@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RIPK1_HUMAN: (2015-10-18 )
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
Atome Classification :
(75 SA)
.........10........20........30------........40.........50-........60........70.........80.......------.90........100-.......---------.--------.-----110.---......----------..120------...--------......130.--......140.......150.......160.......170.......180......-.-190.........200.......------210.......220.-.-..-.--------..230.......240..--.---.-...250-.....--.-----..260----.........270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQPDM
S
L
N
V
I
K
MKSSDF
L
E
SAELDSGGFG
K
V
------
S
L
C
F
HRTQ
G
-
L
M
I
M
K
T
VYKGP-NCI
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
EEG
K
Y
------
S
L
V
M
E
Y
M
EKGN
L
---
M
H
V
L
K
A
E---------M--------S-----T--P---LSVK
G
R
----------
I
I
L
--------
E
I
I
--------
E
G
M
C
Y
LHGKG--
V
I
HKDLKPE
N
I
L
VDND
F
H
I
K
I
ADLG
L
A
S
F
K
M
W
S
KLN
N
E
E
H
N
E
L
R
E
VDGTAKKNG
G
-
T
-
L
--
Y
Y
M
A
P
E
HLNDVNAKPTEK
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
FA-N-KE-
P
--------
Y
E
N
A
I
C
E
Q
Q
L
I
M
C
I
KSG--N---R-P
D
V
D
D
--
I
T
E
Y
C
--
P
-----
R
E
I
------
I
S
L
M
K
L
C
WEANPEARPTFP
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
L
K
K
EYSN
E
N
A
V
V
K
R
M
Q
SLQ
L
D
C
V
AVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENE
P
S
L
Q
S
K
L
Q
DEAN
Y
H
L
YGSRMD
R
Q
T
K
QQPRQNVAYN
R
E
E
E
R
R
RRVSHDP
F
A
QQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQ
P
Q
V
L
Y
QNNGLYSSHGFGTRPLDPGTAGP
R
V
W
Y
RPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDE
S
I
K
Y
T
I
YNST
G
I
Q
I
G
A
Y
N
Y
M
E
IGGTS
S
S
LLDSTNTNFKEEP
A
A
K
Y
Q
A
I
FDNTTSL
T
D
K
H
L
D
P
I
R
E
N
L
G
K
H
W
K
N
C
A
R
KLGF
T
Q
S
Q
I
D
E
ID
H
D
Y
E
RD
G
L
K
E
K
V
Y
Q
M
L
Q
K
W
V
M
REGIKGA
T
V
G
K
L
A
Q
A
L
H
Q
C
S
R
I
D
L
L
S
S
L
I
YVSQN
96
HHSearch
95.42
100%
-108
- C1 -
4NEU
1
RIPK1_HUMAN
A:
[15-322]
-----
S
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
------
S
L
C
F
H
R
T
Q
G
-
L
M
I
M
K
T
V
Y
K
G
P
-
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------
S
-----
T
--
P
---
L
S
V
K
G
R
----------
I
I
L
--------
E
I
I
--------
E
G
M
C
Y
L
H
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
----------------------
G
-
T
-
L
--
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
--------
Y
E
N
A
I
C
E
Q
Q
L
I
M
C
I
K
S
G
--
N
---
R
-
P
D
V
D
D
--
I
T
E
Y
C
--
P
-----
R
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
L
K
K
E
Y
S
N
E
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.42
100%
-108
- C1 -
4NEU
1
RIPK1_HUMAN
A:
[15-322]
-----
S
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
------
S
L
C
F
H
R
T
Q
G
-
L
M
I
M
K
T
V
Y
K
G
P
-
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------
S
-----
T
--
P
---
L
S
V
K
G
R
----------
I
I
L
--------
E
I
I
--------
E
G
M
C
Y
L
H
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
----------------------
G
-
T
-
L
--
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
--------
Y
E
N
A
I
C
E
Q
Q
L
I
M
C
I
K
S
G
--
N
---
R
-
P
D
V
D
D
--
I
T
E
Y
C
--
P
-----
R
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
L
K
K
E
Y
S
N
E
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
94.10
99%
-123
- C1 -
4ITJ
1
RIPK1_HUMAN
A:
[8-294]
-------
N
V
I
K
M
K
S
S
D
F
L
E
--------
F
G
K
V
------
S
L
A
F
H
R
T
Q
G
-
L
M
I
M
K
T
V
Y
K
G
P
-
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------
S
-----
T
--
P
---
L
S
V
K
G
R
----------
I
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
------------------
G
-
T
-
L
--
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
--------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
--
I
T
E
Y
C
--
P
-----
R
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.90
98%
-123
- C1 -
4ITJ
1
RIPK1_HUMAN
A:
[8-294]
-------
N
V
I
K
M
K
S
S
D
F
L
E
--------
F
G
K
V
------
S
L
A
F
H
R
T
Q
G
-
L
M
I
M
K
T
V
Y
K
G
P
-
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------
S
-----
T
--
P
---
L
S
V
K
G
R
----------
I
