@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RON_HUMAN: (2015-10-18 )
MELLPPLPQSFLLLLLLPAKPAAGEDWQCPRTPYAASRDFDVKYVVPSFSAGGLVQAMVTYEGDRNESAVFVAIRNRLHVLGPDLKSVQSLATGPAGDPGCQTCAACGPGPHGPPGDTDTKVLVLDPALPALVSCGSSLQGRCFLHDLEPQGTAVHLAAPACLFSAHHNRPDDCPDCVASPLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVALSVLPKHLVSYSIEYVHSFHTGAFVYFLTVQPASVTDDPSALHTRLARLSATEPELGDYRELVLDCRFAPKRRRRGAPEGGQPYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDGGPGVGPNSVVCAFPIDLLDTLIDEGVERCCESPVHPGLRRGLDFFQSPSFCPNPPGLEALSPNTSCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDNVTVAHMGTMDGRILQVELVRSLNYLLYVSNFSLGDSGQPVQRDVSRLGDHLLFASGDQVFQVPIQGPGCRHFLTCGRCLRAWHFMGCGWCGNMCGQQKECPGSWQQDHCPPKLTEFHPHSGPLRGSTRLTLCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVTNMPPGKHFRVDGTSVLRGFSFMEPVLIAVQPLFGPRAGGTCLTLEGQSLSVGTSRAVLVNGTECLLARVSEGQLLCATPPGATVASVPLSLQVGGAQVPGSWTFQYREDPVVLSISPNCGYINSHITICGQHLTSAWHLVLSFHDGLRAVESRCERQLPEQQLCRLPEYVVRDPQGWVAGNLSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEEHAIKFEYIGLGAVADCVGINVTVGGESCQHEFRGDMVVCPLPPSLQLGQDGAPLQVCVDGECHILGRVVRPGPDGVPQSTLLGILLPLLLLVAALATALVFSYWWRRKQLVLPPNLNDLASLDQTAGATPLPILYSGSDYRSGLALPAIDGLDSTTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLPATYMNLGPSTSHEMNVRPEQPQFSPMPGNVRRPRPLSEPPRPT
Atome Classification :
(48 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050..-....1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MELLPPL
P
Q
S
F
L
L
L
LLLPAKPAAGEDWQCPRTPYAASRD
F
D
V
K
Y
V
VPSFSAG
G
L
V
Q
A
M
V
T
YEGDRNE
S
A
V
F
V
A
I
RN
R
L
H
VLGP
D
L
K
S
V
Q
S
L
ATGPAGDPG
C
Q
T
CAACGPGPHGPPGDTD
T
K
V
L
V
LDPA
L
P
A
L
V
SCGSSLQG
R
C
F
L
H
DLEPQG
T
A
V
H
LA
A
P
A
C
L
F
S
AHHNRPDD
C
P
D
C
V
ASPLG
T
R
V
T
V
V
EQGQ
A
S
Y
F
Y
V
ASSL
D
A
A
V
AASFSPRS
V
S
I
R
R
L
KADASGFA
P
G
F
V
A
L
S
V
L
P
K
H
L
V
S
Y
S
I
E
Y
V
H
SFHT
G
A
F
V
Y
F
L
T
VQPASVTD
D
P
S
A
L
H
T
R
L
A
R
LSATEPELG
D
Y
R
E
L
V
L
DCRFA
P
K
R
RRRGAPEGGQP
Y
P
V
L
R
V
AHSAPVG
A
Q
L
A
T
E
L
SIAEG
Q
E
V
L
F
G
V
F
V
TGKDGGPGVGPN
S
V
V
C
A
F
P
I
D
L
L
D
T
L
I
D
E
G
V
E
R
C
C
ESPV
H
P
G
L
R
R
G
L
D
F
FQSPSFCPNPPGLEALSPNTSC
R
H
F
P
L
L
VSSSF
S
R
V
D
L
F
N
GLLG
P
V
Q
V
T
A
L
Y
V
T
RLD
N
V
T
V
A
H
MGTMD
G
R
I
L
Q
V
E
L
V
R
SLN
Y
L
L
Y
VSNFSLGDSGQ
P
V
Q
R
D
V
S
R
LGD
H
L
L
FASG
D
Q
V
F
Q
VPIQGPGC
R
H
F
L
T
C
G
R
C
L
R
A
W
HFMGCG
W
C
G
N
MCGQQKECPGSWQQDHCPPKLTEFHPHSGPLRGS
T
R
L
T
L
CGS
N
F
Y
LHPSGLVPEGT
H
Q
V
TVGQSPCRPLPKDSSKLRPV
P
R
K
D
F
V
E
E
F
E
CELEPLGTQAVGPT
N
V
S
L
T
V
TNMPPG
K
H
F
R
VD
G
T
S
V
L
RG
F
S
F
M
E
P
V
L
I
A
VQPLFGPRAG
G
T
C
L
T
LEGQSLSVGT
S
R
A
V
L
VNG
T
E
C
L
L
A
RVSEG
Q
L
L
C
ATPPGA
T
V
A
S
V
P
L
S
L
Q
VG
G
A
QVPG
S
W
T
F
Q
Y
RED
P
V
V
L
S
ISPNCGYIN
S
H
I
T
I
C
G
Q
H
L
T
S
A
W
H
L
V
L
S
FH
D
G
L
R
A
V
E
S
R
C
E
RQL
P
E
Q
Q
L
C
RL
P
E
Y
V
VRDPQGWVAGNLSARGDGAAGFTLPGFRFLPPPHPPSANLVPLKPEE
H
A
I
K
F
E
Y
I
GLG
A
V
A
D
C
V
G
I
N
V
T
VGGE
S
C
Q
H
E
FRG
D
M
V
VCPLPPSLQLGQDGA
P
L
Q
V
C
VDGEC
H
I
L
G
R
VVRPGPDGV
P
Q
S
T
L
L
G
I
L
L
P
L
L
L
L
V
A
A
L
A
T
A
L
V
F
S
Y
W
W
RR
K
Q
L
VLPPN
L
N
D
L
A
S
L
D
Q
TAGATP
L
P
I
L
YSGSDYRSGLALPAIDGLDST
T
C
VHGASFSDSEDE
S
C
V
P
L
L
R
KE-SIQL
R
D
L
D
S
A
L
L
A
E
V
K
D
V
LIPHERVVTHS
D
R
V
I
GKG
H
F
G
V
V
YH
G
E
Y
I
D
Q
A
Q
N
R
I
Q
C
A
I
K
S
L
S
R
I
T
E
M
Q
Q
V
E
A
F
L
RE
G
L
L
M
RGLNHPN
V
L
A
L
I
G
I
MLPPEGLP
H
V
L
L
P
Y
MC
H
G
D
L
L
Q
F
I
RSPQRNP
T
V
K
D
L
I
S
F
G
L
Q
V
A
R
S
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
RNCMLDES
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
D
R
E
Y
Y
S
V
Q
Q
HRHARL
P
V
K
W
M
A
L
E
S
L
Q
T
Y
R
FTTK
S
D
V
W
S
F
G
V
L
L
W
E
L
L
TRGAPPYRHI
D
P
F
D
L
T
H
F
L
AQGRRLPQPEYC
P
D
S
L
Y
Q
V
M
Q
Q
C
WEADPAV
R
P
T
F
R
V
L
V
G
E
V
E
Q
I
V
S
A
L
L
GDH
Y
V
QL
P
