@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ROR1_HUMAN: (2015-10-18 )
MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIALLFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRYPNYMFPSQGITPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTGPPRVIQHCPPPKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGITVFGNKSQKPYKIDSKQASLLGDANIHGHTESMISAEL
Atome Classification :
(82 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480......--.490...--..----...--------.500-.......510.......520.......530.......540.......550.......560.......570.......580...--....590.....-----..600.......610.......620.---......630.......640.......650.---......660.......670.......680......-.690.......700...------....710........720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MHRPRRRGTRP
P
L
L
A
L
L
A
A
L
L
L
AARGAAAQE
T
E
L
S
V
S
A
E
L
V
PTSSWNISSELNKD
S
Y
L
T
LDE
P
M
N
N
I
T
T
SLGQ
T
A
E
L
H
C
K
VSGNPP
P
T
I
R
W
FKNDAPVVQEPRRLS
F
R
STIYG
S
R
L
R
I
R
NLDTTDT
G
Y
F
Q
C
VATN
G
K
E
V
VSST
G
V
L
F
V
KFGPPPTASPGYSDEYEEDGFCQ
P
Y
R
G
I
A
C
A
R
F
IGN
R
T
V
Y
M
E
S
LHMQG
E
I
EN
Q
I
T
A
A
F
T
M
IGTS
S
H
L
S
D
K
C
S
Q
F
A
I
P
S
L
C
H
Y
AFPYCDETSSVP
K
P
R
D
L
C
R
D
E
C
E
I
L
E
N
V
LCQ
T
E
Y
I
F
ARSN
P
M
I
L
M
R
LKLP
N
C
EDLPQPESPEAA
N
C
I
R
IGIPMADPINKNHKCYNSTGV
D
Y
R
G
T
V
S
V
TKSGRQCQPWNSQYPHT
H
T
F
T
A
L
RFPELNGG
H
S
Y
CRNPGNQKEA
P
W
C
F
TLDENF
K
S
DLCDIPACDSKDSKEKN
K
M
E
I
L
Y
I
LVPS
V
A
I
P
L
A
I
A
L
L
F
F
F
I
C
V
CRNNQKSSSAPVQRQPKHVRGQNV
E
M
S
M
L
N
AYKPKS
K
A
KEL
P
L
S
A
V
R
F
M
E
E
L
G
E
C
A
FGKIY--KG--
H
L
Y--LP----GMD--------H
A
Q
L
-
V
A
I
K
T
L
K
DYN
N
P
Q
Q
W
T
E
F
Q
Q
E
A
S
L
M
A
E
LHHP
N
I
V
C
L
LGAVTQEQ
P
V
C
M
L
F
E
YINQ
G
D
L
H
E
F
L
I
M
RSPHSDVGCSSDEDGTVKS--SLDHG
D
F
L
H
I
A
I
-----
Q
I
A
A
G
M
E
Y
L
S
S
H
F
F
V
H
KDLAARN
I
L
I---G
E
Q
L
H
V
K
I
SDLGLS
R
E
IYSA
D
Y
Y
R
VQSKSL---
L
P
I
RWMPP
E
A
I
M
Y
GKFSSDS
D
I
W
S
F
G
V
V
L
W
E
I
F
S
F-GLQPYYGF
S
N
Q
E
V
I
E
M
V
------
R
KRQL-LPCSEDC
P
P
R
M
Y
S
L
M
T
E
C
W
N
EIPSRRPRF
K
D
I
H
V
R
L
RSWEGLSSHTSSTTPSGGNA
T
T
Q
T
T
SLSASPVSNLSNPRYPNYMFPSQGITPQG
Q
I
A
GFIGPPIPQN
Q
R
F
I
PIN
G
Y
PIPP
G
Y
AAFPAAHYQPTGPP
R
V
I
QHCPPPKSRSPSSASGSTSTG
H
V
TSLPSSGSNQEANIPLLPHMSIPNHPGG
M
G
I
T
V
FGNKSQK
P
Y
KIDS
K
Q
A
S
LLGDANIHGH
T
E
S
M
ISAEL
94
PsiBlast_CBE
82.90
38%
-121
- C2 -
4KAB
1
FAK1_HUMAN
A:
[5-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
--
Q
G
---
I
Y
--
M
S
----
P
----------
P
A
L
A
-
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
----------------
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
-----
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
C
V
K
L
G
D
F
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
------
E
N
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
82.75
38%
-111
- C2 -
4K8A
1
B:
[7-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
--
Q
G
---
I
Y
--
M
S
----
P
E
N
--------
P
A
L
A
-
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
----------------
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
-----
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
------
E
N
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
82.32
38%
-122
- C2 -
4GU9
1
FAK1_HUMAN
A:
[7-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
--
Q
G
---
I
Y
--
M
S
----
P
----------
P
A
L
A
-
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
----------------
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
-----
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
C
V
K
L
G
D
F
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
------
E
N
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.14
47%
-108
- C2 -
4AT3
1
A:
[20-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
--
L
A
--
E
C
Y
NL
C
----------------
K
I
-
L
-
V
A
V
K
T
L
--
A
S
D
N
A
R
-
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
------
N
P
P
T
--
E
L
T
Q
S
Q
M
L
H
I
A
Q
-----