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
------------------
G
-
T
-
L
--
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
--------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
--
I
T
E
Y
C
--
P
-----
R
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
92.30
98%
-113
- C1 -
4ITJ
1
RIPK1_HUMAN
B:
[7-294]
------
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
------
S
L
A
F
H
R
T
Q
G
-
L
M
I
M
K
T
V
Y
K
G
P
-
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------
S
-----
T
--
P
---
L
S
V
K
G
R
----------
I
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-------------
T
-
L
--
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
--------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
--
I
T
E
Y
C
--
P
-----
R
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.05
98%
-124
- C1 -
4ITI
1
RIPK1_HUMAN
A:
[8-294]
-------
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
------
S
L
A
F
H
R
T
Q
G
-
L
M
I
M
K
T
V
Y
K
G
P
-
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------
S
-----
T
--
P
---
L
S
V
K
G
R
----------
I
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
----------
G
G
-
T
-
L
--
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
--------
Y
E
-----
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
--
I
T
E
Y
C
--
P
-----
R
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
90.02
98%
-121
- C1 -
4ITI
1
RIPK1_HUMAN
B:
[7-294]
------
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
-------
K
V
------
S
L
A
F
H
R
T
Q
G
-
L
M
I
M
K
T
V
Y
K
G
P
-
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------
S
-----
T
--
P
---
L
S
V
K
G
R
----------
I
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-----------
G
-
T
-
L
--
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
--------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
--
I
T
E
Y
C
--
P
-----
R
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
HHSearch
72.18
30%
-114
- C1 -
4C8B
2
RIPK2_HUMAN
A:
[31-329]
------------
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
------
S
S
A
R
H
A
D
W
R
V
Q
V
A
V
K
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------
E
-----
Y
--
P
DVA
W
P
L
R
F
R
----------
I
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
------------------------------
G
-
T
-
I
--
I
Y
M
P
P
E
N
Y
-------
S
I
K
H
------
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
--------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
ES
L
P
Y
D
I
PH
R
-----
A
R
M
------
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
66.49
32%
-122
- C1 -
4C8B
1
RIPK2_HUMAN
B:
[80-328]
-------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------
E
-----
Y
--
P
DVA
W
P
L
R
F
R
----------
I
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
------------------------------
G
-
T
-
I
--
I
Y
M
P
P
E
-----
N
Y
E
P
G
Q
K
S
R
A
SIK
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
--------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
----
E
S
L
--
P
-----
Y
D
I
PH
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
63.17
31%
-96
- C1 -
3LVP
2
IGF1R_HUMAN
A:
[52-335]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
---------
M
--------
E
PVL--
A
--
P
---
P
S
L
S
K
M
----------
I
Q
M
A
G
------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
-------
G
G
K
G
-
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
62.81
31%
-103
- C1 -
1QPE
1
LCK_HUMAN
A:
[21-270]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
E
G
A
K
F
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
62.59
31%
-113
- C1 -
2OFV
1
LCK_HUMAN
A:
[26-273]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
-----------
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
-------------------------------
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
R
M
V
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
62.57
31%
-103
- C1 -
3BYO
1
?
A:
[21-270]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
E
G
A
K
-
F
P
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
62.49
31%
-100
- C1 -
1QPC
2
?