A
T
Y
MNLGPSTSHEMNVRPEQPQFSPMPGNVRRPRPLSEPPRPT
3
PsiBlast_PDB
67.46
99%
-120
- C2 -
3PLS
1
A:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
D
S
A
L
L
A
E
V
K
D
V
L
I
P
H
E
R
V
V
T
H
S
D
R
V
I
G
K
G
H
F
G
V
V
Y
H
G
E
Y
I
D
Q
A
Q
N
R
I
Q
C
A
I
K
S
L
S
R
I
T
E
M
Q
Q
V
E
A
F
L
R
E
G
L
L
M
R
G
L
N
H
P
N
V
L
A
L
I
G
I
M
L
P
P
E
G
L
P
H
V
L
L
P
Y
M
C
H
G
D
L
L
Q
F
I
R
S
P
Q
R
N
P
T
V
K
D
L
I
S
F
G
L
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
S
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
D
R
E
Y
Y
S
V
Q
Q
H
R
H
A
R
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
G
A
P
P
Y
R
H
I
D
P
F
D
L
T
H
F
L
A
Q
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
R
V
L
V
G
E
V
E
Q
I
V
S
A
L
L
G
D
H
Y
V
Q
L
P
-------------------------------------------
29
PsiBlast_CBE
66.71
61%
-122
- C2 -
4XMO
1
A:
[6-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
------
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
---------------------------------------------------
37
PsiBlast_CBE
66.58
61%
-121
- C2 -
3F66
4
MET_HUMAN
A:
[2-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-----
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
-----
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
-----------------------------------------------
28
PsiBlast_CBE
66.47
61%
-121
- C2 -
4XYF
1
A:
[6-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-----
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
31
PsiBlast_CBE
66.33
61%
-121
- C2 -
4DEH
1
A:
[6-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
------
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
40
PsiBlast_CBE
66.32
60%
-122
- C2 -
3RHK
1
MET_HUMAN
A:
[21-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
30
PsiBlast_CBE
65.98
61%
-122
- C2 -
4DEI
1
A:
[6-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
----
K
I
H
C
A
V
K
S
L
N
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
17
PsiBlast_PDB
65.66
61%
-128
- C2 -
2RFN
1
MET_HUMAN
A:
[11-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
----
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
-----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------------
32
PsiBlast_CBE
65.62
61%
-122
- C2 -
4DEG
1
A:
[6-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
------
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
---
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
46
PsiBlast_CBE
65.45
61%
-122
- C2 -
4AOI
1
A:
[4-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
----
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------------
27
PsiBlast_CBE
65.43
61%
-123
- C2 -
2RFN
1
B:
[10-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
----
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
-----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------------
35
PsiBlast_CBE
65.28
61%
-122
- C2 -
3I5N
1
A:
[6-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
-----
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
-----
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
33
PsiBlast_CBE
65.26
61%
-128
- C2 -
3U6I
1
A:
[6-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------------
34
PsiBlast_CBE
65.14
61%
-124
- C2 -
3U6H
1
A:
[6-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
---------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------------
26
PsiBlast_CBE
65.03
61%
-121
- C2 -
3EFJ
1
MET_HUMAN
A:
[8-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------------
19
PsiBlast_PDB
64.95
61%
-119
- C2 -
3CCN
1
A:
[9-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
------
K
I
H
C
A
V
K
S
L
N
R
-----
