------------------
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
------
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
-
D
-
E
Q
V
I
E
N
A
G
E
F
F
R
DQGRQ
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
--
T
V
-----------------------------------------------------------------------------------------------------
125
HHSearch
51.96
44%
-84
- C2 -
2I1M
1
A:
[30-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
T
Q
L
P
Y
N
-
E
K
W
E
F
P
R
N
N
L
Q
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
----------
F
G
L
-
G
K
--
E
-
D
--
A
-
V
-
L
K
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
S
R
V
L
E
T
D
-------------------
S
T
A
S
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
-----
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
-
I
V
K
-
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
-
L
N
P
Y
P
G
I
L
-
V
N
S
K
F
Y
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
E
--
D
R
R
E
R
--------------------------------------------------------------------------------------------------
129
HHSearch
51.55
38%
-83
- C2 -
3L9P
4
A:
[64-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
G
-----------
S
-
P
-
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
-
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-----------------
S
--
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
-
R
K
G
-
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
-
Y
M
P
Y
P
S
K
S
-
N
-
Q
E
V
L
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
---
D
P
D
V
I
N
T
A
L
P
I
E
-------------------------------------------------------------------------------------------