A:
[21-270]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
E
G
A
K
F
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
62.39
31%
-98
- C1 -
2PL0
1
LCK_HUMAN
A:
[31-278]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
R
M
V
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
62.30
30%
-99
- C1 -
4HCU
1
A:
[6-261]
----------
V
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
Y
W
L
N
K
D
-
K
V
A
I
K
T
I
R
E
G
A
-
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
R--------
G
--------
L
-----
F
--
A
---
A
E
T
L
L
G
----------
M
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
Y
------------
T
S
S
T
G
T
K
F
-
P
-
V
--
K
W
A
S
P
E
V
F
S
F
--
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
--------
Y
E
N
R
-
S
N
S
E
V
V
E
D
I
S
T
G
--
F
---
R
-
L
Y
-----
K
P
R
L
A
--
S
-----
T
H
V
------
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
62.23
31%
-105
- C1 -
2OG8
1
?
B:
[16-265]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
------------------------
P
------
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
R
M
V
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.22
31%
-101
- C1 -
2ZM1
2
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
61.77
31%
-110
- C1 -
3BYU
1
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-----------------------
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
61.76
31%
-102
- C1 -
3AC3
1
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
61.44
31%
-99
- C1 -
2ZM4
2
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
61.39
31%
-101
- C1 -
1QPJ
1
LCK_HUMAN
A:
[21-270]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
E
G
A
K
F
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.39
31%
-99
- C1 -
3AC5
2
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.36
31%
-102
- C1 -
2ZYB
1
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.04
31%
-104
- C1 -
3AC2
3
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
60.97
31%
-98
- C1 -
3AC4
2
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
60.95
31%
-101
- C1 -
3AD4
3
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
60.92
31%
-109
- C1 -
2HCK
1
HCK_HUMAN
B:
[189-429]
---------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
T
Y
N
K
H
T
-
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------
G
-----
S
KQ
P
---
L
P
K
L
I
D
----------
F
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
--
R
V
G
A
K
F
---------------------
P
-
I
--
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
--------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
-
M
P
R
-----
P
E
N
C
--
P
-----
E
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
60.91
31%
-102
- C1 -
2OFU
1
LCK_HUMAN
A:
[23-272]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
E
G
A
K
-
F
P
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
60.87
31%
-98
- C1 -
2OF4
1
LCK_HUMAN
A:
[21-270]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
60.84
31%
-98
- C1 -
3ACK
2
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
60.83
31%
-99
- C1 -
2OF2
1
LCK_HUMAN
A:
[21-270]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
60.82
31%
-101
- C1 -
3BYM
1
LCK_HUMAN
A:
[22-271]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
E
G
A
K
-
F
P
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
60.76
31%
-102
- C1 -
3ACJ
2
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
60.72
31%
-98
- C1 -
3AC1
3
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
60.51
31%
-107
- C1 -
1AD5
1
HCK_HUMAN
B:
[189-429]
---------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
T
Y
N
K
H
T
-
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------
G
-----
S
KQ
P
---
L
P
K
L
I
D
----------
F
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
--
R
V
G
A
K
F
---------------------
P
-
I
--
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
--------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
-
M
P
R
-----
P
E
N
C
--
P
-----
E
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
60.37
31%
-101
- C1 -
2OFV
1
?