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
-
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
4
PsiBlast_PDB
64.94
59%
-124
- C2 -
3DKG
1
A:
[5-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
-
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
------
C
V
Y
H
G
T
L
L
D
---
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
-----------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
----------------------------------------
12
PsiBlast_PDB
64.78
59%
-121
- C2 -
3DKF
1
A:
[5-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
-
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-----
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
-------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
E
-----------------------------------
24
PsiBlast_CBE
64.61
61%
-120
- C2 -
3EFK
1
MET_HUMAN
A:
[8-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------------
16
PsiBlast_PDB
64.36
59%
-127
- C2 -
3QTI
1
MET_HUMAN
A:
[7-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
----
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
----------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
---
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------------
23
PsiBlast_CBE
64.30
61%
-121
- C2 -
3EFK
1
B:
[8-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
----
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------------
14
PsiBlast_PDB
64.27
59%
-121
- C2 -
1R0P
1
A:
[5-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
----
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
D
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------------
39
PsiBlast_CBE
64.02
60%
-124
- C2 -
3RHK
1
B:
[18-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Q
N
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------------
41
PsiBlast_CBE
63.69
60%
-123
- C2 -
4EEV
1
A:
[16-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
Q
N
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
-------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
20
PsiBlast_PDB
63.64
61%
-121
- C2 -
3CD8
1
A:
[8-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
------
K
I
H
C
A
V
K
S
L
N
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
-----
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
-
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
60
PsiBlast_CBE
63.62
61%
-119
- C2 -
4R1V
4
A:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
---------------------------------------------------
42
PsiBlast_CBE
63.39
60%
-119
- C2 -
4MXC
1
A:
[25-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
-----
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
10
PsiBlast_PDB
63.25
59%
-119
- C2 -
3L8V
1
A:
[8-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------------
38
PsiBlast_CBE
62.88
61%
-121
- C2 -
3LQ8
1
A:
[5-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
--
D
K
E
Y
Y
S
------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
---------------------------------------------------
36
PsiBlast_CBE
62.72
61%
-119
- C2 -
3F66
3
B:
[11-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
----
K
K
I
H
C
A
V
K
S
L
N
------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
---
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
-----------------------------------------------
59
PsiBlast_CBE
62.66
62%
-121
- C2 -
4KNB
3
MET_HUMAN
A:
[5-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-----
K
I
H
C
A
V
K
S
L
---
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------------
54
PsiBlast_CBE
62.63
61%
-119
- C2 -
4R1Y
3
A:
[8-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