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
---
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
------
T
Q
G
R
V
-
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
82.00
38%
-114
- C2 -
4KAB
1
B:
[7-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
--
Q
G
---
I
Y
--
M
S
----
P
E
---------
P
A
L
A
-
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
----------------
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
-----
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
------
E
N
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
81.95
37%
-117
- C2 -
5BVW
1
?
A:
[15-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
--
L
C
--
E
V
D
--
S
----------------
H
P
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
-------------P-
T
I
S
Y
P
M
L
L
H
V
A
A
-----
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
----
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
---
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
81.53
37%
-112
- C2 -
5BVN
1
?
A:
[15-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
--
L
C
--
E
V
D
--
S
----------------
H
P
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
-------------P-
T
I
S
Y
P
M
L
L
H
V
A
A
-----
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
---
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
80.95
37%
-105
- C2 -
4BKJ
10
B:
[6-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
--
L
C
--
E
V
D
--
S
P
QDLV
S
L
D
FPLNVRKG
H
P
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
-------------G
P
T
I
S
Y
P
M
L
L
H
V
A
A
-----
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
----
R
A
V
---
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
80.81
47%
-109
- C2 -
4AT4
1
A:
[20-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
--
L
A
--
E
C
Y
NL
C
----------------
K
I
-
L
-
V
A
V
K
T
L
K
D
A
S
D
N
A
R
-
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
-------
P
P
T
--
E
L
T
Q
S
Q
M
L
H
I
A
Q
-----
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
---
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
------
T
Q
G
R
V
-
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
80.71
38%
-115
- C2 -
4K8A
1
FAK1_HUMAN
A:
[7-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
--
Q
G
---
I
Y
--
M
S
----
P
----------
P
A
L
A
-
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
----------------
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
-----
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
C
V
K
L
G
D
F
G
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
------
E
N
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.54
47%
-109
- C2 -
4AT5
2
A:
[20-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
--
L
A
--
E
C
Y
NL-----------------
K
I
-
L
-
V
A
V
K
T
L
K
D
A
S
D
N
A
R
-
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
----
E
G
N
P
P
T
--
E
L
T
Q
S
Q
M
L
H
I
A
Q
-----
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
---
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
------
T
Q
G
R
V
-
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
80.24
38%
-115
- C2 -
2J0J
1
FAK1_CHICK
A:
[380-646]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
--
Q
G
---
I
Y
--
M
S
----
P
E
N
--------
P
A
M
A
-
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
----------------
K
F
--
S
L
D
L
A
S
L
I
L
Y
A
Y
-----
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
------
E
N
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
80.24
37%
-106
- C2 -
4BKJ
10
DDR1_HUMAN
A:
[6-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
--
L
C
--
E
V
D
--
S
P
QDLV
S
L
D
FPLNVRKG
H
P
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
--------------P-
T
I
S
Y
P
M
L
L
H
V
A
A
-----
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
----
R
A
V
---
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
80.20
37%
-111
- C2 -
5BVK
1
?