B:
[26-274]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
---------
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
----------------
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
--------
I
Q
N
L
E
-
G
--
Y
R
M
V
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
60.31
31%
-103
- C1 -
3B2W
1
LCK_HUMAN
A:
[26-275]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
--
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
R
M
V
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
60.20
31%
-96
- C1 -
3AC8
1
LCK_HUMAN
A:
[27-276]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
60.13
31%
-83
- C1 -
4M69
1
RIPK3_MOUSE
A:
[31-311]
-------------------------
G
G
F
G
V
V
------
F
R
A
H
H
R
T
W
N
-
H
D
V
A
V
K
--------
I
V
N
S
K
K
I
S
W
E
V
K
A
M
V
N
L
-
R
N
E
N
V
L
L
L
L
G
V
T
-
E
D
L
Q
W
DFVS
G
Q
A
L
V
T
R
F
M
E
N
G
S
L
---
A
G
L
L
Q
P
E
---------
C
--------
P
-----
R
--
P
---
W
P
L
L
C
R
----------
L
L
Q
--------
E
V
V
--------
L
G
M
C
Y
L
H
S
L
D
PP
L
L
H
R
D
L
K
P
S
N
I
L
L
D
P
E
L
H
A
K
L
A
D
F
G
L
S
T
F
Q
--------------
D
-------
S
G
G
-
T
-
L
--
A
Y
L
D
P
E
L
L
F
K
V
N
L
K
A
S
K
A
S
------
D
V
Y
S
F
G
I
L
V
W
A
V
L
A
-
G
-
R
E
-
A
E
LVDKTSL
I
R
E
T
V
C
D
R
Q
----------
S
---
R
-
P
P
L
T
E
--
L
P
P
G
S
--
P
E
T
P
G
L
E
K
L
------
K
E
L
M
I
H
C
W
G
S
Q
S
E
N
R
P
S
F
Q
D
C
E
P
K
T
N
E
V
Y
-
N
L
V
K
D
K
V
D
A
A
V
S
E
V
K
H
Y
L
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
59.34
31%
-78
- C1 -
3NW5
1
A:
[23-306]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
---------
M
--------
E
N
N
P
V
L
A
--
P
---
P
S
L
S
K
M
----------
I
Q
M
A
G
------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
-
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.17
31%
-95
- C1 -
3KXZ
1
LCK_HUMAN
A:
[29-278]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
--------
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
58.79
31%
-78
- C1 -
3NW7
1
A:
[23-306]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
---------
M
--------
E
N
N
P
V
L
A
--
P
---
P
S
L
S
K
M
----------
I
Q
M
A
G
------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
----
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
58.71
31%
-92
- C1 -
3MPM
2
LCK_HUMAN
A:
[17-264]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
----
F
P
------
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
---
R
-
M
V
R
P
D
-----
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
58.32
31%
-76
- C1 -
3NW6
1
A:
[23-306]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
---------
M
--------
E
NNPVL
A
--
P
---
P
S
L
S
K
M
----------
I
Q
M
A
G
------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
-
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
57.40
31%
-76
- C1 -
1JQH
1
IGF1R_HUMAN
B:
[24-307]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----------------------------
P
---
P
S
L
S
K
M
----------
I
Q
M
A
G
------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
--------------------
Y
Y
R
K
G
G
K
G
-
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
56.99
31%
-93
- C1 -
4C3F
1
LCK_HUMAN
A:
[17-264]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
G
H
T
-
K
V
A
V
K
S
L
K
Q
G
S
-
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------
G
-----
I
--
K
---
L
T
I
N
K
L
----------
L
D
M
A
A
------
Q
I
A
--------
E
G
M
A
F
I
E
E
R
N
--
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
----
F
P
------
I
--
K
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
--------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
---
R
-
M
V
R
P
D
-----
N
C
--
P
-----
E
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
56.94
31%
-77
- C1 -
4D2R
1
A:
[18-301]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
---------
M
--------
E
N
N
P
V
L
A
--
P
---
P
S
L
S
K
M
----------
I
Q
M
A
G
------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
-
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
56.92
31%
-76
- C1 -
2OJ9
1
A:
[23-306]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
---------------------------
P
---
P
S
L
S
K
M
----------
I
Q
M
A
G
------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
-
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
56.77
32%
-100
- C1 -
2HK5
1
HCK_HUMAN
A:
[22-269]
---------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
T
Y
N
K
H
T
-
K
V
A
V
K
T
M
K
P
G
S
-
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------
G
-----
S
K
Q
P
---
L
P
K
L
I
D
----------
F
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
--------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
------
P
E
N
C
--
P
-----
E
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
56.48
31%
-80
- C1 -
3I81
1
A:
[23-306]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
------------------
E
N
N
P
V
L
A
--
P
---
P
S
L
S
K
M
----------
I
Q
M
A
G
------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
------
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
56.36
31%
-97
- C1 -
3A4O
1
LYN_HUMAN
X:
[21-271]
----------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
Y
Y
N
N
S
T
-
K
V
A
V
K
T
L
K
P
G
T
-
M
S
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
E
P
I
------
Y
I
I
T
E
Y
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------
G
----------------
G
K
----------
V
L
L
PKLIDFSA
Q
I
A
--------
E
G
M
A
Y
I
E
R
K
N
--