------
I
H
C
A
V
K
S
L
N
--------
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
--
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
5
PsiBlast_PDB
62.40
59%
-123
- C2 -
3C1X
1
A:
[66-372]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------------
57
PsiBlast_CBE
62.26
62%
-119
- C2 -
4KNB
2
MET_HUMAN
C:
[3-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-------
I
H
C
A
V
K
S
L
N
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
--
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
18
PsiBlast_PDB
62.15
61%
-116
- C2 -
2RFS
1
A:
[21-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
------
K
I
H
C
A
V
K
S
L
N
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
--
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
25
PsiBlast_CBE
62.14
61%
-119
- C2 -
3EFJ
1
B:
[8-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
-----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
---------------------------------------------
9
PsiBlast_PDB
62.02
59%
-120
- C2 -
3F82
1
A:
[9-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-----
K
I
H
C
A
V
K
S
L
N
R
----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
-------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------------
55
PsiBlast_CBE
61.94
61%
-120
- C2 -
2WD1
3
A:
[1-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
---
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
22
PsiBlast_CBE
61.45
59%
-124
- C2 -
3QTI
2
B:
[12-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
----
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
----------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
----
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------------
58
PsiBlast_CBE
60.98
62%
-121
- C2 -
4KNB
2
MET_HUMAN
B:
[8-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
-----
K
I
H
C
A
V
K
S
------
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
-------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
13
PsiBlast_PDB
60.59
59%
-118
- C2 -
3A4P
3
A:
[22-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
---
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
----------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------------
11
PsiBlast_PDB
60.51
59%
-114
- C2 -
3DKC
1
A:
[6-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
D
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
E
G
----------------------------------
8
PsiBlast_PDB
59.88
59%
-118
- C2 -
3CE3
1
A:
[8-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------------
7
PsiBlast_PDB
59.07
59%
-117
- C2 -
3CTJ
1
A:
[7-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------------
43
PsiBlast_CBE
58.96
60%
-110
- C2 -
4GG7
1
A:
[37-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------------
56
PsiBlast_CBE
58.66
62%
-119
- C2 -
4KNB
1
D:
[5-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
G
K
K
I
H
C
A
V
K
S
L
----
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
-----------------
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
--------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
---
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--------------------------------------------------
6
PsiBlast_PDB
58.54
59%
-119
- C2 -
3CTH
1
A:
[7-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------------
44
PsiBlast_CBE
57.87
60%
-116
- C2 -
4GG5
1
A:
[37-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
K
K
I
H
C
A
V
K
S
L
N
R
I
T
D
I
----
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
---
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----------------------------------------------------