A:
[15-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
--
L
C
--
E
V
D
--
S
----------------
H
P
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
-------------P-
T
I
S
Y
P
M
L
L
H
V
A
A
-----
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
---
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
80.16
39%
-112
- C2 -
2OJ9
1
A:
[14-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-----------------
P
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
79.88
39%
-110
- C2 -
3NW5
1
A:
[14-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
-------
E
N
N
P
V
L
A
--
P
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
79.85
38%
-112
- C2 -
2J0K
1
FAK1_CHICK
B:
[380-646]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
--
Q
G
---
I
Y
--
M
S
----
P
E
N
--------
P
A
M
A
-
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
----------------
K
F
--
S
L
D
L
A
S
L
I
L
Y
A
Y
-----
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
------
E
N
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
79.77
38%
-116
- C2 -
4GU9
1
B:
[8-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
--
Q
G
---
I
Y
--
M
S
----
P
----------
P
A
L
A
-
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
----------------
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
-----
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
------
E
N
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
79.49
39%
-109
- C2 -
3NW6
1
A:
[14-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
-------
E
N
N
P
V
L
A
--
P
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
79.36
39%
-112
- C2 -
3I81
1
A:
[14-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
--------
E
N
N
P
V
L
A
--
P
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
-----
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
79.18
39%
-109
- C2 -
4FNY
1
A:
[23-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
--
E
G
--
Q
V
S
G-------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
------
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
----------------
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
78.92
40%
-108
- C2 -
2X9F
1
A:
[11-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
--
R
G
--
R
L
K
--
A
P
----
G
K
K
--------
E
S
-
C
-
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----------------------
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
-------------GGK
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
------
E
Q
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
78.91
40%
-112
- C2 -
2YN8
1
B:
[13-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
--
R
G
--
R
L
K
--
A
P
----
G
K
K
--------
E
S
-
C
-
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----------------------
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
------
E
Q
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
78.68
40%
-115
- C2 -
4EBV
3
A:
[46-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
--
Q
G
---
I
Y
--
M
S
----
P
E
N
--------
P
A
L
A
-
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
----------------
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
-----
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
C
V
K
L
G
D
F
G
L
----------------
K
---
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
------
E
N
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
78.48
40%
-108
- C2 -
2VWX
1
A:
[11-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
--
R
G
--
R
L
K
--
A
P
----
G
K
K
--------
E
S
-
C
-
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----------------------
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
S
D
-------GGK
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
------
E
Q
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
78.32
37%
-104
- C2 -
3ZOS
4
DDR1_HUMAN
A:
[6-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
--
L
C
--
E
V
D
--
S
P
QDLV
S
L
D
FP
L
N
V
R
KG
H
P
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
-----------
A
A
Q
G
P
T
I
S
Y
P
M
L
L
H
V
A
A
-----
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
---
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
78.27
39%
-114
- C2 -
4DCE
1
B:
[29-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
----
E
V
Y
--
E
G
--
Q
V
S
-------------------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
---------------
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
78.27
46%
-110
- C2 -
4AOJ
1
NTRK1_HUMAN
B:
[48-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
--
L
P
----------------
K
M
L
-
V
A
V
K
A
L
K
E
A
S
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
--
R
S
H
G
P
D
------------
G
--
P
L
G
L
G
Q
L
L
A
V
A
S
-----
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
----------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
------
T
Q
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
78.15
37%
-102
- C2 -
3ZOS
3
B:
[6-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
--
L
C
--
E
V
D
--
S
P
QDLV
S
L
D
FPLNVRKG
H
P
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
------------
Q
G
P
T
I
S
Y
P
M
L
L
H
V
A
A
-----
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
---
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
78.00
40%
-111
- C2 -
2YN8
1
EPHB4_HUMAN
A:
[14-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
--
R
G
--
R
L
K
-------------------
E
S
-
C
-
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----------------------
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
V
C
K
V
S
D
F
-----------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
------
E
Q
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
77.97
40%
-109
- C2 -
4AW5
1
A:
[8-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
--
R
G
--
R
L
K
--
A
P
----
G
K
K
--------
E
S
-
C
-
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----------------------
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