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
-----------------
E
G
A
K
----
F
-
P
-
I
--
K
W
T
A
P
E
A
I
N
--
F
G
C
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
-
K
I
-
P
--------
Y
P
G
R
-
T
N
A
D
V
M
T
A
L
S
Q
G
--
Y
---
R
M
P
R
V
E
N
------
C
--
P
-----
D
E
L
------
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
A
T
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
56.00
31%
-78
- C1 -
3LW0
3
IGF1R_HUMAN
A:
[20-303]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----------------------------
P
---
P
S
L
S
K
M
----------
I
Q
M
A
G
------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
----
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
55.52
31%
-78
- C1 -
3LW0
4
IGF1R_HUMAN
C:
[20-303]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
YEGVAK
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
KSY
L
R
S
L
R
P
----------------------------
P
---
P
S
L
S
K
M
----------
I
Q
M
AG------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
----
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
LL
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
55.49
31%
-80
- C1 -
3QQU
1
IGF1R_HUMAN
A:
[17-300]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-----------------------------
P
---
P
S
L
S
K
M
----------
I
Q
M
A
G
------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
-
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
55.36
33%
-99
- C1 -
4XCU
1
A:
[69-292]
-------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
RPPGSSEGP
L
--------
S
-----
F
--
P
---
V
L
V
S
------------
C
A
Y
--------
Q
V
A
--------
R
G
M
Q
Y
L
E
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
-
R
-
L
PV
K
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
--------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
--
R
P
P
H
C
--
P
-----
P
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
55.30
31%
-104
- C1 -
5D11
2
?
A:
[24-275]
--------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
T
W
N
G
T
T
-
R
V
A
I
K
T
L
K
P
G
----
T
M
S
------
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------
G
-----
K
--
Y
---
L
R
L
P
Q
L
----------
V
D
M
A
A
------
Q
I
A
--------
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
--------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
------
C
--
P
-----
E
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
55.10
31%
-103
- C1 -
3F3W
1
SRC_CHICK
B:
[24-275]
--------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
T
W
N
G
T
T
-
R
V
A
I
K
T
L
K
P
G
----
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------
G
-----
K
--
Y
---
L
R
L
P
Q
L
----------
V
D
M
A
A
------
Q
I
A
--------
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
--------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
------
C
--
P
-----
E
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
55.04
31%
-104
- C1 -
5D11
2
?
B:
[24-275]
--------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
T
W
N
G
T
T
-
R
V
A
I
K
T
L
-------------
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------
G
-----
K
--
Y
---
L
R
L
P
Q
L
----------
V
D
M
A
A
------
Q
I
A
--------
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------------F
P
-
I
--
K
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
--------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
------
C
--
P
-----
E
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
54.72
31%
-77
- C1 -
3LW0
3
D:
[20-303]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
YEGVAK
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
KSY
L
R
S
L
R
P
----------------------------
P
---
P
S
L
S
K
M
----------
I
Q
M
AG------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
----
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
LL
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
54.72
31%
-74
- C1 -
3QQU
1
IGF1R_HUMAN
B:
[17-300]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
---------------------------------
P
S
L
S
K
M
----------
I
Q
M
A
G
------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
-
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
54.61
32%
-99
- C1 -
4QQC
1
A:
[87-320]
-------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PPGP---------------------------------
L
S
F
--------
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------------------
L
PV
K
W
M
A
P
E
A
L
F
D
E
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
--------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
--
R
P
P
H
C
--
P
-----
P
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
54.60
31%
-78
- C1 -
3QQU
1
D:
[17-300]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
---------
M
---------L----
A
--
P
---
P
S
L
S
K
M
----------
I
Q
M
A
G
------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
-
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
54.52
31%
-77
- C1 -
3QQU
1
IGF1R_HUMAN
C:
[17-300]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
---------
M
---------VL---
A
--
P
---
P
S
L
S
K
M
----------
I
Q
M
A
G
------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
-
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
54.11
31%
-79
- C1 -
3LW0
4
IGF1R_HUMAN
B:
[20-303]
-------------------
S
R
E
L
G
Q
G
S
F
G
M
V
YEGVAK
G
V
V
K
D
E
P
E
T
-
R
V
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
KSY
L
R
S
L
R
P
----------------------------
P
---