V
C
K
V
S
D
F
G
---------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
------
E
Q
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
77.81
40%
-106
- C2 -
2VX1
1
A:
[11-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
--
R
G
--
R
L
K
--
A
P
----
G
K
K
--------
E
S
-
C
-
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----------------------
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
S
D
-------GGK
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
------
E
Q
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.78
46%
-102
- C2 -
4PMP
1
A:
[15-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
--
H
N
L
--
L
----------------
K
-
M
L
-
V
A
V
K
A
L
K
----
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
--
R
S
H
G
P
D
A
K
L
L
A
G
G
E
D
V
A
P
G
--
P
L
G
L
G
Q
L
L
A
V
A
S
-----
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
I
Y
S
T
D
Y
Y
R
V
G
--
T
M
---
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
------
T
Q
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
77.73
39%
-109
- C2 -
3QQU
1
IGF1R_HUMAN
B:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
--------------------
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
77.65
39%
-110
- C2 -
3NW7
1
A:
[14-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
-------
E
N
N
P
V
L
A
--
P
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
77.29
40%
-104
- C2 -
2VX0
1
A:
[11-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
--
R
G
--
R
L
K
--
A
P
----
G
K
K
--------
E
S
-
C
-
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----------------------
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
S
D
-------GK-
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
------
E
Q
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
77.26
46%
-110
- C2 -
4AOJ
1
NTRK1_HUMAN
A:
[48-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
--
L
P
----------------
K
M
L
-
V
A
V
K
A
L
K
E
A
S
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
--
R
S
H
G
P
D
-----------
P
G
--
P
L
G
L
G
Q
L
L
A
V
A
S
-----
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
----------------
T
M
---
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
------
T
Q
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
77.23
40%
-104
- C2 -
2VWY
1
A:
[11-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
--
R
G
--
R
L
K
--
A
P
----
G
K
K
--------
E
S
-
C
-
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----------------------
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
S
D
-------GGK
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
------
E
Q
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.20
46%
-100
- C2 -
4YNE
2
A:
[22-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
--
L
P
------
D
---------
K
M
L
-
V
A
V
K
A
L
K
E
-----
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
--
R
S
H
G
P
D
A
K
L
L
A
G
G
E
D
V
A
P
G
--
P
L
G
L
G
Q
L
L
A
V
A
S
-----
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
-----
T
D
Y
Y
----
R
T
M
---
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
------
T
Q
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
Y
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
77.16
40%
-105
- C2 -
2XVD
1
A:
[10-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
--
R
G
--
R
L
K
--
A
P
----
G
K
K
--------
E
S
-
C
-
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----------------------
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
---------
S
S
L
GGK
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
------
E
Q
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
77.10
39%
-109
- C2 -
4CNH
2
B:
[22-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
--
Q
V
S
--------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
-------------
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
Y
-----
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
77.04
38%
-106
- C2 -
4K9Y
1
A:
[8-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
--
Q
G
---
I
Y
--
M
S
----
P
E
N
--------
P
A
L
A
-
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
----------------
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
-----
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
S
T
Y
Y
K
A
-
S
K
G
K
---
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
------
E
N
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
77.04
40%
-108
- C2 -
4BB4
1
A:
[10-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
--
R
G
--
R
L
K
--
A
P
----
G
K
K
--------
E
S
-
C
-
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----------------------
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
--------------GK-
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
------
E
Q
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
76.96
40%
-103
- C2 -
2VWZ
1
A:
[11-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
--
R
G
--
R
L
K
--
A
P
----
G
K
K
--------
E
S
-
C
-
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----------------------
R
L
N
D
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
S
D
-------GGK
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
------
E
Q
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
76.93
39%
-109
- C2 -
1JQH
1
IGF1R_HUMAN
B:
[15-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------
Y
Y
R
K
G
G
K
G
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
76.90
39%
-113
- C2 -
3LW0
3
IGF1R_HUMAN
C:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
76.74
39%
-107
- C2 -
2XB7
1
A:
[14-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
--
Q
V
S
--------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
--------------
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
76.67
39%
-112
- C2 -
3QQU
1
IGF1R_HUMAN
A:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-------------------
P
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
76.60
40%
-104
- C2 -
4CSV
1
?