P
S
L
S
K
M
----------
I
Q
M
AG------
E
I
A
--------
D
G
M
A
Y
L
N
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
----
L
-
L
PV
R
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
LL
D
---
K
-
P
D
--------
N
C
--
P
-----
D
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
54.04
31%
-95
- C1 -
3F3W
1
SRC_CHICK
A:
[24-275]
--------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
T
W
N
G
T
T
-
R
V
A
I
K
T
L
K
P
G
----
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------
G
-----
K
--
Y
---
L
R
L
P
Q
L
----------
V
D
M
A
A
------
Q
I
A
--------
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
--------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
------
C
--
P
-----
E
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
53.66
32%
-93
- C1 -
4R6V
1
A:
[87-320]
-------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
------
Y
V
I
L
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PPGP---------------------------------
L
S
F
--------
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
--------------------------------PV
K
W
M
A
P
E
A
L
F
D
E
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
--------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
--
R
P
P
H
C
--
P
-----
P
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
53.30
32%
-86
- C1 -
4QRC
1
A:
[87-320]
-------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PPGPDLSP
D
-----
G
--
P
---
R
S
S
E
G
P
----------
L
S
F
--------
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
-
R
-
L
PV
K
W
M
A
P
E
A
L
F
D
E
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
--------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
--
R
P
P
H
C
--
P
-----
P
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
52.37
32%
-90
- C1 -
4TYI
1
A:
[75-308]
-------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PP------------------------
P
----------
L
S
F
--------
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
G
----------------
L
PV
K
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
--------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
--
R
P
P
H
C
--
P
-----
P
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
52.33
32%
-95
- C1 -
4QQ5
1
A:
[87-320]
-------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
------
Y
V
I
L
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PPGP---------------------------------
L
S
F
--------
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------------------------
L
PV
K
W
M
A
P
E
A
L
F
D
E
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
--------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
--
R
P
P
H
C
--
P
-----
P
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
51.87
32%
-83
- C1 -
4UXQ
1
A:
[73-306]
-------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PPGP---------------------------------
L
S
F
--------
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
-
R
-
L
PV
K
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
--------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
--
R
P
P
H
C
--
P
-----
P
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
51.55
31%
-101
- C1 -
5D12
1
?
B:
[24-275]
--------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
T
W
N
G
T
T
-
R
V
A
I
K
T
L
-----------
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------
G
-----
K
--
Y
---
L
R
L
P
Q
L
----------
V
D
M
A
A
------
Q
I
A
--------
S
G
M
A
Y
V
E
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
--------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
------
C
--
P
-----
E
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
51.26
32%
-98
- C1 -
4TYJ
2
A:
[75-311]
-------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PP-----------------------------------
L
S
F
--------
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
-----------------
L
PV
K
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
--------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
--
R
P
P
H
C
--
P
-----
P
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
50.23
32%
-78
- C1 -
3ETA
1
INSR_HUMAN
A:
[23-278]
---------------------
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
-
R
V
A
V
K
T
V
N
E
S
A
-
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
---
K
S
Y
L
R
S
L
---------
R
--------
P
-----
E
--
A
---
E
N
N
P
G
R
PPPT
L
Q
E
M
I
Q
M
A
A
--------
E
I
A
--------
D
G
M
A
Y
L
N
A
K
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
-
K
G
-
L
-
L
PV
R
W
M
A
P
E
S
L
K
D
--
G
V
F
T
T
S
S
------
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
---
Q
-
P
D
--------
N
C
--
P
-----
E
R
V
------
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
49.74
32%
-78
- C1 -
3ETA
1
B:
[23-278]
---------------------
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
-
R
V
A
V
K
T
V
N
E
S
A
-
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
---
K
S
Y
L
R
S
L
---------
R
--------
P
-----
E
--
A
---
E
N
N
P
G
R
PPPT
L
Q
E
M
I
Q
M
A
A
--------
E
I
A
--------
D
G
M
A
Y
L
N
A
K
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
-
L
-
L
PV
R
W
M
A
P
E
S
L
K
D
--
G
V
F
T
T
S
S
------
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
-
A
E
Q
P
--------
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
---
Q
-
P
D
--------
N
C
--
P
-----
E
R
V
------
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------