A:
[7-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
--
E
G
--
K
W
----------
R
N
--------
Y
N
I
E
-
V
A
V
K
T
L
K
E
G
T
M
S
V
E
--
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
------------
R
D
C
---------
V
N
A
Q
A
L
L
D
M
A
A
-----
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
N
V
V
K
V
A
D
F
G
---------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
------
E
R
G
Y
R
-
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
76.51
46%
-108
- C2 -
4AOJ
1
C:
[48-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
--
L
P
-----
Q
D
---------
K
M
L
-
V
A
V
K
A
L
K
E
A
S
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
--
R
S
H
G
P
D
------------
G
--
P
L
G
L
G
Q
L
L
A
V
A
S
-----
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
----------------
M
---
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
------
T
Q
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
76.43
40%
-119
- C2 -
4EBW
1
A:
[46-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
--
Q
G
---
I
Y
--
M
S
------
N
--------
P
A
L
A
-
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
----------------
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
-----
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
C
V
K
L
G
D
F
G
L
----------------
K
---
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
------
E
N
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
76.21
39%
-112
- C2 -
3LW0
3
IGF1R_HUMAN
B:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
76.19
39%
-114
- C2 -
3LW0
2
IGF1R_HUMAN
A:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.00
46%
-106
- C2 -
4PMT
1
A:
[15-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
--
H
N
L
----------
D
--------
K
-
M
L
-
V
A
V
K
A
L
----------
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
--
R
S
H
G
P
D
A
K
L
L
A
G
G
E
D
V
A
P
G
--
P
L
G
L
G
Q
L
L
A
V
A
S
-----
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
--
S
R
D
I
Y
S
T
D
Y
Y
R
V
---
T
M
---
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
------
T
Q
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
75.34
39%
-109
- C2 -
4FNZ
1
A:
[23-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
--
E
G
--
Q
V
S
G------------------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
---------------
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
75.31
39%
-111
- C2 -
3LW0
2
D:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------
P
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
75.25
39%
-111
- C2 -
3QQU
1
D:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
------------
L
A
--
P
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
75.13
39%
-106
- C2 -
3QQU
1
IGF1R_HUMAN
C:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
--
V
A
K
--
G
V
----
V
K
D
--------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
-----------
V
L
A
--
P
P
S
L
S
K
M
I
Q
M
A
G
-----
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
------
M
E
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
74.61
39%
-106
- C2 -
4FOB
1
A:
[49-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
--
Q
V
S
-------------------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
-------------
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
------
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
74.47
39%
-102
- C2 -
4CCU
1
A:
[22-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
--
E
G
--
Q
V
---------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
74.21
39%
-108
- C2 -
4CNH
1
ALK_HUMAN
A:
[22-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
------
E
V
Y
--
E
G
--
Q
V
S
--------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.12
46%
-97
- C2 -
4YPS
1
A:
[22-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
---
G
K
V
F
--
L
A
E
C
H
N
L
--
L
-------
D
---------
K
M
L
-
V
A
V
K
A
L
---
S
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
--
R
S
H
G
P
D
A
K
L
L
A
G
G
E
D
V
A
P
G
--
P
L
G
L
G
Q
L
L
A
V
A
S
-----
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
--
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
---
T
M
---
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
------
T
Q
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
73.86
39%
-104
- C2 -
4CTC
1
A:
[22-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
--
E
G
--
Q
V
---------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--------
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
73.69
39%
-107
- C2 -
4DCE
1
ALK_HUMAN
A:
[29-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
--
E
G
--
Q
V
S
----------
P
--------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
--------------
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
73.47
39%
-105
- C2 -
4FOD
2
A:
[29-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
--
Q
V
S
-------------------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
P
L
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
73.44
39%
-102
- C2 -
4MKC
3
A:
[63-340]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
--
Q
V
S
-------------------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
73.07
39%
-100
- C2 -
3LCS
3
A:
[40-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
--
Q
V
S
G-
M
P
----
N
D
P
--------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
72.92
39%
-108
- C2 -
4FOC
1
A:
[49-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
--
Q
V
S
-------------------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
72.91
39%
-103
- C2 -
3AOX
5
A:
[39-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
--
E
G
--
Q
V
S
--------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
72.79
39%
-105
- C2 -
2YFX
1
A:
[22-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
--
A
F
G
E
V
Y
--
E
G
--
Q
V
---------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
72.67
38%
-100
- C2 -
4ANS
1
A:
[24-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
--
A
F
G
E
V
Y
--
E
G
--
Q
V
---------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
72.63
38%
-99
- C2 -
4ANQ
1
A:
[24-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
--
A
F
G
E
V
Y
--
E
G
--
Q
V
---------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
72.53
39%
-107
- C2 -
4CTB
1
A:
[22-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
---
F
G
E
V
Y
--
E
G
--
Q
V
---------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
72.46
39%
-113
- C2 -
2XBA
1
A:
[14-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
-------
V
Y
--
E
G
--
Q
V
S
--------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
----------
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
72.16
39%
-104
- C2 -
4CMO
1
A:
[22-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
--
Q
V
---------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
71.93
39%
-103
- C2 -
4CLI
1
A:
[22-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
--
Q
V
---------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
71.88
39%
-103
- C2 -
4CLJ
1
A:
[22-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
--
Q
V
S
--------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
71.28
40%
-100
- C2 -
4UEU
1
?
A:
[7-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
--
E
G
--
K
W
----------
R
N
--------
Y
N
I
E
-
V
A
V
K
T
L
K
E
G
T
M
S
V
E
--
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
------------
R
D
C
E
G
---
H
--
T
V
N
A
Q
A
L
L
D
M
A
A
-----
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-----------
A
K
---
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
------
E
R
G
Y
R
-
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
71.21
39%
-104
- C2 -
4CMU
1
A:
[22-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
--
Q
V
---------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
70.75
38%
-99
- C2 -
4CD0
1
A:
[25-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
--
Q
V
S
--------------------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
70.51
39%
-99
- C2 -
3LCT
3
A:
[40-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
--
Q
V
S
G-
M
P
----
N
D
P
--------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
----------
S
Q
P
S
--
S
L
A
M
L
D
L
L
H
V
A
R
-----
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
---
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
------
T
S
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
63.55
45%
-73
- C2 -
4YMJ
4
NTRK3_HUMAN
A:
[22-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
--
L
A
--
E
C
Y
N-
L
S
----
P
T
K
--------
D
K
M
L
-
V
A
V
K
A
L
K
D
P
T
L
A
A
R
-
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
---------------
G
--
E
L
G
L
S
Q
M
L
H
I
A
S
-----
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
L
L
V
K
I
G
D
F
G
---
D
V
Y
S
T
D
Y
Y
R
---
H
T
M
---
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
Q
P
W
F
Q
L
S
N
T
E
V
I
E
C
I
------
T
Q
G
R
V
-
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------